DEFB103B Gene
protein-coding GIFtS: 47
GCID: GC08M007277
|
|
defensin, beta 103B
| |
Aliases
for DEFB103B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Defensin, Beta 103B1 2 | | DEFB1032 3 | | DEFB32 3 5 | | HBP32 5 | | HBD32 3 5 | | Beta-Defensin 1032 | | Beta-Defensin 32 3 | | BD33 | | Defensin, Beta 1032 3 | | DEFB-33 | | Defensin-Like Protein2 3 | | HBD-31 | | BD-32 3 | | DEFB103A5 |
Export aliases for DEFB103B gene to outside databasesPrevious GC identifers: GC08U900480 GC08P007779 GC08M006934 |
Summaries
for DEFB103B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DEFB103B:
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family arehighly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobialactivity and may play an important role in innate epithelial defense. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: D103A_HUMAN, P81534Function: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negativebacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistantE.faecium. No significant hemolytic activity was observed
Gene Wiki entry for DEFB103B (DEFB103A)
|
Genomic Views
for DEFB103B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEFB103B gene promoter:
FOXI1 C/EBPbeta IRF-2 STAT1 p300 FOXD3 AP-4 IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEFB103B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFB103B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1DEFB103B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M007277: view genomic region
(about GC identifiers)
Start:
|
7,286,410 bp from pter |
End:
|
7,287,870 bp from pter |
Size:
|
1,461 bases |
Orientation:
|
minus strand |
|
Proteins
for DEFB103B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: D103A_HUMAN, P81534 (See
protein sequence)Recommended Name: Beta-defensin 103 precursor Size: 67 amino acids; 7697 Da
Subcellular location: Secreted
Mass spectrometry: Mass=5154.59; Method=Electrospray; Range=23-67; Source=PubMed:11085990;
1 PDB 3D structure from  and Proteopedia  for DEFB103B:1KJ6 (3D)
Secondary accessions: Q8NFG6 Q9NPF6Explore the universe of human proteins at neXtProt for DEFB103B: NX_P81534
DEFB103B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061131.1
ENSEMBL proteins: ENSP00000324633 Reactome Protein details: P81534
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
-- | -- | | GO:0005796 | Golgi lumen |
-- | -- |
DEFB103B for ontologies About GeneDecksing
DEFB103B Antibody Products:
Assay Products for DEFB103B: |
Protein
Domains /
Families
for DEFB103B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEFB103B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P81534ProtoNet protein and cluster: P81534 1 Blocks protein family: IPB001855 Beta defensin
UniProtKB/Swiss-Prot: D103A_HUMAN, P81534Similarity: Belongs to the beta-defensin family |
Function
for DEFB103B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: D103A_HUMAN, P81534Function: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negativebacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistantE.faecium. No significant hemolytic activity was observedInduction: By bacterial infection and by IFNG/IFN-gamma
Clone
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|
Pathways & Interactions
for DEFB103B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Beta defensins | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 
Reactome Pathways for DEFB103B (see all 6)
DEFB103B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEFB103B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DEFB103B (P815343 ENSP000003246334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006965 | positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria |
-- | -- | | GO:0042742 | defense response to bacterium |
-- | -- | | GO:0045087 | innate immune response |
-- | -- |
DEFB103B for ontologies About GeneDecksing
|
Drugs & Compounds
for DEFB103B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DEFB103B for compounds About GeneDecksing
 Browse Tocris compounds for DEFB103B
8 Novoseek chemical compound relationships for DEFB103B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hbd2 |
96.8 |
69 |
18806299 (5), 18492183 (4), 12819054 (4), 19554343 (4) (see all 28) |
| alpha-aminobutyric acid |
54.9 |
1 |
12840147 (1) |
| cysteine |
22.7 |
14 |
18180295 (1), 16008365 (1), 19480463 (1), 19108000 (1) |
| anti-fungal |
15.7 |
3 |
18809937 (1), 20337925 (1), 16377704 (1) |
| steroid |
0 |
1 |
12892899 (1) |
| calcium |
0 |
5 |
14714554 (3), 18492183 (1), 17230440 (1) |
| progesterone |
0 |
1 |
12892899 (1) |
| dexamethasone |
0 |
2 |
11162549 (2) |
Search CenterWatch for drugs/clinical trials and news about DEFB103B / D103A
|
Transcripts
for DEFB103B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEFB103B gene: NM_018661.3 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000318124(uc003wrf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFB103B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFB103B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DEFB103B (NM_018661) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEFB103B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFB103B |
8 AceView cDNA sequences: AF301470 AF217245 AF295370 AB037972 NM_018661 AF516673 AJ237673 BQ354967
GeneLoc Exon Structure
|
Expression
for DEFB103B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEFB103B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DEFB103B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEFB103B
UniProtKB/Swiss-Prot: D103A_HUMAN, P81534Tissue specificity: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus,adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. Noexpression in small intestine
SABiosciences Custom PCR Arrays for DEFB103B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEFB103B
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for DEFB103B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DEFB103B (if available)
TreeFam Gene Tree for DEFB103B (if available) |
Paralogs
for DEFB103B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DEFB103B gene
- DEFB103A1 2
5 SIMAP similar genes for DEFB103B using alignment to 1 protein entry: D103A_HUMAN:DEFB103A DEFB4A DEFB4B DEFB130 DEFB130L
DEFB103B for paralogs About GeneDecksing
|
Genomic Variants
for DEFB103B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEFB103B (7286410 - 7287870 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 35 variations for DEFB103B
15/27 CNVs (see all 27): 70259 0734 8593 2117 34519 34453 70271 31424 7702 9081 52607 52617 0733 0296 32996
8 Inversions: 37309 37307 37308 37304 37305 37306 37310 37303 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DEFB103B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DEFB103B for disorders About GeneDecksing
OMIM gene information: 606611
OMIM disorders: --
20/38  diseases for DEFB103B (see all 38): About MalaCardsmiddle ear cholesteatoma localized scleroderma mycosis fungoides lichen planus
candidiasis oral squamous cell carcinoma cystic fibrosis oral candidiasis
squamous cell carcinoma cholesteatoma esophageal candidiasis atopic dermatitis
periodontal disease skin disease ulcerative colitis scleroderma
chorioamnionitis dermatitis periodontitis leukoplakia
10/14 Novoseek disease relationships for DEFB103B gene (see all 14) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bacterial infections |
44 |
4 |
19372483 (1), 12819054 (1), 15729370 (1) |
| dermatitis atopic |
38.8 |
1 |
18538383 (1) |
| skin diseases |
33.8 |
1 |
18620136 (1) |
| necrosis |
29.3 |
7 |
11702237 (1), 15270856 (1), 12902844 (1), 11085990 (1) (see all 6) |
| inflammation |
21.8 |
5 |
15270856 (1), 19372483 (1), 20104491 (1), 14688115 (1) (see all 5) |
| colitis |
18.3 |
2 |
15270856 (1), 18810765 (1) |
| infectious disease |
13.8 |
2 |
19664560 (1), 15729370 (1) |
| respiratory tract infections |
2.11 |
3 |
16452577 (1), 17184289 (1), 19650994 (1) |
| colitis ulcerative |
2.08 |
3 |
15270856 (2), 17387677 (1) |
| inflammatory bowel diseases |
0 |
1 |
15270856 (1) |
Human Genome Epidemiology (HuGE) Navigator: DEFB103B (0 documents)
Export disorders for DEFB103B gene to outside databases
|
Publications
for DEFB103B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEFB103B gene, integrated from 9 sources (see all 202):
(articles sorted by number of sources associating them with DEFB103B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. (PubMed id 11085990)1, 2, 9 Harder J....Schroder J.M. (2001)
- The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. (PubMed id 11741980)1, 2, 9 Schibli D.J.... Vogel H.J. (2002)
- Identification of a novel, multifunctional beta-defensin (human beta- defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. (PubMed id 11702237)1, 2, 9 Conejo-Garcia J.-R.... Bals R. (2001)
- Discovery of new human beta-defensins using a genomics-based approach. (PubMed id 11223260)1, 2, 9 Jia H.P....McCray P.B. Jr. (2001)
- Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3. (PubMed id 18925411)1, 9 Varoga D....Pufe T. (2009)
- Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors. (PubMed id 15934078)1, 9 Varoga D....Paulsen F. (2005)
- Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. (PubMed id 16954397)1, 9 Menzies B.E. and Kenoyer A. (2006)
- Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. (PubMed id 20104491)1, 9 Semple F....Dorin J.R. (2010)
- Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. (PubMed id 20385753)1, 9 Sass V....Sahl H.G. (2010)
- Expression profile of human beta-defensin 3 in oral s quamous cell carcinoma. (PubMed id 19219676)1, 9 Kesting M.R....Steinstraesser L. (2009)
|
External Searches for DEFB103B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DEFB103B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEFB103B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEFB103B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEFB103B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DEFB103B gene:
Search GeneIP for patents involving DEFB103B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEFB103B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DEFB103B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEFB103B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEFB103B | | | OriGene Protein Over-expression Lysate for DEFB103B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DEFB103B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFB103B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFB103B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | |  |  |  | | | | Search ThermoFisher Antibodies for DEFB103B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFB103B |
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