Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DEFB103A Gene

protein-coding   GIFtS: 48
GCID: GC08P007739

Defensin, Beta 103A

(Previous names: defensin, beta 3)
(Previous symbols: DEFB3, DEFB103)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Defensin, Beta 103A1 2     BD-32 3
DEFB31 2 3 5     DEFB-32 3
DEFB1031 2 3     hBD-32 3
HBD32 3 5     HBP32 5
Defensin, Beta 31 2     HBP-32
Beta-Defensin 32 3     Beta-Defensin 1032
Defensin, Beta 1032 3     BD33
Defensin-Like Protein2 3     

External Ids:    HGNC: 159671   Entrez Gene: 4143252   Ensembl: ENSG000001767977   OMIM: 6066115   UniProtKB: P815343   

Export aliases for DEFB103A gene to outside databases

Previous GC identifers: GC08M007274 GC08P007778


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DEFB103A Gene:
DEFB103A (defensin, beta 103A) is a protein-coding gene. Diseases associated with DEFB103A include oral squamous cell carcinoma, and bacteremia. An important paralog of this gene is DEFB103B.

UniProtKB/Swiss-Prot: D103A_HUMAN, P81534
Function: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative
bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant
E.faecium. No significant hemolytic activity was observed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_077531.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the DEFB103A gene promoter:
         C/EBPbeta   STAT1   AP-1   p300   ATF-2   FOXD3   AP-4   IRF-2   c-Jun   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEFB103A promoter sequence
   Search Chromatin IP Primers for DEFB103A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFB103A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

DEFB103A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEFB103A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P007739:  view genomic region     (about GC identifiers)

Start:
7,738,726 bp from pter      End:
7,740,186 bp from pter
Size:
1,461 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: D103A_HUMAN, P81534 (See protein sequence)
Recommended Name: Beta-defensin 103 precursor  
Size: 67 amino acids; 7697 Da
Mass spectrometry: Mass=5154.59; Method=Electrospray; Range=23-67; Source=PubMed:11085990;
1 PDB 3D structure from and Proteopedia for DEFB103A:
1KJ6 (3D)    
Secondary accessions: Q8NFG6 Q9NPF6

Explore the universe of human proteins at neXtProt for DEFB103A: NX_P81534

Explore proteomics data for DEFB103A at MOPED


See DEFB103A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001075020.1  
ENSEMBL proteins: 
 ENSP00000320951  
Reactome Protein details: P81534

DEFB103A Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant DEFB103A Protein
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec
OriGene Custom Protein Services for DEFB103A
GenScript Purified and Recombinant Proteins for DEFB103A
Sino Biological Recombinant Protein for DEFB103A
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for DEFB103A
Browse Proteins at Cloud-Clone Corp.

DEFB103A Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of DEFB103A
Browse R&D Systems for Antibodies
OriGene Antibodies for DEFB103A
OriGene Custom Antibody Services for DEFB103A
Abcam antibodies for DEFB103A
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for DEFB103A
Search LSBio for Antibodies for DEFB103A

DEFB103A Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DEFB103A
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DEFB103A
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
DEFB: Defensins, beta

1 InterPro protein domain:
 IPR001855 Defensin_beta-typ

Graphical View of Domain Structure for InterPro Entry P81534

ProtoNet protein and cluster: P81534

1 Blocks protein domain: IPB001855 Beta defensin

UniProtKB/Swiss-Prot: D103A_HUMAN, P81534
Similarity: Belongs to the beta-defensin family


DEFB103A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: D103A_HUMAN, P81534
Function: Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative
bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant
E.faecium. No significant hemolytic activity was observed
Induction: By bacterial infection and by IFNG/IFN-gamma

Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Defb14):

 immune system 

DEFB103A for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEFB103A
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEFB103A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEFB103A
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEFB103A

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat DEFB103A using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DEFB103A
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DEFB103A
Predesigned siRNA for gene silencing in human, mouse, rat DEFB103A

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DEFB103A

Clone
Products:
     
OriGene clones in human, mouse for DEFB103A (see all 5)
OriGene ORF clones in mouse, rat for DEFB103A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DEFB103A (NM_001081551)
Sino Biological Human cDNA Clone for DEFB103A
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEFB103A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFB103A

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DEFB103A
Browse ESI BIO Cell Lines and PureStem Progenitors for DEFB103A 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFB103A


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
D103A_HUMAN, P81534: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
golgi apparatus4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005796Golgi lumen TAS--

DEFB103A for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for DEFB103A About    
See pathways by source

SuperPathContained pathways About
1Defensins
Defensins0.80
Beta defensins0.80

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Reactome Pathways for DEFB103A
    Defensins
Beta defensins



DEFB103A for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DEFB103A
Interactions:

    GeneGlobe Interaction Network for DEFB103A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for DEFB103A (P815343 ENSP000003209514) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CCR6P516843I2D: score=1 
DEFB103BENSP000003246334STRING: ENSP00000324633
About this table

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006952defense response ----
GO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria TAS11085990
GO:0042742defense response to bacterium IEA--
GO:0045087innate immune response TAS--

DEFB103A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DEFB103A (D103A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DEFB103A gene: 
NM_001081551.2  

Unigene Clusters for DEFB103A:

Defensin, beta 103A
Hs.283082 , Hs.637221
Unigene Representative Sequences: AF301470, NM_001081551
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000314357(uc003wsc.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DEFB103A using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DEFB103A
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DEFB103A
Predesigned siRNA for gene silencing in human, mouse, rat DEFB103A
Clone
Products:
     
OriGene clones in human, mouse for DEFB103A (see all 5)
OriGene ORF clones in mouse, rat for DEFB103A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DEFB103A (NM_001081551)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEFB103A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFB103A
Primer
Products:
    
Browse OriGene qPCR
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEFB103A
  QuantiTect SYBR Green Assays in human, mouse, rat DEFB103A
  QuantiFast Probe-based Assays in human, mouse, rat DEFB103A

Additional mRNA sequence: 

AB037972.1 AF295370.1 AF516673.1 AJ237673.1 AY785153.1 

2 DOTS entries:

DT.91698816  DT.120639826 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DEFB103A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACGAGAGTGT
DEFB103A Expression
About this image

DEFB103A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DEFB103A Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.283082 Hs.637221

UniProtKB/Swiss-Prot: D103A_HUMAN, P81534
Tissue specificity: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney,
thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and
larynx. No expression in small intestine

    Custom PCR Arrays for DEFB103A
Primer
Products:
Browse OriGene qPCR
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEFB103A
QuantiTect SYBR Green Assays in human, mouse, rat DEFB103A
QuantiFast Probe-based Assays in human, mouse, rat DEFB103A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFB103A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and mouse.

Orthologs for DEFB103A gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Defb145 defensin beta 14   --   8 (10.35 cM) 19194357 


ENSEMBL Gene Tree for DEFB103A (if available)
TreeFam Gene Tree for DEFB103A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for DEFB103A gene
DEFB103B1 2  
5 SIMAP similar genes for DEFB103A using alignment to 2 protein entries:     D103A_HUMAN (see all proteins):
DEFB103B    DEFB4A    DEFB4B    DEFB130    DEFB130L

DEFB103A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

10 SNPs for DEFB103A    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2021272941,2
--7738926(+) GCGTGA/GGGTGA 1 -- ut510--------
rs2013264181,2
--7738974(+) CTTTGC/GTCTTC 2 L V mis10--------
rs2019224111,2
----7737697(+) AAATAA/CAACCC 1 -- us2k10--------
rs2007667771,2
----7737005(+) CTGTCC/TTCACC 1 -- us2k10--------
rs39589811,2
----7738407(+) GCCAGC/GTGGTC 1 -- us2k10--------
rs2000859031,2
----7737708(+) ATCCAC/TTGGAT 1 -- us2k10--------
rs1413830591,2
----7738169(+) ACAGAA/TAATTT 1 -- us2k10--------
rs2010154181,2
----7738416(+) TCAGCC/TAACCT 1 -- us2k10--------
rs2016951191,2
----7740183(+) CAAAAA/CAAATT 1 -- ds50010--------
rs2018611621,2
----7739219(+) GATCAC/GGAGGT 1 -- int10--------

HapMap Linkage Disequilibrium report for DEFB103A (7738726 - 7740186 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for DEFB103A (see all 74):    About this table    
Variant IDTypeSubtypePubMed ID
esv2736558CNV Deletion23290073
dgv26n31CNV Duplication19718026
dgv25n31CNV Duplication19718026
nsv471459CNV Duplication19718026
nsv890270CNV Loss21882294
nsv890300CNV Loss21882294
dgv7694n71CNV Loss21882294
dgv7664n71CNV Loss21882294
nsv508496CNV Loss20534489
dgv1170n67CNV Loss20364138

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing DEFB103A
DNA2.0 Custom Variant and Variant Library Synthesis for DEFB103A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 606611    OMIM disorders: --

9 diseases for DEFB103A:    
About MalaCards
oral squamous cell carcinoma    bacteremia    tonsillitis    celiac disease
gingivitis    adenoiditis    squamous cell carcinoma of the head and neck    cystic fibrosis
squamous cell carcinoma


DEFB103A for disorders           About GeneDecksing

Genetic Association Database (GAD): DEFB103A

Export disorders for DEFB103A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DEFB103A gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with DEFB103A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Discovery of new human beta-defensins using a genomics-based approach. (PubMed id 11223260)1, 2, 3 Jia H.P....McCray P.B. Jr. (Gene 2001)
  2. Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. (PubMed id 11085990)1, 2, 3 Harder J.... Schroeder J.-M. (J. Biol. Chem. 2001)
  3. Analysis of beta-defensin and Toll-like receptor gene copy number variation in celiac disease. (PubMed id 20483368)1, 4 Fernandez-Jimenez N....Bilbao J.R. (Hum. Immunol. 2010)
  4. The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. (PubMed id 11741980)1, 2 Schibli D.J.... Vogel H.J. (J. Biol. Chem. 2002)
  5. Human I^-defensin 3 peptide is increased and redistributed in Crohn's ileitis. (PubMed id 23511030)1 Meisch J.P....Levine A.D. (Inflamm. Bowel Dis. 2013)
  6. I^-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-I+ production by human plasmacytoid dendritic cells, and promote inflammation. (PubMed id 23776172)1 Tewary P....Oppenheim J.J. (J. Immunol. 2013)
  7. Variation in human I^-defensin genes: new insights from a multi-population study. (PubMed id 23194186)1 Mehlotra R.K....Jurevic R.J. (Int. J. Immunogenet. 2013)
  8. Human I^-defensin-3 structure motifs that are important in CXCR4 antagonism. (PubMed id 23659571)1 Feng Z....Weinberg A. (FEBS J. 2013)
  9. Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant. (PubMed id 22951718)1 Ferris L.K....Falo L.D. (J. Invest. Dermatol. 2013)
  10. Genetic variability in beta-defensins is not associated with susceptibility to Staphylococcus aureus bacteremia. (PubMed id 22384213)1 Fode P....Andersen P.S. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 414325 HGNC: 15967 Ensembl:ENSG00000176797 euGenes: HUgn414325 ECgene: DEFB103A
H-InvDB: DEFB103A

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DEFB103A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DEFB103A gene:
Search GeneIP for patents involving DEFB103A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 Browse Small Molecules at EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of DEFB103A
 EMD Millipore Purified and/or Recombinant DEFB103A Protein
 Browse Kits and Assays available from EMD Millipore
 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for DEFB103A   OriGene RNAi products in human, mouse, rat for DEFB103A  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for DEFB103A  
 Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for DEFB103A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DEFB103A   OriGene Custom Protein Services for DEFB103A  

 
 
 Block miRNA regulation of human, mouse, rat DEFB103A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DEFB103A
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFB103A Predesigned siRNA for gene silencing in human, mouse, rat DEFB103A
 QuantiFast Probe-based Assays in human, mouse, rat DEFB103A QuantiTect SYBR Green Assays in human, mouse, rat DEFB103A
 Custom PCR Arrays for DEFB103A Search Chromatin IP Primers for DEFB103A
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEFB103A  GeneGlobe Interaction Network for DEFB103A
 Regulatory tfbs in DEFB103A promoter
 GenScript Purified and Recombinant Proteins for DEFB103A GenScript cDNA clones with any tag delivered in your preferred vector for DEFB103A
 GenScript Custom Assay Services for DEFB103A GenScript Custom overexpressing Cell Line Services for DEFB103A
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DEFB103A (D103A)
 Proteins for DEFB103A
 Browse Sino Biological Cell Lysates
 cDNA Clones for DEFB103A
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Biologicals
 Novus Tissue Slides
 Antibodies for DEFB103A
 See all of Abcam's Antibodies, Kits and Proteins for DEFB103A
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for DEFB103A
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for DEFB103A
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFB103A
 Browse SwitchGear 3'UTR luciferase reporter plasmids for DEFB103A
 SwitchGear Promoter luciferase reporter plasmids for DEFB103A
 ThermoFisher Antibodies for DEFB103A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFB103A
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEFB103A
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEFB103A
 Search LSBio for Antibodies for DEFB103A
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DEFB103A gene at Home site.
Version: 3.12.162 20 Aug 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4