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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DEFA6 Gene

protein-coding   GIFtS: 54
GCID: GC08M006769

Defensin, Alpha 6, Paneth Cell-Specific

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Defensin, Alpha 6, Paneth Cell-Specific1 2
DEF62 3 5
HD-62
Defensin 62
defensin-62
Defensin, Alpha 63

External Ids:    HGNC: 27651   Entrez Gene: 16712   Ensembl: ENSG000001648227   OMIM: 6004715   UniProtKB: Q015243   

Export aliases for DEFA6 gene to outside databases

Previous GC identifers: GC08M006846 GC08M007036 GC08M006942 GC08M006562


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DEFA6 Gene:
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are
abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the
intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in
protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be
clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the
secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human
bowel. (provided by RefSeq, Jul 2008)

GeneCards Summary for DEFA6 Gene: 
DEFA6 (defensin, alpha 6, Paneth cell-specific) is a protein-coding gene. Diseases associated with DEFA6 include dacryocystitis, and ulcerative colitis, and among its related super-pathways are Immune System and Beta defensins. An important paralog of this gene is DEFA1B.

UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524
Function: Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells
against infection with HIV-1

Gene Wiki entry for DEFA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_023736.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DEFA6 gene promoter:
         TBP   AREB6   Nkx2-5   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEFA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for DEFA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

DEFA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEFA6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M006769:  view genomic region     (about GC identifiers)

Start:
6,782,215 bp from pter      End:
6,783,598 bp from pter
Size:
1,384 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524 (See protein sequence)
Recommended Name: Defensin-6 precursor  
Size: 100 amino acids; 10975 Da
Subunit: Homodimer
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for DEFA6:
1ZMQ (3D)        3QTE (3D)    

Explore the universe of human proteins at neXtProt for DEFA6: NX_Q01524

Explore proteomics data for DEFA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01524

  • DEFA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DEFA6 Protein Expression
    REFSEQ proteins: NP_001917.1  
    ENSEMBL proteins: 
     ENSP00000297436  
    Reactome Protein details: Q01524
    Human Recombinant Protein Products for DEFA6: 
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    Novus Biologicals DEFA6 Protein
    Novus Biologicals DEFA6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0005796Golgi lumen TAS--

    DEFA6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DEFA: Defensins, alpha

    4 InterPro protein domains:
     IPR016327 Alpha-defensin
     IPR006080 Defensin_beta/neutrophil
     IPR006081 Mammalian_defensins
     IPR002366 Defensin_propep

    Graphical View of Domain Structure for InterPro Entry Q01524

    ProtoNet protein and cluster: Q01524

    1 Blocks protein domain: IPB002366 Defensin propeptide

    UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524
    Similarity: Belongs to the alpha-defensin family


    DEFA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEF6_HUMAN, Q01524
    Function: Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells
    against infection with HIV-1

         Genatlas biochemistry entry for DEFA6:
    defensin alpha 6,3-4kDa,enteric Paneth cells,released from azurophil granules of Paneth cells,oxygen independent
    phagocytosis of Gram+,Gram- bacteria,many fungi,some viruses

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DEFA6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    2Beta defensins
    Defensins0.80
    3Alpha-defensins
    Alpha-defensins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for DEFA6
        Defensins
    Alpha-defensins
    Immune System
    Innate Immune System



    DEFA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEFA6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for DEFA6 (ENSP000002974364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DEFA4ENSP000002974354STRING: ENSP00000297435
    DEFA5ENSP000003298904STRING: ENSP00000329890
    DEFB1ENSP000002974394STRING: ENSP00000297439
    DEFB4AENSP000003035324STRING: ENSP00000303532
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response ----
    GO:0031640killing of cells of other organism IEA--
    GO:0042742defense response to bacterium IEA--
    GO:0045087innate immune response TAS--
    GO:0050832defense response to fungus IEA--

    DEFA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DEFA6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DEFA6 (DEF6)

    1 Novoseek inferred chemical compound relationship for DEFA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hbd2 91.8 4 14568394 (2), 19549264 (1), 10964161 (1)

    Search CenterWatch for drugs/clinical trials and news about DEFA6 / DEF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DEFA6 gene: 
    NM_001926.3  

    Unigene Cluster for DEFA6:

    Defensin, alpha 6, Paneth cell-specific
    Hs.711  [show with all ESTs]
    Unigene Representative Sequence: NM_001926
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000297436(uc003wqt.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DEFA6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DEFA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEFA6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA6
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEFA6

    Additional mRNA sequence: 

    BC069667.1 BC069710.1 BC069728.1 BC069769.1 BC093951.1 BC093953.1 M98331.1 

    2 DOTS entries:

    DT.102820200  DT.106012 

    10 AceView cDNA sequences:

    T29657 BC069769 BC069710 BC069728 BC069667 NM_001926 BM986901 M98331 
    BM855691 AW951409 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DEFA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATTAACC
    DEFA6 Expression
    About this image


    See DEFA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DEFA6

    SOURCE GeneReport for Unigene cluster: Hs.711

    UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524
    Tissue specificity: Paneth cells of the small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for DEFA6 (if available)
    TreeFam Gene Tree for DEFA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DEFA6 gene
    DEFA1B2  DEFA32  DEFA42  DEFA12  DEFA52  
    6 SIMAP similar genes for DEFA6 using alignment to 2 protein entries:     DEF6_HUMAN (see all proteins):
    DEFA4    DEFA5    DEFA1    DEFA1B    DEFA3    Em

    DEFA6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DEFA6
    PGOHUM00000249207


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 SNPs in DEFA6 are shown (see all 158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930669991,2
    --6781757(+) ACGTGC/TGGTGG 1 -- ds50010--------
    rs1846335021,2
    --6781758(+) CGTGCA/GGTGGC 1 -- ds50010--------
    rs1891492331,2
    --6781827(+) GAGTTC/TGAGAC 1 -- ds50010--------
    rs1813778131,2
    --6781899(+) TGGTGC/GATACC 1 -- ds50010--------
    rs1855433471,2
    --6781937(+) GGCAGA/GAGAAT 1 -- ds50010--------
    rs38881521,2
    C,F,A,H--6781962(+) AGGTAA/GAGGTT 1 -- ds50016Minor allele frequency- G:0.28NA WA 18
    rs1460000571,2
    --6782201(+) GAAAAC/GCACAA 1 -- ds50010--------
    rs1162365991,2
    C,F--6782204(+) AAGCAC/GAAACA 1 -- ds50010--------
    rs7122761,2
    C,F,O,A,H--6782271(-) TGTCCT/CATACA 1 -- ut31 ese338Minor allele frequency- C:0.10MN NS EA NA CSA WA 4124
    rs562399091,2
    C,F--6782279(-) CTGTCG/ATGTGT 1 -- ut313Minor allele frequency- A:0.05CSA WA 122

    HapMap Linkage Disequilibrium report for DEFA6 (6782215 - 6783598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for DEFA6 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509248CNV Insertion20534489
    nsv890064CNV Gain21882294
    nsv465436CNV Gain19166990
    nsv831221CNV Gain17160897
    nsv528374CNV Gain19592680
    esv2752262CNV Gain17911159
    nsv890066CNV Gain21882294
    nsv465437CNV Gain19166990
    dgv7656n71CNV Gain21882294
    dgv7657n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DEFA6
    DNA2.0 Custom Variant and Variant Library Synthesis for DEFA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600471    OMIM disorders: --

    16 diseases for DEFA6:    About MalaCards
    dacryocystitis    ulcerative colitis    diarrhea    atopic dermatitis
    crohn's disease    colon adenocarcinoma    herpes simplex    meningioma
    dermatitis    influenza    hepatitis b    adenocarcinoma
    adenoma    hepatitis    gastric cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for DEFA6:
    Crohn's disease

    DEFA6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DEFA6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 21.5 4 15479689 (1), 12519391 (1), 19549264 (1), 18810765 (1)

    Genetic Association Database (GAD): DEFA6
    Human Genome Epidemiology (HuGE) Navigator: DEFA6 (8 documents)

    Export disorders for DEFA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DEFA6 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with DEFA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. (PubMed id 8417977)1, 2, 3, 9 Jones D.E. and Bevins C.L. (1993)
    2. Human enteric defensins. Gene structure and developmental expression. (PubMed id 8626737)1, 2, 9 Mallow E.B.... Bevins C.L. (1996)
    3. Crystal structures of human alpha-defensins HNP4, HD5, and HD6. (PubMed id 17088326)1, 2, 9 Szyk A....Lubkowski J. (2006)
    4. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    5. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    6. Copy number variation of defensin genes and HIV infection in Brazilian children. (PubMed id 19194307)1, 4 Milanese M....Crovella S. (2009)
    7. Single nucleotide polymorphisms and the haplotype in the DEFB1 gene are associated with atopic dermatitis in a Korean population. (PubMed id 19135873)1, 4 Kim E....Yang J.M. (2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Innate immunity and non-Hodgkin's lymphoma (NHL) relat ed genes in a nested case-control study for gastric cancer risk. (PubMed id 23028900)1 Park S.K....Kang D. (2012)
    10. Human a-defensin 6 promotes mucosal innate immunity th rough self-assembled peptide nanonets. (PubMed id 22722251)1 Chu H....Bevins C.L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1671 HGNC: 2765 AceView: DEFA6 Ensembl:ENSG00000164822 euGenes: HUgn1671
    ECgene: DEFA6 H-InvDB: DEFA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DEFA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DEFA6 gene:
    Search GeneIP for patents involving DEFA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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