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Set Analyses:

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DEFA6 Gene

protein-coding GIFtS: 52
GCID: GC08M006769

Defensin, Alpha 6, Paneth Cell-Specific

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Defensin, Alpha 6, Paneth Cell-Specific¹ ²
DEF6² ³ ⁵
HD-6²
Defensin 6²
defensin-6²
Defensin, Alpha 6³

External Ids:	HGNC: 2765¹	Entrez Gene: 1671²	Ensembl: ENSG00000164822⁷	OMIM: 600471⁵	UniProtKB: Q01524³

Export aliases for DEFA6 gene to outside databases

Previous GC identifers: GC08M006846 GC08M007036 GC08M006942 GC08M006562

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DEFA6 Gene:

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are

abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the

intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in

protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be

clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the

secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human

bowel. (provided by RefSeq, Jul 2008)

GeneCards Summary for DEFA6 Gene:

DEFA6 (defensin, alpha 6, Paneth cell-specific) is a protein-coding gene. Diseases associated with DEFA6 include dacryocystitis, and crohn's disease. An important paralog of this gene is DEFA1B.

UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524

Function: Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells

against infection with HIV-1

Gene Wiki entry for DEFA6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000008.11 NC_018919.2 NT_023736.18

Regulatory elements:

Regulatory transcription factor binding sites in the DEFA6 gene promoter:
TBP AREB6 Nkx2-5 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DEFA6 promoter sequence

Search Chromatin IP Primers for DEFA6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFA6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

DEFA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEFA6 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M006769: view genomic region (about GC identifiers)

Start:	6,782,215 bp from pter	End:	6,783,598 bp from pter
Size:	1,384 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524 (See protein sequence)

Recommended Name: Defensin-6 precursor

Size: 100 amino acids; 10975 Da

Subunit: Homodimer

2 PDB 3D structures from and Proteopedia for DEFA6:

1ZMQ (3D)

3QTE (3D)

Secondary accessions: Q6EZF9

Explore the universe of human proteins at neXtProt for DEFA6: NX_Q01524

Explore proteomics data for DEFA6 at MOPED

See DEFA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001917.1

ENSEMBL proteins:

ENSP00000297436

Reactome Protein details: Q01524

DEFA6 Human Recombinant Protein Products:

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DEFA6 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

DEFA: Defensins, alpha

4 InterPro protein domains:

IPR016327 Alpha-defensin

IPR006080 Defensin_beta/neutrophil

IPR006081 Mammalian_defensins

IPR002366 Defensin_propep

Graphical View of Domain Structure for InterPro Entry Q01524

ProtoNet protein and cluster: Q01524

1 Blocks protein domain: IPB002366 Defensin propeptide

UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524

Similarity: Belongs to the alpha-defensin family

DEFA6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DEF6_HUMAN, Q01524

Function: Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells

against infection with HIV-1

Genatlas biochemistry entry for DEFA6:

defensin alpha 6,3-4kDa,enteric Paneth cells,released from azurophil granules of Paneth cells,oxygen independent

phagocytosis of Gram+,Gram- bacteria,many fungi,some viruses

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DEF6_HUMAN, Q01524: Secreted

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
golgi apparatus	4
nucleus	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005796	Golgi lumen	TAS	--

DEFA6 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DEFA6 About

See pathways by source

SuperPath

Contained pathways About

Defensins

Defensins

0.80

Alpha-defensins

0.00

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for DEFA6

	Defensins
	Alpha-defensins

DEFA6 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DEFA6
Interactions:

Search GeneGlobe Interaction Network for DEFA6

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for DEFA6 (ENSP00000297436⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DEFA4	ENSP00000297435⁴	STRING: ENSP00000297435
DEFA5	ENSP00000329890⁴	STRING: ENSP00000329890
DEFB1	ENSP00000297439⁴	STRING: ENSP00000297439
DEFB4A	ENSP00000303532⁴	STRING: ENSP00000303532

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Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	--	--
GO:0019731	antibacterial humoral response	IDA	15616305
GO:0031640	killing of cells of other organism	IEA	--
GO:0042742	defense response to bacterium	--	--
GO:0045087	innate immune response	TAS	--

DEFA6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DEFA6 (DEF6)

1 Novoseek inferred chemical compound relationship for DEFA6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hbd2	91.8	4	14568394 (2), 19549264 (1), 10964161 (1)

DEFA6 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DEFA6 gene:

NM_001926.3

Unigene Cluster for DEFA6:

Defensin, alpha 6, Paneth cell-specific

Hs.711 [show with all ESTs]

Unigene Representative Sequence: NM_001926

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000297436(uc003wqt.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat DEFA6 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate DEFA6
		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		Predesigned siRNA for gene silencing in human, mouse, rat DEFA6

Clone Products:		OriGene clones in human, mouse for DEFA6 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene qPCR primer pairs and template standards for DEFA6 OriGene qSTAR qPCR primer pairs in human, mouse for DEFA6
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		QuantiTect SYBR Green Assays in human, mouse, rat DEFA6
		QuantiFast Probe-based Assays in human, mouse, rat DEFA6

Additional mRNA sequence:

BC069667.1 BC069710.1 BC069728.1 BC069769.1 BC093951.1 BC093953.1 M98331.1

2 DOTS entries:

DT.102820200 DT.106012

10 AceView cDNA sequences:

T29657 M98331 BC069710 BM986901 BC069769 BC069728 NM_001926 BC069667

BM855691 AW951409

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DEFA6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGTATTAACC

About this image

DEFA6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DEFA6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.711

UniProtKB/Swiss-Prot: DEF6_HUMAN, Q01524

Tissue specificity: Paneth cells of the small intestine

Custom PCR Arrays for DEFA6

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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--

ENSEMBL Gene Tree for DEFA6 (if available)
TreeFam Gene Tree for DEFA6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DEFA6 gene

DEFA1B² DEFA3² DEFA4² DEFA1² DEFA5²

6 SIMAP similar genes for DEFA6 using alignment to 1 protein entry: DEF6_HUMAN:

DEFA4 DEFA5 DEFA1 DEFA1B DEFA3 Em

DEFA6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DEFA6
PGOHUM00000249207

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193066999^1,2		--	6781757(+)	`ACGTGC/TGGTGG`	1	--	ds500¹		0	--	--	--	--
rs184633502^1,2		--	6781758(+)	`CGTGCA/GGTGGC`	1	--	ds500¹		0	--	--	--	--
rs189149233^1,2		--	6781827(+)	`GAGTTC/TGAGAC`	1	--	ds500¹		0	--	--	--	--
rs181377813^1,2		--	6781899(+)	`TGGTGC/GATACC`	1	--	ds500¹		0	--	--	--	--
rs185543347^1,2		--	6781937(+)	`GGCAGA/GAGAAT`	1	--	ds500¹		0	--	--	--	--
rs3888152^1,2	C,F,A,H	--	6781962(+)	`AGGTAA/GAGGTT`	1	--	ds500¹		6		NA WA	18
rs146000057^1,2		--	6782201(+)	`GAAAAC/GCACAA`	1	--	ds500¹		0	--	--	--	--
rs116236599^1,2	C,F	--	6782204(+)	`AAGCAC/GAAACA`	1	--	ds500¹		0	--	--	--	--
rs712276^1,2	C,F,O,A,H	--	6782271(-)	`TGTCCT/CATACA`	1	--	ut3¹ ese³		38		MN NS EA NA CSA WA	4124
rs56239909^1,2	C,F	--	6782279(-)	`CTGTCG/ATGTGT`	1	--	ut3¹		3		CSA WA	122

HapMap Linkage Disequilibrium report for DEFA6 (6782215 - 6783598 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for DEFA6 (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
nsv509248	CNV	Insertion	20534489
nsv890064	CNV	Gain	21882294
nsv465436	CNV	Gain	19166990
nsv831221	CNV	Gain	17160897
nsv528374	CNV	Gain	19592680
esv2752262	CNV	Gain	17911159
nsv890066	CNV	Gain	21882294
nsv465437	CNV	Gain	19166990
dgv7656n71	CNV	Gain	21882294
dgv7657n71	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DEFA6

DNA2.0 Custom Variant and Variant Library Synthesis for DEFA6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600471 OMIM disorders: --

19 diseases for DEFA6: About MalaCards

dacryocystitis crohn's disease ulcerative colitis diarrhea

atopic dermatitis childhood leukemia colon adenocarcinoma herpes simplex

meningioma dermatitis influenza hiv-1

hepatitis b non-hodgkin lymphoma hodgkin's lymphoma adenoma

adenocarcinoma hepatitis leukemia

1 disease from the University of Copenhagen DISEASES database for DEFA6:

Crohn's disease

DEFA6 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

1 Novoseek inferred disease relationship for DEFA6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	21.5	4	15479689 (1), 12519391 (1), 19549264 (1), 18810765 (1)

Genetic Association Database (GAD): DEFA6
Human Genome Epidemiology (HuGE) Navigator: DEFA6 (8 documents)

Export disorders for DEFA6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DEFA6 gene, integrated from 10 sources (see all 55):
(articles sorted by number of sources associating them with DEFA6)

Utopia: connect your pdf to the dynamic
world of online information

Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. (PubMed id 8417977)^{1, 2, 3, 9} Jones D.E. and Bevins C.L. (FEBS Lett. 1993)
Human enteric defensins. Gene structure and developmental expression. (PubMed id 8626737)^{1, 2, 9} Mallow E.B.... Bevins C.L. (J. Biol. Chem. 1996)
Crystal structures of human alpha-defensins HNP4, HD5, and HD6. (PubMed id 17088326)^{1, 2, 9} Szyk A.... Lubkowski J. (Protein Sci. 2006)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
Copy number variation of defensin genes and HIV infection in Brazilian children. (PubMed id 19194307)^{1, 4} Milanese M....Crovella S. (J. Acquir. Immune Defic. Syndr. 2009)
Single nucleotide polymorphisms and the haplotype in the DEFB1 gene are associated with atopic dermatitis in a Korean population. (PubMed id 19135873)^{1, 4} Kim E....Yang J.M. (J. Dermatol. Sci. 2009)
Antibacterial activity and specificity of the six human alpha- defensins. (PubMed id 15616305)^{1, 2} Ericksen B.... Lehrer R.I. (Antimicrob. Agents Chemother. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case-control study for gastric cancer risk. (PubMed id 23028900)¹ Park S.K....Kang D. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1671	HGNC: 2765	AceView: DEFA6	Ensembl:ENSG00000164822	euGenes: HUgn1671
ECgene: DEFA6	H-InvDB: DEFA6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DEFA6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DEFA6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DEFA6 gene:
Search GeneIP for patents involving DEFA6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for DEFA6
	OriGene qPCR primer pairs and template standards for DEFA6		OriGene Protein Over-expression Lysate for DEFA6
	OriGene MassSpec something-or-other for DEFA6		OriGene clones in human, mouse for DEFA6
	OriGene qSTAR qPCR primer pairs in human, mouse for DEFA6		OriGene Purified Protein for DEFA6
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DEFA6		OriGene Custom Protein Services for DEFA6

	Block miRNA regulation of human, mouse, rat DEFA6 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing DEFA6
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFA6		Predesigned siRNA for gene silencing in human, mouse, rat DEFA6
	QuantiFast Probe-based Assays in human, mouse, rat DEFA6		QuantiTect SYBR Green Assays in human, mouse, rat DEFA6
	Custom PCR Arrays for DEFA6		Search Chromatin IP Primers for DEFA6
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat DEFA6		Search GeneGlobe Interaction Network for DEFA6
	Regulatory tfbs in DEFA6 promoter

	GenScript Custom Purified and Recombinant Proteins Services for DEFA6		GenScript cDNA clones with any tag delivered in your preferred vector for DEFA6
	GenScript Custom Assay Services for DEFA6		GenScript Custom overexpressing Cell Line Services for DEFA6
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

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Search Tocris compounds for DEFA6 (DEF6)

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	Novus Tissue Slides
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Browse ESI BIO Cell Lines and PureStem Progenitors for DEFA6

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA6

	Browse SwitchGear 3'UTR luciferase reporter plasmids for DEFA6
	SwitchGear Promoter luciferase reporter plasmids for DEFA6

Search ThermoFisher Antibodies for DEFA6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA6

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEFA6
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEFA6

LSBio Antibodies in human, mouse, rat for DEFA6

Customized transgenic rodents for:

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DEFA6 gene at Home site.

Version: 3.12.136 22 July 2014
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DEFA6 Gene

Defensin, Alpha 6, Paneth Cell-Specific

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DEFA6 Gene

Defensin, Alpha 6, Paneth Cell-Specific

Aliasesfor DEFA6 gene

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DEFA6 Human Recombinant Protein Products:

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