DEFA5 Gene
protein-coding GIFtS: 54
GCID: GC08M006900
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|
defensin, alpha 5, Paneth cell-specific
(Previous symbol: DEF5)
| |
Aliases
for DEFA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Defensin, Alpha 5, Paneth Cell-Specific1 2 | | Defensin 52 | | DEF51 2 3 5 | | Defensin, Alpha 5, Preproprotein2 | | HD-51 2 | | Defensin-51 | | HD5(20-94)2 3 | | Defensin, Alpha 53 |
Export aliases for DEFA5 gene to outside databasesPrevious GC identifers: GC08M006957 GC08M007149 GC08M007057 GC08M006654 |
Summaries
for DEFA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DEFA5:
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundantin the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine,respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequenceand distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered onchromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules ofPaneth cells of the ileum. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DEF5_HUMAN, Q01523Function: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to killmicrobes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potencyis affected by peptide processing
Gene Wiki entry for DEFA5
|
Genomic Views
for DEFA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_023736.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEFA5 gene promoter:
FOXC1 POU2F1 FOXF2 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEFA5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFA5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1DEFA5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M006900: view genomic region
(about GC identifiers)
Start:
|
6,912,829 bp from pter |
End:
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6,914,259 bp from pter |
Size:
|
1,431 bases |
Orientation:
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minus strand |
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Proteins
for DEFA5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DEF5_HUMAN, Q01523 (See
protein sequence)Recommended Name: Defensin-5 precursor Size: 94 amino acids; 10071 Da
Subunit: Homodimer
Subcellular location: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Peptides HD5(20-94), HD5(23-94) andHD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) andHD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form
6 PDB 3D structures from  and Proteopedia  for DEFA5:1ZMP (3D)
2LXZ (3D)
3I5W (3D)
4E82 (3D)
4E83 (3D)
4E86 (3D)
Secondary accessions: A0JDY6 Q3KNV2Explore the universe of human proteins at neXtProt for DEFA5: NX_Q01523
Post-translational modifications:
Glycosylated1
View neXtProt modification sites for NX_Q01523
DEFA5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066290.1
ENSEMBL proteins: ENSP00000329890 Reactome Protein details: Q01523
Human Recombinant Protein Products for DEFA5:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DEFA5 for ontologies About GeneDecksing
DEFA5 Antibody Products:
Assay Products for DEFA5: |
Protein
Domains /
Families
for DEFA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEFA5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q01523ProtoNet protein and cluster: Q01523 1 Blocks protein family: IPB002366 Defensin propeptide
UniProtKB/Swiss-Prot: DEF5_HUMAN, Q01523Similarity: Belongs to the alpha-defensin family |
Function
for DEFA5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DEF5_HUMAN, Q01523Function: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to killmicrobes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potencyis affected by peptide processing Genatlas biochemistry entry for DEFA5:defensin alpha 5,3-4kDa,enteric Paneth cells,released from azurophil granules of Paneth cells,oxygen independentphagocytosis of Gram+,Gram- bacteria,many fungi,some viruses,colocolazing and regulated in mice with matrilysin (MMP7)in innate host defense
Phenotypes:
2 GenomeRNAi human phenotypes for DEFA5:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DEFA5 (NM_021010) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEFA5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA5 |
|
Pathways & Interactions
for DEFA5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Alpha-defensins | | | 2 | Immune System | | | 3 | Beta defensins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 
Reactome Pathways for DEFA5 (see all 6)
DEFA5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEFA5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for DEFA5 (Q015233 ENSP000003298904) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031640 | killing of cells of other organism |
IEA | -- | | GO:0042742 | defense response to bacterium |
IEA | -- | | GO:0045087 | innate immune response |
TAS | -- | | GO:0050832 | defense response to fungus |
IEA | -- |
DEFA5 for ontologies About GeneDecksing
|
Drugs & Compounds
for DEFA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DEFA5 for compounds About GeneDecksing
 Browse Tocris compounds for DEFA5
1 Novoseek chemical compound relationship for DEFA5 gene About this table
Search CenterWatch for drugs/clinical trials and news about DEFA5 / DEF5
|
Transcripts
for DEFA5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEFA5 gene: NM_021010.1 Unigene Cluster for DEFA5: Defensin, alpha 5, Paneth cell-specific Hs.655233 [show with all ESTs]Unigene Representative Sequence: BU7293501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330590(uc003wra.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DEFA5 (NM_021010) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEFA5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA5 |
Additional cDNA sequence: BC069690.1 BC107079.2 3 DOTS entries: DT.102579 DT.97859354 DT.121482168 22 AceView cDNA sequences: BM768678 BM830493 BM768516 BM765919 NM_021010 BM703419 BM855276 BM856063 BC069690 BM854660 BM855729 BM830508 BM855593 AA377362 BM855680 AW951437 T29684 AL042376 CA395020 BM715953 BM855702 AL042377
GeneLoc Exon Structure
|
Expression
for DEFA5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEFA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGACCATCG
About this image
See DEFA5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEFA5
SOURCE GeneReport for Unigene cluster: Hs.655233
UniProtKB/Swiss-Prot: DEF5_HUMAN, Q01523Tissue specificity: Paneth cells of the small intestine (at protein level)
SABiosciences Custom PCR Arrays for DEFA5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEFA5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DEFA5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEFA5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEFA5 |
Orthologs
for DEFA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DEFA5 (if available)
TreeFam Gene Tree for DEFA5 (if available) |
Paralogs
for DEFA5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DEFA5 gene
- DEFA1B2 DEFA32 DEFA42 DEFA12 DEFA62
6 SIMAP similar genes for DEFA5 using alignment to 1 protein entry: DEF5_HUMAN:DEFA1 DEFA1B DEFA6 DEFA3 DEFA4 Em
DEFA5 for paralogs About GeneDecksing
|
Genomic Variants
for DEFA5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEFA5 (6912829 - 6914259 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for DEFA5
4 CNVs: 8592 4577 0296 3719 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEFA5 |
|
Disorders
/ Diseases
for DEFA5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DEFA5 for disorders About GeneDecksing
OMIM gene information: 600472
OMIM disorders: --
20/31  diseases for DEFA5 (see all 31): About MalaCardsclostridium difficile vulvovaginal candidiasis bacterial vaginosis inflammatory bowel disease
vulvovaginitis peptic ulcer microsporidiosis atopic dermatitis
candidiasis herpes simplex ulcerative colitis endocervicitis
gastritis urethritis celiac disease dermatitis
chronic cervicitis crohn's disease gastric adenocarcinoma hepatitis b
2 diseases from the University of Copenhagen DISEASES database for DEFA5:Crohn's disease Vulvovaginal candidiasis 10/11 Novoseek disease relationships for DEFA5 gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| metaplasia |
57 |
5 |
19250512 (1), 11871772 (1), 15128357 (1), 15976333 (1) |
| inflammatory bowel diseases |
55.4 |
5 |
11156637 (2), 18394979 (1) |
| gastritis |
45.6 |
1 |
20400909 (1) |
| intestinal infection |
43.5 |
1 |
16619196 (1) |
| colitis |
42.1 |
2 |
15095125 (1), 12519391 (1) |
| colitis ulcerative |
41 |
2 |
15095125 (1), 18523026 (1) |
| inflammation |
28 |
6 |
12519391 (2), 15479689 (1), 19549264 (1), 19904243 (1) (see all 5) |
| systemic disease |
10.9 |
2 |
15123078 (1), 15931529 (1) |
| tumors |
3.18 |
2 |
20428773 (1) |
| reflux |
0.875 |
1 |
16036501 (1) |
Human Genome Epidemiology (HuGE) Navigator: DEFA5 (11 documents)
Export disorders for DEFA5 gene to outside databases
|
Publications
for DEFA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEFA5 gene, integrated from 9 sources (see all 118):
(articles sorted by number of sources associating them with DEFA5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Paneth cells of the human small intestine express an antimicrobial peptide gene. (PubMed id 1429669)1, 2, 3, 9 Jones D.E. and Bevins C.L. (1992)
- Crystal structures of human alpha-defensins HNP4, HD5, and HD6. (PubMed id 17088326)1, 2, 9 Szyk A....Lubkowski J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Paneth cell trypsin is the processing enzyme for human defensin-5. (PubMed id 12021776)1, 2 Ghosh D....Bevins C.L. (2002)
- Multivalent binding of carbohydrates by the human alp ha-defensin, HD5. (PubMed id 19542459)1, 9 Lehrer R.I....Lu W. (2009)
- Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo. (PubMed id 20375624)1, 9 Ishikawa C....Kohgo Y. (2009)
- Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. (PubMed id 12660734)1, 9 Salzman N.H....Bevins C.L. (2003)
- Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. (PubMed id 9588893)1, 9 Quayle A.J....Mok S.C. (1998)
- The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability. (PubMed id 18499668)1, 9 Rajabi M....Lu W. (2008)
- Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells. (PubMed id 18782756)1, 9 Dugan A.S....Atwood W.J. (2008)
|
External Searches for DEFA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DEFA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEFA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEFA5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEFA5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DEFA5 gene:
Search GeneIP for patents involving DEFA5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEFA5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for DEFA5 | | OriGene shRNA RFP for DEFA5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEFA5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEFA5 | | | OriGene Protein Over-expression Lysate for DEFA5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DEFA5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DEFA5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DEFA5 | | OriGene Custom Protein Services for DEFA5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEFA5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEFA5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFA5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEFA5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEFA5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEFA5 |
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| |  |  |  |  | | | | |
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