Aliases for DEFA5 Gene
External Ids for DEFA5 Gene
Previous HGNC Symbols for DEFA5 Gene
Previous GeneCards Identifiers for DEFA5 Gene
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFA5 Gene
DEFA5 (Defensin, Alpha 5, Paneth Cell-Specific) is a Protein Coding gene. Diseases associated with DEFA5 include vulvovaginal candidiasis and acute inflammation of lacrimal passage. Among its related pathways are Immune System and Defensins. An important paralog of this gene is DEFA3.
UniProtKB/Swiss-Prot for DEFA5 Gene
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.