Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DEFA4 Gene

protein-coding   GIFtS: 55
GCID: GC08M006780

Defensin, Alpha 4, Corticostatin


(Previous symbol: DEF4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Defensin, Alpha 4, Corticostatin1 2     corticostatin2
DEF41 2 3 5     Defensin, Alpha 4, Preproprotein2
HNP-42 3     Neutrophil Defensin 42
HP-42 3     Defensin, Alpha 43
HP42 5     

External Ids:    HGNC: 27631   Entrez Gene: 16692   Ensembl: ENSG000001648217   OMIM: 6011575   UniProtKB: P128383   

Export aliases for DEFA4 gene to outside databases

Previous GC identifers: GC08M006857 GC08M007047 GC08M006953 GC08M006572


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DEFA4 Gene:
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are
abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the
intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in
protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on
chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently
the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4,
is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated
corticosterone production. (provided by RefSeq, Jul 2008)

GeneCards Summary for DEFA4 Gene:
DEFA4 (defensin, alpha 4, corticostatin) is a protein-coding gene. Diseases associated with DEFA4 include oral leukoplakia, and leukoplakia. An important paralog of this gene is DEFA1B.

UniProtKB/Swiss-Prot: DEF4_HUMAN, P12838
Function: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against
Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits
corticotropin (ACTH)-stimulated corticosterone production

Gene Wiki entry for DEFA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_023736.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DEFA4 gene promoter:
         ER-alpha   AREB6   POU2F1   POU2F1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEFA4 promoter sequence
   Search Chromatin IP Primers for DEFA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

DEFA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEFA4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M006780:  view genomic region     (about GC identifiers)

Start:
6,793,344 bp from pter      End:
6,795,860 bp from pter
Size:
2,517 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DEF4_HUMAN, P12838 (See protein sequence)
Recommended Name: Neutrophil defensin 4 precursor  
Size: 97 amino acids; 10504 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for DEFA4:
1ZMM (3D)    
Secondary accessions: Q6EZF8

Explore the universe of human proteins at neXtProt for DEFA4: NX_P12838

Explore proteomics data for DEFA4 at MOPED


See DEFA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001916.1  
ENSEMBL proteins: 
 ENSP00000297435  
Reactome Protein details: P12838

DEFA4 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec
OriGene Custom Protein Services for DEFA4
GenScript Custom Purified and Recombinant Proteins Services for DEFA4
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

DEFA4 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for DEFA4
Novus Biologicals DEFA4 Antibodies
Abcam antibodies for DEFA4
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for DEFA4
LSBio Antibodies in human, mouse, rat for DEFA4

DEFA4 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for DEFA4
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for DEFA4
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
DEFA: Defensins, alpha

4 InterPro protein domains:
 IPR016327 Alpha-defensin
 IPR006080 Defensin_beta/neutrophil
 IPR006081 Mammalian_defensins
 IPR002366 Defensin_propep

Graphical View of Domain Structure for InterPro Entry P12838

ProtoNet protein and cluster: P12838

1 Blocks protein domain: IPB002366 Defensin propeptide

UniProtKB/Swiss-Prot: DEF4_HUMAN, P12838
Similarity: Belongs to the alpha-defensin family


DEFA4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DEF4_HUMAN, P12838
Function: Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against
Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits
corticotropin (ACTH)-stimulated corticosterone production

     Genatlas biochemistry entry for DEFA4:
defensin alpha 4,3-4kDa,hematopoietic,released from azurophil granules of neutrophiles,oxygen independent
phagocytosis of Gram+,Gram- bacteria,many fungi,some viruses

Phenotypes:
     1 GenomeRNAi human phenotype for DEFA4:
 Increased G2M DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEFA4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEFA4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEFA4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEFA4

miRNA
Products:
    
miRTarBase miRNAs that target DEFA4:
hsa-mir-335-5p (MIRT017503)

Block miRNA regulation of human, mouse, rat DEFA4 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DEFA4
SwitchGear 3'UTR luciferase reporter plasmidDEFA4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DEFA4
Predesigned siRNA for gene silencing in human, mouse, rat DEFA4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DEFA4

Clone
Products:
     
OriGene clones in human, mouse for DEFA4 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DEFA4 (NM_001925)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEFA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA4

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DEFA4
Browse ESI BIO Cell Lines and PureStem Progenitors for DEFA4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
DEF4_HUMAN, P12838: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
golgi apparatus4
lysosome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005796Golgi lumen TAS--

DEFA4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for DEFA4 About    
See pathways by source

SuperPathContained pathways About
1Defensins
Defensins0.80
Alpha-defensins0.00

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 Reactome Pathways for DEFA4
    Defensins
Alpha-defensins



DEFA4 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DEFA4
Interactions:

    GeneGlobe Interaction Network for DEFA4

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for DEFA4 (ENSP000002974354) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DEFA5ENSP000003298904STRING: ENSP00000329890
DEFA6ENSP000002974364STRING: ENSP00000297436
DEFB1ENSP000002974394STRING: ENSP00000297439
DEFB4AENSP000003035324STRING: ENSP00000303532
About this table

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006952defense response ----
GO:0019731antibacterial humoral response IDA15616305
GO:0031640killing of cells of other organism IEA--
GO:0042742defense response to bacterium ----
GO:0045087innate immune response TAS--

DEFA4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DEFA4 (DEF4)

1 HMDB Compound for DEFA4    About this table
CompoundSynonyms CAS #PubMed Ids
Corticosterone11,21-Dihydroxypregn-4-ene-3,20-dione (see all 8)50-22-6--

1 Novoseek inferred chemical compound relationship for DEFA4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
bactenecin 88.8 1 8145294 (1)



DEFA4 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DEFA4 gene: 
NM_001925.1  

Unigene Cluster for DEFA4:

Defensin, alpha 4, corticostatin
Hs.591391  [show with all ESTs]
Unigene Representative Sequence: BU616655
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000297435(uc003wqu.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DEFA4 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DEFA4
SwitchGear 3'UTR luciferase reporter plasmidDEFA4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DEFA4
Predesigned siRNA for gene silencing in human, mouse, rat DEFA4
Clone
Products:
     
OriGene clones in human, mouse for DEFA4 (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DEFA4 (NM_001925)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEFA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for DEFA4
OriGene qSTAR qPCR primer pairs in human, mouse for DEFA4
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DEFA4
  QuantiTect SYBR Green Assays in human, mouse, rat DEFA4
  QuantiFast Probe-based Assays in human, mouse, rat DEFA4

Additional mRNA sequence: 

BC093959.1 BC106747.2 BC112091.1 X65977.1 

1 DOTS entry:

DT.402738 

19 AceView cDNA sequences:

NM_001925 X65977 AI250799 AI082774 BU616655 BX643610 AW468357 BX099382 
AA722853 AI081728 AJ705655 BI021222 AJ706033 BI024114 BI021150 BI024041 
BI024040 BI024172 BI024046 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DEFA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DEFA4 Expression
About this image


DEFA4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
DEFA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DEFA4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591391
    Custom PCR Arrays for DEFA4
Primer
Products:
OriGene qPCR primer pairs and template standards for DEFA4
OriGene qSTAR qPCR primer pairs in human, mouse for DEFA4
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DEFA4
QuantiTect SYBR Green Assays in human, mouse, rat DEFA4
QuantiFast Probe-based Assays in human, mouse, rat DEFA4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and chimp.

Orthologs for DEFA4 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia DEFA41 defensin, alpha 4, corticostatin 98.63(n)
98.97(a)
  463971  NM_001033906.1  NP_001029078.1 


ENSEMBL Gene Tree for DEFA4 (if available)
TreeFam Gene Tree for DEFA4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for DEFA4 gene
DEFA1B2  DEFA32  DEFA62  DEFA12  DEFA52  
6 SIMAP similar genes for DEFA4 using alignment to 1 protein entry:     DEF4_HUMAN:
DEFA6    DEFA1    DEFA1B    DEFA3    DEFA5    Em

DEFA4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for DEFA4 (see all 207)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0363154
A colorectal cancer sample4--see VAR_0363152 R Q mis40--------
rs1404750551,2
--6792875(+) GTGTTC/GCATGC 1 -- ds50010--------
rs1830541361,2
--6792893(+) CTTTGC/TTAACA 1 -- ds50010--------
rs1504077051,2
--6792911(+) TCCCTC/GTTAAT 1 -- ds50010--------
rs1380609641,2
--6792931(+) TTCAGC/TGGATC 1 -- ds50010--------
rs1143532601,2
F--6792936(+) TGGATC/GTCCTA 1 -- ds50011Minor allele frequency- G:0.02WA 118
rs1491137431,2
--6792982(+) GACATG/TTTCAA 1 -- ds50010--------
rs101030911,2
C,F,A,H--6793006(+) TTTTGA/TCGCAG 1 -- ds500125Minor allele frequency- T:0.22NS EA NA WA CSA 2668
rs1884065221,2
--6793007(+) TTTGAC/TGCAGA 1 -- ds50010--------
rs1919353581,2
--6793059(+) CTAAAC/TTGGAA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for DEFA4 (6793344 - 6795860 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for DEFA4 (see all 17):    About this table    
Variant IDTypeSubtypePubMed ID
dgv1247e201CNV Deletion23290073
esv2662366CNV Deletion23128226
nsv509248CNV Insertion20534489
nsv524367CNV Loss19592680
nsv831221CNV Gain17160897
nsv528374CNV Gain19592680
esv2752262CNV Gain17911159
nsv465437CNV Gain19166990
dgv7657n71CNV Gain21882294
nsv890068CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DEFA4
DNA2.0 Custom Variant and Variant Library Synthesis for DEFA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 601157    OMIM disorders: --

19 diseases for DEFA4:    
About MalaCards
oral leukoplakia    leukoplakia    breast and colorectal cancer    tonsillitis
atopic dermatitis    childhood leukemia    herpes simplex    meningioma
idiopathic pulmonary fibrosis    dermatitis    influenza    pulmonary fibrosis
hepatitis b    hiv-1    tuberculosis    hepatitis
colorectal cancer    neuronitis    leukemia

1 disease from the University of Copenhagen DISEASES database for DEFA4:
Tonsillitis

DEFA4 for disorders           About GeneDecksing

Genetic Association Database (GAD): DEFA4
Human Genome Epidemiology (HuGE) Navigator: DEFA4 (11 documents)

Export disorders for DEFA4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DEFA4 gene, integrated from 10 sources (see all 40):
(articles sorted by number of sources associating them with DEFA4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The gene encoding the human corticostatin HP-4 precursor contains a recent 86-base duplication and is located on chromosome 8. (PubMed id 8469233)1, 2, 3, 9 Palfree R.G.E.... Solomon S. (Mol. Endocrinol. 1993)
  2. Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro. (PubMed id 15620707)1, 2, 9 Wu Z.... Lu W. (FEBS Lett. 2005)
  3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
  6. Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1, and DEFA4 in meningococcal disease in three populations. (PubMed id 20016407)1, 4 Emonts M....de Groot R. (Shock 2010)
  7. Copy number variation of defensin genes and HIV infection in Brazilian children. (PubMed id 19194307)1, 4 Milanese M....Crovella S. (J. Acquir. Immune Defic. Syndr. 2009)
  8. Single nucleotide polymorphisms and the haplotype in the DEFB1 gene are associated with atopic dermatitis in a Korean population. (PubMed id 19135873)1, 4 Kim E....Yang J.M. (J. Dermatol. Sci. 2009)
  9. Crystal structures of human alpha-defensins HNP4, HD5, and HD6. (PubMed id 17088326)1, 2 Szyk A.... Lubkowski J. (Protein Sci. 2006)
  10. Antibacterial activity and specificity of the six human alpha- defensins. (PubMed id 15616305)1, 2 Ericksen B.... Lehrer R.I. (Antimicrob. Agents Chemother. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 1669 HGNC: 2763 AceView: DEFA4 Ensembl:ENSG00000164821 euGenes: HUgn1669
ECgene: DEFA4 H-InvDB: DEFA4

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DEFA4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DEFA4 gene:
Search GeneIP for patents involving DEFA4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DEFA4  
 OriGene qPCR primer pairs and template standards for DEFA4   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for DEFA4  
 OriGene qSTAR qPCR primer pairs in human, mouse for DEFA4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DEFA4   OriGene Custom Protein Services for DEFA4  

 
 
 Block miRNA regulation of human, mouse, rat DEFA4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DEFA4
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFA4 Predesigned siRNA for gene silencing in human, mouse, rat DEFA4
 QuantiFast Probe-based Assays in human, mouse, rat DEFA4 QuantiTect SYBR Green Assays in human, mouse, rat DEFA4
 Custom PCR Arrays for DEFA4 Search Chromatin IP Primers for DEFA4
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat DEFA4  GeneGlobe Interaction Network for DEFA4
 Regulatory tfbs in DEFA4 promoter
 GenScript Custom Purified and Recombinant Proteins Services for DEFA4 GenScript cDNA clones with any tag delivered in your preferred vector for DEFA4
 GenScript Custom Assay Services for DEFA4 GenScript Custom overexpressing Cell Line Services for DEFA4
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DEFA4 (DEF4)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 DEFA4 antibodies
 Antibodies for DEFA4
 See all of Abcam's Antibodies, Kits and Proteins for DEFA4
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for DEFA4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA4
 SwitchGear 3'UTR luciferase reporter plasmids for DEFA4
 SwitchGear Promoter luciferase reporter plasmids for DEFA4
 Search ThermoFisher Antibodies for DEFA4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA4
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEFA4
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEFA4
 LSBio Antibodies in human, mouse, rat for DEFA4
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DEFA4 gene at Home site.
Version: 3.12.166 28 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4