Aliases for DEFA4 Gene
External Ids for DEFA4 Gene
Previous HGNC Symbols for DEFA4 Gene
Previous GeneCards Identifiers for DEFA4 Gene
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]
GeneCards Summary for DEFA4 Gene
DEFA4 (Defensin Alpha 4) is a Protein Coding gene. Diseases associated with DEFA4 include Intestinal Perforation and Clostridium Difficile Colitis. Among its related pathways are Immune System and Defensins. An important paralog of this gene is DEFA3.
UniProtKB/Swiss-Prot for DEFA4 Gene
Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.