Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DEFA1A3 Gene

uncategorized   GIFtS: 12
GCID: GC08U900613

Defensin, Alpha 1 And Alpha 3, Variable Copy Number Locus

  See DEFA1A3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Defensin, Alpha 1 And Alpha 3, Variable Copy Number Locus1 2
DEFA12
DEFA32
DEFT1P2

External Ids:    HGNC: 322311   Entrez Gene: 6132532   

Export aliases for DEFA1A3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DEFA1A3 Gene:
DEFA1A3 (defensin, alpha 1 and alpha 3, variable copy number locus) is an uncategorized gene. Diseases associated with DEFA1A3 include crohn's disease, and systemic lupus erythematosus.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for DEFA1A3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEFA1A3 promoter sequence
   Search Chromatin IP Primers for DEFA1A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFA1A3


Genomic Location:
Chromosome:8   

Entrez Gene cytogenetic band: 8p23.1   HGNC cytogenetic band: 8p23.1

GeneLoc information about chromosome 8        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
DEFA: Defensins, alpha

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DEFA1A3

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat DEFA1A3 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DEFA1A3
SwitchGear 3'UTR luciferase reporter plasmidDEFA1A3 3' UTR sequence
Inhib. RNA
Products:
    
Browse OriGene RNAi
Predesigned siRNA for gene silencing in human, mouse, rat DEFA1A3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for DEFA1A3

Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for DEFA1A3
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEFA1A3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DEFA1A3

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for DEFA1A3
Browse ESI BIO Cell Lines and PureStem Progenitors for DEFA1A3 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA1A3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus
  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DEFA1A3
Interactions:

    Search GeneGlobe Interaction Network for DEFA1A3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DEFA1A3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DEFA1A3 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate DEFA1A3
SwitchGear 3'UTR luciferase reporter plasmidDEFA1A3 3' UTR sequence
Inhib. RNA
Products:
     
Browse OriGene RNAi
Predesigned siRNA for gene silencing in human, mouse, rat DEFA1A3
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for DEFA1A3
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEFA1A3
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DEFA1A3
Primer
Products:
    
Browse OriGene qPCR
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DEFA1A3
  QuantiTect SYBR Green Assays in human, mouse, rat DEFA1A3
  QuantiFast Probe-based Assays in human, mouse, rat DEFA1A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

DEFA1A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for DEFA1A3
Primer
Products:
Browse OriGene qPCR
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DEFA1A3
QuantiTect SYBR Green Assays in human, mouse, rat DEFA1A3
QuantiFast Probe-based Assays in human, mouse, rat DEFA1A3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA1A3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing DEFA1A3
DNA2.0 Custom Variant and Variant Library Synthesis for DEFA1A3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
2 diseases for DEFA1A3:    
About MalaCards
crohn's disease    systemic lupus erythematosus


Find genes that share disorders with DEFA1A3           About GenesLikeMe


Export disorders for DEFA1A3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DEFA1A3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with DEFA1A3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23. (PubMed id 16039093)1, 3, 9 Linzmeier R.M. and Ganz T. (Genomics 2005)
  2. Inter-population variability of DEFA3 gene absence: correlation with haplotype structure and population variability. (PubMed id 17214878)1, 3 Ballana E....Estivill X. (BMC Genomics 2007)
  3. Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3. (PubMed id 15944200)1, 3 Aldred P.M....Armour J.A. (Hum. Mol. Genet. 2005)
  4. Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. (PubMed id 15588320)1, 3 Taudien S....Platzer M. (BMC Genomics 2004)
  5. Alpha-defensin DEFA1A3 gene copy number variation in Asians and its genetic association study in Chinese systemic lupus erythematosus patients. (PubMed id 23333728)1 Cheng F.J....Zhang H. (Gene 2013)
  6. Alpha-defensin DEFA1A3 gene copy number elevation in Danish Crohn's disease patients. (PubMed id 21701837)1 Jespersgaard C....Andersen P.S. (Dig. Dis. Sci. 2011)
  7. Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. (PubMed id 20502117)1 Chen Q....Fang X. (Anesthesiology 2010)
  8. The role of human innate immune factors in nasal colonization by Staphylococcus aureus. (PubMed id 17913546)9 van Belkum A....van Leeuwen W. (Microbes Infect. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 613253 HGNC: 32231 euGenes: HUgn613253 ECgene: DEFA1A3 H-InvDB: DEFA1A3

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for DEFA1A3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for DEFA1A3 gene:
Search GeneIP for patents involving DEFA1A3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   Browse OriGene RNAi products  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   Browse OriGene clones  
 Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for DEFA1A3   OriGene Custom Protein Services for DEFA1A3  

 
 
 Block miRNA regulation of human, mouse, rat DEFA1A3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DEFA1A3
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEFA1A3 Predesigned siRNA for gene silencing in human, mouse, rat DEFA1A3
 QuantiFast Probe-based Assays in human, mouse, rat DEFA1A3 QuantiTect SYBR Green Assays in human, mouse, rat DEFA1A3
 Custom PCR Arrays for DEFA1A3 Search Chromatin IP Primers for DEFA1A3
 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DEFA1A3 Search GeneGlobe Interaction Network for DEFA1A3
 Search Regulatory tfbs for DEFA1A3
 GenScript Custom Purified and Recombinant Proteins Services for DEFA1A3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for DEFA1A3
 GenScript Custom Assay Services for DEFA1A3 GenScript Custom overexpressing Cell Line Services for DEFA1A3
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for DEFA1A3
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Biologicals
 Novus Tissue Slides
 Search for Antibodies for DEFA1A3 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for DEFA1A3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for DEFA1A3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEFA1A3
 SwitchGear 3'UTR luciferase reporter plasmids for DEFA1A3
 SwitchGear Promoter luciferase reporter plasmids for DEFA1A3
 Search ThermoFisher Antibodies for DEFA1A3
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DEFA1A3
 Browse compounds at ApexBio
 Search Addgene for plasmids for DEFA1A3
  Search eBioscience for proteins for DEFA1A3
  Search eBioscience for elisas for DEFA1A3
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for DEFA1A3
 antibodies-online antibodies for DEFA1A3 (22 products)
 antibodies-online kits for DEFA1A3 (6 products)
 antibodies-online peptides for DEFA1A3
 antibodies-online proteins for DEFA1A3 (7 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      DEFA1A3 gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4