DEFA1 Gene
protein-coding GIFtS: 56
GCID: GC08M006822
|
|
defensin, alpha 1(Previous names: defensin, alpha 2, defensin, alpha 1, myeloid-related sequence...)
(Previous symbols: DEF1, MRS, DEFA2)
| |
Aliases
for DEFA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Defensin, Alpha 11 2 3 | | Defensin, Alpha 21 2 | | DEF11 2 3 5 | | HP-12 3 | | MRS1 2 3 5 | | HP12 3 | | DEFA21 2 3 | | Myeloid-Related Sequence2 | | HNP-11 2 3 | | Neutrophil Defensin 12 | | Defensin, Alpha 1, Myeloid-Related Sequence1 2 | | |
Export aliases for DEFA1 gene to outside databasesPrevious GC identifers: GC08M006899 GC08M007089 GC08M007014 GC08M006841 GC08M006615 |
Summaries
for DEFA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DEFA1:
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundantin the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine,respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequenceand distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in themicrobicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alphadefensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. Thisgene and the gene encoding defensin, alpha 3 are both subject to copy number variation. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: DEF1_HUMAN, P59665Function: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activityagainst Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing theirplasma membrane
Gene Wiki entry for DEFA1 (Defensin, alpha 1)
|
Genomic Views
for DEFA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_023736.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEFA1 gene promoter:
AML1a NCX/Ncx c-Myb POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEFA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1DEFA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M006822: view genomic region
(about GC identifiers)
Start:
|
6,835,171 bp from pter |
End:
|
6,837,614 bp from pter |
Size:
|
2,444 bases |
Orientation:
|
minus strand |
|
Proteins
for DEFA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DEF1_HUMAN, P59665 (See
protein sequence)Recommended Name: Neutrophil defensin 1 precursor Size: 94 amino acids; 10201 Da
Subunit: Dimer
Subcellular location: Secreted
6/14 PDB 3D structures from  and Proteopedia  for DEFA1 (see all 14):2KHT (3D)
2PM1 (3D)
3GNY (3D)
3H6C (3D)
3HJ2 (3D)
3HJD (3D)
Secondary accessions: P11479 Q14125 Q6EZF6Explore the universe of human proteins at neXtProt for DEFA1: NX_P59665
Post-translational modifications:
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production1
Phosphorylation at Tyr-85 has been found in some cancer cell lines, and interferes with ADP-rybosylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59665
DEFA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004075.1
ENSEMBL proteins: ENSP00000372139 ENSP00000372126 Reactome Protein details: P59665
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DEFA1 for ontologies About GeneDecksing
DEFA1 Antibody Products:
Assay Products for DEFA1: |
Protein
Domains /
Families
for DEFA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEFA1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59665ProtoNet protein and cluster: P59665 1 Blocks protein family: IPB002366 Defensin propeptide
UniProtKB/Swiss-Prot: DEF1_HUMAN, P59665Similarity: Belongs to the alpha-defensin family |
Function
for DEFA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DEF1_HUMAN, P59665Function: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activityagainst Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing theirplasma membrane Genatlas biochemistry entry for DEFA1:defensin alpha 1,3-4kDa,hematopoietic ,released from azurophil granules of neutrophiles,oxygen independent phagocytosisof Gram+,Gram- bacteria,many fungi,some viruses
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DEFA1 (NM_004084) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEFA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA1 |
1 GenomeRNAi human phenotype for DEFA1:
|
Pathways & Interactions
for DEFA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Alpha-defensins | | | 3 | Beta defensins | | | 4 | Cellular roles of Anthrax toxin | | | 5 | Selected targets of C/EBPalpha | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DEFA1
1  BioSystems Pathway for DEFA1
5/6 
Reactome Pathways for DEFA1 (see all 6)
DEFA1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEFA1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for DEFA1 (P596652, 3 ENSP000003721264) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
DEFA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DEFA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DEFA1 for compounds About GeneDecksing
 Browse Tocris compounds for DEFA1
9 Novoseek chemical compound relationships for DEFA1 gene About this table
Search CenterWatch for drugs/clinical trials and news about DEFA1 / DEF1
|
Transcripts
for DEFA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEFA1 gene: NM_004084.3 Unigene Cluster for DEFA1: Defensin, alpha 1 Hs.380781 [show with all ESTs]Unigene Representative Sequence: BX4270542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382692(uc003wqv.1) ENST00000382679
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DEFA1 (NM_004084) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEFA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA1 |
Additional cDNA sequence: BC069423.1 BC093791.1 BC112188.1 M21130.1 M26602.1 X52053.1 6 DOTS entries: DT.87017167 DT.121471111 DT.40131822 DT.121471118 DT.91893655 DT.97857951 24/377 AceView cDNA sequences (see all 377): BE831411 AJ706312 AA321190 AA321316 AW950276 BE831402 BE831369 BE831403 M21130 BE831405 BP429396 AW468012 BE831407 AW467613 BE831398 BE831397 BE831314 AW291977 AJ713328 BE831404 BE831364 AJ705663 BE831385 BM725836
GeneLoc Exon Structure
|
Expression
for DEFA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEFA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGCTATT
About this image
See DEFA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEFA1
SOURCE GeneReport for Unigene cluster: Hs.380781
SABiosciences Custom PCR Arrays for DEFA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEFA1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DEFA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEFA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEFA1 |
Orthologs
for DEFA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DEFA1 (if available)
TreeFam Gene Tree for DEFA1 (if available) |
Paralogs
for DEFA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DEFA1 gene
- DEFA1B1 2 DEFA31 2 DEFA42 DEFA62 DEFA52
5 SIMAP similar genes for DEFA1 using alignment to 1 protein entry: DEF1_HUMAN:DEFA3 DEFA4 DEFA5 DEFA6 Em
DEFA1 for paralogs About GeneDecksing
|
Genomic Variants
for DEFA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEFA1 (6835171 - 6837614 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for DEFA1
15/18 CNVs (see all 18): 36854 31422 36853 0629 1442 4577 95200 36850 23226 95199 36849 70242 36858 82441 8592 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEFA1 |
|
Disorders
/ Diseases
for DEFA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DEFA1 for disorders About GeneDecksing
OMIM gene information: 125220
OMIM disorders: --
20/52  diseases for DEFA1 (see all 52): About MalaCardsmultidrug-resistant tuberculosis chronic venous leg ulcers clostridium difficile bacterial vaginosis
myelomonocytic leukemia cerebrovascular accident chronic myelomonocytic leukemia oral squamous cell carcinoma
microsporidiosis cystic fibrosis allergic rhinitis leukoplakia
squamous cell carcinoma chronic myeloid leukemia myeloid leukemia rhinitis
renal cell carcinoma sjogren's syndrome cerebral infarction fibrosis
10/15 Novoseek disease relationships for DEFA1 gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bronchoalveolar lavage fluid |
51 |
3 |
19897717 (1), 12488509 (1), 16627471 (1) |
| leukoplakia |
33.5 |
2 |
10522210 (2) |
| fibrosis idiopathic pulmonary |
30.2 |
2 |
19897717 (1), 16627471 (1) |
| inflammation |
25.1 |
5 |
15843081 (1), 16002632 (1), 17599740 (1), 11860065 (1) |
| cystic fibrosis |
24.9 |
1 |
16627471 (1) |
| bacterial infections |
11.8 |
1 |
9788972 (1) |
| metastasis |
5.28 |
1 |
10910038 (1) |
| tuberculosis |
3.18 |
6 |
11158773 (3), 15378441 (1), 10382264 (1), 10933095 (1) |
| stroke |
1.89 |
8 |
20090554 (2), 18757238 (2), 17761925 (1), 20374070 (1) (see all 7) |
| carcinoma squamous cell |
1.44 |
7 |
9891534 (2), 16483834 (2), 10522210 (1), 15519138 (1) (see all 5) |
Human Genome Epidemiology (HuGE) Navigator: DEFA1 (1 document)
Export disorders for DEFA1 gene to outside databases
|
Publications
for DEFA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEFA1 gene, integrated from 9 sources (see all 214):
(articles sorted by number of sources associating them with DEFA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3. (PubMed id 8530462)1, 2, 9 Mars W.M....Saunders G.F. (1995)
- Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3. (PubMed id 15944200)1, 3, 9 Aldred P.M....Armour J.A. (2005)
- NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1. (PubMed id 1445872)1, 2, 9 Zhang X.-L.... Pardi A. (1992)
- The structure of neutrophil defensin genes. (PubMed id 8477861)1, 2, 9 Linzmeier R.... Ganz T. (1993)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. (PubMed id 9030614)1, 3 Feng Y....Hersch S.M. (1997)
- The structure of neutrophil defensin genes. (PubMed id 8325384)1, 2 Linzmeier R....Ganz T. (1993)
- Posttranslational processing of defensins in immature human myeloid cells. (PubMed id 1339298)1, 2 Valore E.V. and Ganz T. (1992)
- NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1. (PubMed id 1445873)1, 2 Pardi A.... Yip P.F. (1992)
|
External Searches for DEFA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DEFA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEFA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEFA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEFA1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DEFA1 gene:
Search GeneIP for patents involving DEFA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEFA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DEFA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEFA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEFA1 | | | OriGene Protein Over-expression Lysate for DEFA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DEFA1 | | OriGene 3'-UTR Clone for DEFA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEFA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DEFA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DEFA1 | | OriGene Custom Protein Services for DEFA1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEFA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEFA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEFA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEFA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEFA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEFA1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DEFA1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DEFA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for DEFA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEFA1 |
|
|
|
|
