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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DEF8 Gene

protein-coding   GIFtS: 45
GCID: GC16P090015

Differentially Expressed In FDCP 8 Homolog (Mouse)

  Search for DEF8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Differentially Expressed In FDCP 8 Homolog (Mouse)1 2
DEF-82 3
Differentially Expressed In FDCP 8 Homolog2

External Ids:    HGNC: 259691   Entrez Gene: 548492   Ensembl: ENSG000001409957   UniProtKB: Q6ZN543   

Export aliases for DEF8 gene to outside databases

Previous GC identifers: GC16P088543 GC16P075708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DEF8 Gene: 
DEF8 (differentially expressed in FDCP 8 homolog (mouse)) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is PLEKHM3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010542.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DEF8 gene promoter:
         CREB   Elk-1   Tal-1beta   C/EBPalpha   E47   Evi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DEF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

DEF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEF8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P090015:  view genomic region     (about GC identifiers)

Start:
90,014,333 bp from pter      End:
90,034,468 bp from pter
Size:
20,136 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DEFI8_HUMAN, Q6ZN54 (See protein sequence)
Recommended Name: Differentially expressed in FDCP 8 homolog  
Size: 512 amino acids; 58710 Da
Sequence caution: Sequence=BAC04802.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites; Sequence=BAG64541.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: B3KT65 B4DK62 B4E0S9 B7Z3H6 H3BUG7 Q8N8N3 Q9NXL0
Alternative splicing: 6 isoforms:  Q6ZN54-1   Q6ZN54-2   Q6ZN54-3   Q6ZN54-4   Q6ZN54-5   Q6ZN54-6   (No experimental confirmation available. Gene prediction based on cDNA data)

Explore the universe of human proteins at neXtProt for DEF8: NX_Q6ZN54

Explore proteomics data for DEF8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZN54

  • DEF8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DEF8 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001229745.1  NP_001229746.1  NP_001229747.1  NP_001229748.1  NP_001229749.1  NP_001229750.1  NP_001229751.1  NP_060172.1  
    NP_997397.1  

    ENSEMBL proteins: 
     ENSP00000458019   ENSP00000457072   ENSP00000456954   ENSP00000455654   ENSP00000455783  
     ENSP00000454534   ENSP00000457309   ENSP00000268676   ENSP00000455987   ENSP00000456501  
     ENSP00000456157   ENSP00000454478   ENSP00000412784   ENSP00000456706   ENSP00000456095  
     ENSP00000456799   ENSP00000457627   ENSP00000454930  

    Human Recombinant Protein Products for DEF8: 
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    OriGene Protein Over-expression Lysate for DEF8
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    Novus Biologicals DEF8 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for DEF8 


    DEF8 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DEF8 

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    Cloud-Clone Corp. ELISAs for DEF8 
    Cloud-Clone Corp. CLIAs for DEF8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR025258 DUF4206
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry Q6ZN54

    ProtoNet protein and cluster: Q6ZN54

    UniProtKB/Swiss-Prot: DEFI8_HUMAN, Q6ZN54
    Similarity: Belongs to the DEF8 family
    Similarity: Contains 2 phorbol-ester/DAG-type zinc fingers


    DEF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    DEF8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DEF8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DEF8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEF8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEF8 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DEF8
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DEF8 (see all 17):
    hsa-miR-106a hsa-miR-15a hsa-miR-29c hsa-miR-29a hsa-miR-424 hsa-miR-93 hsa-miR-195 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidDEF8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of DEF8 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEF8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DEF8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for DEF8 (Q6ZN543 ENSP000002686764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK3Q131883I2D: score=5 
    RASSF8Q8NHQ83I2D: score=4 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035556intracellular signal transduction IEA--

    DEF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DEF8 (DEFI8)

    10/843 HMDB Compounds for DEF8 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Search CenterWatch for drugs/clinical trials and news about DEF8 / DEFI8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DEF8 gene (9 alternative transcripts): 
    NM_001242816.1  NM_001242817.1  NM_001242818.1  NM_001242819.1  NM_001242820.1  NM_001242821.1  NM_001242822.1  NM_017702.3  
    NM_207514.2  

    Unigene Cluster for DEF8:

    Differentially expressed in FDCP 8 homolog (mouse)
    Hs.62771  [show with all ESTs]
    Unigene Representative Sequence: NM_001242820
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000563594(uc002fpo.2 uc002fpp.2 uc021tmv.1 uc010vpq.2)
    ENST00000567999 ENST00000566079 ENST00000561784 ENST00000566820 ENST00000562578
    ENST00000561741 ENST00000268676(uc002fpn.2 uc010vpr.2 uc002fpq.2)
    ENST00000562986 ENST00000569453 ENST00000568096 ENST00000567243 ENST00000567884
    ENST00000569803 ENST00000569061 ENST00000418391(uc021tmu.1 uc002fpl.3 uc002fpm.3)
    ENST00000561959 ENST00000567874
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DEF8 (see all 17):
    hsa-miR-106a hsa-miR-15a hsa-miR-29c hsa-miR-29a hsa-miR-424 hsa-miR-93 hsa-miR-195 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidDEF8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DEF8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEF8
    Clone
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    OriGene clones in human, mouse for DEF8 (see all 11)
    OriGene ORF clones in mouse, rat for DEF8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DEF8 (NM_017702)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEF8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEF8
    Sirion Biotech Customized lentivirus for stable overexpression of DEF8 
                         Customized lentivirus expression plasmids for stable overexpression of DEF8 
    Primer
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    OriGene qPCR primer pairs and template standards for DEF8
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEF8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEF8

    Additional mRNA sequence: 

    AF289561.1 AK000193.1 AK055099.1 AK095051.1 AK096485.1 AK131370.1 AK225539.1 AK295880.1 
    AK296410.1 AK303510.1 AL157465.1 BC015482.2 BC105592.1 BC106751.1 BC130482.1 BC144038.1 

    24/30 DOTS entries (see all 30):

    DT.99938906  DT.95373755  DT.412352  DT.120720774  DT.412691  DT.120720982  DT.95165855  DT.120721056 
    DT.100795531  DT.100795530  DT.120721072  DT.100795529  DT.120720542  DT.40306267  DT.100661029  DT.100795532 
    DT.120720491  DT.95242708  DT.120721115  DT.120720956  DT.424065  DT.100795534  DT.120720538  DT.120720679 

    24/235 AceView cDNA sequences (see all 235):

    AU280037 BQ057163 CB216216 BQ059883 BQ901164 BP870966 CB852465 CA424457 
    CA432276 BQ925331 BQ059253 CK724946 CK430965 BM835901 CF125201 BP360714 
    AW014780 BG758794 BC015482 CD370420 NM_017702 AA303766 AK000193 BM141946 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DEF8 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b · 14c
    SP1:        -                             -                                               -     -                                       
    SP2:                                                                                                                                    
    SP3:                                                                                            -     -                                 
    SP4:                                                                                      -     -     -                                 
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for DEF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DEF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACCAGGCT
    DEF8 Expression
    About this image


    See DEF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DEF8

    SOURCE GeneReport for Unigene cluster: Hs.62771
        SABiosciences Custom PCR Arrays for DEF8
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEF8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DEF8 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Def81 , 5 differentially expressed in FDCP 81, 5 87.7(n)1
    93.01(a)1
      8 (72.10 cM)5
    238541  NM_001253783.11  NP_001240712.11 
     1234429865 
    chicken
    (Gallus gallus)
    Aves DEF81 differentially expressed in FDCP 8 homolog (mouse) 84.28(n)
    88.4(a)
      769452  XM_001232733.2  XP_001232734.2 
    lizard
    (Anolis carolinensis)
    Reptilia DEF86
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343866.1(112286-119828)
    African clawed frog
    (Xenopus laevis)
    Amphibia def8-prov2 differentially expressed in FDCP 8 78.26(n)    BC056097.1 
    zebrafish
    (Danio rerio)
    Actinopterygii def81 differentially expressed in FDCP 8 homolog (mouse) 70.57(n)
    72.83(a)
      492523  NM_001007395.1  NP_001007396.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115341 CG11534 49.49(n)
    39.06(a)
      39381  NM_140292.2  NP_648549.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F20H11.11 Protein F20H11.1 46.39(n)
    39.47(a)
      175933  NM_066053.6  NP_498454.2 


    ENSEMBL Gene Tree for DEF8 (if available)
    TreeFam Gene Tree for DEF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DEF8 gene
    PLEKHM32  KIAA02262  KIAA0226L2  PLEKHM12  

    DEF8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DEF8
    PGOHUM00000262363


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/597 SNPs in DEF8 are shown (see all 597)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129183341,2
    C,F--90013166(+) CTGGCT/CTGTTG 8 -- us2k12Minor allele frequency- C:0.05CSA WA 120
    rs284791821,2
    C,F--90013178(+) GGAGAC/GGAGCC 8 -- us2k14Minor allele frequency- G:0.23NA WA 124
    rs1156935701,2
    F--90013197(+) AAGGTG/AGGGGT 8 -- us2k11Minor allele frequency- A:0.07WA 118
    rs99318701,2
    C,A--90013218(+) CTGGCC/TTGTTG 8 -- us2k10--------
    rs99312591,2
    C,A--90013230(+) GGAGAC/GGAGCC 8 -- us2k1 trp30--------
    rs133350911,2
    C,F--90013255(+) GGGGCC/TGACTT 8 -- us2k16Minor allele frequency- T:0.26WA CSA NA EA 363
    rs620522211,2
    C,F--90013420(+) GCGGCG/AGCTCA 8 -- us2k16Minor allele frequency- A:0.10WA CSA NA EA 364
    rs1487422711,2
    --90013464(+) GGACAC/TGGCGT 8 -- us2k10--------
    rs584134601,2
    C,F--90013467(+) CACGGC/TGTCCG 8 -- us2k12Minor allele frequency- T:0.16WA 120
    rs732779141,2
    C--90013504(+) TCACTG/CCACCC 8 -- us2k14Minor allele frequency- C:0.11WA NA EA 360

    HapMap Linkage Disequilibrium report for DEF8 (90014333 - 90034468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for DEF8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509640CNV Insertion20534489
    dgv3009n71CNV Loss21882294
    nsv907433CNV Loss21882294
    nsv907445CNV Loss21882294
    nsv907429CNV Loss21882294
    nsv907443CNV Loss21882294
    dgv3015n71CNV Loss21882294
    nsv471119CNV Loss18288195
    nsv457626CNV Loss19166990
    nsv428331CNV Gain+Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DEF8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DEF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54849 HGNC: 25969 AceView: FLJ20186 Ensembl:ENSG00000140995 euGenes: HUgn54849
    ECgene: DEF8 H-InvDB: DEF8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DEF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DEF8 gene:
    Search GeneIP for patents involving DEF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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