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DEF6 Gene

protein-coding   GIFtS: 59
GCID: GC06P035265

Differentially Expressed In FDCP 6 Homolog (Mouse)

(Previous name: differentially expressed in FDCP (mouse homolog) 6)
  Search for DEF6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Differentially Expressed In FDCP 6 Homolog (Mouse)1 2     SLAT2 5
IBP2 3 5     Differentially Expressed In FDCP (Mouse Homolog) 61
SWAP-70-Like Adaptor Protein Of T Cells1 2     SWAP70L2
DEF-62 3     Differentially Expressed In FDCP 6 Homolog2
IRF4-Binding Protein2 3     

External Ids:    HGNC: 27601   Entrez Gene: 506192   Ensembl: ENSG000000238927   OMIM: 6100945   UniProtKB: Q9H4E73   

Export aliases for DEF6 gene to outside databases

Previous GC identifers: GC06P035267 GC06P035313 GC06P035314 GC06P035373 GC06P034986


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DEF6 Gene:
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is
highly expressed in B and T cells (Gupta et al., 2003 (PubMed 12923183)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DEF6 Gene:
DEF6 (differentially expressed in FDCP 6 homolog (mouse)) is a protein-coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is SWAP70.

UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays
a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with
activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with
ZAP70 signaling (By similarity)

Gene Wiki entry for DEF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DEF6 gene promoter:
         ER-alpha   RFX1   MyoD   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   AP-4   POU3F2   AREB6   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEF6 promoter sequence
   Search Chromatin IP Primers for DEF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33-p21.1   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.33-p21.1

DEF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEF6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P035265:  view genomic region     (about GC identifiers)

Start:
35,265,595 bp from pter      End:
35,289,548 bp from pter
Size:
23,954 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7 (See protein sequence)
Recommended Name: Differentially expressed in FDCP 6 homolog  
Size: 631 amino acids; 73910 Da
Subunit: Interacts with ZAP70 (By similarity). Interacts with IRF4, activated RAC1 and F-actin. Both the
phosphorylated and non-phosphorylated forms bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3)
Secondary accessions: Q86VF4

Explore the universe of human proteins at neXtProt for DEF6: NX_Q9H4E7

Explore proteomics data for DEF6 at MOPED

Post-translational modifications: 

  • Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DEF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071330.3  
    ENSEMBL proteins: 
     ENSP00000319831   ENSP00000415357   ENSP00000442166  

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    Cloud-Clone Corp. Proteins for DEF6

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H4E7

    ProtoNet protein and cluster: Q9H4E7

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7
    Domain: The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding
    Similarity: Contains 1 PH domain


    Find genes that share domains with DEF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEFI6_HUMAN, Q9H4E7
    Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays
    a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with
    activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with
    ZAP70 signaling (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DEF6           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Def6):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with DEF6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEF6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEF6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEF6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEF6

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    4 qRT-PCR Assays for microRNAs that regulate DEF6:
    hsa-miR-4328 hsa-miR-593* hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidDEF6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DEF6

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    GenScript: all cDNA clones in your preferred vector: DEF6 (NM_022047)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEF6

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    eBioscience FlowRNA Probe Sets ( VA1-10881) for DEF6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEFI6_HUMAN, Q9H4E7: Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon binding
    phosphatidylinositol 3,4,5-trisphosphate
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with DEF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DEF6 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of RhoA activity
    Regulation of RhoA activity
    2Regulation of RAC1 activity
    Regulation of RAC1 activity
    3G protein signaling Regulation of RAC1 activity
    G protein signaling Regulation of RAC1 activity
    4G protein signaling Regulation of CDC42 activity
    G protein signaling Regulation of CDC42 activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DEF6
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity

    2 BioSystems Pathways for DEF6
        Regulation of RhoA activity
    Regulation of RAC1 activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DEF6
    Interactions:

        GeneGlobe Interaction Network for DEF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for DEF6 (Q9H4E72, 3 ENSP000003198314) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BEGAINQ9BUH82, 3, ENSP000003473014MINT-66649 I2D: score=5 STRING: ENSP00000347301
    RAC2P151533, ENSP000002490714I2D: score=3 STRING: ENSP00000249071
    RHOAP615863, ENSP000004001754I2D: score=3 STRING: ENSP00000400175
    LCKP062393, ENSP000003378254I2D: score=1 STRING: ENSP00000337825
    ZAP70P434033, ENSP000002649724I2D: score=1 STRING: ENSP00000264972
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DEF6 (DEFI6)

    3 HMDB Compounds for DEF6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DEF6 gene: 
    NM_022047.3  

    Unigene Cluster for DEF6:

    Differentially expressed in FDCP 6 homolog (mouse)
    Hs.15476  [show with all ESTs]
    Unigene Representative Sequence: AY241694
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316637(uc003okk.3 uc010jvs.3) ENST00000444278 ENST00000468102
    ENST00000542066(uc010jvt.3)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate DEF6:
    hsa-miR-4328 hsa-miR-593* hsa-miR-513c hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidDEF6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DEF6
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DEF6 (NM_022047)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEF6
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      QuantiFast Probe-based Assays in human, mouse, rat DEF6
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10881) for DEF6 

    Additional mRNA sequence: 

    AJ276095.1 AK093613.1 AK314756.1 AL110182.1 AY241694.1 BC007702.2 BC017504.1 

    8 DOTS entries:

    DT.413376  DT.92023911  DT.92029724  DT.100788864  DT.121333468  DT.100788867  DT.91995641  DT.95149917 

    Selected AceView cDNA sequences (see all 124):

    BU155374 BP428529 BU838961 BX379958 AY241694 AK093613 BE880393 AJ276095 
    BX382612 CR624997 BX398587 BQ682207 NM_022047 BX398963 BC007702 AI832774 
    BX398586 AW593052 BE671787 BM923370 AI968859 AW305022 AI205927 BM144767 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DEF6 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -                                               -     -                                             
    SP2:                                -     -     -     -                             -     -                                             
    SP3:                                                                                -     -                                             
    SP4:                                                                                                                                    
    SP5:                                -                                                                                                   


    ECgene alternative splicing isoforms for DEF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DEF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTGTCT
    DEF6 Expression
    About this image


    DEF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
    DEF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DEF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.15476

    UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7
    Tissue specificity: Broadly expressed in the immune system and can be detected in T and B-cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DEF6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Def61 , 5 differentially expressed in FDCP 61, 5 88.62(n)1
    92.54(a)1
      17 (14.64 cM)5
    238531  NM_027185.31  NP_081461.21 
     282077785 
    chicken
    (Gallus gallus)
    Aves DEF61 differentially expressed in FDCP 6 homolog (mouse) 75.38(n)
    76.63(a)
      419893  XM_418019.4  XP_418019.3 
    lizard
    (Anolis carolinensis)
    Reptilia DEF66
    differentially expressed in FDCP 6 homolog (mouse)...
    65(a)
    1 ↔ 1
    4(120554045-120621560)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687752 hypothetical protein MGC68775 74.64(n)    BC060433.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637212 similar to differentially expressed in FDCP 6 77.54(n)   394015  BC054935.1 


    ENSEMBL Gene Tree for DEF6 (if available)
    TreeFam Gene Tree for DEF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DEF6 gene
    SWAP702  
    2 SIMAP similar genes for DEF6 using alignment to 4 protein entries:     DEFI6_HUMAN (see all proteins):
    SWAP70    PHLDB1

    Find genes that share paralogs with DEF6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DEF6 (see all 504)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420237351,2
    C--35264450(+) TGGTGG/TTGCCT 1 -- us2k10--------
    rs1854180481,2
    --35264497(+) CCCTTC/TCTGCC 1 -- us2k10--------
    rs1905696791,2
    --35264640(+) CAGCAC/TCTTAC 1 -- us2k10--------
    rs1809829641,2
    C--35264671(+) CTTAGC/GGGGTA 1 -- us2k10--------
    rs1850543971,2
    C--35264680(+) TAGGGA/GGAGGT 1 -- us2k10--------
    rs1457880611,2
    --35264798(+) ACATGA/GAGGGC 1 -- us2k10--------
    rs1886942891,2
    --35264827(+) TGCTGC/TTGGGA 1 -- us2k10--------
    rs737451821,2
    C,F--35264828(+) GCTGCT/CGGGAC 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1810481881,2
    --35264850(+) AGGTGC/GACCAC 1 -- us2k10--------
    rs1858710251,2
    --35264981(+) CAAGTA/GCCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DEF6 (35265595 - 35289548 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DEF6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528424CNV Loss19592680
    nsv830641CNV Loss17160897
    dgv1939e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610094    OMIM disorders: --


    Find genes that share disorders with DEF6           About GenesLikeMe

    Genetic Association Database (GAD): DEF6
    Human Genome Epidemiology (HuGE) Navigator: DEF6 (9 documents)

    Export disorders for DEF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DEF6 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with DEF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system. (PubMed id 12651066)1, 2, 9 Gupta S....Pernis A.B. (Hum. Immunol. 2003)
    2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages. (PubMed id 19251698)1, 3 Mehta H....Coggeshall K.M. (J. Biol. Chem. 2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. Cooperation of DEF6 with activated Rac in regulating cell morphology. (PubMed id 17121847)1, 2 Oka T.... Fukui Y. (J. Biol. Chem. 2007)
    8. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. (PubMed id 15023524)1, 2 Mavrakis K.J.... Sablitzky F. (Exp. Cell Res. 2004)
    9. T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse. (PubMed id 12923183)1, 2 Gupta S.... Pernis A.B. (J. Biol. Chem. 2003)
    10. The ectopic expression of IFN regulatory factor 4-binding protein is correlated with the malignant behavior of human breast cancer cells. (PubMed id 19393345)1, 9 Li P....Hu C. (Int. Immunopharmacol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50619 HGNC: 2760 AceView: DEF6 Ensembl:ENSG00000023892 euGenes: HUgn50619
    ECgene: DEF6 H-InvDB: DEF6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DEF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DEF6 gene:
    Search GeneIP for patents involving DEF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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