DEF6 Gene
protein-coding GIFtS: 57
GCID: GC06P035265
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|
differentially expressed in FDCP 6 homolog (mouse)(Previous name: differentially expressed in FDCP (mouse homolog) 6 )
| |
Aliases
for DEF6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Differentially Expressed In FDCP 6 Homolog (Mouse)1 2 | | IRF4-Binding Protein2 3 | | IBP1 2 3 | | Differentially Expressed In FDCP (Mouse Homolog) 61 | | SLAT1 2 | | Differentially Expressed In FDCP 6 Homolog2 | | SWAP70L1 2 | | SWAP-70-Like Adaptor Protein Of T Cells2 | | DEF-62 3 | | |
Export aliases for DEF6 gene to outside databasesPrevious GC identifers: GC06P035267 GC06P035313 GC06P035314 GC06P035373 GC06P034986 |
Summaries
for DEF6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DEF6:
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highlyexpressed in B and T cells (Gupta et al., 2003 (PubMed 12923183)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays arole in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activatedRAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling(By similarity)
Gene Wiki entry for DEF6
|
Genomic Views
for DEF6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEF6 gene promoter:
ER-alpha RFX1 MyoD POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) AP-4 POU3F2 AREB6 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEF6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEF6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33-p21.1 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.33-p21.1DEF6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P035265: view genomic region
(about GC identifiers)
Start:
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35,265,595 bp from pter |
End:
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35,289,548 bp from pter |
Size:
|
23,954 bases |
Orientation:
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plus strand |
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Proteins
for DEF6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7 (See
protein sequence)Recommended Name: Differentially expressed in FDCP 6 homolog Size: 631 amino acids; 73910 Da
Subunit: Interacts with ZAP70 (By similarity). Interacts with IRF4, activated RAC1 and F-actin. Both the phosphorylatedand non-phosphorylated forms bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3)
Subcellular location: Cytoplasm. Cell membrane. Nucleus. Note=Recruited to the plasma membrane upon bindingphosphatidylinositol 3,4,5-trisphosphate
Secondary accessions: Q86VF4Explore the universe of human proteins at neXtProt for DEF6: NX_Q9H4E7
Post-translational modifications:
Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H4E7
DEF6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071330.3
ENSEMBL proteins: ENSP00000319831 ENSP00000415357 ENSP00000442166
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DEF6 for ontologies About GeneDecksing
DEF6 Antibody Products:
Assay Products for DEF6: |
Protein
Domains /
Families
for DEF6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEF6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H4E7ProtoNet protein and cluster: Q9H4E7 1 Blocks protein family: IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7Domain: The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate bindingSimilarity: Contains 1 PH domain |
Function
for DEF6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays arole in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activatedRAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling(By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEF6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEF6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DEF6 (NM_022047) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEF6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEF6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEF6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0005543 | phospholipid binding |
IEA | -- |
DEF6 for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Def6):
DEF6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DEF6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling Regulation of RAC1 activity | | | 2 | Regulation of RhoA activity | | | 3 | Regulation of RAC1 activity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for DEF6
2  GeneGo (Thomson Reuters) Pathways for DEF6
2  BioSystems Pathways for DEF6
DEF6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DEF6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/12 Interacting proteins for DEF6 (Q9H4E72, 3 ENSP000003198314) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
|
Drugs & Compounds
for DEF6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DEF6
3 HMDB Compounds for DEF6 About this table
Search CenterWatch for drugs/clinical trials and news about DEF6 / DEFI6
|
Transcripts
for DEF6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEF6 gene: NM_022047.3 Unigene Cluster for DEF6: Differentially expressed in FDCP 6 homolog (mouse) Hs.15476 [show with all ESTs]Unigene Representative Sequence: AY2416944 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316637(uc003okk.3 uc010jvs.3) ENST00000444278 ENST00000468102
ENST00000542066(uc010jvt.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEF6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEF6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DEF6 (NM_022047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEF6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEF6 |
Additional cDNA sequence: AJ276095.1 AK093613.1 AK314756.1 AL110182.1 AY241694.1 BC007702.2 BC017504.1 8 DOTS entries: DT.413376 DT.92023911 DT.92029724 DT.100788864 DT.121333468 DT.100788867 DT.91995641 DT.95149917 24/124 AceView cDNA sequences (see all 124): BE880393 BX379958 BX382612 NM_022047 CR624997 BX398963 BQ682207 BX398587 BU838961 BP428529 AJ276095 AY241694 BC007702 BU155374 AK093613 BQ893321 AW003312 BX412115 BE280697 BM144767 AI652377 AI805237 BX370801 BM546156
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DEF6 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DEF6
|
Expression
for DEF6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGCTGTCT
About this image
See DEF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEF6
SOURCE GeneReport for Unigene cluster: Hs.15476
UniProtKB/Swiss-Prot: DEFI6_HUMAN, Q9H4E7Tissue specificity: Broadly expressed in the immune system and can be detected in T and B-cells
SABiosciences Custom PCR Arrays for DEF6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEF6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DEF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEF6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEF6 |
Orthologs
for DEF6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DEF6 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for DEF6 (if available)
TreeFam Gene Tree for DEF6 (if available) |
Paralogs
for DEF6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DEF6 gene
- SWAP702
2 SIMAP similar genes for DEF6 using alignment to 4 protein entries: DEFI6_HUMAN (see all proteins):SWAP70 PHLDB1
DEF6 for paralogs About GeneDecksing
|
Genomic Variants
for DEF6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEF6 (35265595 - 35289548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DEF6
1 CNV: 3606 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEF6 |
|
Disorders
/ Diseases
for DEF6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DEF6 for disorders About GeneDecksing
OMIM gene information: 610094
OMIM disorders: --
4  diseases for DEF6: About MalaCardsmeningioma colorectal cancer breast cancer leukemia
Human Genome Epidemiology (HuGE) Navigator: DEF6 (9 documents)
Export disorders for DEF6 gene to outside databases
|
Publications
for DEF6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEF6 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with DEF6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system. (PubMed id 12651066)1, 2, 9 Gupta S....Pernis A.B. (2003)
- Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages. (PubMed id 19251698)1, 3 Mehta H....Coggeshall K.M. (2009)
- Cooperation of DEF6 with activated Rac in regulating cell morphology. (PubMed id 17121847)1, 2 Oka T.... Fukui Y. (2007)
- DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. (PubMed id 15023524)1, 2 Mavrakis K.J.... Sablitzky F. (2004)
- T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse. (PubMed id 12923183)1, 2 Gupta S.... Pernis A.B. (2003)
- The ectopic expression of IFN regulatory factor 4-bin ding protein is correlated with the malignant behavior of human breast cancer c ells. (PubMed id 19393345)1, 9 Li P....Hu C. (2009)
- DEF6, a novel substrate for the Tec kinase ITK, contai ns a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. (PubMed id 22829599)1 Hey F....Sablitzky F. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
|
External Searches for DEF6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DEF6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEF6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEF6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEF6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DEF6 gene:
Search GeneIP for patents involving DEF6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEF6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for DEF6 | | OriGene shRNA RFP for DEF6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEF6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEF6 | | | OriGene Protein Over-expression Lysate for DEF6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DEF6 | | OriGene 3'-UTR Clone for DEF6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEF6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEF6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DEF6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DEF6 | | OriGene Custom Protein Services for DEF6 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEF6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEF6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEF6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEF6 |
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 |  |  |  | |
| | | | Search Tocris compounds for DEF6 |
| |  |  |  |  | | | | |
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 | | | DEF6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEF6 |
|  |  |  | | | | ThermoFisher Antibodies for DEF6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEF6 |
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