Aliases for DEF6 Gene
External Ids for DEF6 Gene
Previous GeneCards Identifiers for DEF6 Gene
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DEF6 Gene
DEF6 (Differentially Expressed In FDCP 6 Homolog (Mouse)) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Regulation of RhoA activity. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is SWAP70.
UniProtKB/Swiss-Prot for DEF6 Gene
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).