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Aliases for DEDD2 Gene

Aliases for DEDD2 Gene

  • Death Effector Domain Containing 2 2 3 5
  • FADD-Like Anti-Apoptotic Molecule 3 3 4
  • DED-Containing Protein FLAME-3 3 4
  • FLAME3 3 4
  • DNA-Binding Death Effector Domain-Containing Protein 2 3
  • FLAME-3 3

External Ids for DEDD2 Gene

Previous GeneCards Identifiers for DEDD2 Gene

  • GC19M043343
  • GC19M043094
  • GC19M047378
  • GC19M047394
  • GC19M042702
  • GC19M039134

Summaries for DEDD2 Gene

Entrez Gene Summary for DEDD2 Gene

  • This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for DEDD2 Gene

DEDD2 (Death Effector Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is DEDD.

UniProtKB/Swiss-Prot for DEDD2 Gene

  • May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Additional gene information for DEDD2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEDD2 Gene

Genomics for DEDD2 Gene

Regulatory Elements for DEDD2 Gene

Enhancers for DEDD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H042267 1.9 FANTOM5 ENCODE dbSUPER 19.4 -50.7 -50736 6.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YBX1 ZBTB7B YY1 ZNF526 ZNF574 CCDC97 DEDD2 MEGF8 CEACAM3 PAFAH1B3 PRR19 GSK3A TMEM145
GH19H041800 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +418.2 418190 2.3 HDAC1 CTCF YY2 SOX6 KLF17 ZIC2 ZFHX2 WT1 CEACAM3 CEACAM4 DMRTC2 DEDD2 LYPD4 CEACAM6 CEACAM21 TMEM91 B9D2 TGFB1
GH19H041798 1.2 FANTOM5 Ensembl dbSUPER 17.1 +421.7 421681 2.5 CTCF FOXA2 TEAD1 FOXA3 THRB TEAD3 CEACAM4 CEACAM3 DEDD2 LYPD4 DMRTC2 CEACAM6 TMEM91 CEACAM21 PCAT19 B9D2
GH19H042276 1.8 FANTOM5 ENCODE dbSUPER 9.3 -61.8 -61762 11.1 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZBTB7B ZNF416 ZNF143 ZNF526 ZNF574 MEGF8 CCDC97 CEACAMP1 CEACAMP10 CIC PSG6 GRIK5 DEDD2
GH19H042110 1.5 Ensembl ENCODE dbSUPER 11 +106.3 106281 7.1 HDGF PKNOX1 ATF1 ZNF133 SIN3A ZNF2 GLIS2 ZNF143 FOS ATF7 POU2F2 CIC GSK3A PAFAH1B3 PRR19 MEGF8 DEDD2 ZNF526 ATP1A3 CNFN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DEDD2 on UCSC Golden Path with GeneCards custom track

Promoters for DEDD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000288484 -348 1401 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF143 FOS

Genomic Locations for DEDD2 Gene

Genomic Locations for DEDD2 Gene
chr19:42,198,593-42,220,152
(GRCh38/hg38)
Size:
21,560 bases
Orientation:
Minus strand
chr19:42,702,750-42,724,292
(GRCh37/hg19)

Genomic View for DEDD2 Gene

Genes around DEDD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEDD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEDD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEDD2 Gene

Proteins for DEDD2 Gene

  • Protein details for DEDD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF8-DEDD2_HUMAN
    Recommended name:
    DNA-binding death effector domain-containing protein 2
    Protein Accession:
    Q8WXF8
    Secondary Accessions:
    • Q8NBR2
    • Q8NES1
    • Q8TAA8
    • Q96D35

    Protein attributes for DEDD2 Gene

    Size:
    326 amino acids
    Molecular mass:
    36179 Da
    Quaternary structure:
    • Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD.
    SequenceCaution:
    • Sequence=AAH13372.2; Type=Frameshift; Positions=186; Evidence={ECO:0000305};

    Alternative splice isoforms for DEDD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEDD2 Gene

Post-translational modifications for DEDD2 Gene

  • Ubiquitination at isoforms=2193
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DEDD2 Gene

Domains & Families for DEDD2 Gene

Gene Families for DEDD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DEDD2 Gene

Suggested Antigen Peptide Sequences for DEDD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXF8

UniProtKB/Swiss-Prot:

DEDD2_HUMAN :
  • Interactions with CASP8 and CASP10 are mediated by the DED domain.
Domain:
  • Interactions with CASP8 and CASP10 are mediated by the DED domain.
genes like me logo Genes that share domains with DEDD2: view

Function for DEDD2 Gene

Molecular function for DEDD2 Gene

UniProtKB/Swiss-Prot Function:
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Gene Ontology (GO) - Molecular Function for DEDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 11741985
GO:0030159 receptor signaling complex scaffold activity NAS 11741985
genes like me logo Genes that share ontologies with DEDD2: view
genes like me logo Genes that share phenotypes with DEDD2: view

miRNA for DEDD2 Gene

miRTarBase miRNAs that target DEDD2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEDD2 Gene

Localization for DEDD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEDD2 Gene

Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEDD2 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DEDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IDA 11741985
genes like me logo Genes that share ontologies with DEDD2: view

Pathways & Interactions for DEDD2 Gene

SuperPathways for DEDD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DEDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing NAS 11741985
GO:0006915 apoptotic process IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP 11741985
genes like me logo Genes that share ontologies with DEDD2: view

No data available for Pathways by source and SIGNOR curated interactions for DEDD2 Gene

Drugs & Compounds for DEDD2 Gene

No Compound Related Data Available

Transcripts for DEDD2 Gene

Unigene Clusters for DEDD2 Gene

Death effector domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEDD2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - -
SP12: - -
SP13:

Relevant External Links for DEDD2 Gene

GeneLoc Exon Structure for
DEDD2
ECgene alternative splicing isoforms for
DEDD2

Expression for DEDD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEDD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DEDD2 Gene

This gene is overexpressed in Whole Blood (x11.0).

Protein differential expression in normal tissues from HIPED for DEDD2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DEDD2 Gene



Protein tissue co-expression partners for DEDD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DEDD2 Gene:

DEDD2

SOURCE GeneReport for Unigene cluster for DEDD2 Gene:

Hs.515432

mRNA Expression by UniProt/SwissProt for DEDD2 Gene:

Q8WXF8-DEDD2_HUMAN
Tissue specificity: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitts lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels.

Evidence on tissue expression from TISSUES for DEDD2 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DEDD2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DEDD2 Gene

Orthologs for DEDD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEDD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEDD2 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DEDD2 33 34
  • 91 (n)
cow
(Bos Taurus)
Mammalia DEDD2 33 34
  • 89.26 (n)
mouse
(Mus musculus)
Mammalia Dedd2 33 16 34
  • 85.28 (n)
rat
(Rattus norvegicus)
Mammalia Dedd2 33
  • 84.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DEDD2 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DEDD2 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEDD2 34
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dedd1 33 34 34
  • 56.34 (n)
Species where no ortholog for DEDD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEDD2 Gene

ENSEMBL:
Gene Tree for DEDD2 (if available)
TreeFam:
Gene Tree for DEDD2 (if available)

Paralogs for DEDD2 Gene

Paralogs for DEDD2 Gene

(1) SIMAP similar genes for DEDD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DEDD2: view

Variants for DEDD2 Gene

Sequence variations from dbSNP and Humsavar for DEDD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000562467 -- 42,202,193(+) GGAAC(C/T)GTAAT intron-variant
rs1000596705 -- 42,218,776(+) GTCTG(C/T)AATCC intron-variant, upstream-variant-2KB
rs1000664607 -- 42,213,220(+) GTCTA(C/T)AGTGA intron-variant
rs1000684775 -- 42,203,010(+) CTGCT(G/T)ACCCC intron-variant
rs1000758480 -- 42,202,648(+) TGGGA(C/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEDD2 Gene

Variant ID Type Subtype PubMed ID
nsv833833 CNV loss 17160897
nsv526186 CNV gain 19592680
nsv522854 CNV gain 19592680
nsv520239 CNV loss 19592680
nsv1160627 CNV deletion 26073780
esv3644398 CNV loss 21293372
esv2670755 CNV deletion 23128226

Variation tolerance for DEDD2 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEDD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEDD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEDD2 Gene

Disorders for DEDD2 Gene

Relevant External Links for DEDD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DEDD2

No disorders were found for DEDD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEDD2 Gene

Publications for DEDD2 Gene

  1. DEDD regulates degradation of intermediate filaments during apoptosis. (PMID: 12235123) Lee JC … Peter ME (The Journal of cell biology 2002) 2 3 4 22 60
  2. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. (PMID: 11965497) Zhan Y … Alnemri ES (Cell death and differentiation 2002) 2 3 4 22 60
  3. Identification and characterization of DEDD2, a death effector domain-containing protein. (PMID: 11741985) Roth W … Reed JC (The Journal of biological chemistry 2002) 3 4 22 60
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for DEDD2 Gene

Sources for DEDD2 Gene

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