 |
 | Services
| |
 |
Aliases & Descriptions for DEDD2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLAME-3 1, 2 | | FLAME3 3 |
| | | Descriptions |
|---|
| DED-containing protein FLAME-3 3 | | FADD-like anti-apoptotic molecule 3 3 | | death effector domain containing 2 2 | | death effector domain-containing DNA binding protein 2 2 |
|
| | Search outside databases for aliases for DEDD2 genePrevious GC identifers: GC19M043343 GC19M043094 GC19M047378 |
Summaries for DEDD2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 |
Genomic Location for DEDD2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DEDD2 gene 
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.31DEDD2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M047394:
(about GC identifiers)
Start:
|
47,394,592 bp from pter |
End:
|
47,416,115 bp from pter |
Size:
|
21,524 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for DEDD2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8 (See
protein sequence)Recommended Name: DNA-binding death effector domain-containing protein 2 Size: 326 amino acids; 36179 Da
Subunit: Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD
Subcellular location: Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli
Sequence caution: Sequence=AAH13372.2; Type=Frameshift; Positions=186;
Secondary accessions: Q8NBR2 Q8NES1 Q8TAA8 Q96D35Alternative splicing: 2 isoforms: Q8WXF8-1 Q8WXF8-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_579874.1
ENSEMBL proteins: ENSP00000384031 ENSP00000336972
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DEDD2: Assays for DEDD2: | Protein
Domains/ Families for DEDD2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8WXF8
ProtoNet protein and cluster: Q8WXF8 1 Blocks protein family: IPB001875 Death effector protein
UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Domain: Interactions with CASP8 and CASP10 are mediated by the DED domainSimilarity: Contains 1 DED (death effector) domain | Gene Function for DEDD2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_133328
Applied Biosystems Silencer® siRNAs for DEDD2
Sigma-Aldrich siRNA for DEDD2  Sigma-Aldrich shRNA for DEDD2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_133328                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_133328                                  untagged cDNA clones in CMV expression vector (see all 2): NM_133328 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_133328
UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C33 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for DEDD2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for DEDD2 
5/7 Interacting proteins for DEDD2 (ENSP000003369723) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10
): About this table
|
Drugs & Compounds for DEDD2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DEDD2
|
Transcripts for DEDD2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_133328
Sigma-Aldrich siRNA for DEDD2  Sigma-Aldrich shRNA for DEDD2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_133328 REFSEQ mRNAs for DEDD2 gene: NM_133328.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_133328               OriGene GFP tagged cDNA clone in CMV expression vector: NM_133328                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_133328                                  untagged cDNA clones in CMV expression vector (see all 2): NM_133328  Additional cDNA sequence: AF443591.1 AF457575.1 AK075328.1 AK130203.1 AK307895.1 AY125488.1 BC013372.2 BC027930.1 CR590827.1 CR593642.1 CR599685.1 CR604307.1 CR619301.1 CR625070.1 11 DOTS entries: DT.92426460 DT.101972579 DT.100817959 DT.454872 DT.100817965 DT.86847429 DT.95290001 DT.95304008 DT.95304009 DT.100691056 DT.95304007 24/167 AceView cDNA sequences (see all 167
):CR604307 AW263988 BM979999 CA416835 F35595 BG251151 BI907024 BI520263 BM928759 AK130203 BQ072022 BF665646 CR625070 AW270125 CR593642 CR590827 AI432940 BU191631 CR619301 BM670485 BM908148 BU682972 AK075328 BM672838
highest scoring ESTs for DEDD2:AA218681 AA662107 AK130203 AL562850 AY125488 BC013372 BC027930 BE242821 BG122215 BG393347 Unigene Cluster for DEDD2: Death effector domain containing 2 Hs.515432 [show with all ESTs]Unigene Representative Sequence: AY125488
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DEDD2 (see all 13
)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for DEDD2
2 Ensembl transcripts including schematic representations: ENST00000403271
ENST00000336034
|
Expression for DEDD2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DEDD2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DEDD2
1 / 2 / 3 3 probe-sets matching DEDD2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGCCAAAAC
SOURCE GeneReport for Unigene cluster: Hs.515432 UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Tissue specificity: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A549, and the melanoma G361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels |
Orthologs for DEDD2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DEDD2 gene from 5 species
About this table Species with no ortholog for DEDD2
ENSEMBL Gene Tree for DEDD2 | Paralogs for DEDD2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for DEDD2 gene
- DEDD2
|
SNPs/Variants for DEDD2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DEDD2 (up to first 250kb)
|
Disorders & Mutations for DEDD2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for DEDD2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DEDD2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for DEDD2 gene:- Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. (PubMed id 11965497)1, 2, 3, 4 Zhan Y....Alnemri E.S. (2002)
- DEDD regulates degradation of intermediate filaments during apoptosis. (PubMed id 12235123)1, 2, 3, 4 Lee J.C....Peter M.E. (2002)
- Identification and characterization of DEDD2, a death effector domain-containing protein. (PubMed id 11741985)1, 3, 4 Roth W.... Reed J.C. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- DEDD and DEDD2 associate with caspase-8/10 and signal cell death. (PubMed id 12527898)3, 4 Alcivar A.... Yang X. (2003)
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)3 Otsuki T....Isogai T. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for DEDD2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DEDD2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DEDD2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEDD2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DEDD2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for DEDD2:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for DEDD2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|