DEDD2 Gene
protein-coding GIFtS: 46
GCID: GC19M042702
|
|
death effector domain containing 2
| |
Aliases
for DEDD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Death Effector Domain Containing 21 2 | | FLAME-31 2 | | DED-Containing Protein FLAME-32 3 | | FADD-Like Anti-Apoptotic Molecule 32 3 | | DNA-Binding Death Effector Domain-Containing Protein 22 | | FLAME33 |
Export aliases for DEDD2 gene to outside databasesPrevious GC identifers: GC19M043343 GC19M043094 GC19M047378 GC19M047394 GC19M039134 |
Summaries
for DEDD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DEDD2:
This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein mayregulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis.Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2012)
UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus.May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcriptionmachinery in the nucleus and might be an important regulator of the activity of GTF3C3
|
Genomic Views
for DEDD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEDD2 gene promoter:
GR C/EBPbeta Tal-1 CUTL1 E47 Arnt HOXA5 c-Myb GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEDD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEDD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.31DEDD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M042702: view genomic region
(about GC identifiers)
Start:
|
42,702,752 bp from pter |
End:
|
42,721,813 bp from pter |
Size:
|
19,062 bases |
Orientation:
|
minus strand |
|
Proteins
for DEDD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8 (See
protein sequence)Recommended Name: DNA-binding death effector domain-containing protein 2 Size: 326 amino acids; 36179 Da
Subunit: Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD
Subcellular location: Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli
Sequence caution: Sequence=AAH13372.2; Type=Frameshift; Positions=186;
Secondary accessions: Q8NBR2 Q8NES1 Q8TAA8 Q96D35Alternative splicing: 2 isoforms: Q8WXF8-1 Q8WXF8-2 Explore the universe of human proteins at neXtProt for DEDD2: NX_Q8WXF8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXF8
DEDD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001257543.1 NP_001257544.1 NP_579874.1
ENSEMBL proteins: ENSP00000336972
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
DEDD2 for ontologies About GeneDecksing
DEDD2 Antibody Products:
Assay Products for DEDD2: |
Protein
Domains /
Families
for DEDD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DEDD2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXF8ProtoNet protein and cluster: Q8WXF8 1 Blocks protein family: IPB001875 Death effector protein
UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Domain: Interactions with CASP8 and CASP10 are mediated by the DED domainSimilarity: Contains 1 DED (death effector) domain |
Function
for DEDD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus.May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcriptionmachinery in the nucleus and might be an important regulator of the activity of GTF3C3
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEDD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEDD2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
DEDD2 for ontologies About GeneDecksing
|
Pathways & Interactions
for DEDD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DEDD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/11 Interacting proteins for DEDD2 (Q8WXF83 ENSP000003369724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
DEDD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DEDD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DEDD2
Search CenterWatch for drugs/clinical trials and news about DEDD2
|
Transcripts
for DEDD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEDD2 gene (3 alternative transcripts): NM_001270614.1 NM_001270615.1 NM_133328.3 Unigene Cluster for DEDD2: Death effector domain containing 2 Hs.515432 [show with all ESTs]Unigene Representative Sequence: NM_1333281 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000336034(uc002osu.1 uc002osv.1 uc002osw.1 uc010eid.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEDD2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEDD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DEDD2 (NM_133328) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEDD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEDD2 |
Additional cDNA sequence: AF443591.1 AF457575.1 AK075328.1 AK130203.1 AK307895.1 AY125488.1 BC013372.2 BC027930.1 NR_073046.1 NR_073047.1 NR_073048.1 NR_073049.1 NR_073050.1 NR_073051.1 NR_073052.1 11 DOTS entries: DT.101972579 DT.100817959 DT.454872 DT.92426460 DT.100817965 DT.86847429 DT.95304009 DT.100691056 DT.95290001 DT.95304007 DT.95304008 24/167 AceView cDNA sequences (see all 167): BM979999 BE907425 BI910416 CR625070 AI358311 BU682972 AF443591 AK075328 BM928759 CA416835 BI520263 AW263988 BI907024 BF665646 CR604307 BG251151 BG284887 BM908148 F35595 BG681575 CD366811 CR619301 BU191631 CK429257
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DEDD2 (see all 13) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DEDD2
|
Expression
for DEDD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEDD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCCAAAAC
About this image
See DEDD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEDD2
SOURCE GeneReport for Unigene cluster: Hs.515432
UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8Tissue specificity: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes,skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expressionis relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480.Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and themelanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblasticleukemia), show relatively low levels
SABiosciences Expression via Pathway-Focused PCR Array including DEDD2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEDD2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEDD2 |
Orthologs
for DEDD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DEDD2 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Dedd21 , 5 |
death effector domain-containing DNA binding protein more1, 5 |
87.73(n)1
93.25(a)1 |
|
7 (13.73 cM)5
673791 NM_207677.31 NP_997560.31
252028405 |
zebrafish
(Danio rerio) |
Actinopterygii |
dedd12 |
death effector domain-conatining 1 |
72.9(n) |
|
58125 AF232226.1 |
ENSEMBL Gene Tree for DEDD2 (if available)
TreeFam Gene Tree for DEDD2 (if available) |
Paralogs
for DEDD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DEDD2 gene
- DEDD2
1 SIMAP similar gene for DEDD2 using alignment to 3 protein entries: DEDD2_HUMAN (see all proteins):DEDD
DEDD2 for paralogs About GeneDecksing
|
Genomic Variants
for DEDD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEDD2 (42702752 - 42721813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DEDD2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEDD2 |
|
Disorders
/ Diseases
for DEDD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DEDD2 for disorders About GeneDecksing
9  diseases for DEDD2: About MalaCardsburkitt's lymphoma lymphoblastic leukemia cervical carcinoma cervicitis
lung carcinoma leukemia carcinoma melanoma
adenocarcinoma
Export disorders for DEDD2 gene to outside databases
|
Publications
for DEDD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEDD2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with DEDD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. (PubMed id 11965497)1, 2, 3, 9 Zhan Y....Alnemri E.S. (2002)
- DEDD regulates degradation of intermediate filaments during apoptosis. (PubMed id 12235123)1, 2, 3, 9 Lee J.C....Peter M.E. (2002)
- Identification and characterization of DEDD2, a death effector domain-containing protein. (PubMed id 11741985)1, 2, 9 Roth W.... Reed J.C. (2002)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DEDD and DEDD2 associate with caspase-8/10 and signal cell death. (PubMed id 12527898)1, 2 Alcivar A.... Yang X. (2003)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Death effector domain-containing proteins. (PubMed id 18989622)1 Valmiki M.G. and Ramos J.W. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for DEDD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DEDD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEDD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEDD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DEDD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DEDD2 gene:
Search GeneIP for patents involving DEDD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEDD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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