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DEDD2 Gene

protein-coding   GIFtS: 50
GCID: GC19M042702

Death Effector Domain Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Death Effector Domain Containing 21 2
DED-Containing Protein FLAME-32 3
FADD-Like Anti-Apoptotic Molecule 32 3
FLAME-32
DNA-Binding Death Effector Domain-Containing Protein 22
FLAME33

External Ids:    HGNC: 244501   Entrez Gene: 1629892   Ensembl: ENSG000001605707   UniProtKB: Q8WXF83   
ORGUL members:         

Export aliases for DEDD2 gene to outside databases

Previous GC identifers: GC19M043343 GC19M043094 GC19M047378 GC19M047394 GC19M039134


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DEDD2 Gene:
This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may
regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2012)

GeneCards Summary for DEDD2 Gene:
DEDD2 (death effector domain containing 2) is a protein-coding gene. Diseases associated with DEDD2 include burkitt's lymphoma, and lymphoblastic leukemia. GO annotations related to this gene include receptor signaling complex scaffold activity. An important paralog of this gene is DEDD.

UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8
Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the
nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general
transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DEDD2 gene promoter:
         GR   C/EBPbeta   Tal-1   CUTL1   E47   Arnt   HOXA5   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DEDD2 promoter sequence
   Search Chromatin IP Primers for DEDD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEDD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.31

DEDD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEDD2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042702:  view genomic region     (about GC identifiers)

Start:
42,702,750 bp from pter      End:
42,724,292 bp from pter
Size:
21,543 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8 (See protein sequence)
Recommended Name: DNA-binding death effector domain-containing protein 2  
Size: 326 amino acids; 36179 Da
Subunit: Interacts with CASP8, CASP10 and GTF3C3. Homodimerizes and heterodimerizes with DEDD
Sequence caution: Sequence=AAH13372.2; Type=Frameshift; Positions=186;
Secondary accessions: Q8NBR2 Q8NES1 Q8TAA8 Q96D35
Alternative splicing: 2 isoforms:  Q8WXF8-1   Q8WXF8-2   

Explore the universe of human proteins at neXtProt for DEDD2: NX_Q8WXF8

Explore proteomics data for DEDD2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys193
  • Modification sites at PhosphoSitePlus

  • See DEDD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257543.1  NP_001257544.1  NP_579874.1  

    ENSEMBL proteins: 
     ENSP00000336972   ENSP00000470082   ENSP00000471512   ENSP00000469233   ENSP00000469898  

    DEDD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for DEDD2
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    Novus Biologicals DEDD2 Proteins
    Novus Biologicals DEDD2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DEDD2

    DEDD2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DEDD2

    DEDD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DEDD2
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    Cloud-Clone Corp. ELISAs for DEDD2
    Cloud-Clone Corp. CLIAs for DEDD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001875 DED

    Graphical View of Domain Structure for InterPro Entry Q8WXF8

    ProtoNet protein and cluster: Q8WXF8

    1 Blocks protein domain: IPB001875 Death effector protein

    UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8
    Domain: Interactions with CASP8 and CASP10 are mediated by the DED domain
    Similarity: Contains 1 DED (death effector) domain


    DEDD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEDD2_HUMAN, Q8WXF8
    Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the
    nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general
    transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI11741985
    GO:0030159receptor signaling complex scaffold activity NAS11741985
         
    DEDD2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEDD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEDD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEDD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEDD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DEDD2:
    hsa-mir-92a-3p (MIRT049538)

    Block miRNA regulation of human, mouse, rat DEDD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEDD2 (see all 20):
    hsa-miR-576-3p hsa-miR-644 hsa-miR-4265 hsa-miR-1224-3p hsa-miR-938 hsa-miR-9 hsa-miR-204 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidDEDD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DEDD2
    Predesigned siRNA for gene silencing in human, mouse, rat DEDD2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DEDD2

    Clone
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    OriGene clones in human, mouse for DEDD2 (see all 8)
    OriGene ORF clones in mouse, rat for DEDD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DEDD2 (NM_133328)
    Sino Biological Human cDNA Clone for DEDD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEDD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEDD2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DEDD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DEDD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEDD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEDD2_HUMAN, Q8WXF8: Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA11741985

    DEDD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DEDD2: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DEDD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for DEDD2 (Q8WXF83 ENSP000003369724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP10Q928513, ENSP000002861864I2D: score=3 STRING: ENSP00000286186
    CASP8Q147903, ENSP000003512734I2D: score=3 STRING: ENSP00000351273
    DEDDO756183, ENSP000003569854I2D: score=3 STRING: ENSP00000356985
    RHOXF2Q9BQY43, ENSP000003604414I2D: score=1 STRING: ENSP00000360441
    CFLARO155193, ENSP000003124554I2D: score=2 STRING: ENSP00000312455
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006396RNA processing NAS11741985
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IMP11741985
    GO:0016075rRNA catabolic process NAS11741985
    GO:0019725cellular homeostasis NAS11741985

    DEDD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DEDD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DEDD2 gene (3 alternative transcripts): 
    NM_001270614.1  NM_001270615.1  NM_133328.3  

    Unigene Cluster for DEDD2:

    Death effector domain containing 2
    Hs.515432  [show with all ESTs]
    Unigene Representative Sequence: NM_133328
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336034(uc002osu.1 uc002osv.1 uc002osw.1 uc010eid.3)
    ENST00000595337 ENST00000593804 ENST00000596251 ENST00000601135 ENST00000598415
    ENST00000602075 ENST00000600559 ENST00000598090 ENST00000598727 ENST00000593561
    ENST00000602201 ENST00000598200
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DEDD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEDD2 (see all 20):
    hsa-miR-576-3p hsa-miR-644 hsa-miR-4265 hsa-miR-1224-3p hsa-miR-938 hsa-miR-9 hsa-miR-204 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidDEDD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DEDD2
    Predesigned siRNA for gene silencing in human, mouse, rat DEDD2
    Clone
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    OriGene clones in human, mouse for DEDD2 (see all 8)
    OriGene ORF clones in mouse, rat for DEDD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DEDD2 (NM_133328)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEDD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEDD2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DEDD2
    OriGene qSTAR qPCR primer pairs in human, mouse for DEDD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEDD2
      QuantiTect SYBR Green Assays in human, mouse, rat DEDD2
      QuantiFast Probe-based Assays in human, mouse, rat DEDD2

    Additional mRNA sequence: 

    AF443591.1 AF457575.1 AK075328.1 AK130203.1 AK307895.1 AY125488.1 BC013372.2 BC027930.1 
    NR_073046.1 NR_073047.1 NR_073048.1 NR_073049.1 NR_073050.1 NR_073051.1 NR_073052.1 

    11 DOTS entries:

    DT.101972579  DT.100817959  DT.454872  DT.92426460  DT.100817965  DT.86847429  DT.95304009  DT.100691056 
    DT.95290001  DT.95304007  DT.95304008 

    Selected AceView cDNA sequences (see all 167):

    BM672838 CA416835 BG284887 AK130203 BM979999 BI910416 BM908148 CK429257 
    CR625070 CR590827 BU191631 BU682972 CB153442 BM928759 CR599685 AW263988 
    BQ956773 BM670485 BQ072022 BE781207 AW270125 CR593642 CA306521 AK075328 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DEDD2 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
    SP1:                                            -     -     -                       -                       -                                       
    SP2:                                            -                             -                                                                     
    SP3:                                            -                             -     -                 -     -                                       
    SP4:                                            -     -     -                 -     -                       -                                       
    SP5:                                            -                             -                                                                     


    ECgene alternative splicing isoforms for DEDD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DEDD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCAAAAC
    DEDD2 Expression
    About this image


    DEDD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    DEDD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DEDD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515432

    UniProtKB/Swiss-Prot: DEDD2_HUMAN, Q8WXF8
    Tissue specificity: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen,
    testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small
    intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the
    colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma
    Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60
    (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels

        Pathway & Disease-focused RT2 Profiler PCR Array including DEDD2: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DEDD2
    OriGene qSTAR qPCR primer pairs in human, mouse for DEDD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEDD2
    QuantiTect SYBR Green Assays in human, mouse, rat DEDD2
    QuantiFast Probe-based Assays in human, mouse, rat DEDD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEDD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DEDD2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dedd21 , 5 death effector domain-containing DNA binding protein more1, 5 85.28(n)1
    90.49(a)1
      7 (13.73 cM)5
    673791  NM_207677.31  NP_997560.31 
     252028405 
    lizard
    (Anolis carolinensis)
    Reptilia DEDD26
    death effector domain containing 2
    41(a)
    1 ↔ 1
    GL343909.1(20342-24100)
    zebrafish
    (Danio rerio)
    Actinopterygii dedd12 death effector domain-conatining 1 72.9(n)   58125  AF232226.1 


    ENSEMBL Gene Tree for DEDD2 (if available)
    TreeFam Gene Tree for DEDD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DEDD2 gene
    DEDD2  
    1 SIMAP similar gene for DEDD2 using alignment to 3 protein entries:     DEDD2_HUMAN (see all proteins):
    DEDD

    DEDD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DEDD2 (see all 365)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401978661,2
    C--42702271(+) GCAGTC/GAGCTG 10 -- ds50010--------
    rs1429553071,2
    --42702396(+) AACATA/GGTTGG 10 -- ds50010--------
    rs1511146011,2
    --42702418(+) ACTCCA/GAGGCA 10 -- ds50010--------
    rs1399714801,2
    C--42702482(+) CAAGCA/GTGTGG 10 -- ds50010--------
    rs774732451,2
    C,F--42702522(+) GCCCAC/TACTCC 10 -- ds50011Minor allele frequency- T:0.30EA 120
    rs1887424141,2
    --42702670(+) GCTGGC/GCTGGG 10 -- ds50010--------
    rs1922406091,2
    C--42702683(+) ACATAG/TCAAGA 10 -- ds50010--------
    rs31771461,2
    C--42702751(-) GTGGGC/AATCGG 10 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.00NA 4
    rs1399086131,2
    C--42702814(+) CATCAA/CCCCCA 10 -- ut31 nc-transcript-variant0--------
    rs10442321,2
    H--42702843(-) ACCTTC/TTTGGA 10 -- ut31 nc-transcript-variant7Minor allele frequency- T:0.01MN NS EA NA 606

    HapMap Linkage Disequilibrium report for DEDD2 (42702750 - 42724292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DEDD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670755CNV Deletion23128226
    nsv520239CNV Loss19592680
    nsv911782CNV Loss21882294
    nsv833833CNV Loss17160897
    nsv522854CNV Gain19592680
    nsv526186CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for DEDD2:    
    About MalaCards
    burkitt's lymphoma    lymphoblastic leukemia    cervicitis    melanoma
    adenocarcinoma    leukemia


    DEDD2 for disorders           About GeneDecksing


    Export disorders for DEDD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DEDD2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DEDD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. (PubMed id 11965497)1, 2, 3, 9 Zhan Y....Alnemri E.S. (Cell Death Differ. 2002)
    2. DEDD regulates degradation of intermediate filaments during apoptosis. (PubMed id 12235123)1, 2, 3, 9 Lee J.C.... Peter M.E. (J. Cell Biol. 2002)
    3. Identification and characterization of DEDD2, a death effector domain-containing protein. (PubMed id 11741985)1, 2, 9 Roth W.... Reed J.C. (J. Biol. Chem. 2002)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. (PubMed id 12527898)1, 2 Alcivar A.... Yang X. (Oncogene 2003)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (Cancer Cell 2011)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    10. Death effector domain-containing proteins. (PubMed id 18989622)1 Valmiki M.G. and Ramos J.W. (Cell. Mol. Life Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 162989 HGNC: 24450 AceView: DEDD2 Ensembl:ENSG00000160570 euGenes: HUgn162989
    ECgene: DEDD2 H-InvDB: DEDD2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DEDD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DEDD2 gene:
    Search GeneIP for patents involving DEDD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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