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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DEDD Gene

protein-coding   GIFtS: 53
GCID: GC01M161090

death effector domain containing

(Previous name: death effector domain-containing )
 Explore 2 diseases affiliated with
DEDD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DEDD    

Aliases
for DEDD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Death Effector Domain Containing1 2     DEDPro12 3
DEFT1 2 3 5     FLDED-12 3
CASP8IP11 2     KE051
DEDD11 2     Death Effector Domain-Containing1
FLDED11 2     Death Effector Domain-Containing Protein2
Death Effector Domain-Containing Testicular Molecule2 3     DEDPRO13

External Ids:    HGNC: 27551   Entrez Gene: 91912   Ensembl: ENSG000001587967   OMIM: 6068415   UniProtKB: O756183   

Export aliases for DEDD gene to outside databases

Previous GC identifers: GC01M158802 GC01M156823 GC01M157868 GC01M158308 GC01M158309 GC01M157903 GC01M159357 GC01M132448


Summaries
for DEDD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DEDD:
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain
shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was
shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and
colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618
Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during
apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments
during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important
regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity)

Gene Wiki entry for DEDD


Genomic Views
for DEDD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DEDD gene promoter:
         CREB   p53   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DEDD promoter sequence
   Search SABiosciences Chromatin IP Primers for DEDD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEDD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1

DEDD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEDD gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161090:  view genomic region     (about GC identifiers)

Start:
 161,090,764 bp from pter      End:
 161,102,478 bp from pter
Size:
 11,715 bases      Orientation:
 minus strand

Proteins
for DEDD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618 (See protein sequence)
Recommended Name: Death effector domain-containing protein  
Size: 318 amino acids; 36794 Da
Subunit: Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2
Subcellular location: Cytoplasm. Nucleus, nucleolus (By similarity). Note=Translocated to the nucleus during
CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono
and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18
intermediate filament network in simple epithelial cells
Secondary accessions: D3DVF5 O60737
Alternative splicing: 2 isoforms:  O75618-1   O75618-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DEDD: NX_O75618

Post-translational modifications:

  • Exists predominantly in a mono- or diubiquitinated form1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75618

    • DEDD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034800.1  NP_001034801.1  NP_127491.1  

    ENSEMBL proteins: 
     ENSP00000356985   ENSP00000356984   ENSP00000376027   ENSP00000445835   ENSP00000414821  
     ENSP00000442587   ENSP00000439094  

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    Novus Biologicals DEDD Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DEDD

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ISS--
    GO:0005737cytoplasm ISS--


    DEDD for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DEDD

    Protein Domains /
    Families
    for DEDD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DEDD for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011029 DEATH-like_dom
     IPR001875 DED

    Graphical View of Domain Structure for InterPro Entry O75618

    ProtoNet protein and cluster: O75618

    1 Blocks protein family: IPB001875 Death effector protein

    UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618
    Similarity: Contains 1 DED (death effector) domain


    Function
    for DEDD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618
    Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during
    apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments
    during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important
    regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity)

    miRNA
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    hsa-miR-194* hsa-miR-124* hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: DEDD 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEDD (see all 7)
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI--


    DEDD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DEDD:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Deddtm1Tmiy for DEDD
         10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dedd):
     cardiovascular system  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     liver/biliary system  nervous system  renal/urinary system  reproductive system  respiratory system 

    DEDD for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DEDD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DEDD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/34 Interacting proteins for DEDD (O756181, 2, 3 ENSP000003569854) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-7895480 I2D: score=1 STRING: ENSP00000332973
    APLP2Q064811, 3EBI-1043164,EBI-79306 I2D: score=1 
    CASP8Q147903, ENSP000003512734I2D: score=3 STRING: ENSP00000351273
    DEDD2Q8WXF83, ENSP000003369724I2D: score=3 STRING: ENSP00000336972
    CASP10Q928513, ENSP000002861864I2D: score=2 STRING: ENSP00000286186
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process ----
    GO:0006917induction of apoptosis ISS--
    GO:0007283spermatogenesis IEA--
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors TAS9774341


    DEDD for ontologies           About GeneDecksing



    Drugs & Compounds
    for DEDD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DEDD
    Search CenterWatch for drugs/clinical trials and news about DEDD 

    Transcripts
    for DEDD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DEDD gene (4 alternative transcripts): 
    NM_001039711.1  NM_001039712.1  NM_032998.2  NM_004216.2  

    Unigene Cluster for DEDD:

    Death effector domain containing
    Hs.744092  [show with all ESTs]
    Unigene Representative Sequence: NM_032998
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472996 ENST00000368006 ENST00000489249 ENST00000486041 ENST00000368005
    ENST00000464113 ENST00000473679 ENST00000490843 ENST00000463227 ENST00000496632
    ENST00000392188(uc009wty.3 uc001fya.3 uc010pkb.2) ENST00000545495(uc001fyb.3)
    ENST00000458050(uc001fxz.3) ENST00000541906 ENST00000535389

    miRNA
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    hsa-miR-194* hsa-miR-124* hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: DEDD 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF043733.1 AF064605.3 AF083236.1 AF100341.1 AJ010973.1 AK001497.1 AK022531.1 AK296629.1 
    BC013910.2 BC016724.1 CR536556.1 

    21 DOTS entries:

    DT.100878742  DT.449341  DT.100878721  DT.100878736  DT.92449686  DT.95171244  DT.100878730  DT.100878722 
    DT.100878733  DT.100878720  DT.91810806  DT.100878725  DT.95350460  DT.121398695  DT.91869741  DT.91941342 
    DT.100038736  DT.100878746  DT.121398575  DT.121398673  DT.95171160 

    24/277 AceView cDNA sequences (see all 277):

    BF109781 CR619646 CA428654 BQ421970 CR612611 BF437002 BF196668 AW204961 
    BQ008500 AI805211 BU194660 BG953144 AA577591 AF083236 BU726785 BX384292 
    AW337208 AI669773 BU528998 BX364263 CR596035 CB160575 BF195222 H95383 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DEDD (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:                          -                 -                                                                                       
    SP2:                                                                                      -                                             
    SP3:                                            -                                         -                                             
    SP4:                                                                                      -                                             
    SP5:                                                              -     -                 -                                             


    ECgene alternative splicing isoforms for DEDD

    Expression
    for DEDD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DEDD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCAAGTGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DEDD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DEDD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DEDD

    SOURCE GeneReport for Unigene cluster: Hs.744092

    UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618
    Tissue specificity: Widely expressed with highest levels in testis

        SABiosciences Expression via Pathway-Focused PCR Array including DEDD: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for DEDD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DEDD gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DEDD1 death effector domain containing 80.61(n)
    88.68(a)    		   425378  XM_423146.3  XP_423146.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DEDD6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL344298.1(7023-16330)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.84192 Xenopus laevis transcribed sequence with moderate similarity more 75.25(n)    CD254010.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.161452 Transcribed sequence with moderate similarity to protein more 80.42(n)    AL925092.1 


    ENSEMBL Gene Tree for DEDD (if available)
    TreeFam Gene Tree for DEDD (if available) 

    Paralogs
    for DEDD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DEDD gene
    DEDD22  
    1 SIMAP similar gene for DEDD using alignment to 3 protein entries:     DEDD_HUMAN (see all proteins):
    DEDD2

    DEDD for paralogs           About GeneDecksing



    Genomic Variants
    for DEDD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 NCBI SNPs in DEDD are shown (see all 99)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1401133931,2
    		--161095768(+) ATTCAA/GCAACT 3 -- int10--------
    rs1131625051,2
    		--161095852(+) CTCCAG/ATCACA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1381059711,2
    		--161095884(+) TAATGC/TTACTT 3 -- int10--------
    rs2004674491,2
    		--161096392(+) CTCCG-/AAAGTG 3 -- int10--------
    rs1436057861,2
    		--161096470(+) CTTCTA/GAGATC 3 -- int10--------
    rs784987531,2
    		F,--161096497(+) CCTCAT/CTTCCC 3 -- int11Minor allele frequency- C:0.05NA 120
    rs1866745281,2
    		--161096633(+) ACACCC/TCCATC 3 -- int10--------
    rs1924541221,2
    		--161096797(+) ATCACC/TATGTA 3 -- int10--------
    rs120453401,2
    		C,H--161096803(+) ATGTAC/GTAAAA 3 -- int14Minor allele frequency- G:0.00NS EA 416
    rs1821960981,2
    		--161096838(+) TAGATA/CCTACT 3 -- int10--------

    HapMap Linkage Disequilibrium report for DEDD (161090764 - 161102478 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DEDD: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DEDD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DEDD for disorders           About GeneDecksing

    OMIM gene information: 606841    OMIM disorders: --

    2 diseases for DEDD:    About MalaCards
    dental fluorosis    dental caries

    2 diseases from the University of Copenhagen DISEASES database for DEDD:
    Dental caries     Dental fluorosis

    Export disorders for DEDD gene to outside databases

    Publications
    for DEDD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DEDD gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with DEDD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. (PubMed id 9774341)1, 2, 3, 9 Stegh A.H.... Peter M.E. (1998)
    2. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. (PubMed id 9832420)1, 2, 3, 9 Leo C.P....Hsueh A.J. (1998)
    3. DEDD regulates degradation of intermediate filaments during apoptosis. (PubMed id 12235123)1, 2, 9 Lee J.C....Peter M.E. (2002)
    4. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. (PubMed id 11965497)1, 2, 9 Zhan Y....Alnemri E.S. (2002)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. (PubMed id 12527898)1, 2 Alcivar A.... Yang X. (2003)
    8. Identification and characterization of DEDD2, a death effector domain-containing protein. (PubMed id 11741985)1, 9 Roth W.... Reed J.C. (2002)
    9. DEDD interacts with PI3KC3 to activate autophagy and a ttenuate epithelial-mesenchymal transition in human breast cancer. (PubMed id 22719072)1 Lv Q....Hu Z.W. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    External Searches for DEDD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DEDD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9191 HGNC: 2755 AceView: DEDD Ensembl:ENSG00000158796 euGenes: HUgn9191
    ECgene: DEDD H-InvDB: DEDD

    Other Databases showing DEDD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DEDD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DEDD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DEDD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DEDD gene:
    Search GeneIP for patents involving DEDD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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