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Aliases for DEDD Gene

Aliases for DEDD Gene

  • Death Effector Domain Containing 2 3
  • DEFT 3 4 6
  • Death Effector Domain-Containing Testicular Molecule 3 4
  • DEDPro1 3 4
  • FLDED-1 3 4
  • Death Effector Domain-Containing Protein 3
  • Death Effector Domain-Containing 2
  • CASP8IP1 3
  • FLDED1 3
  • DEDD1 3
  • KE05 3

External Ids for DEDD Gene

Previous GeneCards Identifiers for DEDD Gene

  • GC01M158802
  • GC01M156823
  • GC01M157868
  • GC01M158308
  • GC01M158309
  • GC01M157903
  • GC01M159357
  • GC01M132448

Summaries for DEDD Gene

Entrez Gene Summary for DEDD Gene

  • This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DEDD Gene

DEDD (Death Effector Domain Containing) is a Protein Coding gene. Diseases associated with DEDD include dental fluorosis. An important paralog of this gene is DEDD2.

UniProtKB/Swiss-Prot for DEDD Gene

  • A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).

Gene Wiki entry for DEDD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEDD Gene

Genomics for DEDD Gene

Regulatory Elements for DEDD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DEDD Gene

Start:
161,120,974 bp from pter
End:
161,132,783 bp from pter
Size:
11,810 bases
Orientation:
Minus strand

Genomic View for DEDD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEDD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEDD Gene

Proteins for DEDD Gene

  • Protein details for DEDD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75618-DEDD_HUMAN
    Recommended name:
    Death effector domain-containing protein
    Protein Accession:
    O75618
    Secondary Accessions:
    • D3DVF5
    • O60737

    Protein attributes for DEDD Gene

    Size:
    318 amino acids
    Molecular mass:
    36794 Da
    Quaternary structure:
    • Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.

    Alternative splice isoforms for DEDD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DEDD Gene

Proteomics data for DEDD Gene at MOPED

Post-translational modifications for DEDD Gene

No data available for DME Specific Peptides for DEDD Gene

Domains for DEDD Gene

Protein Domains for DEDD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DEDD Gene

Graphical View of Domain Structure for InterPro Entry

O75618

UniProtKB/Swiss-Prot:

DEDD_HUMAN :
  • O75618
Domain:
  • Contains 1 DED (death effector) domain.
genes like me logo Genes that share domains with DEDD: view

No data available for Gene Families for DEDD Gene

Function for DEDD Gene

Molecular function for DEDD Gene

UniProtKB/Swiss-Prot Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).

Gene Ontology (GO) - Molecular Function for DEDD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IPI 15688372
genes like me logo Genes that share ontologies with DEDD: view
genes like me logo Genes that share phenotypes with DEDD: view

Animal Models for DEDD Gene

MGI Knock Outs for DEDD:

Animal Model Products

CRISPR Products

miRNA for DEDD Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEDD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DEDD Gene

Localization for DEDD Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEDD Gene

Cytoplasm. Nucleus, nucleolus. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DEDD Gene COMPARTMENTS Subcellular localization image for DEDD gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DEDD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with DEDD: view

Pathways for DEDD Gene

SuperPathways for DEDD Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DEDD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007283 spermatogenesis IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA --
GO:0042177 negative regulation of protein catabolic process IEA --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with DEDD: view

No data available for Pathways by source for DEDD Gene

Transcripts for DEDD Gene

Unigene Clusters for DEDD Gene

Death effector domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DEDD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEDD Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: - - - - -
SP8:
SP9: - - - - -
SP10: - - - -
SP11:

Relevant External Links for DEDD Gene

GeneLoc Exon Structure for
DEDD
ECgene alternative splicing isoforms for
DEDD

Expression for DEDD Gene

mRNA expression in normal human tissues for DEDD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for DEDD Gene Hs.744092

mRNA Expression by UniProt/SwissProt for DEDD Gene

O75618-DEDD_HUMAN
Tissue specificity: Widely expressed with highest levels in testis.
genes like me logo Genes that share expressions with DEDD: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein expression for DEDD Gene

Orthologs for DEDD Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEDD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEDD 35
  • 99.69 (n)
  • 100 (a)
DEDD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DEDD 35
  • 94.98 (n)
  • 98.72 (a)
DEDD 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DEDD 35
  • 94.44 (n)
  • 99.69 (a)
DEDD 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dedd 35
  • 93.71 (n)
  • 98.74 (a)
Dedd 16
Dedd 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dedd 35
  • 93.29 (n)
  • 98.43 (a)
chicken
(Gallus gallus)
Aves DEDD 35
  • 80.61 (n)
  • 88.68 (a)
DEDD 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DEDD 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8419 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dedd 35
  • 76.87 (n)
  • 86.12 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1276 35
zebrafish
(Danio rerio)
Actinopterygii dedd 35
  • 71.36 (n)
  • 78.52 (a)
dedd 36
  • 58 (a)
OneToOne
Dr.16145 35
Species with no ortholog for DEDD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEDD Gene

ENSEMBL:
Gene Tree for DEDD (if available)
TreeFam:
Gene Tree for DEDD (if available)

Paralogs for DEDD Gene

Paralogs for DEDD Gene

Selected SIMAP similar genes for DEDD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DEDD: view

Variants for DEDD Gene

Sequence variations from dbSNP and Humsavar for DEDD Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4288617 -- 161,134,232(+) AAAAT(A/G)AAATA upstream-variant-2KB
rs4540676 -- 161,134,334(+) gcctg(A/G)tcaac upstream-variant-2KB
rs7517289 -- 161,132,100(+) CCTTT(A/C)CCCAC intron-variant, utr-variant-5-prime
rs10797093 -- 161,133,655(+) GGAGA(G/T)AATGA upstream-variant-2KB
rs11265555 -- 161,128,338(+) GCTCC(C/T)GTCTG intron-variant

Relevant External Links for DEDD Gene

HapMap Linkage Disequilibrium report
DEDD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DEDD Gene

Disorders for DEDD Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DEDD Gene including...

Search for DEDD Gene in MalaCards »

(2) University of Copenhagen DISEASES for DEDD Gene

genes like me logo Genes that share disorders with DEDD: view

No data available for UniProtKB/Swiss-Prot for DEDD Gene

Publications for DEDD Gene

  1. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. (PMID: 9774341) Stegh A.H. … Peter M.E. (EMBO J. 1998) 2 3 4 23
  2. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. (PMID: 9832420) Leo C.P. … Hsueh A.J.W. (Endocrinology 1998) 2 3 4 23
  3. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. (PMID: 11965497) Zhan Y. … Alnemri E.S. (Cell Death Differ. 2002) 3 4 23
  4. DEDD regulates degradation of intermediate filaments during apoptosis. (PMID: 12235123) Lee J.C. … Peter M.E. (J. Cell Biol. 2002) 3 4 23
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for DEDD Gene

Sources for DEDD Gene

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