Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DEDD Gene

protein-coding   GIFtS: 51
GCID: GC01M161090

Death Effector Domain Containing

(Previous name: death effector domain-containing)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Death Effector Domain Containing1 2     CASP8IP12
DEFT2 3 5     DEDD12
Death Effector Domain-Containing Testicular Molecule2 3     FLDED12
DEDPro12 3     Death Effector Domain-Containing Protein2
FLDED-12 3     DEDPRO13
Death Effector Domain-Containing1     

External Ids:    HGNC: 27551   Entrez Gene: 91912   Ensembl: ENSG000001587967   OMIM: 6068415   UniProtKB: O756183   
ORGUL members:         

Export aliases for DEDD gene to outside databases

Previous GC identifers: GC01M158802 GC01M156823 GC01M157868 GC01M158308 GC01M158309 GC01M157903 GC01M159357 GC01M132448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DEDD Gene:
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction
domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this
gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm
to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the
nucleolus. At least three transcript variants encoding the same protein have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for DEDD Gene:
DEDD (death effector domain containing) is a protein-coding gene. Diseases associated with DEDD include dental fluorosis, and dental caries. An important paralog of this gene is DEDD2.

UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618
Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation
during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of
intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus
and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By
similarity)

Gene Wiki entry for DEDD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the DEDD gene promoter:
         CREB   p53   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDEDD promoter sequence
   Search Chromatin IP Primers for DEDD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEDD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1

DEDD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DEDD gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161090:  view genomic region     (about GC identifiers)

Start:
161,090,764 bp from pter      End:
161,102,478 bp from pter
Size:
11,715 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618 (See protein sequence)
Recommended Name: Death effector domain-containing protein  
Size: 318 amino acids; 36794 Da
Subunit: Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2
Secondary accessions: D3DVF5 O60737
Alternative splicing: 2 isoforms:  O75618-1   O75618-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DEDD: NX_O75618

Explore proteomics data for DEDD at MOPED

Post-translational modifications: 

  • Exists predominantly in a mono- or diubiquitinated form1
  • Ubiquitination2 at Lys237
  • Modification sites at PhosphoSitePlus

  • See DEDD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034800.1  NP_001034801.1  NP_127491.1  

    ENSEMBL proteins: 
     ENSP00000356985   ENSP00000476946   ENSP00000356984   ENSP00000476316   ENSP00000376027  
     ENSP00000445835   ENSP00000414821  

    DEDD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DEDD
    OriGene Protein Over-expression Lysate for DEDD
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DEDD
    GenScript Custom Purified and Recombinant Proteins Services for DEDD
    Novus Biologicals DEDD Proteins
    Novus Biologicals DEDD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DEDD
    Cloud-Clone Corp. Proteins for DEDD

    DEDD Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DEDD
    OriGene Custom Antibody Services for DEDD
    Novus Biologicals DEDD Antibodies
    Abcam antibodies for DEDD
    Cloud-Clone Corp. Antibodies for DEDD
    ThermoFisher Antibodies for DEDD
    LSBio Antibodies in human, mouse, rat for DEDD

    DEDD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DEDD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DEDD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DEDD
    Cloud-Clone Corp. CLIAs for DEDD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001875 DED

    Graphical View of Domain Structure for InterPro Entry O75618

    ProtoNet protein and cluster: O75618

    1 Blocks protein domain: IPB001875 Death effector protein

    UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618
    Similarity: Contains 1 DED (death effector) domain


    DEDD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEDD_HUMAN, O75618
    Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation
    during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of
    intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus
    and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI15688372
         
    DEDD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DEDD:
     Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dedd):
     cardiovascular system  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     liver/biliary system  nervous system  renal/urinary system  reproductive system  respiratory system 

    DEDD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Deddtm1Tmiy for DEDD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEDD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEDD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DEDD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DEDD

    miRNA
    Products:
        
    miRTarBase miRNAs that target DEDD:
    hsa-mir-24-3p (MIRT030548), hsa-mir-935 (MIRT036647), hsa-let-7b-5p (MIRT052117), hsa-mir-615-3p (MIRT040264)

    Block miRNA regulation of human, mouse, rat DEDD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEDD (see all 60):
    hsa-miR-194* hsa-miR-124* hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidDEDD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DEDD
    Predesigned siRNA for gene silencing in human, mouse, rat DEDD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DEDD

    Clone
    Products:
         
    OriGene clones in human, mouse for DEDD (see all 18)
    OriGene ORF clones in mouse, rat for DEDD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DEDD (NM_032998)
    Sino Biological Human cDNA Clone for DEDD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEDD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEDD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DEDD
    Browse ESI BIO Cell Lines and PureStem Progenitors for DEDD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEDD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DEDD_HUMAN, O75618: Cytoplasm. Nucleus, nucleolus (By similarity). Note=Translocated to the nucleus during
    CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the
    mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18
    intermediate filament network in simple epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ISS--
    GO:0005737cytoplasm ISS--

    DEDD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Array including DEDD: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DEDD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for DEDD (O756181, 2, 3 ENSP000003569854) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3, ENSP000003329734MINT-7895480 I2D: score=1 STRING: ENSP00000332973
    APLP2Q064811, 3EBI-1043164,EBI-79306 I2D: score=1 
    CASP8Q147903, ENSP000003512734I2D: score=3 STRING: ENSP00000351273
    DEDD2Q8WXF83, ENSP000003369724I2D: score=3 STRING: ENSP00000336972
    CASP10Q928513, ENSP000002861864I2D: score=2 STRING: ENSP00000286186
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0007283spermatogenesis IEA--
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IEA--
    GO:0042177negative regulation of protein catabolic process IEA--
    GO:0042981regulation of apoptotic process IEA--

    DEDD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DEDD



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DEDD gene (4 alternative transcripts): 
    NM_001039711.1  NM_001039712.1  NM_032998.2  NM_004216.2  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472996 ENST00000368006 ENST00000489249 ENST00000490843 ENST00000486041
    ENST00000368005 ENST00000464113 ENST00000473679 ENST00000463227 ENST00000496632
    ENST00000392188(uc009wty.3 uc001fya.3 uc010pkb.2) ENST00000545495(uc001fyb.3)
    ENST00000458050(uc001fxz.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DEDD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DEDD (see all 60):
    hsa-miR-194* hsa-miR-124* hsa-miR-1321 hsa-miR-106a hsa-miR-15a hsa-miR-29a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidDEDD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DEDD
    Predesigned siRNA for gene silencing in human, mouse, rat DEDD
    Clone
    Products:
         
    OriGene clones in human, mouse for DEDD (see all 18)
    OriGene ORF clones in mouse, rat for DEDD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DEDD (NM_032998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DEDD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEDD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DEDD
    OriGene qSTAR qPCR primer pairs in human, mouse for DEDD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEDD
      QuantiTect SYBR Green Assays in human, mouse, rat DEDD
      QuantiFast Probe-based Assays in human, mouse, rat DEDD

    Selected AceView cDNA sequences (see all 277):

    BF196668 AK001497 W21260 CR625264 AW204961 T63500 AW467842 BG953144 
    AA639798 H95383 CA311971 CB160575 BX364263 AF083236 BQ008500 BU624713 
    BQ962098 AI092128 CA313604 AW247048 AF043733 AI382701 BF437002 AL522631 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DEDD (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:                          -                 -                                                                                       
    SP2:                                                                                      -                                             
    SP3:                                            -                                         -                                             
    SP4:                                                                                      -                                             
    SP5:                                                              -     -                 -                                             


    ECgene alternative splicing isoforms for DEDD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DEDD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAAGTGAA
    DEDD Expression
    About this image


    DEDD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
    DEDD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DEDD Protein Expression

    UniProtKB/Swiss-Prot: DEDD_HUMAN, O75618
    Tissue specificity: Widely expressed with highest levels in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including DEDD: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DEDD
    OriGene qSTAR qPCR primer pairs in human, mouse for DEDD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEDD
    QuantiTect SYBR Green Assays in human, mouse, rat DEDD
    QuantiFast Probe-based Assays in human, mouse, rat DEDD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEDD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DEDD gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dedd1 , 5 death effector domain-containing1, 5 93.71(n)1
    98.74(a)1
      1 (79.34 cM)5
    219451  NM_001128609.11  NP_001122081.11 
     1713291455 
    chicken
    (Gallus gallus)
    Aves DEDD1 death effector domain containing 80.61(n)
    88.68(a)
      425378  XM_423146.4  XP_423146.1 
    lizard
    (Anolis carolinensis)
    Reptilia DEDD6
    death effector domain containing
    85(a)
    1 ↔ 1
    GL344298.1(6465-24954)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84192 Xenopus laevis transcribed sequence with moderate similarity more 75.25(n)    CD254010.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.161452 Transcribed sequence with moderate similarity to protein more 80.42(n)    AL925092.1 


    ENSEMBL Gene Tree for DEDD (if available)
    TreeFam Gene Tree for DEDD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DEDD gene
    DEDD22  
    1 SIMAP similar gene for DEDD using alignment to 3 protein entries:     DEDD_HUMAN (see all proteins):
    DEDD2

    DEDD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DEDD (see all 122)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401133931,2
    --161095768(+) ATTCAA/GCAACT 3 -- int10--------
    rs1131625051,2
    F--161095852(+) CTCCAG/ATCACA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1381059711,2
    --161095884(+) TAATGC/TTACTT 3 -- int10--------
    rs2004674491,2
    C--161096392(+) CCTCC-/AAAGTG 3 -- int10--------
    rs1436057861,2
    --161096470(+) CTTCTA/GAGATC 3 -- int10--------
    rs784987531,2
    C,F--161096497(+) CCTCAT/CTTCCC 3 -- int11Minor allele frequency- C:0.05NA 120
    rs1866745281,2
    --161096633(+) ACACCC/TCCATC 3 -- int10--------
    rs1924541221,2
    --161096797(+) ATCACC/TATGTA 3 -- int10--------
    rs120453401,2
    C,H--161096803(+) ATGTAC/GTAAAA 3 -- int14Minor allele frequency- G:0.00NS EA 416
    rs1821960981,2
    --161096838(+) TAGATA/CCTACT 3 -- int10--------

    HapMap Linkage Disequilibrium report for DEDD (161090764 - 161102478 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DEDD: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DEDD
    DNA2.0 Custom Variant and Variant Library Synthesis for DEDD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606841    OMIM disorders: --

    3 diseases for DEDD:    
    About MalaCards
    dental fluorosis    dental caries    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for DEDD:
    Dental caries     Dental fluorosis

    DEDD for disorders           About GeneDecksing


    Export disorders for DEDD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DEDD gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DEDD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. (PubMed id 9774341)1, 2, 3, 9 Stegh A.H.... Peter M.E. (EMBO J. 1998)
    2. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. (PubMed id 9832420)1, 2, 3, 9 Leo C.P.... Hsueh A.J.W. (Endocrinology 1998)
    3. DEDD regulates degradation of intermediate filaments during apoptosis. (PubMed id 12235123)1, 2, 9 Lee J.C.... Peter M.E. (J. Cell Biol. 2002)
    4. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. (PubMed id 11965497)1, 2, 9 Zhan Y....Alnemri E.S. (Cell Death Differ. 2002)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. (PubMed id 12527898)1, 2 Alcivar A.... Yang X. (Oncogene 2003)
    8. Identification and characterization of DEDD2, a death effector domain-containing protein. (PubMed id 11741985)1, 9 Roth W.... Reed J.C. (J. Biol. Chem. 2002)
    9. DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. (PubMed id 22719072)1 Lv Q....Hu Z.W. (Cancer Res. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9191 HGNC: 2755 AceView: DEDD Ensembl:ENSG00000158796 euGenes: HUgn9191
    ECgene: DEDD H-InvDB: DEDD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DEDD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DEDD gene:
    Search GeneIP for patents involving DEDD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DEDD   OriGene RNAi products in human, mouse, rat for DEDD  
     OriGene qPCR primer pairs and template standards for DEDD   OriGene Protein Over-expression Lysate for DEDD  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DEDD  
     OriGene qSTAR qPCR primer pairs in human, mouse for DEDD   OriGene Purified Protein for DEDD  
     OriGene ORF clones in mouse, rat for DEDD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DEDD   OriGene Custom Protein Services for DEDD  

     
     
     Block miRNA regulation of human, mouse, rat DEDD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DEDD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DEDD Predesigned siRNA for gene silencing in human, mouse, rat DEDD
     QuantiFast Probe-based Assays in human, mouse, rat DEDD QuantiTect SYBR Green Assays in human, mouse, rat DEDD
     PCR Arrays including human, mouse, rat DEDD Search Chromatin IP Primers for DEDD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DEDD  GeneGlobe Interaction Network for DEDD
     Regulatory tfbs in DEDD promoter
     GenScript Custom Purified and Recombinant Proteins Services for DEDD GenScript cDNA clones with any tag delivered in your preferred vector for DEDD
     GenScript Custom Assay Services for DEDD GenScript Custom overexpressing Cell Line Services for DEDD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DEDD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DEDD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DEDD antibodies
     DEDD proteins
     DEDD lysates
     Antibodies for DEDD
     See all of Abcam's Antibodies, Kits and Proteins for DEDD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DEDD
     Proteins for DEDD
     Antibodies for DEDD
     ELISAs for DEDD
     CLIAs for DEDD



     Browse ESI BIO Cell Lines and PureStem Progenitors for DEDD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEDD
     SwitchGear 3'UTR luciferase reporter plasmids for DEDD
     SwitchGear Promoter luciferase reporter plasmids for DEDD
     ThermoFisher Antibodies for DEDD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEDD
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DEDD
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DEDD
     LSBio Antibodies in human, mouse, rat for DEDD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DEDD gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4