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Aliases for DECR2 Gene

Aliases for DECR2 Gene

  • 2,4-Dienoyl-CoA Reductase 2, Peroxisomal 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 17C Member 1 3 4
  • 2,4-Dienoyl-CoA Reductase 2 3 4
  • EC 1.3.1.34 4 61
  • SDR17C1 3 4
  • PDCR 3 4
  • Short Chain Dehydrogenase/Reductase Family 17C, Member 1 2
  • Peroxisomal 2,4-Dienoyl-CoA Reductase 3
  • EC 1.3.1 61

External Ids for DECR2 Gene

Previous GeneCards Identifiers for DECR2 Gene

  • GC16P000471
  • GC16P000391
  • GC16P000451
  • GC16P000370

Summaries for DECR2 Gene

GeneCards Summary for DECR2 Gene

DECR2 (2,4-Dienoyl-CoA Reductase 2, Peroxisomal) is a Protein Coding gene. Among its related pathways are Peroxisome and Metabolism. GO annotations related to this gene include receptor binding and 2,4-dienoyl-CoA reductase (NADPH) activity. An important paralog of this gene is PECR.

UniProtKB/Swiss-Prot for DECR2 Gene

  • Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Gene Wiki entry for DECR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DECR2 Gene

Genomics for DECR2 Gene

Regulatory Elements for DECR2 Gene

Enhancers for DECR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DECR2 on UCSC Golden Path with GeneCards custom track

Promoters for DECR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DECR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DECR2 Gene

Chromosome:
16
Start:
401,826 bp from pter
End:
412,487 bp from pter
Size:
10,662 bases
Orientation:
Plus strand

Genomic View for DECR2 Gene

Genes around DECR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DECR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DECR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DECR2 Gene

Proteins for DECR2 Gene

  • Protein details for DECR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUI1-DECR2_HUMAN
    Recommended name:
    Peroxisomal 2,4-dienoyl-CoA reductase
    Protein Accession:
    Q9NUI1
    Secondary Accessions:
    • Q6ZRS7
    • Q96ET0

    Protein attributes for DECR2 Gene

    Size:
    292 amino acids
    Molecular mass:
    30778 Da
    Quaternary structure:
    • Monomer, dimer and oligomer.

    Three dimensional structures from OCA and Proteopedia for DECR2 Gene

    Alternative splice isoforms for DECR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DECR2 Gene

Selected DME Specific Peptides for DECR2 Gene

Post-translational modifications for DECR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DECR2 Gene

Gene Families for DECR2 Gene

Suggested Antigen Peptide Sequences for DECR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUI1

UniProtKB/Swiss-Prot:

DECR2_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
genes like me logo Genes that share domains with DECR2: view

Function for DECR2 Gene

Molecular function for DECR2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=59 uM for 2,4-hexadienoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; KM=6 uM for 2,4-decadienoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; KM=102 uM for 2,4,7,10,13,16,19-docosaheptaenoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; Vmax=1.75 umol/min/mg enzyme toward 2,4-Hexadienoyl CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; Vmax=1.37 umol/min/mg enzyme toward 2,4-Decadienoyl CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130};
UniProtKB/Swiss-Prot CatalyticActivity:
Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Enzyme Numbers (IUBMB) for DECR2 Gene

Gene Ontology (GO) - Molecular Function for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity IDA 11514237
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity TAS --
genes like me logo Genes that share ontologies with DECR2: view

Phenotypes for DECR2 Gene

GenomeRNAi human phenotypes for DECR2:
genes like me logo Genes that share phenotypes with DECR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DECR2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DECR2 Gene

Localization for DECR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DECR2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DECR2 Gene COMPARTMENTS Subcellular localization image for DECR2 gene
Compartment Confidence
peroxisome 5
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005778 peroxisomal membrane TAS --
genes like me logo Genes that share ontologies with DECR2: view

Pathways & Interactions for DECR2 Gene

genes like me logo Genes that share pathways with DECR2: view

Pathways by source for DECR2 Gene

Gene Ontology (GO) - Biological Process for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006636 unsaturated fatty acid biosynthetic process IDA 11514237
GO:0044255 cellular lipid metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DECR2: view

No data available for SIGNOR curated interactions for DECR2 Gene

Drugs & Compounds for DECR2 Gene

(2) Additional Compounds for DECR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with DECR2: view

Transcripts for DECR2 Gene

Unigene Clusters for DECR2 Gene

2,4-dienoyl CoA reductase 2, peroxisomal:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DECR2 Gene

No ASD Table

Relevant External Links for DECR2 Gene

GeneLoc Exon Structure for
DECR2
ECgene alternative splicing isoforms for
DECR2

Expression for DECR2 Gene

mRNA expression in normal human tissues for DECR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DECR2 Gene

This gene is overexpressed in Liver (x12.0).

Protein differential expression in normal tissues from HIPED for DECR2 Gene

This gene is overexpressed in Gallbladder (22.6), Bone (12.0), and Liver (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DECR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of DECR2 Gene:

DECR2

SOURCE GeneReport for Unigene cluster for DECR2 Gene:

Hs.628831
genes like me logo Genes that share expression patterns with DECR2: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DECR2 Gene

Orthologs for DECR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DECR2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DECR2 34
  • 83.14 (n)
  • 86.42 (a)
DECR2 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Decr2 34
  • 78.77 (n)
  • 82.19 (a)
Decr2 16
Decr2 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DECR2 34
  • 97.49 (n)
  • 96.18 (a)
DECR2 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Decr2 34
  • 79 (n)
  • 83.22 (a)
cow
(Bos Taurus)
Mammalia DECR2 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DECR2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DECR2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858408 34
  • 71.38 (n)
  • 73.76 (a)
DECR2 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DECR2 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia decr2 34
  • 64.11 (n)
  • 69.71 (a)
LOC394884 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8872 34
zebrafish
(Danio rerio)
Actinopterygii decr2 34
  • 63.77 (n)
  • 70.14 (a)
decr2 35
  • 66 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL163W 34
  • 51.63 (n)
  • 43.09 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18909g 34
  • 45.61 (n)
  • 41.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 34
  • 46.37 (n)
  • 43.15 (a)
SPS19 35
  • 38 (a)
OneToMany
SPS19 37
thale cress
(Arabidopsis thaliana)
eudicotyledons SDRB 34
  • 49.34 (n)
  • 45.67 (a)
rice
(Oryza sativa)
Liliopsida Os04g0614000 34
  • 49.87 (n)
  • 46.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2344 34
bread mold
(Neurospora crassa)
Ascomycetes NCU07958 34
  • 48.88 (n)
  • 38.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3261 35
  • 52 (a)
OneToOne
Species where no ortholog for DECR2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DECR2 Gene

ENSEMBL:
Gene Tree for DECR2 (if available)
TreeFam:
Gene Tree for DECR2 (if available)

Paralogs for DECR2 Gene

(6) SIMAP similar genes for DECR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DECR2: view

Variants for DECR2 Gene

Sequence variations from dbSNP and Humsavar for DECR2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3743889 -- 401,719(+) CCCCC(A/G)GCCCC upstream-variant-2KB
rs3743890 -- 406,416(+) TCCCA(C/G/T)GGTCC intron-variant
rs3743891 -- 410,415(+) TGCCT(C/T)GTGCG intron-variant
rs3743892 -- 410,448(+) TGGGT(A/G)CCTTG intron-variant
rs3743893 -- 410,504(+) GGCCT(C/T)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DECR2 Gene

Variant ID Type Subtype PubMed ID
dgv32n68 CNV loss 17160897
dgv4809n54 CNV loss 21841781
dgv4810n54 CNV loss 21841781
esv1430579 CNV deletion 17803354
esv2422427 CNV duplication 17116639
esv3637563 CNV gain 21293372
nsv1131218 CNV deletion 24896259
nsv457303 CNV loss 19166990
nsv570954 CNV loss 21841781
nsv570956 CNV gain 21841781

Variation tolerance for DECR2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DECR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DECR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DECR2 Gene

Disorders for DECR2 Gene

Relevant External Links for DECR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DECR2

No disorders were found for DECR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DECR2 Gene

Publications for DECR2 Gene

  1. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. (PMID: 11514237) De Nys K. … Van Veldhoven P.P. (Biochim. Biophys. Acta 2001) 2 3 4 65
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 65

Products for DECR2 Gene

Sources for DECR2 Gene

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