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Aliases for DECR2 Gene

Aliases for DECR2 Gene

  • 2,4-Dienoyl-CoA Reductase 2, Peroxisomal 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 17C Member 1 3 4
  • 2,4-Dienoyl-CoA Reductase 2 3 4
  • EC 1.3.1.34 4 63
  • SDR17C1 3 4
  • PDCR 3 4
  • Short Chain Dehydrogenase/Reductase Family 17C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 17C 2
  • 2,4-Dienoyl CoA Reductase 2, Peroxisomal 3
  • Member 1 2
  • EC 1.3.1 63

External Ids for DECR2 Gene

Previous GeneCards Identifiers for DECR2 Gene

  • GC16P000471
  • GC16P000391
  • GC16P000451
  • GC16P000370

Summaries for DECR2 Gene

GeneCards Summary for DECR2 Gene

DECR2 (2,4-Dienoyl-CoA Reductase 2, Peroxisomal) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include receptor binding and 2,4-dienoyl-CoA reductase (NADPH) activity. An important paralog of this gene is HSD17B10.

UniProtKB/Swiss-Prot for DECR2 Gene

  • Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Gene Wiki entry for DECR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DECR2 Gene

Genomics for DECR2 Gene

Regulatory Elements for DECR2 Gene

Promoters for DECR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DECR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DECR2 Gene

Chromosome:
16
Start:
401,826 bp from pter
End:
412,487 bp from pter
Size:
10,662 bases
Orientation:
Plus strand

Genomic View for DECR2 Gene

Genes around DECR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DECR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DECR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DECR2 Gene

Proteins for DECR2 Gene

  • Protein details for DECR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUI1-DECR2_HUMAN
    Recommended name:
    Peroxisomal 2,4-dienoyl-CoA reductase
    Protein Accession:
    Q9NUI1
    Secondary Accessions:
    • Q6ZRS7
    • Q96ET0

    Protein attributes for DECR2 Gene

    Size:
    292 amino acids
    Molecular mass:
    30778 Da
    Quaternary structure:
    • Monomer, dimer and oligomer.

    Three dimensional structures from OCA and Proteopedia for DECR2 Gene

    Alternative splice isoforms for DECR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DECR2 Gene

Proteomics data for DECR2 Gene at MOPED

Selected DME Specific Peptides for DECR2 Gene

Post-translational modifications for DECR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for DECR2 Gene

Gene Families for DECR2 Gene

Suggested Antigen Peptide Sequences for DECR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUI1

UniProtKB/Swiss-Prot:

DECR2_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
genes like me logo Genes that share domains with DECR2: view

Function for DECR2 Gene

Molecular function for DECR2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=59 uM for 2,4-hexadienoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; KM=6 uM for 2,4-decadienoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; KM=102 uM for 2,4,7,10,13,16,19-docosaheptaenoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; Vmax=1.75 umol/min/mg enzyme toward 2,4-Hexadienoyl CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; Vmax=1.37 umol/min/mg enzyme toward 2,4-Decadienoyl CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130};
UniProtKB/Swiss-Prot CatalyticActivity:
Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Enzyme Numbers (IUBMB) for DECR2 Gene

Gene Ontology (GO) - Molecular Function for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity IDA 11514237
genes like me logo Genes that share ontologies with DECR2: view

Phenotypes for DECR2 Gene

GenomeRNAi human phenotypes for DECR2:
genes like me logo Genes that share phenotypes with DECR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DECR2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DECR2 Gene

Localization for DECR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DECR2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DECR2 Gene COMPARTMENTS Subcellular localization image for DECR2 gene
Compartment Confidence
peroxisome 5
cytoskeleton 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for DECR2 Gene

Pathways & Interactions for DECR2 Gene

genes like me logo Genes that share pathways with DECR2: view

Pathways by source for DECR2 Gene

Gene Ontology (GO) - Biological Process for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with DECR2: view

No data available for SIGNOR curated interactions for DECR2 Gene

Drugs & Compounds for DECR2 Gene

(2) Additional Compounds for DECR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with DECR2: view

Transcripts for DECR2 Gene

Unigene Clusters for DECR2 Gene

2,4-dienoyl CoA reductase 2, peroxisomal:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DECR2 Gene

No ASD Table

Relevant External Links for DECR2 Gene

GeneLoc Exon Structure for
DECR2
ECgene alternative splicing isoforms for
DECR2

Expression for DECR2 Gene

mRNA expression in normal human tissues for DECR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DECR2 Gene

This gene is overexpressed in Liver (x12.0).

Protein differential expression in normal tissues from HIPED for DECR2 Gene

This gene is overexpressed in Gallbladder (22.6), Bone (12.0), and Liver (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DECR2 Gene



SOURCE GeneReport for Unigene cluster for DECR2 Gene Hs.628831

genes like me logo Genes that share expression patterns with DECR2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DECR2 Gene

Orthologs for DECR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DECR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DECR2 36
  • 95 (a)
OneToOne
DECR2 35
  • 97.49 (n)
  • 96.18 (a)
cow
(Bos Taurus)
Mammalia DECR2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DECR2 36
  • 86 (a)
OneToOne
DECR2 35
  • 83.14 (n)
  • 86.42 (a)
mouse
(Mus musculus)
Mammalia Decr2 36
  • 82 (a)
OneToOne
Decr2 16
Decr2 35
  • 78.77 (n)
  • 82.19 (a)
oppossum
(Monodelphis domestica)
Mammalia DECR2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DECR2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Decr2 35
  • 79 (n)
  • 83.22 (a)
chicken
(Gallus gallus)
Aves LOC100858408 35
  • 71.38 (n)
  • 73.76 (a)
DECR2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DECR2 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8872 35
tropical clawed frog
(Silurana tropicalis)
Amphibia decr2 35
  • 64.11 (n)
  • 69.71 (a)
LOC394884 35
zebrafish
(Danio rerio)
Actinopterygii decr2 36
  • 66 (a)
OneToOne
decr2 35
  • 63.77 (n)
  • 70.14 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL163W 35
  • 51.63 (n)
  • 43.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 36
  • 38 (a)
OneToMany
SPS19 38
SPS19 35
  • 46.37 (n)
  • 43.15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18909g 35
  • 45.61 (n)
  • 41.7 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SDRB 35
  • 49.34 (n)
  • 45.67 (a)
rice
(Oryza sativa)
Liliopsida Os04g0614000 35
  • 49.87 (n)
  • 46.06 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07958 35
  • 48.88 (n)
  • 38.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2344 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3261 36
  • 52 (a)
OneToOne
Species with no ortholog for DECR2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DECR2 Gene

ENSEMBL:
Gene Tree for DECR2 (if available)
TreeFam:
Gene Tree for DECR2 (if available)

Paralogs for DECR2 Gene

(6) SIMAP similar genes for DECR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DECR2: view

Variants for DECR2 Gene

Sequence variations from dbSNP and Humsavar for DECR2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1204503 -- 409,422(+) gcctc(A/G)gcctc intron-variant
rs1204504 -- 411,762(+) TGGTG(C/T)ACTTG intron-variant
rs877904 -- 405,232(+) CAGTG(A/G)AGATT intron-variant
rs1045090 -- 412,315(+) TGCCC(A/C)CAAGG utr-variant-3-prime
rs1045098 -- 412,343(+) GCACC(A/C)CCTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DECR2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904652 CNV Loss 21882294
dgv32n68 CNV Loss 17160897
dgv2469n71 CNV Loss 21882294
dgv2473n71 CNV Loss 21882294
nsv904707 CNV Loss 21882294
dgv2474n71 CNV Loss 21882294
nsv904709 CNV Gain+Loss 21882294
nsv904711 CNV Loss 21882294
nsv457303 CNV Loss 19166990
nsv904714 CNV Loss 21882294
nsv904715 CNV Gain 21882294
esv1430579 CNV Deletion 17803354

Variation tolerance for DECR2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DECR2 Gene

HapMap Linkage Disequilibrium report
DECR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DECR2 Gene

Disorders for DECR2 Gene

Relevant External Links for DECR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DECR2

No disorders were found for DECR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DECR2 Gene

Publications for DECR2 Gene

  1. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. (PMID: 11514237) De Nys K. … Van Veldhoven P.P. (Biochim. Biophys. Acta 2001) 2 3 4 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for DECR2 Gene

Sources for DECR2 Gene

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