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Aliases for DECR2 Gene

Aliases for DECR2 Gene

  • 2,4-Dienoyl-CoA Reductase 2 2 3 4 5
  • Short Chain Dehydrogenase/Reductase Family 17C Member 1 3 4
  • 2,4-Dienoyl-CoA Reductase 2, Peroxisomal 2 3
  • EC 1.3.1.34 4 61
  • SDR17C1 3 4
  • PDCR 3 4
  • Short Chain Dehydrogenase/Reductase Family 17C, Member 1 2
  • Peroxisomal 2,4-Dienoyl-CoA Reductase 3
  • EC 1.3.1 61

External Ids for DECR2 Gene

Previous GeneCards Identifiers for DECR2 Gene

  • GC16P000471
  • GC16P000391
  • GC16P000451
  • GC16P000370
  • GC16P000403

Summaries for DECR2 Gene

GeneCards Summary for DECR2 Gene

DECR2 (2,4-Dienoyl-CoA Reductase 2) is a Protein Coding gene. Among its related pathways are Peroxisome and Metabolism. GO annotations related to this gene include receptor binding and 2,4-dienoyl-CoA reductase (NADPH) activity. An important paralog of this gene is PECR.

UniProtKB/Swiss-Prot for DECR2 Gene

  • Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Gene Wiki entry for DECR2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DECR2 Gene

Genomics for DECR2 Gene

Regulatory Elements for DECR2 Gene

Enhancers for DECR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G000456 1.4 FANTOM5 Ensembl ENCODE 29.2 +55.9 55944 2.3 HDAC1 TBL1XR1 GATA2 EGR1 EGR2 ZNF263 PPARG PRDM6 KLF16 SMARCA4 DECR2 NHLRC4 NME4 PRR35 PIGQ ENSG00000230428 GC16P000492
GH16G000404 1.3 ENCODE dbSUPER 29.2 +3.8 3802 1.8 ATF1 MLX CREB3L1 ARID4B DMAP1 ZNF48 YY1 SLC30A9 GATA2 ZNF263 DECR2 NME4 ENSG00000276984
GH16G000423 1.1 ENCODE 23.2 +23.7 23696 3.9 HNRNPUL1 PKNOX1 CREB3L1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 ZBTB7B YY1 DECR2 NME4 TMEM8A ENSG00000276984 RAB11FIP3
GH16G000428 1 Ensembl ENCODE 25.3 +27.3 27307 1.9 RFX1 HLF BHLHE40 ZIC2 ATF2 ZNF664 ZNF121 GLIS1 ZSCAN5C ZNF629 DECR2 NME4 CAPN15 PRR35 PIGQ NHLRC4 GC16M000427 RAB11FIP3
GH16G000477 1.3 Ensembl ENCODE 14.9 +75.9 75892 1.0 HDGF CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 DECR2 GC16P000492 ENSG00000230428
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DECR2 on UCSC Golden Path with GeneCards custom track

Promoters for DECR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082176 -26 2001 HDGF PKNOX1 FOXA2 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF2 YY1

Genomic Location for DECR2 Gene

Chromosome:
16
Start:
401,826 bp from pter
End:
412,487 bp from pter
Size:
10,662 bases
Orientation:
Plus strand

Genomic View for DECR2 Gene

Genes around DECR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DECR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DECR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DECR2 Gene

Proteins for DECR2 Gene

  • Protein details for DECR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUI1-DECR2_HUMAN
    Recommended name:
    Peroxisomal 2,4-dienoyl-CoA reductase
    Protein Accession:
    Q9NUI1
    Secondary Accessions:
    • Q6ZRS7
    • Q96ET0

    Protein attributes for DECR2 Gene

    Size:
    292 amino acids
    Molecular mass:
    30778 Da
    Quaternary structure:
    • Monomer, dimer and oligomer.

    Three dimensional structures from OCA and Proteopedia for DECR2 Gene

    Alternative splice isoforms for DECR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DECR2 Gene

Selected DME Specific Peptides for DECR2 Gene

Q9NUI1:
  • VAFITGGGSGIGFRIAE
  • FITGGGSG
  • AAGNFLCPA
  • DAMTRHLAVEWGP

Post-translational modifications for DECR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DECR2 Gene

Gene Families for DECR2 Gene

Suggested Antigen Peptide Sequences for DECR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUI1

UniProtKB/Swiss-Prot:

DECR2_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
genes like me logo Genes that share domains with DECR2: view

Function for DECR2 Gene

Molecular function for DECR2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=59 uM for 2,4-hexadienoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; KM=6 uM for 2,4-decadienoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; KM=102 uM for 2,4,7,10,13,16,19-docosaheptaenoyl-CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; Vmax=1.75 umol/min/mg enzyme toward 2,4-Hexadienoyl CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130}; Vmax=1.37 umol/min/mg enzyme toward 2,4-Decadienoyl CoA {ECO:0000269 PubMed:11514237, ECO:0000269 PubMed:22745130};
UniProtKB/Swiss-Prot CatalyticActivity:
Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Enzyme Numbers (IUBMB) for DECR2 Gene

Gene Ontology (GO) - Molecular Function for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity IDA,IEA 11514237
GO:0016491 oxidoreductase activity IEA --
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity TAS --
genes like me logo Genes that share ontologies with DECR2: view

Phenotypes for DECR2 Gene

GenomeRNAi human phenotypes for DECR2:
genes like me logo Genes that share phenotypes with DECR2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DECR2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DECR2 Gene

Localization for DECR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DECR2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DECR2 gene
Compartment Confidence
peroxisome 5
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane TAS --
genes like me logo Genes that share ontologies with DECR2: view

Pathways & Interactions for DECR2 Gene

genes like me logo Genes that share pathways with DECR2: view

Pathways by source for DECR2 Gene

Gene Ontology (GO) - Biological Process for DECR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006636 unsaturated fatty acid biosynthetic process IDA 11514237
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase TAS --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with DECR2: view

No data available for SIGNOR curated interactions for DECR2 Gene

Drugs & Compounds for DECR2 Gene

(2) Additional Compounds for DECR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with DECR2: view

Transcripts for DECR2 Gene

Unigene Clusters for DECR2 Gene

2,4-dienoyl CoA reductase 2, peroxisomal:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DECR2 Gene

No ASD Table

Relevant External Links for DECR2 Gene

GeneLoc Exon Structure for
DECR2
ECgene alternative splicing isoforms for
DECR2

Expression for DECR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DECR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DECR2 Gene

This gene is overexpressed in Liver (x12.0).

Protein differential expression in normal tissues from HIPED for DECR2 Gene

This gene is overexpressed in Gallbladder (22.6), Bone (12.0), and Liver (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DECR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of DECR2 Gene:

DECR2

SOURCE GeneReport for Unigene cluster for DECR2 Gene:

Hs.628831

Evidence on tissue expression from TISSUES for DECR2 Gene

  • Lung(4.1)
  • Liver(2.7)
genes like me logo Genes that share expression patterns with DECR2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DECR2 Gene

Orthologs for DECR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DECR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DECR2 34 35
  • 97.49 (n)
dog
(Canis familiaris)
Mammalia DECR2 34 35
  • 83.14 (n)
cow
(Bos Taurus)
Mammalia DECR2 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Decr2 34
  • 79 (n)
mouse
(Mus musculus)
Mammalia Decr2 34 16 35
  • 78.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DECR2 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DECR2 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858408 34
  • 71.38 (n)
DECR2 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DECR2 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia decr2 34
  • 64.11 (n)
LOC394884 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8872 34
zebrafish
(Danio rerio)
Actinopterygii decr2 34 35
  • 63.77 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL163W 34
  • 51.63 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 34 35 37
  • 46.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18909g 34
  • 45.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SDRB 34
  • 49.34 (n)
rice
(Oryza sativa)
Liliopsida Os04g0614000 34
  • 49.87 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3261 35
  • 52 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07958 34
  • 48.88 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2344 34
Species where no ortholog for DECR2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DECR2 Gene

ENSEMBL:
Gene Tree for DECR2 (if available)
TreeFam:
Gene Tree for DECR2 (if available)

Paralogs for DECR2 Gene

(6) SIMAP similar genes for DECR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DECR2: view

Variants for DECR2 Gene

Sequence variations from dbSNP and Humsavar for DECR2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000052107 -- 404,480(+) GGTGA(C/T)CCGCC intron-variant
rs1000502172 -- 408,974(+) TTACA(A/G)GCGCC intron-variant
rs1000941534 -- 409,876(+) GTGGC(C/G)TGTGT intron-variant
rs1001093788 -- 401,832(+) AGCAA(A/T)CAGGG upstream-variant-2KB
rs1001358969 -- 404,061(+) CCAGC(G/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DECR2 Gene

Variant ID Type Subtype PubMed ID
dgv32n68 CNV loss 17160897
dgv4809n54 CNV loss 21841781
dgv4810n54 CNV loss 21841781
esv1430579 CNV deletion 17803354
esv2422427 CNV duplication 17116639
esv3637563 CNV gain 21293372
nsv1131218 CNV deletion 24896259
nsv457303 CNV loss 19166990
nsv570954 CNV loss 21841781
nsv570956 CNV gain 21841781

Variation tolerance for DECR2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DECR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DECR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DECR2 Gene

Disorders for DECR2 Gene

Relevant External Links for DECR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DECR2

No disorders were found for DECR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DECR2 Gene

Publications for DECR2 Gene

  1. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. (PMID: 11514237) De Nys K. … Van Veldhoven P.P. (Biochim. Biophys. Acta 2001) 2 3 4 64
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64

Products for DECR2 Gene

Sources for DECR2 Gene

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