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Aliases for DECR1 Gene

Aliases for DECR1 Gene

  • 2,4-Dienoyl CoA Reductase 1, Mitochondrial 2 3
  • Short Chain Dehydrogenase/Reductase Family 18C Member 1 3 4
  • SDR18C1 3 4
  • DECR 3 4
  • Short Chain Dehydrogenase/Reductase Family 18C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 18C 2
  • 2,4-Dienoyl-CoA Reductase, Mitochondrial 3
  • 2,4-Dienoyl-CoA Reductase [NADPH] 4
  • 4-Enoyl-CoA Reductase [NADPH] 4
  • 4-Enoyl-CoA Reductase 3
  • EC 1.3.1.34 4
  • Member 1 2
  • NADPH 3

External Ids for DECR1 Gene

Previous HGNC Symbols for DECR1 Gene

  • DECR

Previous GeneCards Identifiers for DECR1 Gene

  • GC08P089445
  • GC08P090745
  • GC08P090970
  • GC08P091082
  • GC08P086223

Summaries for DECR1 Gene

Entrez Gene Summary for DECR1 Gene

  • This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]

GeneCards Summary for DECR1 Gene

DECR1 (2,4-Dienoyl CoA Reductase 1, Mitochondrial) is a Protein Coding gene. Diseases associated with DECR1 include 2,4-dienoyl-coa reductase deficiency and glucosephosphate dehydrogenase deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADPH binding and 2,4-dienoyl-CoA reductase (NADPH) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DECR1 Gene

  • Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DECR1 Gene

Genomics for DECR1 Gene

Regulatory Elements for DECR1 Gene

Transcription factor binding sites by QIAGEN in the DECR1 gene promoter:

Genomic Location for DECR1 Gene

Start:
90,001,352 bp from pter
End:
90,052,092 bp from pter
Size:
50,741 bases
Orientation:
Plus strand

Genomic View for DECR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DECR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DECR1 Gene

Proteins for DECR1 Gene

  • Protein details for DECR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16698-DECR_HUMAN
    Recommended name:
    2,4-dienoyl-CoA reductase, mitochondrial
    Protein Accession:
    Q16698
    Secondary Accessions:
    • B7Z6B8
    • Q2M304
    • Q93085

    Protein attributes for DECR1 Gene

    Size:
    335 amino acids
    Molecular mass:
    36068 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for DECR1 Gene

    Alternative splice isoforms for DECR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DECR1 Gene

Proteomics data for DECR1 Gene at MOPED

Post-translational modifications for DECR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DECR1 Gene

Domains for DECR1 Gene

Gene Families for DECR1 Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Graphical View of Domain Structure for InterPro Entry

Q16698

UniProtKB/Swiss-Prot:

DECR_HUMAN :
  • Q16698
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
genes like me logo Genes that share domains with DECR1: view

Function for DECR1 Gene

Molecular function for DECR1 Gene

GENATLAS Biochemistry: 2-4-dienoyl-CoA reductase,mitochondrial,auxiliary enzyme of beta oxidation participating in the metabolism of (poly) unsaturated fatty enoyl-CoA esters
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=7.7 uM for NADPH {ECO:0000269 PubMed:15531764}; KM=14.3 uM for trans-2,trans-4-hexadienoyl-CoA {ECO:0000269 PubMed:15531764}; Vmax=30.3 umol/min/mg enzyme {ECO:0000269 PubMed:15531764};
UniProtKB/Swiss-Prot CatalyticActivity: Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA

Enzyme Numbers (IUBMB) for DECR1 Gene

Gene Ontology (GO) - Molecular Function for DECR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity IDA 15531764
GO:0016491 oxidoreductase activity --
GO:0016651 oxidoreductase activity, acting on NAD(P)H TAS --
GO:0070402 NADPH binding IDA 15531764
genes like me logo Genes that share ontologies with DECR1: view
genes like me logo Genes that share phenotypes with DECR1: view

Animal Models for DECR1 Gene

MGI Knock Outs for DECR1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for DECR1 Gene

Localization for DECR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DECR1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DECR1 Gene COMPARTMENTS Subcellular localization image for DECR1 gene
Compartment Confidence
mitochondrion 5
nucleus 4
chloroplast 3
cytosol 3
endoplasmic reticulum 3
extracellular 3
plasma membrane 3
cytoskeleton 2
golgi apparatus 2
lysosome 2
peroxisome 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for DECR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion NAS 7818482
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with DECR1: view

Pathways for DECR1 Gene

genes like me logo Genes that share pathways with DECR1: view

Gene Ontology (GO) - Biological Process for DECR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006635 fatty acid beta-oxidation TAS --
GO:0008152 metabolic process --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0051289 protein homotetramerization IDA 15531764
genes like me logo Genes that share ontologies with DECR1: view

Compounds for DECR1 Gene

(3) HMDB Compounds for DECR1 Gene

Compound Synonyms Cas Number PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6
trans-3-Hexenoyl-CoA
  • S-(3E)-3-hexenoate Coenzyme A
6599-65-1

(4) Drugbank Compounds for DECR1 Gene

genes like me logo Genes that share compounds with DECR1: view

Transcripts for DECR1 Gene

Unigene Clusters for DECR1 Gene

2,4-dienoyl CoA reductase 1, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DECR1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5: -

Relevant External Links for DECR1 Gene

GeneLoc Exon Structure for
DECR1
ECgene alternative splicing isoforms for
DECR1

Expression for DECR1 Gene

mRNA expression in normal human tissues for DECR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DECR1 Gene

This gene is overexpressed in Heart - Left Ventricle (5.8) and Liver (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DECR1 Gene

SOURCE GeneReport for Unigene cluster for DECR1 Gene Hs.492212

mRNA Expression by UniProt/SwissProt for DECR1 Gene

Q16698-DECR_HUMAN
Tissue specificity: Heart = liver = pancreas > kidney >> skeletal muscle = lung.
genes like me logo Genes that share expressions with DECR1: view

Orthologs for DECR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DECR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DECR1 35
  • 99.6 (n)
  • 99.7 (a)
DECR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DECR1 35
  • 90.15 (n)
  • 90.25 (a)
DECR1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DECR1 35
  • 88.75 (n)
  • 89.36 (a)
DECR1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Decr1 35
  • 82.69 (n)
  • 82.39 (a)
Decr1 16
Decr1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DECR1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DECR1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Decr1 35
  • 82.29 (n)
  • 82.99 (a)
chicken
(Gallus gallus)
Aves DECR1 35
  • 78.98 (n)
  • 82.17 (a)
DECR1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DECR1 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22226 35
tropical clawed frog
(Silurana tropicalis)
Amphibia decr1 35
  • 71.66 (n)
  • 75.8 (a)
zebrafish
(Danio rerio)
Actinopterygii decr1 35
  • 67.95 (n)
  • 70.19 (a)
decr1 36
  • 67 (a)
OneToOne
wufe38b07 35
worm
(Caenorhabditis elegans)
Secernentea decr-1.2 36
  • 45 (a)
OneToMany
decr-1.3 36
  • 47 (a)
OneToMany
F53C11.3 36
  • 50 (a)
OneToMany
F53C11.3 37
  • 52 (a)
W01C9.4 37
  • 46 (a)
T05C12.3 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 36
  • 33 (a)
OneToMany
Species with no ortholog for DECR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DECR1 Gene

ENSEMBL:
Gene Tree for DECR1 (if available)
TreeFam:
Gene Tree for DECR1 (if available)

Paralogs for DECR1 Gene

Selected SIMAP similar genes for DECR1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with DECR1: view

Variants for DECR1 Gene

Sequence variations from dbSNP and Humsavar for DECR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7162 -- 90,051,898(+) CCTAA(A/G)ACCAC utr-variant-3-prime
rs9495 -- 90,051,681(+) AGTCA(C/T)TAAAT missense, reference
rs10235 -- 90,044,921(+) GTCGC(A/C)TGGGG missense, reference
rs15094 - 90,051,888(+) ACAAA(A/T)GGTTC reference, missense
rs395719 -- 90,021,887(+) AATGA(A/C)TTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DECR1 Gene

Variant ID Type Subtype PubMed ID
nsv891183 CNV Gain 21882294
essv345 CNV CNV 17122850
nsv8365 CNV Gain 18304495

Relevant External Links for DECR1 Gene

HapMap Linkage Disequilibrium report
DECR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DECR1 Gene

Disorders for DECR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for DECR1 Gene including...

Search for DECR1 Gene in MalaCards »

UniProtKB/Swiss-Prot

DECR_HUMAN
  • 2,4-dienoyl-CoA reductase deficiency (DECRD) [MIM:616034]: A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia. {ECO:0000269 PubMed:24847004}. Note=The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. {ECO:0000269 PubMed:24847004}.

Relevant External Links for DECR1

Genetic Association Database (GAD)
DECR1
Human Genome Epidemiology (HuGE) Navigator
DECR1
genes like me logo Genes that share disorders with DECR1: view

Publications for DECR1 Gene

  1. Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR). (PMID: 9403065) Helander H.M. … Hiltunen J.K. (Genomics 1997) 3 4 23
  2. Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase. (PMID: 7818482) Koivuranta K.T. … Hiltunen J.K. (Biochem. J. 1994) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4

Products for DECR1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Fatty Acid Metabolism in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DECR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DECR1
    • Block miRNA regulation of DECR1 using miScript Target Protectors

    Sources for DECR1 Gene

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