Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DECR1 Gene

Aliases for DECR1 Gene

  • 2,4-Dienoyl-CoA Reductase 1, Mitochondrial 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 18C Member 1 3 4
  • SDR18C1 3 4
  • DECR 3 4
  • Short Chain Dehydrogenase/Reductase Family 18C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 18C 2
  • 2,4-Dienoyl CoA Reductase 1, Mitochondrial 3
  • 2,4-Dienoyl-CoA Reductase [NADPH] 4
  • 4-Enoyl-CoA Reductase [NADPH] 4
  • 4-Enoyl-CoA Reductase 3
  • EC 1.3.1.34 4
  • Member 1 2
  • NADPH 3

External Ids for DECR1 Gene

Previous HGNC Symbols for DECR1 Gene

  • DECR

Previous GeneCards Identifiers for DECR1 Gene

  • GC08P089445
  • GC08P090745
  • GC08P090970
  • GC08P091082
  • GC08P086223

Summaries for DECR1 Gene

Entrez Gene Summary for DECR1 Gene

  • This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]

GeneCards Summary for DECR1 Gene

DECR1 (2,4-Dienoyl-CoA Reductase 1, Mitochondrial) is a Protein Coding gene. Diseases associated with DECR1 include 2,4-dienoyl-coa reductase deficiency and chronic granulomatous disease. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include oxidoreductase activity and NADPH binding. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for DECR1 Gene

  • Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DECR1 Gene

Genomics for DECR1 Gene

Regulatory Elements for DECR1 Gene

Enhancers for DECR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DECR1 on UCSC Golden Path with GeneCards custom track

Promoters for DECR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DECR1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DECR1 gene promoter:

Genomic Location for DECR1 Gene

Chromosome:
8
Start:
90,001,352 bp from pter
End:
90,052,092 bp from pter
Size:
50,741 bases
Orientation:
Plus strand

Genomic View for DECR1 Gene

Genes around DECR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DECR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DECR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DECR1 Gene

Proteins for DECR1 Gene

  • Protein details for DECR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16698-DECR_HUMAN
    Recommended name:
    2,4-dienoyl-CoA reductase, mitochondrial
    Protein Accession:
    Q16698
    Secondary Accessions:
    • B7Z6B8
    • Q2M304
    • Q93085

    Protein attributes for DECR1 Gene

    Size:
    335 amino acids
    Molecular mass:
    36068 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for DECR1 Gene

    Alternative splice isoforms for DECR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DECR1 Gene

Proteomics data for DECR1 Gene at MOPED

Post-translational modifications for DECR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DECR1 Gene

Domains & Families for DECR1 Gene

Gene Families for DECR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16698

UniProtKB/Swiss-Prot:

DECR_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
genes like me logo Genes that share domains with DECR1: view

Function for DECR1 Gene

Molecular function for DECR1 Gene

GENATLAS Biochemistry:
2-4-dienoyl-CoA reductase,mitochondrial,auxiliary enzyme of beta oxidation participating in the metabolism of (poly) unsaturated fatty enoyl-CoA esters
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.7 uM for NADPH {ECO:0000269 PubMed:15531764}; KM=14.3 uM for trans-2,trans-4-hexadienoyl-CoA {ECO:0000269 PubMed:15531764}; Vmax=30.3 umol/min/mg enzyme {ECO:0000269 PubMed:15531764};
UniProtKB/Swiss-Prot CatalyticActivity:
Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

Enzyme Numbers (IUBMB) for DECR1 Gene

Gene Ontology (GO) - Molecular Function for DECR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity IDA 15531764
genes like me logo Genes that share ontologies with DECR1: view
genes like me logo Genes that share phenotypes with DECR1: view

Human Phenotype Ontology for DECR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DECR1 Gene

MGI Knock Outs for DECR1:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for DECR1 Gene

Localization for DECR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DECR1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DECR1 Gene COMPARTMENTS Subcellular localization image for DECR1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 4
chloroplast 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
peroxisome 2
vacuole 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DECR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DECR1: view

Pathways & Interactions for DECR1 Gene

genes like me logo Genes that share pathways with DECR1: view

Gene Ontology (GO) - Biological Process for DECR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with DECR1: view

No data available for SIGNOR curated interactions for DECR1 Gene

Drugs & Compounds for DECR1 Gene

(2) Drugs for DECR1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0
6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL Experimental Pharma Target 0

(3) Additional Compounds for DECR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
trans-3-Hexenoyl-CoA
  • (E)-S-3-hexenoate
  • (E)-S-3-hexenoate CoA
  • (E)-S-3-hexenoate Coenzyme A
  • (E)-S-3-hexenoic acid
  • 3-trans-Hexenoylcoenzyme A
6599-65-1
genes like me logo Genes that share compounds with DECR1: view

Transcripts for DECR1 Gene

Unigene Clusters for DECR1 Gene

2,4-dienoyl CoA reductase 1, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DECR1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5: -

Relevant External Links for DECR1 Gene

GeneLoc Exon Structure for
DECR1
ECgene alternative splicing isoforms for
DECR1

Expression for DECR1 Gene

mRNA expression in normal human tissues for DECR1 Gene

mRNA differential expression in normal tissues according to GTEx for DECR1 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.8) and Liver (x4.5).

Protein differential expression in normal tissues from HIPED for DECR1 Gene

This gene is overexpressed in Heart (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DECR1 Gene



SOURCE GeneReport for Unigene cluster for DECR1 Gene Hs.492212

mRNA Expression by UniProt/SwissProt for DECR1 Gene

Q16698-DECR_HUMAN
Tissue specificity: Heart = liver = pancreas > kidney >> skeletal muscle = lung.
genes like me logo Genes that share expression patterns with DECR1: view

Protein tissue co-expression partners for DECR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DECR1 Gene

Orthologs for DECR1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DECR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DECR1 35
  • 90.15 (n)
  • 90.25 (a)
DECR1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DECR1 35
  • 88.75 (n)
  • 89.36 (a)
DECR1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Decr1 35
  • 82.69 (n)
  • 82.39 (a)
Decr1 16
Decr1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DECR1 35
  • 99.6 (n)
  • 99.7 (a)
DECR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Decr1 35
  • 82.29 (n)
  • 82.99 (a)
oppossum
(Monodelphis domestica)
Mammalia DECR1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DECR1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DECR1 35
  • 78.98 (n)
  • 82.17 (a)
DECR1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DECR1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia decr1 35
  • 71.66 (n)
  • 75.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22226 35
zebrafish
(Danio rerio)
Actinopterygii decr1 35
  • 67.95 (n)
  • 70.19 (a)
wufe38b07 35
decr1 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53C11.3 37
  • 52 (a)
T05C12.3 37
  • 47 (a)
W01C9.4 37
  • 46 (a)
decr-1.2 36
  • 45 (a)
OneToMany
decr-1.3 36
  • 47 (a)
OneToMany
F53C11.3 36
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 36
  • 33 (a)
OneToMany
Species with no ortholog for DECR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DECR1 Gene

ENSEMBL:
Gene Tree for DECR1 (if available)
TreeFam:
Gene Tree for DECR1 (if available)

Paralogs for DECR1 Gene

genes like me logo Genes that share paralogs with DECR1: view

Variants for DECR1 Gene

Sequence variations from dbSNP and Humsavar for DECR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs15094 - 90,051,888(+) ACAAA(A/T)GGTTC reference, missense
rs2072656 -- 90,001,120(+) AAACA(C/T)ATACG upstream-variant-2KB
rs2074593 -- 90,001,138(+) AAGAG(C/T)TTCGC upstream-variant-2KB
rs2074594 -- 90,043,117(+) CTTTC(A/G)TGACA intron-variant
rs2074595 -- 90,043,183(+) TAACT(A/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DECR1 Gene

Variant ID Type Subtype PubMed ID
nsv891183 CNV Gain 21882294
essv345 CNV CNV 17122850
nsv8365 CNV Gain 18304495

Variation tolerance for DECR1 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DECR1 Gene

HapMap Linkage Disequilibrium report
DECR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DECR1 Gene

Disorders for DECR1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for DECR1 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
2,4-dienoyl-coa reductase deficiency
  • 2,4-dienoyl coa reductase
chronic granulomatous disease
  • bridges-good syndrome
kabuki syndrome 1
  • kabuki syndrome
suppurative lymphadenitis
  • suppurative lymphadenopathy
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search DECR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DECR_HUMAN
  • 2,4-dienoyl-CoA reductase deficiency (DECRD) [MIM:616034]: A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia. {ECO:0000269 PubMed:24847004}. Note=The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS. {ECO:0000269 PubMed:24847004}.

Relevant External Links for DECR1

Genetic Association Database (GAD)
DECR1
Human Genome Epidemiology (HuGE) Navigator
DECR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DECR1
genes like me logo Genes that share disorders with DECR1: view

No data available for Genatlas for DECR1 Gene

Publications for DECR1 Gene

  1. Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase. (PMID: 7818482) Koivuranta K.T. … Hiltunen J.K. (Biochem. J. 1994) 2 3 4 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR). (PMID: 9403065) Helander H.M. … Hiltunen J.K. (Genomics 1997) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DECR1 Gene

Sources for DECR1 Gene

Content