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Aliases for DEC1 Gene

Aliases for DEC1 Gene

  • Deleted In Esophageal Cancer 1 2 3
  • Candidate Tumor Suppressor CTS9 3 4
  • CTS9 3 4

External Ids for DEC1 Gene

Previous GeneCards Identifiers for DEC1 Gene

  • GC09P108702
  • GC09P109636
  • GC09P111357
  • GC09P113280
  • GC09P114983
  • GC09P116943
  • GC09P117904
  • GC09P087508

Summaries for DEC1 Gene

Entrez Gene Summary for DEC1 Gene

  • The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for DEC1 Gene

DEC1 (Deleted In Esophageal Cancer 1) is a Protein Coding gene. Diseases associated with DEC1 include esophageal cancer and oropharynx cancer. Among its related pathways are Circadian rhythm pathway.

UniProtKB/Swiss-Prot for DEC1 Gene

  • Candidate tumor suppressor.

Gene Wiki entry for DEC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEC1 Gene

Genomics for DEC1 Gene

Regulatory Elements for DEC1 Gene

Genomic Location for DEC1 Gene

115,112,617 bp from pter
115,402,644 bp from pter
290,028 bases
Plus strand

Genomic View for DEC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEC1 Gene

Proteins for DEC1 Gene

  • Protein details for DEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deleted in esophageal cancer 1
    Protein Accession:

    Protein attributes for DEC1 Gene

    70 amino acids
    Molecular mass:
    7542 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEC1 Gene

Proteomics data for DEC1 Gene at MOPED

Post-translational modifications for DEC1 Gene

No Post-translational modifications

Other Protein References for DEC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEC1 Gene

Domains & Families for DEC1 Gene

Protein Domains for DEC1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DEC1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DEC1 Gene

Function for DEC1 Gene

Molecular function for DEC1 Gene

UniProtKB/Swiss-Prot Function:
Candidate tumor suppressor.
genes like me logo Genes that share phenotypes with DEC1: view

miRNA for DEC1 Gene

miRTarBase miRNAs that target DEC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DEC1 Gene

Localization for DEC1 Gene

Subcellular locations from

Jensen Localization Image for DEC1 Gene COMPARTMENTS Subcellular localization image for DEC1 gene
Compartment Confidence
chloroplast 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEC1 Gene

Pathways & Interactions for DEC1 Gene

SuperPathways for DEC1 Gene

Superpath Contained pathways
1 Circadian rhythm pathway
genes like me logo Genes that share pathways with DEC1: view

Pathways by source for DEC1 Gene

1 BioSystems pathway for DEC1 Gene

Gene Ontology (GO) - Biological Process for DEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS 10612805
genes like me logo Genes that share ontologies with DEC1: view

No data available for SIGNOR curated interactions for DEC1 Gene

Drugs & Compounds for DEC1 Gene

No Compound Related Data Available

Transcripts for DEC1 Gene

mRNA/cDNA for DEC1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEC1 Gene

Deleted in esophageal cancer 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DEC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for DEC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEC1 Gene

mRNA expression in normal human tissues for DEC1 Gene

mRNA differential expression in normal tissues according to GTEx for DEC1 Gene

This gene is overexpressed in Nerve - Tibial (x6.3).

SOURCE GeneReport for Unigene cluster for DEC1 Gene Hs.148841

mRNA Expression by UniProt/SwissProt for DEC1 Gene

Tissue specificity: Expressed in many tissues, with highest expression in prostate and testis. Reduced expression in esophageal carcinomas.
genes like me logo Genes that share expression patterns with DEC1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DEC1 Gene

Orthologs for DEC1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DEC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEC1 36
  • 97 (a)
Species with no ortholog for DEC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEC1 Gene

Gene Tree for DEC1 (if available)
Gene Tree for DEC1 (if available)

Paralogs for DEC1 Gene

No data available for Paralogs for DEC1 Gene

Variants for DEC1 Gene

Sequence variations from dbSNP and Humsavar for DEC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs849023 -- 115,281,148(+) CATTT(C/T)GTCAG intron-variant
rs849024 -- 115,285,628(+) TATAT(A/G)TGTGT intron-variant
rs849025 -- 115,288,800(+) aacac(A/G)gtgaa intron-variant
rs849026 -- 115,292,932(+) GTTCC(C/T)GGTGG intron-variant
rs849027 -- 115,294,427(+) CCTCA(C/T)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DEC1 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
nsv7434 OTHER Inversion 18451855
nsv831697 CNV Loss 17160897
nsv6681 CNV Loss 18451855
nsv507528 CNV Insertion 20534489
esv269376 CNV Insertion 20981092
esv273535 CNV Insertion 20981092
nsv893769 CNV Loss 21882294
nsv6682 CNV Loss 18451855
esv2674932 CNV Deletion 23128226
esv2176591 CNV Deletion 18987734
esv2738968 CNV Deletion 23290073
nsv527294 CNV Loss 19592680
nsv525037 CNV Loss 19592680
esv1206387 CNV Insertion 17803354
nsv512115 CNV Loss 21212237
esv2494923 CNV Deletion 19546169
esv2068341 CNV Deletion 18987734
esv3290 CNV Deletion 18987735
esv2738969 CNV Deletion 23290073
esv8511 CNV Loss 19470904
esv1089105 CNV Deletion 17803354
esv2677881 CNV Deletion 23128226
nsv519995 CNV Loss 19592680

Variation tolerance for DEC1 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DEC1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEC1 Gene

Disorders for DEC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DEC1 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
oropharynx cancer
  • primary malignant neoplasm of lateral wall of oropharynx
- elite association
Search DEC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DEC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DEC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DEC1 Gene

Publications for DEC1 Gene

  1. Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor-suppressor locus on chromosome 9q32. (PMID: 10612805) Nishiwaki T. … Nakamura Y. (Genes Chromosomes Cancer 2000) 2 23 67
  2. ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. (PMID: 18556654) Qian Y. … Chen X. (J. Biol. Chem. 2008) 23 67
  3. Cellular senescence in oral cancer and precancer and treatment implications: a review. (PMID: 18607883) Campo-Trapero J. … Bascones-MartA-nez A. (Acta Oncol 2008) 23 67
  4. Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells. (PMID: 18834862) Pedersen M. … RAPnnstrand L. (Biochem. Biophys. Res. Commun. 2008) 23 67
  5. Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer. (PMID: 16827797) Koukourakis M.I. … Sivridis E. (Cancer Sci. 2006) 23 67

Products for DEC1 Gene

Sources for DEC1 Gene

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