DEC1 Gene
protein-coding GIFtS: 45
GCID: GC09P117904
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deleted in esophageal cancer 1
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Aliases
for DEC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Deleted In Esophageal Cancer 11 2 | | CTS91 2 3 | | Candidate Tumor Suppressor CTS92 3 |
Export aliases for DEC1 gene to outside databasesPrevious GC identifers: GC09P108702 GC09P109636 GC09P111357 GC09P113280 GC09P114983 GC09P116943 GC09P087508 |
Summaries
for DEC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DEC1:
The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cellcarcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressorgene for esophageal squamous cell carcinomas. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DEC1_HUMAN, Q9P2X7Function: Candidate tumor supressor
Gene Wiki entry for DEC1
|
Genomic Views
for DEC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DEC1 gene promoter:
c-Fos Pbx1a Sp1 AP-1 ATF-2 STAT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for DEC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q33.1 HGNC cytogenetic band: 9q32DEC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P117904: view genomic region
(about GC identifiers)
Start:
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117,904,097 bp from pter |
End:
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118,164,923 bp from pter |
Size:
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260,827 bases |
Orientation:
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plus strand |
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Proteins
for DEC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DEC1_HUMAN, Q9P2X7 (See
protein sequence)Recommended Name: Deleted in esophageal cancer 1 Size: 70 amino acids; 7542 DaExplore the universe of human proteins at neXtProt for DEC1: NX_Q9P2X7
DEC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_059114.1
ENSEMBL proteins: ENSP00000363128
Human Recombinant Protein Products:
DEC1 Antibody Products:
Assay Products for DEC1: |
Protein
Domains /
Families
for DEC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9P2X7 |
Function
for DEC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DEC1_HUMAN, Q9P2X7Function: Candidate tumor supressor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for DEC1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEC1 |
1 GenomeRNAi human phenotype for DEC1:
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Pathways & Interactions
for DEC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Circadian rhythm pathway | |
1  BioSystems Pathway for DEC1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DEC1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DEC1 (Q9P2X73 ENSP000003631284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008285 | negative regulation of cell proliferation |
TAS | 10612805 |
DEC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DEC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DEC1
Search CenterWatch for drugs/clinical trials and news about DEC1
|
Transcripts
for DEC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DEC1 gene: NM_017418.2 Unigene Cluster for DEC1: Deleted in esophageal cancer 1 Hs.148841 [show with all ESTs]Unigene Representative Sequence: AK0561533 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374016(uc004bjk.1 uc004bjl.1) ENST00000477580 ENST00000484171
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for DEC1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DEC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEC1 |
Additional cDNA sequence: AB022761.1 AK056153.1 BC030567.1 BC107103.1 4 DOTS entries: DT.97812535 DT.121165088 DT.436858 DT.95353682 14 AceView cDNA sequences: BX116042 AK056153 CA436809 AI989497 AB022761 BM452178 BC030567 BV197968 AI365209 R13987 NM_017418 BQ575832 H09707 R40050
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for DEC1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
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| SP1: | | | | | | | | | | | |
| SP2: | | | - | | | | | | | |
ECgene alternative splicing isoforms for DEC1
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Expression
for DEC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DEC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCTTACCC
About this image
See DEC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DEC1
SOURCE GeneReport for Unigene cluster: Hs.148841
UniProtKB/Swiss-Prot: DEC1_HUMAN, Q9P2X7Tissue specificity: Expressed in many tissues, with highest expression in prostate and testis. Reduced expression inesophageal carcinomas
SABiosciences Custom PCR Arrays for DEC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DEC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEC1 |
Orthologs
for DEC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for DEC1 (if available)
TreeFam Gene Tree for DEC1 (if available) |
Paralogs
for DEC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DEC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DEC1 (117904097 - 118154097 bp, first 250kb of DEC1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for DEC1
3 CNVs: 52685 100765 23885
4 Indels: 29044 62945 42696 47635
Human Gene Mutation Database (HGMD): DEC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEC1 |
|
Disorders
/ Diseases
for DEC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 DEC1 for disorders About MalaCards
DEC1 for disorders About GeneDecksing
OMIM gene information: 604767
OMIM disorders: 133239
Human Genome Epidemiology (HuGE) Navigator: DEC1 (10 documents)
Export disorders for DEC1 gene to outside databases
|
Publications
for DEC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DEC1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with DEC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor-suppressor locus on chromosome 9q32. (PubMed id 10612805)1, 2, 3, 9 Nishiwaki T.... Nakamura Y. (2000)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. (PubMed id 8603412)1, 3 Miura K....Nakamura Y. (1996)
- Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma . (PubMed id 22844531)1 Xu Q....Lu N. (2012)
- The increased expression of DEC1 gene is related to HI F-1a protein in gastric cancer cell lines. (PubMed id 21779800)1 Zheng Y....Wang Y. (2012)
- Differentiated embryo-chondrocyte expressed gene 1 reg ulates p53-dependent cell survival versus cell death through macrophage inhibito ry cytokine-1. (PubMed id 22723347)1 Qian Y....Chen X. (2012)
- DEC1 binding to the proximal promoter of CYP3A4 ascrib es to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocyt es. (PubMed id 22728071)1 Mao Z....Yan B. (2012)
- IL-1b-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway. (PubMed id 22644784)1 Bhawal U.K....Abiko Y. (2012)
- The rexinoid bexarotene represses cyclin D1 transcrip tion by inducing the DEC2 transcriptional repressor. (PubMed id 20821348)1 Li Y....Brown P.H. (2011)
- SUMOylation of DEC1 protein regulates its transcripti onal activity and enhances its stability. (PubMed id 21829689)1 Hong Y....Wu H. (2011)
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External Searches for DEC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DEC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DEC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DEC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DEC1 gene:
Search GeneIP for patents involving DEC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DEC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DEC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DEC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DEC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DEC1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DEC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DEC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DEC1 | | OriGene Custom Protein Services for DEC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DEC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DEC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DEC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DEC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DEC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DEC1 |
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| | | | Search Tocris compounds for DEC1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DEC1 |
|  |  |  | | | | ThermoFisher Antibodies for DEC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DEC1 |
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