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Aliases for DDX60L Gene

Aliases for DDX60L Gene

  • DEAD-Box Helicase 60-Like 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60-Like 2
  • DEAD Box Protein 60-Like 4
  • EC 4

External Ids for DDX60L Gene

Previous GeneCards Identifiers for DDX60L Gene

  • GC04M169515
  • GC04M169277
  • GC04M165030

Summaries for DDX60L Gene

Entrez Gene Summary for DDX60L Gene

  • This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for DDX60L Gene

DDX60L (DEAD-Box Helicase 60-Like) is a Protein Coding gene. Diseases associated with DDX60L include Hepatitis C Virus. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX60.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX60L Gene

Genomics for DDX60L Gene

Regulatory Elements for DDX60L Gene

Enhancers for DDX60L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F168479 1.4 FANTOM5 Ensembl ENCODE 57.3 +53.0 52957 11.3 HDGF ATF1 ARID4B SIN3A ZNF48 ZNF2 YY1 GLIS2 ELK1 FOS DDX60L DDX60 GC04P168471 PALLD
GH04F168502 1.5 FANTOM5 Ensembl ENCODE 50.6 +34.1 34070 2.4 CTCF JUN DDX60L DDX60 PALLD
GH04F168509 1.6 FANTOM5 Ensembl ENCODE 45.3 +27.8 27756 1.1 HLF JUN CEBPB EP300 ZBTB40 JUND ATF3 FOS DDX60L ENSG00000249623 DDX60 PALLD
GH04F168439 1.7 FANTOM5 Ensembl ENCODE 22.5 +97.1 97086 1.4 PKNOX1 MTA2 NR2F1 JUN CEBPB RAD21 JUND ATF3 SMARCA4 PBX2 DDX60L DDX60 GC04P168471 GC04M168258
GH04F168511 1 Ensembl ENCODE 20.1 +25.8 25801 0.8 CTCF TCF7L2 DDX60L ENSG00000249623 PALLD
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DDX60L on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX60L Gene

168,356,735 bp from pter
168,537,786 bp from pter
181,052 bases
Minus strand

Genomic View for DDX60L Gene

Genes around DDX60L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX60L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX60L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX60L Gene

Proteins for DDX60L Gene

  • Protein details for DDX60L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX60-like
    Protein Accession:
    Secondary Accessions:
    • Q96ND6

    Protein attributes for DDX60L Gene

    1706 amino acids
    Molecular mass:
    197674 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX60L Gene


neXtProt entry for DDX60L Gene

Post-translational modifications for DDX60L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDX60L Gene

Domains & Families for DDX60L Gene

Protein Domains for DDX60L Gene

Suggested Antigen Peptide Sequences for DDX60L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the helicase family.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the helicase family.
genes like me logo Genes that share domains with DDX60L: view

No data available for Gene Families for DDX60L Gene

Function for DDX60L Gene

Molecular function for DDX60L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX60L Gene

Gene Ontology (GO) - Molecular Function for DDX60L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DDX60L: view
genes like me logo Genes that share phenotypes with DDX60L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDX60L Gene

Localization for DDX60L Gene

Subcellular locations from

Jensen Localization Image for DDX60L Gene COMPARTMENTS Subcellular localization image for DDX60L gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX60L Gene

Pathways & Interactions for DDX60L Gene

SuperPathways for DDX60L Gene

No Data Available

Interacting Proteins for DDX60L Gene

Gene Ontology (GO) - Biological Process for DDX60L Gene


No data available for Pathways by source and SIGNOR curated interactions for DDX60L Gene

Drugs & Compounds for DDX60L Gene

(3) Drugs for DDX60L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX60L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX60L: view

Transcripts for DDX60L Gene

Unigene Clusters for DDX60L Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX60L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP2: - -
SP3: -

Relevant External Links for DDX60L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX60L Gene

mRNA expression in normal human tissues for DDX60L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDX60L Gene

This gene is overexpressed in Whole Blood (x10.9).

Protein differential expression in normal tissues from HIPED for DDX60L Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (33.3), Tlymphocyte (23.4), and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX60L Gene

NURSA nuclear receptor signaling pathways regulating expression of DDX60L Gene:


SOURCE GeneReport for Unigene cluster for DDX60L Gene:

genes like me logo Genes that share expression patterns with DDX60L: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DDX60L Gene

Orthologs for DDX60L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX60L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX60L 34 35
  • 99.1 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
-- 35
  • 54 (a)
-- 35
  • 16 (a)
-- 35
  • 14 (a)
(Caenorhabditis elegans)
Secernentea C28H8.3 35
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR4 35
  • 15 (a)
Species where no ortholog for DDX60L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX60L Gene

Gene Tree for DDX60L (if available)
Gene Tree for DDX60L (if available)

Paralogs for DDX60L Gene

Paralogs for DDX60L Gene

(2) SIMAP similar genes for DDX60L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DDX60L: view

Variants for DDX60L Gene

Sequence variations from dbSNP and Humsavar for DDX60L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs201155959 Uncertain significance 168,430,522(+) TGGCC(A/G/T)AGTAG nc-transcript-variant, reference, synonymous-codon, missense, utr-variant-5-prime
rs10002007 -- 168,478,409(+) ACTAA(C/T)TAGAG intron-variant
rs10002308 -- 168,478,672(+) TAATC(A/C)TGAGA intron-variant
rs10002730 -- 168,399,370(+) CCCCC(A/G)TGCCA intron-variant
rs10004447 -- 168,469,566(+) ggtca(C/T)ccaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX60L Gene

Variant ID Type Subtype PubMed ID
nsv474731 CNV novel sequence insertion 20440878

Variation tolerance for DDX60L Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.96; 98.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX60L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX60L Gene

Disorders for DDX60L Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX60L Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DDX60L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DDX60L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX60L Gene

Publications for DDX60L Gene

  1. DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture. (PMID: 26269178) GrA1nvogel O. … Lohmann V. (J. Virol. 2015) 2 3 64
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for DDX60L Gene

Sources for DDX60L Gene

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