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Aliases for DDX60L Gene

Aliases for DDX60L Gene

  • DEAD-Box Helicase 60 Like 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60-Like 2
  • DEAD Box Protein 60-Like 4
  • EC 4

External Ids for DDX60L Gene

Previous GeneCards Identifiers for DDX60L Gene

  • GC04M169515
  • GC04M169277
  • GC04M165030

Summaries for DDX60L Gene

Entrez Gene Summary for DDX60L Gene

  • This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for DDX60L Gene

DDX60L (DEAD-Box Helicase 60 Like) is a Protein Coding gene. Diseases associated with DDX60L include Hepatitis C Virus. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX60.

Additional gene information for DDX60L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX60L Gene

Genomics for DDX60L Gene

Regulatory Elements for DDX60L Gene

Enhancers for DDX60L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H168479 1.9 FANTOM5 Ensembl ENCODE dbSUPER 57.3 +53.0 52957 11.3 HDGF ATF1 ARID4B SIN3A ZNF2 YY1 GLIS2 ELK1 FOS ATF7 DDX60L DDX60 PALLD ENSG00000207171
GH04H168509 1.6 FANTOM5 Ensembl ENCODE dbSUPER 45.3 +27.9 27856 0.9 FOSL1 JUND JUN HLF CEBPB FOS CEBPG EP300 DDX60L ENSG00000207171 ENSG00000249623 DDX60 PALLD
GH04H168502 1.4 FANTOM5 Ensembl ENCODE dbSUPER 50.6 +34.1 34070 2.4 CTCF JUN MAX CEBPG DDX60L DDX60 ENSG00000207171 PALLD
GH04H168439 1.3 FANTOM5 Ensembl ENCODE 22.5 +97.1 97086 1.4 PKNOX1 JUN NR2F1 CEBPB FOSL1 JUND IKZF1 ZNF629 ZNF24 ATF7 DDX60L DDX60 GC04P168472 GC04M168258
GH04H168449 1.5 FANTOM5 Ensembl ENCODE 18.5 +87.3 87260 1.5 ATF1 ZBTB21 INSM2 BACH1 FOSL1 DIDO1 ZNF366 ZSCAN5C PRDM10 KLF8 DDX60L ENSG00000207171 DDX60 GC04P168472 GC04M168258
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX60L on UCSC Golden Path with GeneCards custom track

Genomic Locations for DDX60L Gene

Genomic Locations for DDX60L Gene
181,052 bases
Minus strand

Genomic View for DDX60L Gene

Genes around DDX60L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX60L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX60L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX60L Gene

Proteins for DDX60L Gene

  • Protein details for DDX60L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX60-like
    Protein Accession:
    Secondary Accessions:
    • Q96ND6

    Protein attributes for DDX60L Gene

    1706 amino acids
    Molecular mass:
    197674 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX60L Gene


neXtProt entry for DDX60L Gene

Post-translational modifications for DDX60L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDX60L Gene

Domains & Families for DDX60L Gene

Gene Families for DDX60L Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DDX60L Gene

Suggested Antigen Peptide Sequences for DDX60L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the helicase family.
  • Belongs to the helicase family.
genes like me logo Genes that share domains with DDX60L: view

Function for DDX60L Gene

Molecular function for DDX60L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX60L Gene

Phenotypes From GWAS Catalog for DDX60L Gene

Gene Ontology (GO) - Molecular Function for DDX60L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DDX60L: view
genes like me logo Genes that share phenotypes with DDX60L: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDX60L Gene

Localization for DDX60L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX60L gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX60L Gene

Pathways & Interactions for DDX60L Gene

SuperPathways for DDX60L Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX60L Gene


No data available for Pathways by source and SIGNOR curated interactions for DDX60L Gene

Drugs & Compounds for DDX60L Gene

(3) Drugs for DDX60L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DDX60L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX60L: view

Transcripts for DDX60L Gene

Unigene Clusters for DDX60L Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX60L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP2: - -
SP3: -

Relevant External Links for DDX60L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX60L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX60L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDX60L Gene

This gene is overexpressed in Whole Blood (x10.9).

Protein differential expression in normal tissues from HIPED for DDX60L Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (33.3), Tlymphocyte (23.4), and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX60L Gene

NURSA nuclear receptor signaling pathways regulating expression of DDX60L Gene:


SOURCE GeneReport for Unigene cluster for DDX60L Gene:

genes like me logo Genes that share expression patterns with DDX60L: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX60L Gene

Orthologs for DDX60L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX60L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX60L 33 34
  • 99.1 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
-- 34
  • 54 (a)
-- 34
  • 16 (a)
-- 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea C28H8.3 34
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR4 34
  • 15 (a)
Species where no ortholog for DDX60L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX60L Gene

Gene Tree for DDX60L (if available)
Gene Tree for DDX60L (if available)

Paralogs for DDX60L Gene

Paralogs for DDX60L Gene

(2) SIMAP similar genes for DDX60L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DDX60L: view

Variants for DDX60L Gene

Sequence variations from dbSNP and Humsavar for DDX60L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs201155959 Uncertain significance 168,430,522(+) TGGCC(A/G/T)AGTAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000094871 -- 168,432,086(+) TACCA(G/T)GCATA intron-variant, upstream-variant-2KB
rs1000108977 -- 168,419,628(+) CTTAA(A/G)TGTCT intron-variant
rs1000115492 -- 168,388,006(+) ATACC(A/G)CAACT intron-variant
rs1000124713 -- 168,467,861(+) CAAAC(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX60L Gene

Variant ID Type Subtype PubMed ID
nsv474731 CNV novel sequence insertion 20440878

Variation tolerance for DDX60L Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.96; 98.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX60L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX60L Gene

Disorders for DDX60L Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX60L Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, response to therapy of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DDX60L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DDX60L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX60L Gene

Publications for DDX60L Gene

  1. DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture. (PMID: 26269178) Grünvogel O … Lohmann V (Journal of virology 2015) 2 3 60
  2. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N … Nonalcoholic Steatohepatitis Clinical Research Network (Gastroenterology 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 60
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for DDX60L Gene

Sources for DDX60L Gene

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