DDX60L Gene
protein-coding GIFtS: 39
GCID: GC04M169277
|
|
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
| |
Aliases
for DDX60L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60-Like1 2 | | DEAD Box Protein 60-Like2 3 | | FLJ310331 | | Probable ATP-Dependent RNA Helicase DDX60-Like2 | | EC 3.6.4.133 |
Export aliases for DDX60L gene to outside databasesPrevious GC identifers: GC04M169515 GC04M165030 |
Summaries
for DDX60L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DDX60L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDX60L gene promoter:
GR AML1a GR-beta Pax-2 Pax-2a RelA NF-kappaB C/EBPalpha GATA-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX60L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX60L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.3 Ensembl cytogenetic band: 4q32.3 HGNC cytogenetic band: 4q32.3DDX60L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M169277: view genomic region
(about GC identifiers)
Start:
|
169,277,886 bp from pter |
End:
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169,458,937 bp from pter |
Size:
|
181,052 bases |
Orientation:
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minus strand |
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Proteins
for DDX60L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDX6L_HUMAN, Q5H9U9 (See
protein sequence)Recommended Name: Probable ATP-dependent RNA helicase DDX60-like Size: 1706 amino acids; 197674 Da
Sequence caution: Sequence=BAB70966.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q96ND6Alternative splicing: 2 isoforms: Q5H9U9-1 Q5H9U9-2 Explore the universe of human proteins at neXtProt for DDX60L: NX_Q5H9U9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5H9U9
DDX60L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012985.1
ENSEMBL proteins: ENSP00000422423 ENSP00000422202 ENSP00000422920 ENSP00000421026 ENSP00000424310 ENSP00000424396 ENSP00000427386 ENSP00000260184
Human Recombinant Protein Products:
DDX60L Antibody Products:
Assay Products for DDX60L: |
Protein
Domains /
Families
for DDX60L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX60L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5H9U9ProtoNet protein and cluster: Q5H9U9 UniProtKB/Swiss-Prot: DDX6L_HUMAN, Q5H9U9Similarity: Belongs to the helicase familySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Function
for DDX60L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DDX6L_HUMAN, Q5H9U9Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Number (IUBMB): EC 3.6.4.131
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX60L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX60L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: DDX60L (NM_001012967) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX60L |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DDX60L for ontologies About GeneDecksing
|
Pathways & Interactions
for DDX60L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX60L
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for DDX60L (ENSP000002601844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DDX60L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DDX60L
Search CenterWatch for drugs/clinical trials and news about DDX60L / DDX6L
|
Transcripts
for DDX60L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDX60L gene: NM_001012967.1 Unigene Cluster for DDX60L: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like Hs.535011 [show with all ESTs]Unigene Representative Sequence: NM_00101296716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000510590 ENST00000511577(uc003irq.4) ENST00000513103 ENST00000505890(uc003irr.1 uc003irs.1)
ENST00000514580 ENST00000503190 ENST00000505863 ENST00000504793 ENST00000505696
ENST00000514748 ENST00000515088(uc003irt.1) ENST00000513901 ENST00000512371
ENST00000505150 ENST00000512958 ENST00000260184(uc021xuh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX60L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX60L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDX60L (NM_001012967) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX60L | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DDX60L |
Additional cDNA sequence: AK023530.1 AK023743.1 AK055595.1 AK092461.1 AK096369.1 AL832950.1 CR933601.1 8 DOTS entries: DT.410440 DT.100761694 DT.100761696 DT.99947973 DT.121228785 DT.121228807 DT.40202257 DT.91637985 24/47 AceView cDNA sequences (see all 47): AA195070 BQ002315 AW514774 BU685618 BQ003151 BQ003169 BM798838 AA194980 CB160878 BF686215 BX106755 AI684705 BU675004 BQ268277 AA922376 AI340138 CK906029 CK906028 AI089830 BQ029552 CA415446 AA972403 CD104855 BU754444
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DDX60L About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DDX60L
|
Expression
for DDX60L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX60L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATTCAAC
About this image
See DDX60L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX60L
SOURCE GeneReport for Unigene cluster: Hs.535011
SABiosciences Custom PCR Arrays for DDX60L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX60L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DDX60L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX60L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX60L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX60L |
Orthologs
for DDX60L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DDX60L gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
Uncharacterized protein |
48(a) |
possible ortholog |
4(26056227-26081660) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
50(a) |
possible ortholog |
GL343216.1(130853-184202) |
worm
(Caenorhabditis elegans) |
Secernentea |
C28H8.36 |
Uncharacterized helicase C28H8.3 |
24(a) |
1 → many |
III(5908653-5914689) |
ENSEMBL Gene Tree for DDX60L (if available)
TreeFam Gene Tree for DDX60L (if available) |
Paralogs
for DDX60L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDX60L gene
- DDX602 SKIV2L2
2 SIMAP similar genes for DDX60L using alignment to 6 protein entries: DDX6L_HUMAN (see all proteins):DDX60 DKFZp686E11248
DDX60L for paralogs About GeneDecksing
|
Genomic Variants
for DDX60L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX60L |
|
Disorders
/ Diseases
for DDX60L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDX60L for disorders About GeneDecksing
5  diseases for DDX60L: About MalaCardsfatty liver disease liver disease tuberculosis malaria
mycobacterium tuberculosis
Export disorders for DDX60L gene to outside databases
|
Publications
for DDX60L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDX60L gene integrated from 9 sources:
(articles sorted by number of sources associating them with DDX60L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide association study identifies variants ass ociated with histologic features of nonalcoholic Fatty liver disease. (PubMed id 20708005)1 Chalasani N....Rotter J.I. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
|
External Searches for DDX60L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DDX60L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDX60L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDX60L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DDX60L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DDX60L gene:
Search GeneIP for patents involving DDX60L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDX60L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DDX60L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX60L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX60L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDX60L | | OriGene 3'-UTR Clone for DDX60L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX60L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX60L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DDX60L | | OriGene Custom Protein Services for DDX60L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX60L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX60L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX60L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX60L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX60L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX60L |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DDX60L |
| |  |  |  |  | | | | |
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 |
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 | | | DDX60L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX60L |
|  |  |  | | | | Search ThermoFisher Antibodies for DDX60L |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DDX60L |
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