Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX60L Gene

Aliases for DDX60L Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60-Like 2 3
  • DEAD Box Protein 60-Like 4
  • EC 4

External Ids for DDX60L Gene

Previous GeneCards Identifiers for DDX60L Gene

  • GC04M169515
  • GC04M169277
  • GC04M165030

Summaries for DDX60L Gene

GeneCards Summary for DDX60L Gene

DDX60L (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60-Like) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX60.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX60L Gene

Genomics for DDX60L Gene

Regulatory Elements for DDX60L Gene

Genomic Location for DDX60L Gene

168,356,735 bp from pter
168,537,786 bp from pter
181,052 bases
Minus strand

Genomic View for DDX60L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX60L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX60L Gene

Proteins for DDX60L Gene

  • Protein details for DDX60L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX60-like
    Protein Accession:
    Secondary Accessions:
    • Q96ND6

    Protein attributes for DDX60L Gene

    1706 amino acids
    Molecular mass:
    197674 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB70966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX60L Gene


neXtProt entry for DDX60L Gene

Proteomics data for DDX60L Gene at MOPED

Post-translational modifications for DDX60L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDX60L Gene

Domains for DDX60L Gene

Protein Domains for DDX60L Gene

Suggested Antigen Peptide Sequences for DDX60L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the helicase family.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the helicase family.
genes like me logo Genes that share domains with DDX60L: view

No data available for Gene Families for DDX60L Gene

Function for DDX60L Gene

Molecular function for DDX60L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX60L Gene

Gene Ontology (GO) - Molecular Function for DDX60L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003723 RNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX60L: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDX60L Gene

Localization for DDX60L Gene

Subcellular locations from

Jensen Localization Image for DDX60L Gene COMPARTMENTS Subcellular localization image for DDX60L gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX60L Gene

Pathways for DDX60L Gene

SuperPathways for DDX60L Gene

No Data Available

Interacting Proteins for DDX60L Gene

Gene Ontology (GO) - Biological Process for DDX60L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DDX60L: view

No data available for Pathways by source for DDX60L Gene

Transcripts for DDX60L Gene

Unigene Clusters for DDX60L Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX60L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP2: - -
SP3: -

Relevant External Links for DDX60L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX60L Gene

mRNA expression in normal human tissues for DDX60L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDX60L Gene

This gene is overexpressed in Whole Blood (10.9).

Protein differential expression in normal tissues for DDX60L Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (33.3), Tlymphocyte (23.4), and Blymphocyte (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX60L Gene

SOURCE GeneReport for Unigene cluster for DDX60L Gene Hs.535011

genes like me logo Genes that share expressions with DDX60L: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for DDX60L Gene

Orthologs for DDX60L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX60L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX60L 35
  • 99.1 (n)
  • 98.36 (a)
DDX60L 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
-- 36
  • 16 (a)
-- 36
  • 14 (a)
-- 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea C28H8.3 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR4 36
  • 15 (a)
Species with no ortholog for DDX60L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX60L Gene

Gene Tree for DDX60L (if available)
Gene Tree for DDX60L (if available)

Paralogs for DDX60L Gene

Paralogs for DDX60L Gene

(2) SIMAP similar genes for DDX60L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DDX60L: view

Variants for DDX60L Gene

Sequence variations from dbSNP and Humsavar for DDX60L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12880 -- 168,357,010(+) AAAAC(C/G)CACCT utr-variant-3-prime
rs496945 -- 168,357,941(+) TACTC(C/T)GGTTT utr-variant-3-prime
rs497151 -- 168,358,019(+) AGCTG(A/G)TATCT utr-variant-3-prime
rs647736 -- 168,357,838(+) CTACT(A/T)AAAAA utr-variant-3-prime
rs720584 -- 168,465,879(+) CCATG(C/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX60L Gene

Variant ID Type Subtype PubMed ID
nsv881291 CNV Gain 21882294
nsv880400 CNV Gain 21882294
nsv881379 CNV Gain 21882294

Relevant External Links for DDX60L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX60L Gene

Disorders for DDX60L Gene

Relevant External Links for DDX60L

Genetic Association Database (GAD)

No disorders were found for DDX60L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DDX60L Gene

Publications for DDX60L Gene

  1. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. (PMID: 20708005) Chalasani N. … Rotter J.I. (Gastroenterology 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for DDX60L Gene

Sources for DDX60L Gene

Back to Top