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Aliases for DDX60 Gene

Aliases for DDX60 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 2 3
  • DEAD Box Protein 60 4
  • EC 3.6.4.13 4

External Ids for DDX60 Gene

Previous GeneCards Identifiers for DDX60 Gene

  • GC04M169375
  • GC04M169137
  • GC04M164890

Summaries for DDX60 Gene

GeneCards Summary for DDX60 Gene

DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX60L.

UniProtKB/Swiss-Prot for DDX60 Gene

  • Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX60 Gene

Genomics for DDX60 Gene

Regulatory Elements for DDX60 Gene

Genomic Location for DDX60 Gene

Chromosome:
4
Start:
168,216,291 bp from pter
End:
168,318,807 bp from pter
Size:
102,517 bases
Orientation:
Minus strand

Genomic View for DDX60 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX60 Gene

Proteins for DDX60 Gene

  • Protein details for DDX60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY21-DDX60_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX60
    Protein Accession:
    Q8IY21
    Secondary Accessions:
    • Q6PK35
    • Q9NVE3

    Protein attributes for DDX60 Gene

    Size:
    1712 amino acids
    Molecular mass:
    197853 Da
    Quaternary structure:
    • Interacts with EXOSC1, EXOSC4, DDX58/RIG-I, IFIH1/MDA5 and DHX58/LGP2.

neXtProt entry for DDX60 Gene

Proteomics data for DDX60 Gene at MOPED

Post-translational modifications for DDX60 Gene

  • Ubiquitination at Lys 834
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX60 Gene

No data available for DME Specific Peptides for DDX60 Gene

Domains & Families for DDX60 Gene

Gene Families for DDX60 Gene

Protein Domains for DDX60 Gene

Suggested Antigen Peptide Sequences for DDX60 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IY21

UniProtKB/Swiss-Prot:

DDX60_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the helicase family.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the helicase family.
genes like me logo Genes that share domains with DDX60: view

Function for DDX60 Gene

Molecular function for DDX60 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).
UniProtKB/Swiss-Prot Induction:
By interferon (IFN). Up-regulated during vesicular stomatitis virus (VSV), or poliovirus (PV) infection.

Enzyme Numbers (IUBMB) for DDX60 Gene

Gene Ontology (GO) - Molecular Function for DDX60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003690 double-stranded DNA binding IDA 21791617
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IDA 21791617
GO:0003727 single-stranded RNA binding IDA 21791617
genes like me logo Genes that share ontologies with DDX60: view

Phenotypes for DDX60 Gene

genes like me logo Genes that share phenotypes with DDX60: view

Animal Model Products

miRNA for DDX60 Gene

miRTarBase miRNAs that target DDX60

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX60

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX60 Gene

Localization for DDX60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX60 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX60 Gene COMPARTMENTS Subcellular localization image for DDX60 gene
Compartment Confidence
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21791617
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with DDX60: view

Pathways & Interactions for DDX60 Gene

SuperPathways for DDX60 Gene

No Data Available

Interacting Proteins for DDX60 Gene

Gene Ontology (GO) - Biological Process for DDX60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009615 response to virus IDA 21791617
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IEA --
GO:1900245 positive regulation of MDA-5 signaling pathway IMP 21791617
genes like me logo Genes that share ontologies with DDX60: view

No data available for Pathways by source and SIGNOR curated interactions for DDX60 Gene

Drugs & Compounds for DDX60 Gene

(1) Drugs for DDX60 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX60 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX60: view

Transcripts for DDX60 Gene

Unigene Clusters for DDX60 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX60

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX60 Gene

No ASD Table

Relevant External Links for DDX60 Gene

GeneLoc Exon Structure for
DDX60
ECgene alternative splicing isoforms for
DDX60

Expression for DDX60 Gene

mRNA expression in normal human tissues for DDX60 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX60 Gene

This gene is overexpressed in Cervix (13.3), CD8 Tcells (9.7), Peripheral blood mononuclear cells (8.3), and Placenta (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX60 Gene



SOURCE GeneReport for Unigene cluster for DDX60 Gene Hs.591710

mRNA Expression by UniProt/SwissProt for DDX60 Gene

Q8IY21-DDX60_HUMAN
Tissue specificity: Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine.
genes like me logo Genes that share expression patterns with DDX60: view

Protein tissue co-expression partners for DDX60 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DDX60 Gene

Orthologs for DDX60 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX60 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DDX60 35
  • 84.48 (n)
  • 79.2 (a)
DDX60 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx60 35
  • 79.55 (n)
  • 75.31 (a)
Ddx60 16
Ddx60 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX60 35
  • 99.51 (n)
  • 99.07 (a)
DDX60 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX60 35
  • 63.31 (n)
  • 55.18 (a)
DDX60 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX60 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx60 35
  • 59.46 (n)
  • 52.32 (a)
worm
(Caenorhabditis elegans)
Secernentea C28H8.3 35
  • 45.2 (n)
  • 32.12 (a)
C28H8.3 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR4 36
  • 16 (a)
OneToMany
Species with no ortholog for DDX60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX60 Gene

ENSEMBL:
Gene Tree for DDX60 (if available)
TreeFam:
Gene Tree for DDX60 (if available)

Paralogs for DDX60 Gene

Paralogs for DDX60 Gene

(3) SIMAP similar genes for DDX60 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DDX60 Gene

genes like me logo Genes that share paralogs with DDX60: view

Variants for DDX60 Gene

Sequence variations from dbSNP and Humsavar for DDX60 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_055895 -
VAR_055896 -

Structural Variations from Database of Genomic Variants (DGV) for DDX60 Gene

Variant ID Type Subtype PubMed ID
nsv830146 CNV Gain 17160897
nsv881291 CNV Gain 21882294
nsv4596 CNV Insertion 18451855
esv2728712 CNV Deletion 23290073
esv2728713 CNV Deletion 23290073

Variation tolerance for DDX60 Gene

Residual Variation Intolerance Score: 4.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX60 Gene

HapMap Linkage Disequilibrium report
DDX60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX60 Gene

Disorders for DDX60 Gene

Relevant External Links for DDX60

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX60
genes like me logo Genes that share disorders with DDX60: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX60 Gene

Publications for DDX60 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. (PMID: 21791617) Miyashita M. … Seya T. (Mol. Cell. Biol. 2011) 67
  3. A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins J.W. … Rice C.M. (Nature 2011) 67
  4. Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. (PMID: 18271526) Tong J. … Moran M.F. (J. Proteome Res. 2008) 67
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67

Products for DDX60 Gene

Sources for DDX60 Gene

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