Aliases for DDX60 Gene
External Ids for DDX60 Gene
Previous GeneCards Identifiers for DDX60 Gene
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]
GeneCards Summary for DDX60 Gene
DDX60 (DExD/H-Box Helicase 60) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX60L.
UniProtKB/Swiss-Prot for DDX60 Gene
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).