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DDX60 Gene

protein-coding   GIFtS: 49
GCID: GC04M169137

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 601 2
DEAD Box Protein 602 3
Probable ATP-Dependent RNA Helicase DDX602
EC 3.6.4.133

External Ids:    HGNC: 259421   Entrez Gene: 556012   Ensembl: ENSG000001376287   OMIM: 6139745   UniProtKB: Q8IY213   

Export aliases for DDX60 gene to outside databases

Previous GC identifers: GC04M169375 GC04M164890


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDX60 Gene:
DDX60 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 60) is a protein-coding gene. GO annotations related to this gene include double-stranded RNA binding and double-stranded DNA binding. An important paralog of this gene is SKIV2L2.

UniProtKB/Swiss-Prot: DDX60_HUMAN, Q8IY21
Function: Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible
gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of
DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX60 gene promoter:
         RORalpha1   NF-AT4   NF-AT2   p300   NF-AT3   AP-4   NF-AT   NF-AT1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX60 promoter sequence
   Search Chromatin IP Primers for DDX60

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX60


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

DDX60 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX60 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M169137:  view genomic region     (about GC identifiers)

Start:
169,137,442 bp from pter      End:
169,239,958 bp from pter
Size:
102,517 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX60_HUMAN, Q8IY21 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX60  
Size: 1712 amino acids; 197853 Da
Subunit: Interacts with EXOSC1, EXOSC4, DDX58/RIG-I, IFIH1/MDA5 and DHX58/LGP2
Secondary accessions: Q6PK35 Q9NVE3

Explore the universe of human proteins at neXtProt for DDX60: NX_Q8IY21

Explore proteomics data for DDX60 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys834
  • Modification sites at PhosphoSitePlus

  • See DDX60 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060101.3  
    ENSEMBL proteins: 
     ENSP00000377344   ENSP00000422669   ENSP00000423678   ENSP00000423647  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q8IY21

    ProtoNet protein and cluster: Q8IY21

    UniProtKB/Swiss-Prot: DDX60_HUMAN, Q8IY21
    Similarity: Belongs to the helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX60           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX60_HUMAN, Q8IY21
    Function: Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible
    gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of
    DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV)
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: By interferon (IFN). Up-regulated during vesicular stomatitis virus (VSV), or poliovirus (PV) infection

         Enzyme Number (IUBMB): EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IDA--
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA--
         
    Find genes that share ontologies with DDX60           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX60_HUMAN, Q8IY21: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0045111intermediate filament cytoskeleton IDA--

    Find genes that share ontologies with DDX60           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX60
    Interactions:

        Search GeneGlobe Interaction Network for DDX60

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for DDX60 (ENSP000003773444) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX58ENSP000002516424STRING: ENSP00000251642
    EXOSC1ENSP000003599394STRING: ENSP00000359939
    EXOSC4ENSP000003154764STRING: ENSP00000315476
    DDX58ENSP000003692134STRING: ENSP00000369213
    IFIH1ENSP000002636424STRING: ENSP00000263642
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IDA--
    GO:0045087innate immune response IEA--
    GO:0051607defense response to virus IEA--
    GO:1900245positive regulation of MDA-5 signaling pathway IMP--
    GO:1900246positive regulation of RIG-I signaling pathway IMP--

    Find genes that share ontologies with DDX60           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX60



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX60 gene: 
    NM_017631.5  

    Unigene Cluster for DDX60:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
    Hs.591710  [show with all ESTs]
    Unigene Representative Sequence: NM_017631
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393743(uc003irp.3 uc003iro.3) ENST00000511317 ENST00000507815
    ENST00000505393 ENST00000513997 ENST00000514995
    miRNA
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    Additional mRNA sequence: 

    AK000042.1 AK001649.1 AK026333.1 AK223184.1 AK225191.1 AK307404.1 AL137464.1 BC007820.2 
    BC020601.1 BC038115.2 BC074781.2 BX648655.1 

    6 DOTS entries:

    DT.40121440  DT.100779132  DT.92417354  DT.100861376  DT.95269757  DT.95269760 

    Selected AceView cDNA sequences (see all 102):

    BC020601 BC074781 BX648655 AI990745 BC007820 AK026333 AW002659 AI383115 
    CB126090 CA390354 BU185203 BX646368 AW150758 AK001649 AI926267 AI520911 
    CB157224 BP346012 BF508126 AW512348 BU161524 AI625970 AL137464 BG622111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX60 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACTCACA
    DDX60 Expression
    About this image


    DDX60 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Gonad
             Primordial Germ Cells Allantois
             Primordial germ cell-like cells
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
    DDX60 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX60 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591710

    UniProtKB/Swiss-Prot: DDX60_HUMAN, Q8IY21
    Tissue specificity: Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle,
    spleen, kidney, liver and small intestine

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDX60 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx601 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 601, 5 79.55(n)1
    75.31(a)1
      8 (31.51 cM)5
    2343111  NM_001081215.11  NP_001074684.11 
     619280875 
    chicken
    (Gallus gallus)
    Aves DDX601 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 63.31(n)
    55.18(a)
      422427  XM_004940918.1  XP_004940975.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX606
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
    57(a)
    1 ↔ 1
    GL343216.1(130853-193356)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ddx601 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 59.46(n)
    52.32(a)
      100489902  XM_002933330.2  XP_002933376.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.31 C28H8.3 45.2(n)
    32.12(a)
      175834  NM_065882.4  NP_498283.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTR46
    ATP-dependent 3'-5' RNA helicase of the Dead-box f...
    16(a)
    1 → many
    X(342522-345743) YJL050W


    ENSEMBL Gene Tree for DDX60 (if available)
    TreeFam Gene Tree for DDX60 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX60 gene
    SKIV2L22  DDX60L2  
    3 SIMAP similar genes for DDX60 using alignment to 6 protein entries:     DDX60_HUMAN (see all proteins):
    DKFZp434E1722    DKFZp686E11248    DDX60L

    Find genes that share paralogs with DDX60           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DDX60
    PGOHUM00000244479


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX60 (see all 2308)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829910021,2
    --169137285(+) AAAAAA/TTTTAT 1 -- int10--------
    rs1866673811,2
    --169137324(+) TAGAAA/CTCTGA 1 -- int10--------
    rs1397715331,2
    C--169137586(+) AAAGTA/GCTATC 1 -- ut310--------
    rs109751,2
    C,F--169137587(-) AGATAG/ATACTT 1 -- ut312Minor allele frequency- A:0.02MN NA 304
    rs1918615801,2
    --169137772(+) AATTGA/TTATTC 1 -- ut310--------
    rs1839893261,2
    --169137873(+) ATTCAA/GGTATA 1 -- ut310--------
    rs802205111,2
    C,F--169138229(+) ATTGAA/CTATTA 1 -- int11Minor allele frequency- C:0.11EA 120
    rs1169690871,2
    C,F--169138278(+) TCCCAT/CCAGAT 1 -- int11Minor allele frequency- C:0.11EA 120
    rs176110961,2
    C,F,H--169138291(+) TGAAAT/CTATGT 1 -- int119Minor allele frequency- C:0.12NA NS EA 2254
    rs1412569611,2
    C--169138350(+) TCTTG-/TATAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DDX60 (169137442 - 169239958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DDX60:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728712CNV Deletion23290073
    esv2728713CNV Deletion23290073
    nsv4596CNV Insertion18451855
    nsv881291CNV Gain21882294
    nsv830146CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613974    OMIM disorders: --


    Find genes that share disorders with DDX60           About GenesLikeMe


    Export disorders for DDX60 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX60 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DDX60)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. (PubMed id 21791617)1, 2 Miyashita M.... Seya T. (Mol. Cell. Biol. 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. A diverse range of gene products are effectors of the type I interferon antiviral response. (PubMed id 21478870)2 Schoggins J.W.... Rice C.M. (Nature 2011)
    6. Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. (PubMed id 18271526)1 Tong J....Moran M.F. (J. Proteome Res. 2008)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55601 HGNC: 25942 AceView: FLJ20035 Ensembl:ENSG00000137628 euGenes: HUgn55601
    ECgene: DDX60 H-InvDB: DDX60

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX60 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX60 gene:
    Search GeneIP for patents involving DDX60

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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