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Aliases for DDX60 Gene

Aliases for DDX60 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 2 3
  • DEAD Box Protein 60 4
  • EC 3.6.4.13 4

External Ids for DDX60 Gene

Previous GeneCards Identifiers for DDX60 Gene

  • GC04M169375
  • GC04M169137
  • GC04M164890

Summaries for DDX60 Gene

GeneCards Summary for DDX60 Gene

DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60) is a Protein Coding gene. GO annotations related to this gene include double-stranded DNA binding and double-stranded RNA binding. An important paralog of this gene is DDX60L.

UniProtKB/Swiss-Prot for DDX60 Gene

  • Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX60 Gene

Genomics for DDX60 Gene

Regulatory Elements for DDX60 Gene

Genomic Location for DDX60 Gene

Start:
168,216,291 bp from pter
End:
168,318,807 bp from pter
Size:
102,517 bases
Orientation:
Minus strand

Genomic View for DDX60 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX60 Gene

Proteins for DDX60 Gene

  • Protein details for DDX60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY21-DDX60_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX60
    Protein Accession:
    Q8IY21
    Secondary Accessions:
    • Q6PK35
    • Q9NVE3

    Protein attributes for DDX60 Gene

    Size:
    1712 amino acids
    Molecular mass:
    197853 Da
    Quaternary structure:
    • Interacts with EXOSC1, EXOSC4, DDX58/RIG-I, IFIH1/MDA5 and DHX58/LGP2.

neXtProt entry for DDX60 Gene

Proteomics data for DDX60 Gene at MOPED

Post-translational modifications for DDX60 Gene

  • Ubiquitination at Lys834
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX60 Gene

No data available for DME Specific Peptides for DDX60 Gene

Domains for DDX60 Gene

Protein Domains for DDX60 Gene

Suggested Antigen Peptide Sequences for DDX60 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IY21

UniProtKB/Swiss-Prot:

DDX60_HUMAN :
  • Q8IY21
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the helicase family.
genes like me logo Genes that share domains with DDX60: view

No data available for Gene Families for DDX60 Gene

Function for DDX60 Gene

Molecular function for DDX60 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).
UniProtKB/Swiss-Prot Induction: By interferon (IFN). Up-regulated during vesicular stomatitis virus (VSV), or poliovirus (PV) infection.

Enzyme Numbers (IUBMB) for DDX60 Gene

Gene Ontology (GO) - Molecular Function for DDX60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IDA 21791617
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IDA 21791617
genes like me logo Genes that share ontologies with DDX60: view

Animal Model Products

CRISPR Products

miRNA for DDX60 Gene

miRTarBase miRNAs that target DDX60

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX60

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX60 Gene

Localization for DDX60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX60 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX60 Gene COMPARTMENTS Subcellular localization image for DDX60 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DDX60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with DDX60: view

Pathways for DDX60 Gene

SuperPathways for DDX60 Gene

No Data Available

Interacting Proteins for DDX60 Gene

Gene Ontology (GO) - Biological Process for DDX60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0009615 response to virus IDA 21791617
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IEA --
GO:1900245 positive regulation of MDA-5 signaling pathway IMP 21791617
genes like me logo Genes that share ontologies with DDX60: view

No data available for Pathways by source for DDX60 Gene

Transcripts for DDX60 Gene

Unigene Clusters for DDX60 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX60

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX60 Gene

No ASD Table

Relevant External Links for DDX60 Gene

GeneLoc Exon Structure for
DDX60
ECgene alternative splicing isoforms for
DDX60

Expression for DDX60 Gene

mRNA expression in normal human tissues for DDX60 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX60 Gene

SOURCE GeneReport for Unigene cluster for DDX60 Gene Hs.591710

mRNA Expression by UniProt/SwissProt for DDX60 Gene

Q8IY21-DDX60_HUMAN
Tissue specificity: Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine.
genes like me logo Genes that share expressions with DDX60: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DDX60 Gene

Orthologs for DDX60 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX60 35
  • 99.51 (n)
  • 99.07 (a)
DDX60 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX60 35
  • 84.48 (n)
  • 79.2 (a)
DDX60 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx60 35
  • 79.55 (n)
  • 75.31 (a)
Ddx60 16
Ddx60 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX60 35
  • 63.31 (n)
  • 55.18 (a)
DDX60 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX60 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx60 35
  • 59.46 (n)
  • 52.32 (a)
worm
(Caenorhabditis elegans)
Secernentea C28H8.3 35
  • 45.2 (n)
  • 32.12 (a)
C28H8.3 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR4 36
  • 16 (a)
OneToMany
Species with no ortholog for DDX60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX60 Gene

ENSEMBL:
Gene Tree for DDX60 (if available)
TreeFam:
Gene Tree for DDX60 (if available)

Paralogs for DDX60 Gene

Paralogs for DDX60 Gene

Selected SIMAP similar genes for DDX60 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DDX60 Gene

genes like me logo Genes that share paralogs with DDX60: view

Variants for DDX60 Gene

Sequence variations from dbSNP and Humsavar for DDX60 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10975 -- 168,216,436(-) AGATA(A/G)TACTT utr-variant-3-prime
rs471276 -- 168,275,052(-) TTTCC(C/G)TGTGT intron-variant
rs474865 -- 168,274,676(-) AGGCA(C/G)TAATG intron-variant
rs475075 -- 168,274,607(-) TGGCC(A/G)GGAGT intron-variant
rs477355 -- 168,264,986(-) CTACC(A/G)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX60 Gene

Variant ID Type Subtype PubMed ID
nsv830146 CNV Gain 17160897
nsv881291 CNV Gain 21882294
nsv4596 CNV Insertion 18451855
esv2728712 CNV Deletion 23290073
esv2728713 CNV Deletion 23290073

Relevant External Links for DDX60 Gene

HapMap Linkage Disequilibrium report
DDX60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX60 Gene

Disorders for DDX60 Gene

No disorders were found for DDX60 Gene.

No data available for UniProtKB/Swiss-Prot for DDX60 Gene

Publications for DDX60 Gene

  1. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. (PMID: 21791617) Miyashita M. … Seya T. (Mol. Cell. Biol. 2011) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor. (PMID: 18271526) Tong J. … Moran M.F. (J. Proteome Res. 2008) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for DDX60 Gene

Sources for DDX60 Gene

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