DDX6 Gene
protein-coding GIFtS: 62
GCID: GC11M118619
|
|
DEAD (Asp-Glu-Ala-Asp) box helicase 6(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase,...)
(Previous symbol: HLR2)
| |
Aliases
for DDX6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DEAD (Asp-Glu-Ala-Asp) Box Helicase 61 2 | | DEAD Box Protein 62 3 | | HLR21 2 3 5 | | P542 | | RCK1 2 3 | | DEAD Box-62 | | DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 61 2 | | Probable ATP-Dependent RNA Helicase DDX62 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD)1 2 | | EC 3.6.4.133 | | Oncogene RCK2 3 | | EC 3.6.18 | | ATP-Dependent RNA Helicase P542 3 | | |
Export aliases for DDX6 gene to outside databasesPrevious GC identifers: GC11M120959 GC11M120132 GC11M118654 GC11M118160 GC11M118162 GC11M118125 GC11M114556 |
Summaries
for DDX6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DDX6:
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stressgranules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced genesilencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided byRefSeq, Mar 2012)
UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196Function: In the process of mRNA degradation, may play a role in mRNA decapping
Gene Wiki entry for DDX6
|
Genomic Views
for DDX6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDX6 gene promoter:
c-Fos AP-1 Pbx1a Pax-5 MAZR FOXO3 FOXO3b CREB deltaCREB FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3DDX6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M118619: view genomic region
(about GC identifiers)
Start:
|
118,618,472 bp from pter |
End:
|
118,661,972 bp from pter |
Size:
|
43,501 bases |
Orientation:
|
minus strand |
|
Proteins
for DDX6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196 (See
protein sequence)Recommended Name: Probable ATP-dependent RNA helicase DDX6 Size: 483 amino acids; 54417 Da
Subunit: Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. Interacts withAPOBEC3G in an RNA-dependent manner
Subcellular location: Cytoplasm, P-body
3 PDB 3D structures from  and Proteopedia  for DDX6:1VEC (3D)
2WAX (3D)
2WAY (3D)
Secondary accessions: Q5D048Explore the universe of human proteins at neXtProt for DDX6: NX_P26196
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P26196
4/31 DME Specific Peptides for DDX6 (P26196) (see all 31)
DDX6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001244120.1 NP_004388.2
ENSEMBL proteins: ENSP00000264018 ENSP00000433704 ENSP00000442266 Reactome Protein details: P26196
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DDX6 for ontologies About GeneDecksing
DDX6 Antibody Products:
Assay Products for DDX6: |
Protein
Domains /
Families
for DDX6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX6 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P26196ProtoNet protein and cluster: P26196 1 Blocks protein family: IPB000629 ATP-dependent helicase
UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196Similarity: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamilySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Function
for DDX6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196Function: In the process of mRNA degradation, may play a role in mRNA decappingCatalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for DDX6:DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific helicaseME31,overexpressed in colorectal adenocarcinomas
Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DDX6 (NM_004397) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX6 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
DDX6 for ontologies About GeneDecksing
|
Pathways & Interactions
for DDX6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Metabolism of mRNA | | | 3 | Translational Control | | | 4 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for DDX6
5 
Reactome Pathways for DDX6
1 
Kegg Pathway (Kegg details for DDX6):
DDX6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDX6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/684 Interacting proteins for DDX6 (P261961, 2, 3 ENSP000002640184) via UniProtKB, MINT, STRING, and/or I2D (see all 684)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0016070 | RNA metabolic process |
TAS | -- | | GO:0016071 | mRNA metabolic process |
TAS | -- | | GO:0033962 | cytoplasmic mRNA processing body assembly |
IDA | -- |
DDX6 for ontologies About GeneDecksing
|
Drugs & Compounds
for DDX6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DDX6
1 DrugBank Compound for DDX6 About this table
Search CenterWatch for drugs/clinical trials and news about DDX6
|
Transcripts
for DDX6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDX6 gene (2 alternative transcripts): NM_001257191.1 NM_004397.4 Unigene Cluster for DDX6: DEAD (Asp-Glu-Ala-Asp) box helicase 6 Hs.408461 [show with all ESTs]Unigene Representative Sequence: NM_0043977 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264018(uc001pua.2 uc001pub.2 uc001puc.2) ENST00000529162
ENST00000526070 ENST00000525082 ENST00000531971 ENST00000533239 ENST00000534980
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDX6 (NM_004397) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX6 |
Additional cDNA sequence: AK021715.1 AK093657.1 AK313244.1 BC026228.1 BC039826.1 BC065007.1 D17532.1 Z11685.1 12 DOTS entries: DT.114770 DT.308523 DT.120746679 DT.99982967 DT.100745112 DT.440336 DT.95271131 DT.95357307 DT.91696854 DT.100810839 DT.91838654 DT.40268466 24/181 AceView cDNA sequences (see all 181): W48640 AU118867 BM728565 BM720697 BM716423 BQ707967 AI539409 W03083 BM696691 AI252635 BE535847 BP363379 AI566453 BI039766 BC039826 CF528439 BQ447869 BG397536 BG259835 AW015315 BU625208 BX329622 BC026228 AI400911
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DDX6
|
Expression
for DDX6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGTCAGAGG
About this image
See DDX6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX6
SOURCE GeneReport for Unigene cluster: Hs.408461
UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196Tissue specificity: Abundantly expressed in most tissues
SABiosciences Custom PCR Arrays for DDX6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX6 |
Orthologs
for DDX6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DDX6 gene from 9/41 species (see all 41) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DDX61 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 |
91.22(n)
99.17(a) |
|
419783 NM_001006319.2 NP_001006319.2 |
lizard
(Anolis carolinensis) |
Reptilia |
DDX66 |
-- |
96(a) |
1 ↔ 1 |
GL344088.1(31499-37854) |
African clawed frog
(Xenopus laevis) |
Amphibia |
P54H2 |
RNA helicase p54 |
80.72(n) |
|
X92421.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufk48d072 |
Transcribed sequence with moderate similarity to protein more |
75.72(n) |
|
57039187 |
fruit fly
(Drosophila melanogaster) |
Insecta |
me31B1 , 3 |
ATP dependent RNA helicase3
maternal expression at 31B1 |
71(a)
(best of 2)3
66.03(n)1
72.92(a)1 |
|
31B13
343641 NM_078809.31 NP_523533.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
cgh-11 |
Protein CGH-1 |
64.48(n)
72.02(a) |
|
176061 NM_066245.4 NP_498646.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
DHH1(YDL160C)4
DHH11 |
Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, more4
Dhh1p1 |
63.01(n)1
67.06(a)1 |
|
4(171930-170410)4
8513941, 4 NP_010121.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RH81 |
DEAD-box ATP-dependent RNA helicase 8 |
64.58(n)
68.29(a) |
|
828042 NM_116291.4 NP_191975.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.25942 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
75.54(n) |
|
AK073085.1 |
ENSEMBL Gene Tree for DDX6 (if available)
TreeFam Gene Tree for DDX6 (if available) |
Paralogs
for DDX6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDX6 gene
18/22 SIMAP similar genes for DDX6 using alignment to 1 protein entry: DDX6_HUMAN(see all similar genes):EIF4A1 EIF4A2 EIF4A3 DDX46 DDX39A DDX25
DDX19A DDX19B DDX19L DDX47 DDX59 E4-DBP
DDX39B DDX27 DDX20 DDX49 DDX10 DDX54
DDX6 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for DDX6 (see all 7)
PGOHUM00000248655 PGOHUM00000243117 PGOHUM00000245324 PGOHUM00000236807 PGOHUM00000242943
|
Genomic Variants
for DDX6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDX6 (118618472 - 118661972 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DDX6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX6 |
|
Disorders
/ Diseases
for DDX6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDX6 for disorders About GeneDecksing
OMIM gene information: 600326
OMIM disorders: --
UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196
Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas.Translocation t(11;14)(q23;q32)
16  diseases for DDX6: About MalaCardsnon-hodgkin lymphoma b-cell lymphomas hodgkin's lymphoma rheumatoid arthritis
hepatitis c hermaphroditism arthritis colorectal cancer
adenoma hepatitis pneumonia neuroblastoma
immunodeficiency adenocarcinoma malaria neuronitis
1 Novoseek disease relationship for DDX6 gene About this table
Human Genome Epidemiology (HuGE) Navigator: DDX6 (1 document)
Export disorders for DDX6 gene to outside databases
|
Publications
for DDX6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDX6 gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with DDX6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PubMed id 1579499)1, 2, 3 Lu D. and Yunis J.J. (1992)
- RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PubMed id 11839790)1, 3, 9 Smillie D.A. and Sommerville J. (2002)
- Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PubMed id 14684915)1, 2, 9 Matsui T....Tanaka N. (2004)
- Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. (PubMed id 19285948)1, 2 Tritschler F....Weichenrieder O. (2009)
- Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2 Wichroski M.J....Rana T.M. (2006)
- Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. (PubMed id 1394235)1, 2 Akao Y.... Ueda R. (1992)
- The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues. (PubMed id 7614484)1, 9 Akao Y....Tsujimoto Y. (1995)
- Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly. (PubMed id 19297524)1, 9 Minshall N....Standart N. (2009)
|
External Searches for DDX6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DDX6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDX6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDX6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DDX6 gene:
Search GeneIP for patents involving DDX6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DDX6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for DDX6 | | OriGene shRNA RFP for DDX6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX6 | | | OriGene Protein Over-expression Lysate for DDX6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDX6 | | OriGene 3'-UTR Clone for DDX6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DDX6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DDX6 | | OriGene Custom Protein Services for DDX6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX6 |
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| | Antibodies & Assays for DDX6 |
| | | | Search Tocris compounds for DDX6 |
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 | | | DDX6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX6 |
|  |  |  | | | | ThermoFisher Antibodies for DDX6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX6 |
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