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DDX6 Gene

protein-coding   GIFtS: 66
GCID: GC11M118619

DEAD (Asp-Glu-Ala-Asp) Box Helicase 6

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase,...)
(Previous symbol: HLR2)
  Search for DDX6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 61 2     DEAD Box Protein 62 3
HLR21 2 3 5     P542
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 61 2     DEAD Box-62
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD)1 2     Probable ATP-Dependent RNA Helicase DDX62
Oncogene RCK2 3     EC 3.6.4.133
RCK2 3     EC 3.6.18
ATP-Dependent RNA Helicase P542 3     

External Ids:    HGNC: 27471   Entrez Gene: 16562   Ensembl: ENSG000001103677   OMIM: 6003265   UniProtKB: P261963   

Export aliases for DDX6 gene to outside databases

Previous GC identifers: GC11M120959 GC11M120132 GC11M118654 GC11M118160 GC11M118162 GC11M118125 GC11M114556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX6 Gene:
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and
stress granules, and functions in translation suppression and mRNA degradation. It is required for
microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been
identified. (provided by RefSeq, Mar 2012)

GeneCards Summary for DDX6 Gene:
DDX6 (DEAD (Asp-Glu-Ala-Asp) box helicase 6) is a protein-coding gene. GO annotations related to this gene include RNA binding and helicase activity.

UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196
Function: In the process of mRNA degradation, may play a role in mRNA decapping

Gene Wiki entry for DDX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX6 gene promoter:
         c-Fos   AP-1   Pbx1a   Pax-5   MAZR   FOXO3   FOXO3b   CREB   deltaCREB   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX6 promoter sequence
   Search Chromatin IP Primers for DDX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

DDX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118619:  view genomic region     (about GC identifiers)

Start:
118,618,472 bp from pter      End:
118,661,972 bp from pter
Size:
43,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX6  
Size: 483 amino acids; 54417 Da
Subunit: Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. Interacts
with APOBEC3G in an RNA-dependent manner. Interacts with RC3H1 (By similarity)
3 PDB 3D structures from and Proteopedia for DDX6:
1VEC (3D)        2WAX (3D)        2WAY (3D)    
Secondary accessions: Q5D048

Explore the universe of human proteins at neXtProt for DDX6: NX_P26196

Explore proteomics data for DDX6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys104
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX6 (P26196) (see all 31)
     VPTRELA  LLMGIFE  PSPIQEE  PYEINLM 


    See DDX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244120.1  NP_004388.2  

    ENSEMBL proteins: 
     ENSP00000264018   ENSP00000433704   ENSP00000442266  
    Reactome Protein details: P26196

    DDX6 Human Recombinant Protein Products:

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    Novus Biologicals DDX6 Protein
    Novus Biologicals DDX6 Lysates
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    Cloud-Clone Corp. Proteins for DDX6

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry P26196

    ProtoNet protein and cluster: P26196

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196
    Similarity: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX6_HUMAN, P26196
    Function: In the process of mRNA degradation, may play a role in mRNA decapping
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for DDX6:
    DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific
    helicase ME31,overexpressed in colorectal adenocarcinomas

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003724RNA helicase activity TAS1579499
    GO:0004386helicase activity TAS1394235
    GO:0005515protein binding IPI16364915
         
    Find genes that share ontologies with DDX6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX6
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    miRNA
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    miRTarBase miRNAs that target DDX6:
    hsa-mir-16-5p (MIRT051097), hsa-mir-484 (MIRT041644), hsa-mir-505-3p (MIRT041022), hsa-mir-1 (MIRT023959), hsa-mir-19b-3p (MIRT031272), hsa-mir-26b-5p (MIRT030008), hsa-mir-877-3p (MIRT037013), hsa-mir-124-3p (MIRT022934), hsa-mir-425-5p (MIRT016661), hsa-mir-92a-3p (MIRT049444), hsa-mir-130b-3p (MIRT020341), hsa-mir-331-3p (MIRT043327)

    Block miRNA regulation of human, mouse, rat DDX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX6 (see all 67):
    hsa-miR-194* hsa-miR-300 hsa-miR-128 hsa-miR-3916 hsa-miR-629* hsa-miR-3116 hsa-miR-130b hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidDDX6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX6

    Gene Editing
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    Addgene plasmids for DDX6 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX6_HUMAN, P26196: Cytoplasm, P-body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA16699599
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0010494cytoplasmic stress granule IDA17392519
    GO:0016442RISC complex IDA--

    Find genes that share ontologies with DDX6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDX6 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control


    Find genes that share SuperPaths with DDX6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DDX6
        Translational Control

    1 Reactome Pathway for DDX6
        mRNA decay by 5' to 3' exoribonuclease


    1 Kegg Pathway  (Kegg details for DDX6):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX6
    Interactions:

        GeneGlobe Interaction Network for DDX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX6 (P261961, 2, 3 ENSP000002640184) via UniProtKB, MINT, STRING, and/or I2D (see all 852)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TIAL1Q010852, 3, ENSP000003580894MINT-7947479 I2D: score=4 STRING: ENSP00000358089
    EDC3Q96F861, 3, ENSP000003205034EBI-351257,EBI-997311 I2D: score=2 STRING: ENSP00000320503
    EEF1A1P681042, 3, ENSP000003300544MINT-7947479 I2D: score=2 STRING: ENSP00000330054
    PRPF6O949062, 3, ENSP000002660794MINT-7947479 I2D: score=2 STRING: ENSP00000266079
    CNOT3O751752, 3, ENSP000002212324MINT-7947479 I2D: score=1 STRING: ENSP00000221232
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--
    GO:0033962cytoplasmic mRNA processing body assembly IDA--

    Find genes that share ontologies with DDX6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX6

    1 DrugBank Compound for DDX6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-tartaric acid(-)-Tartaric acid (see all 7)147-71-7target----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX6 gene (2 alternative transcripts): 
    NM_001257191.2  NM_004397.5  

    Unigene Cluster for DDX6:

    DEAD (Asp-Glu-Ala-Asp) box helicase 6
    Hs.408461  [show with all ESTs]
    Unigene Representative Sequence: NM_004397
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264018(uc001pua.2 uc001pub.2 uc001puc.2) ENST00000529162
    ENST00000526070 ENST00000525082 ENST00000531971 ENST00000533239 ENST00000534980

    miRNA
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    Block miRNA regulation of human, mouse, rat DDX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX6 (see all 67):
    hsa-miR-194* hsa-miR-300 hsa-miR-128 hsa-miR-3916 hsa-miR-629* hsa-miR-3116 hsa-miR-130b hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidDDX6 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX6
      QuantiTect SYBR Green Assays in human, mouse, rat DDX6
      QuantiFast Probe-based Assays in human, mouse, rat DDX6

    Additional mRNA sequence: 

    AK021715.1 AK093657.1 AK313244.1 BC026228.1 BC039826.1 BC065007.1 D17532.1 Z11685.1 

    12 DOTS entries:

    DT.114770  DT.308523  DT.120746679  DT.99982967  DT.100745112  DT.440336  DT.95271131  DT.95357307 
    DT.91696854  DT.100810839  DT.91838654  DT.40268466 

    Selected AceView cDNA sequences (see all 181):

    BQ707967 AU118867 AI539409 BM720697 BM728565 BM716423 W48640 W03083 
    BM696691 AA704321 BI544556 AV718351 AI523572 BG397536 AK093657 BU735206 
    BU902635 BE535847 AI186870 BU742251 BM918484 AL697132 CB409500 BC065007 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -     -     -           -     -                                   -                                                         
    SP2:        -     -     -     -     -           -     -                                                                                             
    SP3:                                                                                                                                                
    SP4:                    -     -     -           -     -     -     -     -                                                                           
    SP5:                                -           -     -                                                                                             


    ECgene alternative splicing isoforms for DDX6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DDX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCAGAGG
    DDX6 Expression
    About this image


    DDX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    DDX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408461

    UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196
    Tissue specificity: Abundantly expressed in most tissues

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    QuantiFast Probe-based Assays in human, mouse, rat DDX6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX6 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx61 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 61, 5 93.58(n)1
    97.72(a)1
      9 (24.84 cM)5
    132091  NM_181324.31  NP_851841.21 
     446048925 
    chicken
    (Gallus gallus)
    Aves DDX61 DEAD (Asp-Glu-Ala-Asp) box helicase 6 91.22(n)
    99.17(a)
      419783  NM_001006319.2  NP_001006319.2 
    lizard
    (Anolis carolinensis)
    Reptilia DDX66
    DEAD (Asp-Glu-Ala-Asp) box helicase 6
    96(a)
    1 ↔ 1
    GL344088.1(31499-39625)
    African clawed frog
    (Xenopus laevis)
    Amphibia P54H2 RNA helicase p54 80.72(n)    X92421.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk48d072 Transcribed sequence with moderate similarity to protein more 75.72(n)    57039187 
    fruit fly
    (Drosophila melanogaster)
    Insecta me31B1 , 3 ATP dependent RNA helicase3
    maternal expression at 31B1
    71(a)
    (best of 2)3
    67.08(n)1
    75.19(a)1
      31B13
    343641  NM_078809.41  NP_523533.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cgh-11 cgh-1 64.48(n)
    72.02(a)
      176061  NM_066245.5  NP_498646.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DHH1(YDL160C)4
    DHH11
    Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, more4
    DHH11
    64.09(n)1
    68.83(a)1
      4(171930-170410)4
    8513941, 4  NP_010121.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RH81 RH8 67.08(n)
    71.68(a)
      828042  NM_179204.2  NP_849535.1 
    rice
    (Oryza sativa)
    Liliopsida Os.25942 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.54(n)    AK073085.1 


    ENSEMBL Gene Tree for DDX6 (if available)
    TreeFam Gene Tree for DDX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX6 gene
    Selected SIMAP similar genes for DDX6 using alignment to 1 protein entry:     DDX6_HUMAN(see all similar genes):
    EIF4A1    EIF4A2    EIF4A3    DDX46    DDX39A    DDX25
    DDX19A    DDX19B    DDX19L    DDX47    DDX59    E4-DBP
    DDX27    DDX39B    DDX20    DDX49    DDX10    DDX54

    Find genes that share paralogs with DDX6           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for DDX6 (see all 7)
    PGOHUM00000248655 PGOHUM00000243117 PGOHUM00000245324 PGOHUM00000236807 PGOHUM00000242943


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for DDX6 (see all 1091)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774852291,2
    F--118618085(+) TTATTT/ACCCAA 2 -- ds50011Minor allele frequency- A:0.05WA 118
    rs763125691,2
    F--118618086(+) TATTTC/ACCAAT 2 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1400027981,2
    --118618092(+) CCAATC/GTTTTA 2 -- ds50010--------
    rs1867270631,2
    --118618292(+) ATTTAC/GGCTGT 2 -- ds50010--------
    rs1436315511,2
    --118618332(+) TACAAC/TAGATG 2 -- ds50010--------
    rs1916795451,2
    C--118618341(+) TGAAGG/TGGCTC 2 -- ds50010--------
    rs1834472571,2
    --118618537(+) TTTTGG/TAACCT 2 -- ut310--------
    rs1889520951,2
    C--118618580(+) GTACAC/TACAAC 2 -- ut310--------
    rs1128178071,2
    C--118618611(+) CAGAG-/C/CC  
            
    CCCCC
    4 -- ut311CSA 2
    rs796949061,2
    C--118618618(+) CCCCCG/CCCCCC 2 -- ut311Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for DDX6 (118618472 - 118661972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DDX6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673492CNV Deletion23128226
    nsv832283CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX6
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600326    OMIM disorders: --

    UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196
  • Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell
    lymphomas. Translocation t(11;14)(q23;q32)


  • Find genes that share disorders with DDX6           About GenesLikeMe

    1 Novoseek inferred disease relationship for DDX6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 70.2 7 12823589 (2), 10360675 (1), 8108133 (1), 14684915 (1) (see all 6)

    Genetic Association Database (GAD): DDX6
    Human Genome Epidemiology (HuGE) Navigator: DDX6 (1 document)

    Export disorders for DDX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX6 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with DDX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PubMed id 1579499)1, 2, 3 Lu D. and Yunis J.J. (Nucleic Acids Res. 1992)
    2. RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PubMed id 11839790)1, 3, 9 Smillie D.A. and Sommerville J. (J. Cell. Sci. 2002)
    3. Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PubMed id 14684915)1, 2, 9 Matsui T....Tanaka N. (Acta Crystallogr. D 2004)
    4. Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. (PubMed id 19285948)1, 2 Tritschler F....Weichenrieder O. (Mol. Cell 2009)
    5. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2 Wichroski M.J.... Rana T.M. (PLoS Pathog. 2006)
    6. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (Mol. Cell 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. (PubMed id 1394235)1, 2 Akao Y.... Ueda R. (Cancer Res. 1992)
    9. The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues. (PubMed id 7614484)1, 9 Akao Y....Tsujimoto Y. (Cancer Res. 1995)
    10. Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly. (PubMed id 19297524)1, 9 Minshall N....Standart N. (Mol. Biol. Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1656 HGNC: 2747 AceView: DDX6 Ensembl:ENSG00000110367 euGenes: HUgn1656
    ECgene: DDX6 Kegg: 1656 H-InvDB: DDX6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDX6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX6 gene:
    Search GeneIP for patents involving DDX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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