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Aliases for DDX6 Gene

Aliases for DDX6 Gene

  • DEAD-Box Helicase 6 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 6 2 3
  • ATP-Dependent RNA Helicase P54 3 4
  • DEAD Box Protein 6 3 4
  • Oncogene RCK 3 4
  • HLR2 3 4
  • RCK 3 4
  • Probable ATP-Dependent RNA Helicase DDX6 3
  • EC 4
  • DEAD Box-6 3
  • EC 3.6.1 61
  • P54 3

External Ids for DDX6 Gene

Previous HGNC Symbols for DDX6 Gene

  • HLR2

Previous GeneCards Identifiers for DDX6 Gene

  • GC11M120959
  • GC11M120132
  • GC11M118654
  • GC11M118160
  • GC11M118162
  • GC11M118125
  • GC11M114556
  • GC11M118619

Summaries for DDX6 Gene

Entrez Gene Summary for DDX6 Gene

  • This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX6 Gene

DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include B-Cell Lymphomas. Among its related pathways are Deadenylation-dependent mRNA decay and Translational Control. GO annotations related to this gene include nucleic acid binding and protein domain specific binding.

UniProtKB/Swiss-Prot for DDX6 Gene

  • In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Gene Wiki entry for DDX6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX6 Gene

Genomics for DDX6 Gene

Regulatory Elements for DDX6 Gene

Enhancers for DDX6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F118868 1.6 FANTOM5 Ensembl ENCODE 26.3 -79.6 -79559 5.6 HDAC1 ATF1 PKNOX1 WRNIP1 SIN3A RAD21 ZBTB40 ETV6 CREM JUNB DDX6 CCDC84 TREHP1 UPK2 ENSG00000222529 FOXR1 BCL9L RN7SL688P ENSG00000255176 MIR6716
GH11F119090 1.4 Ensembl ENCODE 19.3 -302.1 -302139 6.4 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 HINFP BCL9L ENSG00000254909 UBE4A RPL23AP64 IFT46 ARCN1 RNF26 ENSG00000254428 DDX6
GH11F118874 1.6 FANTOM5 Ensembl ENCODE 10.3 -85.7 -85672 5.9 HDGF PKNOX1 YY1 GATA2 ZNF207 PAF1 TBX21 PPARG ZNF585B SMARCA4 IFT46 RPL5P30 TREHP1 UPK2 ENSG00000255121 BCL9L RN7SL688P DDX6 MIR6716 PHLDB1
GH11F119167 1.1 ENCODE 11.2 -377.7 -377666 2.8 PKNOX1 ARNT WRNIP1 ZFP64 ARID4B DMAP1 ZNF2 YY1 ZNF302 ZNF207 ENSG00000254909 UBE4A ARCN1 RPL23AP64 RPL5P30 ENSG00000254428 HINFP BCL9L RNF26 IFT46
GH11F118886 1 ENCODE 11.1 -97.7 -97664 4.7 ATF1 PKNOX1 CREB3L1 GLIS2 FOS REST TBX21 CREB3 MBD2 SMARCA4 UPK2 BCL9L RN7SL688P DDX6 ENSG00000222529 FOXR1 LOC105369519 TRAPPC4 LOC101929133 CXCR5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX6 on UCSC Golden Path with GeneCards custom track

Promoters for DDX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000569801 463 5201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for DDX6 Gene

118,747,763 bp from pter
118,791,263 bp from pter
43,501 bases
Minus strand

Genomic View for DDX6 Gene

Genes around DDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX6 Gene

Proteins for DDX6 Gene

  • Protein details for DDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX6
    Protein Accession:
    Secondary Accessions:
    • Q5D048

    Protein attributes for DDX6 Gene

    483 amino acids
    Molecular mass:
    54417 Da
    Quaternary structure:
    • Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915, PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657). Interacts with MCRIP1 (PubMed:26184334). Interacts with MCRIP2 (PubMed:26184334). Interacts with NUFIP2 (PubMed:26184334).

    Three dimensional structures from OCA and Proteopedia for DDX6 Gene

neXtProt entry for DDX6 Gene

Selected DME Specific Peptides for DDX6 Gene


Post-translational modifications for DDX6 Gene

Domains & Families for DDX6 Gene

Gene Families for DDX6 Gene

Suggested Antigen Peptide Sequences for DDX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
genes like me logo Genes that share domains with DDX6: view

Function for DDX6 Gene

Molecular function for DDX6 Gene

GENATLAS Biochemistry:
DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific helicase ME31,overexpressed in colorectal adenocarcinomas
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Enzyme Numbers (IUBMB) for DDX6 Gene

Gene Ontology (GO) - Molecular Function for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003724 RNA helicase activity TAS 1579499
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 1394235
genes like me logo Genes that share ontologies with DDX6: view
genes like me logo Genes that share phenotypes with DDX6: view

Animal Model Products

miRNA for DDX6 Gene

miRTarBase miRNAs that target DDX6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX6 Gene

Localization for DDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX6 Gene

Cytoplasm, P-body. Cytoplasm. Nucleus. Note=Upon cellular stress, relocalizes to stress granules (PubMed:26184334). {ECO:0000269 PubMed:26184334}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0000932 cytoplasmic mRNA processing body IMP 22022269
GO:0001520 outer dense fiber IEA --
GO:0005634 nucleus IDA 26184334
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with DDX6: view

Pathways & Interactions for DDX6 Gene

genes like me logo Genes that share pathways with DDX6: view

Pathways by source for DDX6 Gene

1 Cell Signaling Technology pathway for DDX6 Gene
1 KEGG pathway for DDX6 Gene

SIGNOR curated interactions for DDX6 Gene

Other effect:

Gene Ontology (GO) - Biological Process for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IBA --
GO:0007283 spermatogenesis IEA --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0019074 viral RNA genome packaging IMP 22022269
GO:0019827 stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with DDX6: view

Drugs & Compounds for DDX6 Gene

(4) Drugs for DDX6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
D-tartaric acid Experimental Pharma Target 0

(1) Additional Compounds for DDX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX6: view

Transcripts for DDX6 Gene

Unigene Clusters for DDX6 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: - - -

Relevant External Links for DDX6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX6 Gene

Protein differential expression in normal tissues from HIPED for DDX6 Gene

This gene is overexpressed in Lymph node (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX6 Gene

Protein tissue co-expression partners for DDX6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX6 Gene:


SOURCE GeneReport for Unigene cluster for DDX6 Gene:


mRNA Expression by UniProt/SwissProt for DDX6 Gene:

Tissue specificity: Abundantly expressed in most tissues.
genes like me logo Genes that share expression patterns with DDX6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDX6 Gene

Orthologs for DDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX6 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia DDX6 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia DDX6 35
  • 99 (a)
(Canis familiaris)
Mammalia DDX6 34 35
  • 98 (n)
(Bos Taurus)
Mammalia DDX6 34 35
  • 97.99 (n)
(Rattus norvegicus)
Mammalia Ddx6 34
  • 94.48 (n)
(Mus musculus)
Mammalia Ddx6 34 16 35
  • 93.58 (n)
(Gallus gallus)
Aves DDX6 34 35
  • 91.22 (n)
(Anolis carolinensis)
Reptilia DDX6 35
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx6 34
  • 85.21 (n)
Str.1861 34
African clawed frog
(Xenopus laevis)
Amphibia P54H 34
(Danio rerio)
Actinopterygii ddx6 34 35
  • 76.9 (n)
wufk48d07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9736 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009135 34
  • 67.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta me31B 36 34 35
  • 67.08 (n)
Dhh1 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea cgh-1 34 35
  • 64.48 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DHH1 34 35
  • 64.09 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR197W 34
  • 62.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16599g 34
  • 60.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH8 34
  • 67.08 (n)
(Glycine max)
eudicotyledons Gma.10855 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12384 34
(Oryza sativa)
Liliopsida Os04g0533000 34
  • 65.91 (n)
Os.2594 34
(Hordeum vulgare)
Liliopsida Hv.6031 34
(Triticum aestivum)
Liliopsida Ta.7626 34
(Zea mays)
Liliopsida Zm.12922 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ste13 34
  • 65.67 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06149 34
  • 63.43 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11700 34
Species where no ortholog for DDX6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX6 Gene

Gene Tree for DDX6 (if available)
Gene Tree for DDX6 (if available)

Paralogs for DDX6 Gene

(21) SIMAP similar genes for DDX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDX6: view

No data available for Paralogs for DDX6 Gene

Variants for DDX6 Gene

Sequence variations from dbSNP and Humsavar for DDX6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1042093 -- 118,749,900(-) GCTCA(A/T)CTATT downstream-variant-500B, utr-variant-3-prime
rs1048022 -- 118,748,076(-) AACAG(A/G)AAAAA utr-variant-3-prime
rs1048024 -- 118,748,067(-) AAAAA(A/T)TATTT utr-variant-3-prime
rs1048033 -- 118,747,937(-) TTTCT(C/T)TTAAT utr-variant-3-prime
rs1048036 -- 118,747,926(-) TGGCA(A/G)ATGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX6 Gene

Variant ID Type Subtype PubMed ID
esv2673492 CNV deletion 23128226
esv2762946 CNV gain 21179565
nsv1134179 CNV deletion 24896259
nsv832283 CNV loss 17160897

Variation tolerance for DDX6 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX6 Gene

Disorders for DDX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphomas
  • b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search DDX6 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Relevant External Links for DDX6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DDX6: view

No data available for Genatlas for DDX6 Gene

Publications for DDX6 Gene

  1. Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PMID: 14684915) Matsui T. … Tanaka N. (Acta Crystallogr. D 2004) 3 4 22 64
  2. RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PMID: 11839790) Smillie D.A. … Sommerville J. (J. Cell. Sci. 2002) 2 3 22 64
  3. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PMID: 1579499) Lu D. … Yunis J.J. (Nucleic Acids Res. 1992) 2 3 4 64
  4. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R. … Vogel C. (Biomolecules 2015) 3 4 64
  5. HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PMID: 22915799) Phalora P.K. … Malim M.H. (J. Virol. 2012) 3 4 64

Products for DDX6 Gene

Sources for DDX6 Gene

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