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DDX6 Gene

protein-coding GIFtS: 63

GC11M118125

DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HLR2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.6.1.- ^³
FLJ36338 ^²
HLR2 ^², ³, ⁵
P54 ^²
RCK ^¹, ², ³

Descriptions
ATP-dependent RNA helicase p54 ^³
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 ^²
DEAD box protein 6 ^³
DEAD box-6 ^²
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD) ^¹, ²
Oncogene RCK ^³

External Ids
HGNC: 2747¹
Entrez Gene: 1656²
UniProtKB: P26196³
Ensembl: ENSG00000110367⁷

Search outside databases for aliases for DDX6 gene

Previous GC identifers: GC11M120959 GC11M120132 GC11M118654 GC11M118160 GC11M118162

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for DDX6:

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in

P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is

required for microRNA-induced gene silencing. [provided by RefSeq]

UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196

Function: In the process of mRNA degradation, may play a role in mRNA decapping

Gene Wiki entry for DDX6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DDX6 gene

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

DDX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M118125: (about GC identifiers)

Start:	118,125,623 bp from pter
End:	118,167,082 bp from pter
Size:	41,460 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196 (See protein sequence)

Recommended Name: Probable ATP-dependent RNA helicase DDX6

Size: 483 amino acids; 54417 Da

Subunit: Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS

Subcellular location: Cytoplasm, P-body. Note=Processing bodies (PB)

PDB structures from and Proteopedia :

1VEC (3D)

2WAX (3D)

2WAY (3D)

Secondary accessions: Q5D048

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004388.2

ENSEMBL proteins:

ENSP00000264018

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DDX6)
	Human Recombinant Proteins from Abnova (DDX6)

OriGene Purified Recombinant Human Protein: DDX6

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0010494	stress granule	IDA	17392519

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Antibodies for DDX6:

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	Sigma-Aldrich Antibodies for DDX6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DDX6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DDX6)
	Novus Biologicals Antibodies for DDX6

Assays for DDX6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P26196

ProtoNet protein and cluster: P26196

1 Blocks protein family: IPB000629 ATP-dependent helicase

UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196

Similarity: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DDX6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DDX6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004397

Applied Biosystems Silencer® siRNAs for DDX6

Sigma-Aldrich siRNA for DDX6

Sigma-Aldrich shRNA Panels and shRNA for DDX6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DDX6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004397
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004397
untagged cDNA clones in CMV expression vector (see all 2): NM_004397

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004397

UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196

Function: In the process of mRNA degradation, may play a role in mRNA decapping

Enzyme Number (IUBMB): EC 3.6.1.-

Genatlas biochemistry entry for DDX6:

DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila

oocyte specific helicase ME31,overexpressed in colorectal adenocarcinomas

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0003724	RNA helicase activity	TAS	1579499
GO:0005515	protein binding	IPI	17392519
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for DDX6 (Your Favorite Gene powered by Ingenuity)

Folate Biosynthesis
Starch and Sucrose Metabolism

GeneDecks DDX6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for DDX6

5/10 Interacting proteins for DDX6 (P26196¹ ENSP00000264018³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDC3	Q96F86¹, ENSP00000320503³	EBI-351257, EBI-997311 STRING (score=.975)
DCP1A	Q9NPI6¹, ENSP00000294241³	EBI-351257, EBI-374238 STRING (score=.974)
POLR1E	Q9GZS1¹	EBI-351257, EBI-359458
YWHAQ	P27348¹	EBI-351257, EBI-359854
ATXN2	ENSP00000366843³	STRING (score=.92)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DDX6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DDX6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DDX6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004397

Sigma-Aldrich siRNA for DDX6

Sigma-Aldrich shRNA Panels and shRNA for DDX6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004397

REFSEQ mRNAs for DDX6 gene:

NM_004397.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004397

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004397
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004397
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004397

Additional cDNA sequence:

AK093657.1 AK313244.1 BC026228.1 BC039826.1 BC065007.1 D17532.1 Z11685.1

12 DOTS entries:

DT.308523 DT.114770 DT.120746679 DT.99982967 DT.440336 DT.100745112 DT.95271131 DT.95357307

DT.91696854 DT.100810839 DT.40268466 DT.91838654

24/181 AceView cDNA sequences (see all 181 ):

W48640 W03083 AI539409 AU118867 BM696691 BM728565 BM720697 BQ707967

BM716423 BQ017952 BM972001 BM013673 BQ438803 CA423151 CD000872 BP362051

AA865492 BE218820 W51956 BP355911 BG259835 AW149702 AI566453 Z11685

highest scoring ESTs for DDX6:

D17532 AL697132 BC026228 BE242871 BG546189 BI601100 BM012472 BM905603 CF137516 AA523483

Unigene Cluster for DDX6:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 6

Hs.654366 [show with all ESTs]

Unigene Representative Sequence: NM_004397

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 (see all 7 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:							-		-		-				-		-												-
SP2:			-		-		-		-		-				-		-
SP3:
SP4:							-		-		-				-		-		-		-		-
SP5:											-				-		-

About this scheme

ECgene alternative splicing isoforms for DDX6

1 Ensembl transcript including schematic representation:

ENST00000264018

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DDX6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DDX6

¹ / ² / ³

8 probe-sets matching DDX6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52993_at²	U95-B	1	1.00	1.00	0.66	1.68	--	--	--	--	--
36283_at²^{, 3}	U95-A	1	1.00	1.00	0.89	0.46	D17532	1.00	1.00	1.00	1
70792_at²^{, 3}	U95-E	2	1.00	0.97	0.54	1.28	AI351662	0.20	1.00	0.72	1
79233_at*²^{, 3}	U95-D	1	--	--	0.26	0.66	R95094	0.40	1.00	0.76	1
225549_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
204909_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004397	0.60	1.00	0.82	1
225549_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204909_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DDX6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGTCAGAGG

SOURCE GeneReport for Unigene cluster: Hs.654366
Expression variation in blood from EXPOLDB for DDX6
UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196
Tissue specificity: Abundantly expressed in most tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DDX6 gene from 5/28 species (see all 28 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DDX6¹	--	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	97.95(n) 99.79(a)	479414 XM_536551.2 XP_536551.1
chimpanzee (Pan troglodytes)	DDX6¹	--	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	100(n) 100(a)	451594 XM_508798.2 XP_508798.2
cow (Bos taurus)	DDX6¹	--	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	97.95(n) 99.79(a)	513906 XM_591668.3 XP_591668.2
rat (Rattus norvegicus)	RGD1564560¹	--	similar to RCK	94.49(n) 98.09(a)	500988 XM_576400.2 XP_576400.1
mouse (Mus musculus)	Ddx6^{1, 5}	9 (26.00 cM)⁵	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6^{1, 5}	93.5(n)¹ 97.67(a)¹	13209¹ NM_007841.3¹ NP_031867.1¹ AF038995⁵ AK003265⁵ (see all 14)

About this table Species with no ortholog for DDX6

ENSEMBL Gene Tree for DDX6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/345 NCBI SNPs in DDX6 are shown (see all 345 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs640120^1,2	A,C,F,H	118124047(-)	`TTGTGG/TGGGAA`	1	--	ut3¹		5		MN EU EA WA	588
--	rs2077579^1,2	A,C,F,H	118124257(+)	`ATGAGT/GTTTTA`	1	--	ut3¹		8		EU EA WA NA	2032
--	rs1961138^1,2	A,C,F,H	118124633(-)	`CCCCAA/GAAGGG`	1	--	ut3¹		8		MN EU EA WA NA	730
--	rs487728^1,2	A,C,F,H	118126705(+)	`TAAATC/GTTGAA`	1	--	ut3¹		8		EA NA MN EU WA	658
--	rs488219^1,2	A,C,F,H	118125907(-)	`ATCCTA/GCAGAT`	1	--	ut3¹ ese³		9		MN EU EA WA NA	959
--	rs3889239^1,2	A,C,F	118125170(-)	`TTCCAG/ATGGCT`	1	--	ut3¹		3		NA	142
--	rs1048024^1,2	A,C,F	118123986(-)	`AAAAAT/ATATTT`	1	--	ut3¹		1		MN	184
--	rs485901^1,2	A,C	118127455(+)	`AATAAA/GAAGAC`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs3741328^1,2	F,H	118124036(-)	`GGGGAG/ACCTGG`	1	--	ut3¹		5		EA EU WA	1922
--	rs1048040^1,2	C,F	118123828(-)	`TGGGGG/CGGGGG`	1	--	ut3¹		2		MN	368

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HapMap Linkage Disequilibrium images for DDX6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600326

UniProtKB/Swiss-Prot: DDX6_HUMAN, P26196

A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as

B-cell lymphomas. Translocation t(11;14)(q23;q32)

1 Novoseek disease relationship for DDX6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma b-cell	71.23	7	12823589 (2), 10360675 (1), 8108133 (1), 14684915 (1) (see all 6)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/30 PubMed articles for DDX6 gene (see all 30 ):

Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PubMed id 1579499)^{2, 3, 4} Lu D. and Yunis J.J. (1992)
Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PubMed id 14684915)^{1, 3, 4} Matsui T....Tanaka N. (2004)
Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)^{3, 4} Fenger-Groen M.... Lykke-Andersen J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. (PubMed id 1394235)^{3, 4} Akao Y.... Ueda R. (1992)
The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues. (PubMed id 7614484)^{1, 3} Akao Y....Tsujimoto Y. (1995)
RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PubMed id 11839790)^{1, 3} Smillie D.A. and Sommerville J. (2002)
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis. (PubMed id 12823589)^{1, 3} Miyaji K....Akao Y. (2003)
Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours. (PubMed id 10360675)^{1, 3} Nakagawa Y....Akao Y. (1999)
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. (PubMed id 19285948)³ Tritschler F....Weichenrieder O. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1656	HGNC: 2747	AceView: DDX6	Ensembl:ENSG00000110367	euGenes: HUgn1656
ECgene: DDX6	H-InvDB: DDX6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for DDX6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DDX6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DDX6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DDX6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DDX6		Antibodies for DDX6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DDX6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Recombinant & Natural Proteins

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	shRNA in GFP-retroviral vector

Search Tocris compounds for DDX6

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DDX6 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for DDX6

Summaries
for DDX6

Genomic Location
for DDX6

Proteins
for DDX6

Protein Domains/
Families
for DDX6

Gene Function
for DDX6

Pathways & Interactions
for DDX6

Drugs & Compounds
for DDX6

Transcripts
for DDX6

Expression
for DDX6

Orthologs
for DDX6

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Disorders & Mutations
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Medical News
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Other Databases showing DDX6

Specialized Databases showing DDX6

Licensable Technologies
for DDX6

Services
for DDX6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DDX6 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor DDX6

Summariesfor DDX6

Genomic Locationfor DDX6

Proteinsfor DDX6

Protein Domains/Familiesfor DDX6

Gene Functionfor DDX6

Pathways & Interactionsfor DDX6

Drugs & Compoundsfor DDX6

Transcriptsfor DDX6

Expression for DDX6

Orthologsfor DDX6

Paralogsfor DDX6

SNPs/Variantsfor DDX6

Disorders & Mutationsfor DDX6

Medical Newsfor DDX6

Publicationsfor DDX6

Search for DDX6

Genome Databases showing DDX6

Other Databases showing DDX6

Specialized Databases showing DDX6

Licensable Technologiesfor DDX6

Servicesfor DDX6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DDX6

Summaries
for DDX6

Genomic Location
for DDX6

Proteins
for DDX6

Protein Domains/
Families
for DDX6

Gene Function
for DDX6

Pathways & Interactions
for DDX6

Drugs & Compounds
for DDX6

Transcripts
for DDX6

Expression
for DDX6

Orthologs
for DDX6

Paralogs
for DDX6

SNPs/Variants
for DDX6

Disorders & Mutations
for DDX6

Medical News
for DDX6

Publications
for DDX6

Licensable Technologies
for DDX6

Services
for DDX6