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Aliases for DDX6 Gene

Aliases for DDX6 Gene

  • DEAD-Box Helicase 6 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 6 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 6 (RNA Helicase, 54kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 2 3
  • ATP-Dependent RNA Helicase P54 3 4
  • DEAD Box Protein 6 3 4
  • Oncogene RCK 3 4
  • HLR2 3 4
  • RCK 3 4
  • EC 4
  • DEAD Box-6 3
  • EC 3.6.1 63
  • P54 3

External Ids for DDX6 Gene

Previous HGNC Symbols for DDX6 Gene

  • HLR2

Previous GeneCards Identifiers for DDX6 Gene

  • GC11M120959
  • GC11M120132
  • GC11M118654
  • GC11M118160
  • GC11M118162
  • GC11M118125
  • GC11M114556
  • GC11M118619

Summaries for DDX6 Gene

Entrez Gene Summary for DDX6 Gene

  • This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX6 Gene

DDX6 (DEAD-Box Helicase 6) is a Protein Coding gene. Diseases associated with DDX6 include B-Cell Lymphomas. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. GO annotations related to this gene include nucleic acid binding and protein domain specific binding.

UniProtKB/Swiss-Prot for DDX6 Gene

  • In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Gene Wiki entry for DDX6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX6 Gene

Genomics for DDX6 Gene

Regulatory Elements for DDX6 Gene

Enhancers for DDX6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX6 on UCSC Golden Path with GeneCards custom track

Promoters for DDX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX6 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX6 Gene

118,747,763 bp from pter
118,791,263 bp from pter
43,501 bases
Minus strand

Genomic View for DDX6 Gene

Genes around DDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX6 Gene

Proteins for DDX6 Gene

  • Protein details for DDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX6
    Protein Accession:
    Secondary Accessions:
    • Q5D048

    Protein attributes for DDX6 Gene

    483 amino acids
    Molecular mass:
    54417 Da
    Quaternary structure:
    • Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS (PubMed:16364915,PubMed:19285948). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with RC3H1 (By similarity). Interacts with ATXN2L (PubMed:23209657).

    Three dimensional structures from OCA and Proteopedia for DDX6 Gene

neXtProt entry for DDX6 Gene

Proteomics data for DDX6 Gene at MOPED

Post-translational modifications for DDX6 Gene

  • Ubiquitination at Lys 104
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX6 Gene

Domains & Families for DDX6 Gene

Gene Families for DDX6 Gene

Suggested Antigen Peptide Sequences for DDX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
genes like me logo Genes that share domains with DDX6: view

Function for DDX6 Gene

Molecular function for DDX6 Gene

GENATLAS Biochemistry:
DEAD/H box protein 6,proliferation associated nuclear antigen p68,with homology to Drosophila oocyte specific helicase ME31,overexpressed in colorectal adenocarcinomas
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).

Enzyme Numbers (IUBMB) for DDX6 Gene

Gene Ontology (GO) - Molecular Function for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003724 RNA helicase activity TAS 1579499
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX6: view
genes like me logo Genes that share phenotypes with DDX6: view

Animal Model Products

miRNA for DDX6 Gene

miRTarBase miRNAs that target DDX6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX6 Gene

Localization for DDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX6 Gene

Cytoplasm, P-body.

Subcellular locations from

Jensen Localization Image for DDX6 Gene COMPARTMENTS Subcellular localization image for DDX6 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016442 RISC complex IDA 20616046
genes like me logo Genes that share ontologies with DDX6: view

Pathways & Interactions for DDX6 Gene

genes like me logo Genes that share pathways with DDX6: view

Pathways by source for DDX6 Gene

1 Cell Signaling Technology pathway for DDX6 Gene
1 KEGG pathway for DDX6 Gene

SIGNOR curated interactions for DDX6 Gene

Other effect:

Gene Ontology (GO) - Biological Process for DDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010467 gene expression TAS --
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with DDX6: view

Drugs & Compounds for DDX6 Gene

(2) Drugs for DDX6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
D-tartaric acid Experimental Pharma Target 0

(3) Additional Compounds for DDX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX6: view

Transcripts for DDX6 Gene

Unigene Clusters for DDX6 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: - - -

Relevant External Links for DDX6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX6 Gene

mRNA expression in normal human tissues for DDX6 Gene

Protein differential expression in normal tissues from HIPED for DDX6 Gene

This gene is overexpressed in Lymph node (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DDX6 Gene

SOURCE GeneReport for Unigene cluster for DDX6 Gene Hs.408461

mRNA Expression by UniProt/SwissProt for DDX6 Gene

Tissue specificity: Abundantly expressed in most tissues.
genes like me logo Genes that share expression patterns with DDX6: view

Protein tissue co-expression partners for DDX6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDX6 Gene

Orthologs for DDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX6 35
  • 97.99 (n)
  • 99.79 (a)
DDX6 36
  • 100 (a)
(Canis familiaris)
Mammalia DDX6 35
  • 98 (n)
  • 99.79 (a)
DDX6 36
  • 100 (a)
(Mus musculus)
Mammalia Ddx6 35
  • 93.58 (n)
  • 97.72 (a)
Ddx6 16
Ddx6 36
  • 98 (a)
(Pan troglodytes)
Mammalia DDX6 35
  • 100 (n)
  • 100 (a)
DDX6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx6 35
  • 94.48 (n)
  • 98.14 (a)
(Monodelphis domestica)
Mammalia DDX6 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia DDX6 36
  • 99 (a)
(Gallus gallus)
Aves DDX6 35
  • 91.22 (n)
  • 99.17 (a)
DDX6 36
  • 99 (a)
(Anolis carolinensis)
Reptilia DDX6 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx6 35
  • 85.21 (n)
  • 95.42 (a)
Str.1861 35
African clawed frog
(Xenopus laevis)
Amphibia P54H 35
(Danio rerio)
Actinopterygii ddx6 35
  • 76.9 (n)
  • 89.42 (a)
wufk48d07 35
ddx6 36
  • 89 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9736 35
fruit fly
(Drosophila melanogaster)
Insecta Dhh1 37
  • 33 (a)
me31B 37
  • 71 (a)
me31B 35
  • 67.08 (n)
  • 75.19 (a)
me31B 36
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009135 35
  • 67.49 (n)
  • 76.43 (a)
(Caenorhabditis elegans)
Secernentea cgh-1 35
  • 64.48 (n)
  • 72.02 (a)
cgh-1 36
  • 70 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR197W 35
  • 62.2 (n)
  • 68.73 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16599g 35
  • 60.68 (n)
  • 65.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DHH1 35
  • 64.09 (n)
  • 68.83 (a)
DHH1 36
  • 56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH8 35
  • 67.08 (n)
  • 71.68 (a)
(Glycine max)
eudicotyledons Gma.10855 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.12384 35
(Hordeum vulgare)
Liliopsida Hv.6031 35
(Oryza sativa)
Liliopsida Os.2594 35
Os04g0533000 35
  • 65.91 (n)
  • 71.93 (a)
(Triticum aestivum)
Liliopsida Ta.7626 35
(Zea mays)
Liliopsida Zm.12922 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11700 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06149 35
  • 63.43 (n)
  • 67.96 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ste13 35
  • 65.67 (n)
  • 72.5 (a)
Species with no ortholog for DDX6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX6 Gene

Gene Tree for DDX6 (if available)
Gene Tree for DDX6 (if available)

Paralogs for DDX6 Gene

(21) SIMAP similar genes for DDX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDX6: view

No data available for Paralogs for DDX6 Gene

Variants for DDX6 Gene

Sequence variations from dbSNP and Humsavar for DDX6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs522612 -- 118,769,622(-) tgttt(G/T)gtttt intron-variant
rs524590 -- 118,769,354(-) ACATT(A/T)CAGAA intron-variant
rs529107 -- 118,749,425(-) GGAAT(A/T)GTTAA utr-variant-3-prime
rs529717 -- 118,769,372(-) GAACC(C/T)TCAAT intron-variant
rs535996 -- 118,766,958(+) TTGGC(C/T)GACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX6 Gene

Variant ID Type Subtype PubMed ID
nsv832283 CNV Loss 17160897
esv2673492 CNV Deletion 23128226

Variation tolerance for DDX6 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDX6 Gene

Disorders for DDX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphomas
  • b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search DDX6 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).

Relevant External Links for DDX6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DDX6: view

No data available for Genatlas for DDX6 Gene

Publications for DDX6 Gene

  1. Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. (PMID: 1579499) Lu D. … Yunis J.J. (Nucleic Acids Res. 1992) 2 3 4 67
  2. RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles. (PMID: 11839790) Smillie D.A. … Sommerville J. (J. Cell. Sci. 2002) 2 3 23
  3. Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly. (PMID: 19297524) Minshall N. … Standart N. (Mol. Biol. Cell 2009) 3 23
  4. Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. (PMID: 14684915) Matsui T. … Tanaka N. (Acta Crystallogr. D 2004) 3 23
  5. Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis. (PMID: 12823589) Miyaji K. … Akao Y. (J. Viral Hepat. 2003) 3 23

Products for DDX6 Gene

Sources for DDX6 Gene