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DDX59 Gene

protein-coding   GIFtS: 50
GCID: GC01M200594

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 59

  See DDX59-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 591 2     OFD52 5
Zinc Finger HIT Domain-Containing Protein 52 3     Probable ATP-Dependent RNA Helicase DDX592
ZNHIT52 3     EC 3.6.4.133
DEAD Box Protein 592 3     EC 3.6.18

External Ids:    HGNC: 253601   Entrez Gene: 834792   Ensembl: ENSG000001181977   OMIM: 6154645   UniProtKB: Q5T1V63   

Export aliases for DDX59 gene to outside databases

Previous GC identifers: GC01M197325 GC01M198859 GC01M171779


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDX59 Gene:
DDX59 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 59) is a protein-coding gene. Diseases associated with DDX59 include orofaciodigital syndrome type 14, and orofaciodigital syndrome 5. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX23.

Gene Wiki entry for DDX59 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX59 gene promoter:
         Nkx3-1   Nkx3-1 v4   Brachyury   HTF   Nkx3-1 v1   Nkx3-1 v2   c-Myb   FOXO1a   Nkx3-1 v3   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX59 promoter sequence
   Search Chromatin IP Primers for DDX59

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX59


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

DDX59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX59 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M200594:  view genomic region     (about GC identifiers)

Start:
200,593,024 bp from pter      End:
200,639,126 bp from pter
Size:
46,103 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX59_HUMAN, Q5T1V6 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX59  
Size: 619 amino acids; 68810 Da
Sequence caution: Sequence=AAH14183.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence starting in position 433;
1 PDB 3D structure from and Proteopedia for DDX59:
2YQP (3D)    
Secondary accessions: Q6PJL2 Q8IVW3 Q9H0W3
Alternative splicing: 2 isoforms:  Q5T1V6-1   Q5T1V6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX59: NX_Q5T1V6

Explore proteomics data for DDX59 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX59 (Q5T1V6) (see all 9)
     TPTRELA  PPVLVFV  TGVLGRG  IATPGRL 


    See DDX59 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001026895.2  
    ENSEMBL proteins: 
     ENSP00000394367   ENSP00000416331   ENSP00000394304   ENSP00000330460   ENSP00000408662  
     ENSP00000409954   ENSP00000398152   ENSP00000391312   ENSP00000356317  

    DDX59 Human Recombinant Protein Products:

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    Novus Biologicals DDX59 Protein
    Novus Biologicals DDX59 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX59

     
    Search eBioscience for Proteins for DDX59 

    DDX59 Antibody Products:

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    DDX59 Assay Products:

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    Cloud-Clone Corp. ELISAs for DDX59
    Cloud-Clone Corp. CLIAs for DDX59
    Search eBioscience for ELISAs for DDX59 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNHIT: Zinc fingers, HIT-type
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR007529 Znf_HIT
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q5T1V6

    ProtoNet protein and cluster: Q5T1V6

    1 Blocks protein domain: IPB007529 HIT Zn-finger

    UniProtKB/Swiss-Prot: DDX59_HUMAN, Q5T1V6
    Domain: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP
    binding and hydrolysis
    Similarity: Belongs to the DEAD box helicase family. DDX59 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 HIT-type zinc finger


    Find genes that share domains with DDX59           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX59_HUMAN, Q5T1V6
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DDX59           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX59
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX59

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DDX59
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX59 (NM_001031725)
    Sino Biological Human cDNA Clone for DDX59
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX59
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX59

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX59


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX59_HUMAN, Q5T1V6: Cytoplasm. Nucleus. Note=Exhibits granular localization in the nucleus, as well as in the
    cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DDX59           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX59
    Interactions:

        Search GeneGlobe Interaction Network for DDX59

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX59 (Q5T1V63 ENSP000003304604) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG10Q9H0Y03I2D: score=1 
    GAR1ENSP000002267964STRING: ENSP00000226796
    KRR1ENSP000002292144STRING: ENSP00000229214
    NHP2ENSP000002746064STRING: ENSP00000274606
    NOP58ENSP000002642794STRING: ENSP00000264279
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX59



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX59 gene (2 alternative transcripts): 
    NM_031306.2  NM_001031725.4  

    Unigene Cluster for DDX59:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
    Hs.497332  [show with all ESTs]
    Unigene Representative Sequence: NM_001031725
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447706 ENST00000452560 ENST00000413408 ENST00000331314(uc009wzk.3)
    ENST00000429498 ENST00000433235 ENST00000453944 ENST00000436897 ENST00000367348(uc010ppl.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDX59 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DDX59
    SwitchGear 3'UTR luciferase reporter plasmidDDX59 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX59
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX59 (NM_001031725)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX59
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX59
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX59
      QuantiTect SYBR Green Assays in human, mouse, rat DDX59
      QuantiFast Probe-based Assays in human, mouse, rat DDX59

    Additional mRNA sequence: 

    AK299219.1 AK307569.1 BC014183.2 BC020201.1 BC041801.1 

    8 DOTS entries:

    DT.101979471  DT.114579  DT.100749750  DT.95154815  DT.100749751  DT.91878139  DT.91976982  DT.431573 

    Selected AceView cDNA sequences (see all 113):

    BM699773 N45921 BM683465 BM718409 BU844924 AI140393 AA703341 AI376219 
    AI275860 CR607985 AI271779 BU754283 AI769217 CA420001 BU737588 AW612041 
    AA055554 AA743760 AI088970 CD674799 BQ059956 AA361065 AA026414 BM753000 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX59 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DDX59 Expression
    About this image


    DDX59 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    DDX59 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX59 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497332

    UniProtKB/Swiss-Prot: DDX59_HUMAN, Q5T1V6
    Tissue specificity: Expressed in fibroblasts (at protein level)

        Custom PCR Arrays for DDX59
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    QuantiFast Probe-based Assays in human, mouse, rat DDX59
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX59

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX59 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx591 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 591, 5 81.53(n)1
    83.68(a)1
      1 (59.73 cM)5
    679971  NM_026500.31  NP_080776.11 
     1364152715 
    chicken
    (Gallus gallus)
    Aves DDX591 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 72.34(n)
    74.07(a)
      424346  XM_004943104.1  XP_004943161.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX596
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
    71(a)
    1 ↔ 1
    GL343211.1(1864535-1881144)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37672 Xenopus laevis transcribed sequence with moderate similarity more 74.42(n)    BM262613.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddx591 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 62(n)
    64.08(a)
      562123  NM_001044978.2  NP_001038443.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP286
    RNA helicase in the DEAD-box family, involved in R...
    24(a)
    1 → many
    IV(948518-950284) YDR243C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G020651 AT3G02065 52.48(n)
    47.17(a)
      821155  NM_001035544.2  NP_001030621.1 


    ENSEMBL Gene Tree for DDX59 (if available)
    TreeFam Gene Tree for DDX59 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX59 gene
    DDX232  
    Selected SIMAP similar genes for DDX59 using alignment to 9 protein entries:     DDX59_HUMAN (see all proteins) (see all similar genes):
    mcdrh    EIF4A1    DDX54    DDX1    DDX46    EIF4A2
    DDX6    EIF4A3    DDX5    DDX41    DDX17    DDX10
    DDX3Y    DDX25    DDX39A    DDX39B    DDX52    E4-DBP

    Find genes that share paralogs with DDX59           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX59 (see all 610)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0701984
    Orofaciodigital syndrome 5 (OFD5)4--see VAR_0701982 V G mis40--------
    VAR_0701994
    Orofaciodigital syndrome 5 (OFD5)4--see VAR_0701992 G R mis40--------
    VAR_0358424
    A breast cancer sample4--see VAR_0358422 P T mis40--------
    rs1883760991,2
    --200612680(+) GAAAGA/GGAATG 1 -- int10--------
    rs1449848141,2
    --200612684(+) GGGAAC/TGGCAT 1 -- int10--------
    rs1926144491,2
    --200612744(+) CCAGCA/CTGGGC 1 -- int10--------
    rs1996279531,2
    C--200612869(+) AGTAG-/CCTATC 1 -- int10--------
    rs616720301,2
    C--200612871(+) TAGCC-/TATCTT 1 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs1475893251,2
    --200613032(+) TAAGTA/GCCAAT 1 -- int10--------
    rs1848621111,2
    --200613124(+) AGTAGA/CTCTGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DDX59 (200593024 - 200639126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDX59:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873095CNV Gain21882294

    Human Gene Mutation Database (HGMD): DDX59
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX59
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX59

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615464   
    OMIM disorders: 174300  
    UniProtKB/Swiss-Prot: DDX59_HUMAN, Q5T1V6
  • Orofaciodigital syndrome 5 (OFD5) [MIM:174300]: A form of orofaciodigital syndrome, a group of
    heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated
    phenotypic abnormalities that lead to the delineation of various subtypes. OFD5 patients show the core features
    of cleft palate, lobulated tongue, and polydactyly. Additional features include frontal bossing and intellectual
    disability. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for DDX59:    
    About MalaCards
    orofaciodigital syndrome type 14    orofaciodigital syndrome 5    orofaciodigital syndrome


    Find genes that share disorders with DDX59           About GenesLikeMe

    Genetic Association Database (GAD): DDX59

    Export disorders for DDX59 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX59 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DDX59)
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    1. Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome. (PubMed id 23972372)1, 2 Shamseldin H.E....Alkuraya F.S. (Am. J. Hum. Genet. 2013)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PubMed id 19389651)4 Smith J.G....Newton-Cheh C. (Heart Rhythm 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83479 HGNC: 25360 AceView: DKFZP564B1023 Ensembl:ENSG00000118197 euGenes: HUgn83479
    ECgene: DDX59 H-InvDB: DDX59

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDX59 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX59 gene:
    Search GeneIP for patents involving DDX59

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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