Aliases for DDX58 Gene
External Ids for DDX58 Gene
Previous GeneCards Identifiers for DDX58 Gene
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
GeneCards Summary for DDX58 Gene
DDX58 (DEXD/H-Box Helicase 58) is a Protein Coding gene. Diseases associated with DDX58 include Singleton-Merten Syndrome 2 and Singleton-Merten Dysplasia. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is IFIH1.
UniProtKB/Swiss-Prot for DDX58 Gene
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5-triphosphate moiety, blunt-end base pairing at the 5-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3overhang at the 5triphosphate end decreases and any 5overhang at the 5 triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.