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Aliases for DDX56 Gene

Aliases for DDX56 Gene

  • DEAD-Box Helicase 56 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 56 2 3 5
  • ATP-Dependent 61 KDa Nucleolar RNA Helicase 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 56 2 3
  • Nucleolar Helicase Of 61 KDa 2 3
  • DEAD Box Protein 21 3 4
  • DEAD Box Protein 56 3 4
  • DDX21 3 4
  • NOH61 3 4
  • Putative Nucleolar RNA Helicase 3
  • 61-Kd Nucleolar Helicase 3
  • DEAD-Box RNA Helicase 3
  • EC 4
  • EC 3.6.1 63
  • DDX26 3

External Ids for DDX56 Gene

Previous GeneCards Identifiers for DDX56 Gene

  • GC07M044311
  • GC07M044346
  • GC07M044378
  • GC07M044571
  • GC07M044489

Summaries for DDX56 Gene

Entrez Gene Summary for DDX56 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX56 Gene

DDX56 (DEAD-Box Helicase 56) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for DDX56 Gene

  • May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.

Gene Wiki entry for DDX56 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX56 Gene

Genomics for DDX56 Gene

Regulatory Elements for DDX56 Gene

Enhancers for DDX56 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX56 on UCSC Golden Path with GeneCards custom track

Promoters for DDX56 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX56 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX56 Gene

44,565,417 bp from pter
44,575,051 bp from pter
9,635 bases
Minus strand

Genomic View for DDX56 Gene

Genes around DDX56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX56 Gene

Proteins for DDX56 Gene

  • Protein details for DDX56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX56
    Protein Accession:
    Secondary Accessions:
    • A4D2K9
    • C9JV95
    • Q6IAE2
    • Q9H9I8

    Protein attributes for DDX56 Gene

    547 amino acids
    Molecular mass:
    61590 Da
    Quaternary structure:
    • May form homooligomeric complexes.

    Alternative splice isoforms for DDX56 Gene


neXtProt entry for DDX56 Gene

Proteomics data for DDX56 Gene at MOPED

Selected DME Specific Peptides for DDX56 Gene

Post-translational modifications for DDX56 Gene

  • Ubiquitination at Lys 45
  • Modification sites at PhosphoSitePlus

Domains & Families for DDX56 Gene

Gene Families for DDX56 Gene

Suggested Antigen Peptide Sequences for DDX56 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
genes like me logo Genes that share domains with DDX56: view

Function for DDX56 Gene

Molecular function for DDX56 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.

Enzyme Numbers (IUBMB) for DDX56 Gene

Gene Ontology (GO) - Molecular Function for DDX56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX56: view
genes like me logo Genes that share phenotypes with DDX56: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX56 Gene

Localization for DDX56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX56 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for DDX56 Gene COMPARTMENTS Subcellular localization image for DDX56 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for DDX56 Gene

Pathways & Interactions for DDX56 Gene

SuperPathways for DDX56 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX56 Gene


No data available for Pathways by source and SIGNOR curated interactions for DDX56 Gene

Drugs & Compounds for DDX56 Gene

(1) Drugs for DDX56 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX56 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX56: view

Transcripts for DDX56 Gene

Unigene Clusters for DDX56 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 56:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX56 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - -
SP2: -
SP4: -
SP5: -

ExUns: 15b ^ 16
SP1: -
SP2: -

Relevant External Links for DDX56 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX56 Gene

mRNA expression in normal human tissues for DDX56 Gene

Protein differential expression in normal tissues from HIPED for DDX56 Gene

This gene is overexpressed in Lung (59.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX56 Gene

SOURCE GeneReport for Unigene cluster for DDX56 Gene Hs.654762

mRNA Expression by UniProt/SwissProt for DDX56 Gene

Tissue specificity: Detected in heart, brain, liver, pancreas, placenta and lung.
genes like me logo Genes that share expression patterns with DDX56: view

Protein tissue co-expression partners for DDX56 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDX56 Gene

Orthologs for DDX56 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX56 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX56 35
  • 87.67 (n)
  • 93.22 (a)
DDX56 36
  • 93 (a)
(Canis familiaris)
Mammalia DDX56 35
  • 84.85 (n)
  • 90.45 (a)
DDX56 36
  • 90 (a)
(Mus musculus)
Mammalia Ddx56 35
  • 85.47 (n)
  • 91.03 (a)
Ddx56 16
Ddx56 36
  • 91 (a)
(Pan troglodytes)
Mammalia DDX56 35
  • 99.45 (n)
  • 99.63 (a)
DDX56 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx56 35
  • 84.65 (n)
  • 90.66 (a)
(Monodelphis domestica)
Mammalia DDX56 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 85 (a)
-- 36
  • 72 (a)
-- 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx56 35
  • 64.29 (n)
  • 68.86 (a)
(Danio rerio)
Actinopterygii ddx56 35
  • 63.17 (n)
  • 66.29 (a)
ddx56 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011147 35
  • 54.38 (n)
  • 49.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hlc 35
  • 55.17 (n)
  • 50.6 (a)
Hlc 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea CELE_C24H12.4 35
  • 52.03 (n)
  • 45.29 (a)
C24H12.4 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR278C 35
  • 51.46 (n)
  • 47.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04576g 35
  • 50.38 (n)
  • 45.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP9 35
  • 50.32 (n)
  • 46.96 (a)
DBP9 36
  • 40 (a)
DBP9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34910 35
  • 47.3 (n)
  • 41.89 (a)
(Oryza sativa)
Liliopsida Os03g0728800 35
  • 49.72 (n)
  • 42.53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7432 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07070 35
  • 52.2 (n)
  • 47.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1494.06c 35
  • 49.84 (n)
  • 46.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for DDX56:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX56 Gene

Gene Tree for DDX56 (if available)
Gene Tree for DDX56 (if available)

Paralogs for DDX56 Gene Pseudogenes for DDX56 Gene

genes like me logo Genes that share paralogs with DDX56: view

No data available for Paralogs for DDX56 Gene

Variants for DDX56 Gene

Sequence variations from dbSNP and Humsavar for DDX56 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1044373 -- 44,565,929(-) AGGCT(C/T)TGGTG utr-variant-3-prime
rs1127809 -- 44,566,500(-) CCTGG(A/C/T)GCGCC reference, missense
rs1434958 -- 44,573,312(+) ATTCT(C/G)TAAGT intron-variant
rs1434959 -- 44,573,366(+) AAGTG(C/G)TTTGT intron-variant
rs1434960 -- 44,573,393(+) GTTGG(C/T)GGTAG intron-variant

Variation tolerance for DDX56 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DDX56 Gene

Disorders for DDX56 Gene

Relevant External Links for DDX56

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX56 Gene

Publications for DDX56 Gene

  1. A novel helicase-type protein in the nucleolus: protein NOH61. (PMID: 10749921) Zirwes R.F. … Schmidt-Zachmann M.S. (Mol. Biol. Cell 2000) 2 3 4 23 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DDX56 Gene

Sources for DDX56 Gene