Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX56 Gene

Aliases for DDX56 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 56 2 3
  • ATP-Dependent 61 KDa Nucleolar RNA Helicase 3 4
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 56 2 3
  • Nucleolar Helicase Of 61 KDa 2 3
  • DEAD Box Protein 21 3 4
  • DEAD Box Protein 56 3 4
  • DDX21 3 4
  • NOH61 3 4
  • Probable ATP-Dependent RNA Helicase DDX56 3
  • Putative Nucleolar RNA Helicase 3
  • 61-Kd Nucleolar Helicase 3
  • DEAD-Box RNA Helicase 3
  • EC 4
  • EC 3.6.1 63
  • DDX26 3

External Ids for DDX56 Gene

Previous GeneCards Identifiers for DDX56 Gene

  • GC07M044311
  • GC07M044346
  • GC07M044378
  • GC07M044571
  • GC07M044489

Summaries for DDX56 Gene

Entrez Gene Summary for DDX56 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for DDX56 Gene

DDX56 (DEAD (Asp-Glu-Ala-Asp) Box Helicase 56) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX56 Gene

  • May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity

Gene Wiki entry for DDX56 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX56 Gene

Genomics for DDX56 Gene

Regulatory Elements for DDX56 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX56 Gene

44,565,417 bp from pter
44,575,051 bp from pter
9,635 bases
Minus strand

Genomic View for DDX56 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX56 Gene

Proteins for DDX56 Gene

  • Protein details for DDX56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX56
    Protein Accession:
    Secondary Accessions:
    • A4D2K9
    • C9JV95
    • Q6IAE2
    • Q9H9I8

    Protein attributes for DDX56 Gene

    547 amino acids
    Molecular mass:
    61590 Da
    Quaternary structure:
    • May form homooligomeric complexes

    Alternative splice isoforms for DDX56 Gene


neXtProt entry for DDX56 Gene

Proteomics data for DDX56 Gene at MOPED

Selected DME Specific Peptides for DDX56 Gene

Post-translational modifications for DDX56 Gene

  • Ubiquitination at Lys45
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for DDX56 Gene

Gene Families for DDX56 Gene

  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX56 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NY93
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
genes like me logo Genes that share domains with DDX56: view

Function for DDX56 Gene

Molecular function for DDX56 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity

Enzyme Numbers (IUBMB) for DDX56 Gene

Gene Ontology (GO) - Molecular Function for DDX56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0004004 ATP-dependent RNA helicase activity TAS 10749921
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX56: view

Phenotypes for DDX56 Gene

genes like me logo Genes that share phenotypes with DDX56: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX56

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX56 Gene

Localization for DDX56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX56 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for DDX56 Gene COMPARTMENTS Subcellular localization image for DDX56 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX56: view

Pathways for DDX56 Gene

SuperPathways for DDX56 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006364 rRNA processing IBA --
GO:0008152 metabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX56: view

No data available for Pathways by source for DDX56 Gene

Transcripts for DDX56 Gene

Unigene Clusters for DDX56 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 56:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX56

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX56 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - -
SP2: -
SP4: -
SP5: -

ExUns: 15b ^ 16
SP1: -
SP2: -

Relevant External Links for DDX56 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX56 Gene

mRNA expression in normal human tissues for DDX56 Gene

Protein differential expression in normal tissues for DDX56 Gene

This gene is overexpressed in Lung (59.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX56 Gene

SOURCE GeneReport for Unigene cluster for DDX56 Gene Hs.654762

mRNA Expression by UniProt/SwissProt for DDX56 Gene

Tissue specificity: Detected in heart, brain, liver, pancreas, placenta and lung
genes like me logo Genes that share expressions with DDX56: view

Expression partners for DDX56 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDX56 Gene

Orthologs for DDX56 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX56 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX56 35
  • 87.67 (n)
  • 93.22 (a)
DDX56 36
  • 93 (a)
(Canis familiaris)
Mammalia DDX56 35
  • 84.85 (n)
  • 90.45 (a)
DDX56 36
  • 90 (a)
(Mus musculus)
Mammalia Ddx56 35
  • 85.47 (n)
  • 91.03 (a)
Ddx56 16
Ddx56 36
  • 91 (a)
(Pan troglodytes)
Mammalia DDX56 35
  • 99.45 (n)
  • 99.63 (a)
DDX56 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx56 35
  • 84.65 (n)
  • 90.66 (a)
(Monodelphis domestica)
Mammalia DDX56 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 85 (a)
-- 36
  • 72 (a)
-- 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx56 35
  • 64.29 (n)
  • 68.86 (a)
(Danio rerio)
Actinopterygii ddx56 35
  • 63.17 (n)
  • 66.29 (a)
ddx56 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011147 35
  • 54.38 (n)
  • 49.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hlc 35
  • 55.17 (n)
  • 50.6 (a)
Hlc 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea CELE_C24H12.4 35
  • 52.03 (n)
  • 45.29 (a)
C24H12.4 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR278C 35
  • 51.46 (n)
  • 47.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04576g 35
  • 50.38 (n)
  • 45.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP9 35
  • 50.32 (n)
  • 46.96 (a)
DBP9 36
  • 40 (a)
DBP9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34910 35
  • 47.3 (n)
  • 41.89 (a)
(Oryza sativa)
Liliopsida Os03g0728800 35
  • 49.72 (n)
  • 42.53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7432 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07070 35
  • 52.2 (n)
  • 47.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1494.06c 35
  • 49.84 (n)
  • 46.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for DDX56:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX56 Gene

Gene Tree for DDX56 (if available)
Gene Tree for DDX56 (if available)

Paralogs for DDX56 Gene Pseudogenes for DDX56 Gene

genes like me logo Genes that share paralogs with DDX56: view

No data available for Paralogs for DDX56 Gene

Variants for DDX56 Gene

Sequence variations from dbSNP and Humsavar for DDX56 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6656 -- 44,566,499(-) CTGGT(A/G)CGCCC synonymous-codon, reference
rs217367 -- 44,576,389(-) AAATT(A/T)TATCC upstream-variant-2KB
rs217368 -- 44,575,928(-) gggcg(C/T)ggtgg upstream-variant-2KB
rs217369 -- 44,575,587(-) CCCCA(A/G)TACTA upstream-variant-2KB
rs217370 -- 44,575,562(-) AATTC(C/T)TGCTT upstream-variant-2KB

Relevant External Links for DDX56 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DDX56 Gene

Disorders for DDX56 Gene

Relevant External Links for DDX56

Genetic Association Database (GAD)

No disorders were found for DDX56 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DDX56 Gene

Publications for DDX56 Gene

  1. A novel helicase-type protein in the nucleolus: protein NOH61. (PMID: 10749921) Zirwes R.F. … Schmidt-Zachmann M.S. (Mol. Biol. Cell 2000) 2 3 4 23
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DDX56 Gene

Sources for DDX56 Gene

Back to Top