Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX55 Gene

Aliases for DDX55 Gene

  • DEAD-Box Helicase 55 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 55 2 5
  • DEAD Box Protein 55 4
  • EC 4
  • KIAA1595 4
  • EC 3.6.1 63

External Ids for DDX55 Gene

Previous GeneCards Identifiers for DDX55 Gene

  • GC12P123810
  • GC12P122439
  • GC12P122611
  • GC12P124086
  • GC12P121048

Summaries for DDX55 Gene

Entrez Gene Summary for DDX55 Gene

  • This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016]

GeneCards Summary for DDX55 Gene

DDX55 (DEAD-Box Helicase 55) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for DDX55 Gene

  • Probable ATP-binding RNA helicase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX55 Gene

Genomics for DDX55 Gene

Regulatory Elements for DDX55 Gene

Enhancers for DDX55 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX55 on UCSC Golden Path with GeneCards custom track

Promoters for DDX55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX55 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX55 Gene

123,602,077 bp from pter
123,620,941 bp from pter
18,865 bases
Plus strand

Genomic View for DDX55 Gene

Genes around DDX55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX55 Gene

Proteins for DDX55 Gene

  • Protein details for DDX55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX55
    Protein Accession:
    Secondary Accessions:
    • Q658L6
    • Q8IYH0
    • Q9HCH7

    Protein attributes for DDX55 Gene

    600 amino acids
    Molecular mass:
    68547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX55 Gene


neXtProt entry for DDX55 Gene

Proteomics data for DDX55 Gene at MOPED

Post-translational modifications for DDX55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX55 Gene

Domains & Families for DDX55 Gene

Gene Families for DDX55 Gene

Suggested Antigen Peptide Sequences for DDX55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
genes like me logo Genes that share domains with DDX55: view

Function for DDX55 Gene

Molecular function for DDX55 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.

Enzyme Numbers (IUBMB) for DDX55 Gene

Gene Ontology (GO) - Molecular Function for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX55: view
genes like me logo Genes that share phenotypes with DDX55: view

Animal Models for DDX55 Gene

MGI Knock Outs for DDX55:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX55 Gene

Localization for DDX55 Gene

Subcellular locations from

Jensen Localization Image for DDX55 Gene COMPARTMENTS Subcellular localization image for DDX55 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX55 Gene

Pathways & Interactions for DDX55 Gene

SuperPathways for DDX55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DDX55: view

No data available for Pathways by source and SIGNOR curated interactions for DDX55 Gene

Drugs & Compounds for DDX55 Gene

(1) Drugs for DDX55 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX55 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX55: view

Transcripts for DDX55 Gene

Unigene Clusters for DDX55 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX55 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^
SP1: - - -
SP3: - - -
SP4: - - - - - -
SP7: - - - - -
SP9: - -
SP10: - - -
SP11: -

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP6: -
SP9: - -

Relevant External Links for DDX55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX55 Gene

mRNA expression in normal human tissues for DDX55 Gene

Protein differential expression in normal tissues from HIPED for DDX55 Gene

This gene is overexpressed in Lung (47.4) and Cerebrospinal fluid (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX55 Gene

SOURCE GeneReport for Unigene cluster for DDX55 Gene Hs.286173

genes like me logo Genes that share expression patterns with DDX55: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DDX55 Gene

Orthologs for DDX55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX55 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX55 35
  • 88.94 (n)
  • 93.83 (a)
DDX55 36
  • 94 (a)
(Canis familiaris)
Mammalia DDX55 35
  • 89.54 (n)
  • 91.15 (a)
DDX55 36
  • 74 (a)
(Mus musculus)
Mammalia Ddx55 35
  • 85.75 (n)
  • 91.32 (a)
Ddx55 16
Ddx55 36
  • 91 (a)
(Pan troglodytes)
Mammalia DDX55 35
  • 99.72 (n)
  • 99.67 (a)
DDX55 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx55 35
  • 85.92 (n)
  • 90.98 (a)
(Monodelphis domestica)
Mammalia DDX55 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia DDX55 36
  • 90 (a)
(Gallus gallus)
Aves DDX55 35
  • 77.36 (n)
  • 86.28 (a)
DDX55 36
  • 85 (a)
(Anolis carolinensis)
Reptilia DDX55 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx55 35
  • 72.32 (n)
  • 79.28 (a)
Str.10301 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6290 35
(Danio rerio)
Actinopterygii ddx55 35
  • 69.03 (n)
  • 74.87 (a)
ddx55 36
  • 75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14198 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001223 35
  • 56.24 (n)
  • 53.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9630 35
  • 54.48 (n)
  • 49.91 (a)
CG9630 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea ZK512.2 36
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL004C 35
  • 49.93 (n)
  • 42.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14367g 35
  • 50.54 (n)
  • 43.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB4 35
  • 49.76 (n)
  • 43.84 (a)
SPB4 36
  • 37 (a)
SPB4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05450 35
  • 52.94 (n)
  • 49.8 (a)
(Oryza sativa)
Liliopsida Os01g0164500 35
  • 52.19 (n)
  • 47.92 (a)
(Triticum aestivum)
Liliopsida Ta.10429 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03380 35
  • 51.18 (n)
  • 44.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC24C6.02 35
  • 47.56 (n)
  • 42.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7893 36
  • 52 (a)
Species with no ortholog for DDX55:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX55 Gene

Gene Tree for DDX55 (if available)
Gene Tree for DDX55 (if available)

Paralogs for DDX55 Gene

(12) SIMAP similar genes for DDX55 Gene using alignment to 6 proteins: Pseudogenes for DDX55 Gene

genes like me logo Genes that share paralogs with DDX55: view

No data available for Paralogs for DDX55 Gene

Variants for DDX55 Gene

Sequence variations from dbSNP and Humsavar for DDX55 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17881657 - 123,607,486(+) ACGAG(C/G)TCCTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17886035 - 123,608,739(+) GGCCG(A/G)AGGCT nc-transcript-variant, reference, missense
VAR_027791 -
rs10773019 - 123,620,004(+) TCTTA(A/G)TGACA nc-transcript-variant, downstream-variant-500B, reference, missense
rs7302183 -- 123,619,913(+) CACTA(C/G)AACAC intron-variant, downstream-variant-500B

Variation tolerance for DDX55 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.21; 88.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DDX55 Gene

Disorders for DDX55 Gene

Relevant External Links for DDX55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX55 Gene

Publications for DDX55 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DDX55 Gene

Sources for DDX55 Gene