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Aliases for DDX55 Gene

Aliases for DDX55 Gene

  • DEAD-Box Helicase 55 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 55 2
  • DEAD Box Protein 55 4
  • EC 4
  • KIAA1595 4
  • EC 3.6.1 58

External Ids for DDX55 Gene

Previous GeneCards Identifiers for DDX55 Gene

  • GC12P123810
  • GC12P122439
  • GC12P122611
  • GC12P124086
  • GC12P121048

Summaries for DDX55 Gene

Entrez Gene Summary for DDX55 Gene

  • This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016]

GeneCards Summary for DDX55 Gene

DDX55 (DEAD-Box Helicase 55) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for DDX55 Gene

  • Probable ATP-binding RNA helicase.

Additional gene information for DDX55 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX55 Gene

Genomics for DDX55 Gene

Regulatory Elements for DDX55 Gene

Enhancers for DDX55 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H122919 1.2 ENCODE dbSUPER 126.2 -682.1 -682071 1.5 ZNF493 ZFP64 ZEB1 ZNF155 ZNF121 ZNF138 ZNF354C FOS KLF7 ZNF202 EIF2B1 RSRC2 DDX55 ZCCHC8 ENSG00000235423 ATP6V0A2 LOC101927415 C12orf65 TCTN2 OGFOD2
GH12H124504 1.9 FANTOM5 Ensembl ENCODE dbSUPER 70 +914.5 914527 24.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 EIF2B1 DDX55 NCOR2 TCTN2 LOC101927415 ATP6V0A2 ENSG00000270130 GTF2H3 ENSG00000270061 DHX37
GH12H123231 1.4 ENCODE dbSUPER 49.8 -368.6 -368561 3.7 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RSRC2 ZCCHC8 DDX55 EIF2B1 KNTC1 CDK2AP1 LOC101927415 MPHOSPH9 OGFOD2 C12orf65
GH12H123512 1.1 ENCODE dbSUPER 53.1 -89.1 -89069 0.2 HDGF ZNF493 ZNF2 EGR1 EGR2 ZNF680 ZNF658 SALL1 ZNF18 ZNF211 DDX55 RSRC2 EIF2B1 ENSG00000235423 C12orf65 KNTC1 GTF2H3 TCTN2 OGFOD2 ATP6V0A2
GH12H123362 1.4 ENCODE dbSUPER 39.3 -237.3 -237254 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 DDX55 RSRC2 ZCCHC8 EIF2B1 CDK2AP1 LOC101927415 ENSG00000256092 ENSG00000239215 ENSG00000235423 ATP6V0A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX55 on UCSC Golden Path with GeneCards custom track

Promoters for DDX55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058762 23 2201 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A ZFP41 MEF2D

Genomic Locations for DDX55 Gene

Genomic Locations for DDX55 Gene
18,865 bases
Plus strand

Genomic View for DDX55 Gene

Genes around DDX55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX55 Gene

Proteins for DDX55 Gene

  • Protein details for DDX55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX55
    Protein Accession:
    Secondary Accessions:
    • Q658L6
    • Q8IYH0
    • Q9HCH7

    Protein attributes for DDX55 Gene

    600 amino acids
    Molecular mass:
    68547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX55 Gene


neXtProt entry for DDX55 Gene

Selected DME Specific Peptides for DDX55 Gene


Post-translational modifications for DDX55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX55 Gene

Gene Families for DDX55 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
genes like me logo Genes that share domains with DDX55: view

Function for DDX55 Gene

Molecular function for DDX55 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.

Enzyme Numbers (IUBMB) for DDX55 Gene

Phenotypes From GWAS Catalog for DDX55 Gene

Gene Ontology (GO) - Molecular Function for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DDX55: view
genes like me logo Genes that share phenotypes with DDX55: view

Animal Models for DDX55 Gene

MGI Knock Outs for DDX55:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX55 Gene

Localization for DDX55 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX55 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IBA,IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX55: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX55 Gene

Pathways & Interactions for DDX55 Gene

SuperPathways for DDX55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX55: view

No data available for Pathways by source and SIGNOR curated interactions for DDX55 Gene

Drugs & Compounds for DDX55 Gene

(3) Drugs for DDX55 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DDX55 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX55: view

Transcripts for DDX55 Gene

Unigene Clusters for DDX55 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 55:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX55 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^
SP1: - - -
SP3: - - -
SP4: - - - - - -
SP7: - - - - -
SP9: - -
SP10: - - -
SP11: -

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP6: -
SP9: - -

Relevant External Links for DDX55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX55 Gene

Protein differential expression in normal tissues from HIPED for DDX55 Gene

This gene is overexpressed in Lung (47.4) and Cerebrospinal fluid (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX55 Gene

NURSA nuclear receptor signaling pathways regulating expression of DDX55 Gene:


SOURCE GeneReport for Unigene cluster for DDX55 Gene:


Evidence on tissue expression from TISSUES for DDX55 Gene

  • Stomach(4.2)
genes like me logo Genes that share expression patterns with DDX55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX55 Gene

Orthologs for DDX55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX55 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX55 33 34
  • 99.72 (n)
(Ornithorhynchus anatinus)
Mammalia DDX55 34
  • 90 (a)
(Canis familiaris)
Mammalia DDX55 33 34
  • 89.54 (n)
(Monodelphis domestica)
Mammalia DDX55 34
  • 89 (a)
(Bos Taurus)
Mammalia DDX55 33 34
  • 88.94 (n)
(Rattus norvegicus)
Mammalia Ddx55 33
  • 85.92 (n)
(Mus musculus)
Mammalia Ddx55 33 16 34
  • 85.75 (n)
(Gallus gallus)
Aves DDX55 33 34
  • 77.36 (n)
(Anolis carolinensis)
Reptilia DDX55 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx55 33
  • 72.32 (n)
Str.10301 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6290 33
(Danio rerio)
Actinopterygii ddx55 33 34
  • 69.03 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14198 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001223 33
  • 56.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9630 33 34
  • 54.48 (n)
(Caenorhabditis elegans)
Secernentea ZK512.2 34
  • 36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14367g 33
  • 50.54 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL004C 33
  • 49.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB4 33 34 36
  • 49.76 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05450 33
  • 52.94 (n)
(Oryza sativa)
Liliopsida Os01g0164500 33
  • 52.19 (n)
(Triticum aestivum)
Liliopsida Ta.10429 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7893 34
  • 52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03380 33
  • 51.18 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC24C6.02 33
  • 47.56 (n)
Species where no ortholog for DDX55 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX55 Gene

Gene Tree for DDX55 (if available)
Gene Tree for DDX55 (if available)

Paralogs for DDX55 Gene

(12) SIMAP similar genes for DDX55 Gene using alignment to 6 proteins: Pseudogenes for DDX55 Gene

genes like me logo Genes that share paralogs with DDX55: view

No data available for Paralogs for DDX55 Gene

Variants for DDX55 Gene

Sequence variations from dbSNP and Humsavar for DDX55 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10846532 Likely benign 123,621,025(+) ACATC(A/G)GCGTC downstream-variant-500B, utr-variant-3-prime
rs113041500 Likely benign 123,621,330(+) AGGCA(C/G)CGCGT downstream-variant-500B, utr-variant-3-prime
rs2707 Likely benign 123,621,091(-) CTAAA(C/T)AGCTT downstream-variant-500B, utr-variant-3-prime
rs150711091 Uncertain significance 123,621,404(+) CTCGC(C/G)TGCTT downstream-variant-500B, utr-variant-3-prime
rs529880752 Uncertain significance 123,621,334(+) ACCGC(A/G)TGTAA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX55 Gene

Variant ID Type Subtype PubMed ID
nsv1042181 CNV gain 25217958
esv3385376 CNV insertion 20981092
dgv524e212 CNV loss 25503493
dgv1566n100 CNV gain 25217958

Variation tolerance for DDX55 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.21; 88.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX55 Gene

Disorders for DDX55 Gene

Relevant External Links for DDX55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX55 Gene

Publications for DDX55 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 60
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60

Products for DDX55 Gene

Sources for DDX55 Gene

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