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Aliases for DDX55 Gene

Aliases for DDX55 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 55 2 3
  • DEAD Box Protein 55 4
  • EC 3.6.4.13 4
  • KIAA1595 4
  • EC 3.6.1 63

External Ids for DDX55 Gene

Previous GeneCards Identifiers for DDX55 Gene

  • GC12P123810
  • GC12P122439
  • GC12P122611
  • GC12P124086
  • GC12P121048

Summaries for DDX55 Gene

Entrez Gene Summary for DDX55 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been confirmed. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX55 Gene

DDX55 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 55) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for DDX55 Gene

  • Probable ATP-binding RNA helicase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX55 Gene

Genomics for DDX55 Gene

Regulatory Elements for DDX55 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX55 Gene

Start:
123,602,077 bp from pter
End:
123,620,941 bp from pter
Size:
18,865 bases
Orientation:
Plus strand

Genomic View for DDX55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX55 Gene

Proteins for DDX55 Gene

  • Protein details for DDX55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHQ9-DDX55_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX55
    Protein Accession:
    Q8NHQ9
    Secondary Accessions:
    • Q658L6
    • Q8IYH0
    • Q9HCH7

    Protein attributes for DDX55 Gene

    Size:
    600 amino acids
    Molecular mass:
    68547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX55 Gene

Proteomics data for DDX55 Gene at MOPED

Post-translational modifications for DDX55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX55 Gene

Domains for DDX55 Gene

Gene Families for DDX55 Gene

HGNC:
  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHQ9

UniProtKB/Swiss-Prot:

DDX55_HUMAN :
  • Q8NHQ9
Domain:
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
genes like me logo Genes that share domains with DDX55: view

Function for DDX55 Gene

Molecular function for DDX55 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-binding RNA helicase

Enzyme Numbers (IUBMB) for DDX55 Gene

Gene Ontology (GO) - Molecular Function for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003723 RNA binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DDX55: view
genes like me logo Genes that share phenotypes with DDX55: view

Animal Model Products

CRISPR Products

miRNA for DDX55 Gene

miRTarBase miRNAs that target DDX55

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX55

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX55 Gene

Localization for DDX55 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX55 Gene COMPARTMENTS Subcellular localization image for DDX55 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX55: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX55 Gene

Pathways for DDX55 Gene

SuperPathways for DDX55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX55: view

No data available for Pathways by source for DDX55 Gene

Transcripts for DDX55 Gene

Unigene Clusters for DDX55 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 55:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX55

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX55 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^
SP1: - - -
SP2:
SP3: - - -
SP4: - - - - - -
SP5:
SP6:
SP7: - - - - -
SP8:
SP9: - -
SP10: - - -
SP11: -
SP12:

ExUns: 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:

Relevant External Links for DDX55 Gene

GeneLoc Exon Structure for
DDX55
ECgene alternative splicing isoforms for
DDX55

Expression for DDX55 Gene

mRNA expression in normal human tissues for DDX55 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX55 Gene

SOURCE GeneReport for Unigene cluster for DDX55 Gene Hs.286173

genes like me logo Genes that share expressions with DDX55: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX55 Gene

Orthologs for DDX55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX55 35
  • 99.72 (n)
  • 99.67 (a)
DDX55 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX55 35
  • 88.94 (n)
  • 93.83 (a)
DDX55 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX55 35
  • 89.54 (n)
  • 91.15 (a)
DDX55 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx55 35
  • 85.75 (n)
  • 91.32 (a)
Ddx55 16
Ddx55 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX55 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX55 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx55 35
  • 85.92 (n)
  • 90.98 (a)
chicken
(Gallus gallus)
Aves DDX55 35
  • 77.36 (n)
  • 86.28 (a)
DDX55 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX55 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6290 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx55 35
  • 72.32 (n)
  • 79.28 (a)
Str.10301 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14198 35
zebrafish
(Danio rerio)
Actinopterygii ddx55 35
  • 69.03 (n)
  • 74.87 (a)
ddx55 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001223 35
  • 56.24 (n)
  • 53.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9630 35
  • 54.48 (n)
  • 49.91 (a)
CG9630 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK512.2 36
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL004C 35
  • 49.93 (n)
  • 42.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB4 35
  • 49.76 (n)
  • 43.84 (a)
SPB4 36
  • 37 (a)
OneToOne
SPB4 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14367g 35
  • 50.54 (n)
  • 43.57 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05450 35
  • 52.94 (n)
  • 49.8 (a)
rice
(Oryza sativa)
Liliopsida Os01g0164500 35
  • 52.19 (n)
  • 47.92 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.10429 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03380 35
  • 51.18 (n)
  • 44.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC24C6.02 35
  • 47.56 (n)
  • 42.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7893 36
  • 52 (a)
OneToOne
Species with no ortholog for DDX55:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX55 Gene

ENSEMBL:
Gene Tree for DDX55 (if available)
TreeFam:
Gene Tree for DDX55 (if available)

Paralogs for DDX55 Gene

Selected SIMAP similar genes for DDX55 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DDX55 Gene

genes like me logo Genes that share paralogs with DDX55: view

No data available for Paralogs for DDX55 Gene

Variants for DDX55 Gene

Sequence variations from dbSNP and Humsavar for DDX55 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs15587 -- 123,619,502(-) TGCTT(C/T)CCTCT reference, synonymous-codon, utr-variant-3-prime, nc-transcript-variant
rs786424 -- 123,600,368(+) atgca(A/G)tggtg upstream-variant-2KB
rs786425 -- 123,600,955(+) TTTTA(A/G)GTTTT upstream-variant-2KB
rs786426 -- 123,601,539(+) AACAA(A/C)AAAAA upstream-variant-2KB
rs786427 -- 123,602,073(-) CTTCC(C/G)GCAGC upstream-variant-2KB

Relevant External Links for DDX55 Gene

HapMap Linkage Disequilibrium report
DDX55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DDX55 Gene

Disorders for DDX55 Gene

Relevant External Links for DDX55

Genetic Association Database (GAD)
DDX55
Human Genome Epidemiology (HuGE) Navigator
DDX55
genes like me logo Genes that share disorders with DDX55: view

No data available for UniProtKB/Swiss-Prot for DDX55 Gene

Publications for DDX55 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for DDX55 Gene

Sources for DDX55 Gene

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