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Aliases for DDX54 Gene

Aliases for DDX54 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 54 2 3
  • ATP-Dependent RNA Helicase DP97 3 4
  • DEAD Box RNA Helicase 97 KDa 3 4
  • DEAD Box Protein 54 3 4
  • DP97 3 6
  • ATP-Dependent RNA Helicase DDX54 3
  • DEAD Box Helicase 97 KDa 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64

External Ids for DDX54 Gene

Summaries for DDX54 Gene

Entrez Gene Summary for DDX54 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX54 Gene

DDX54 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 54) is a Protein Coding gene. GO annotations related to this gene include RNA binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for DDX54 Gene

  • Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX54 Gene

Genomics for DDX54 Gene

Genomic Location for DDX54 Gene

Start:
113,157,173 bp from pter
End:
113,185,479 bp from pter
Size:
28,307 bases
Orientation:
Minus strand

Genomic View for DDX54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX54 Gene

Regulatory Elements for DDX54 Gene

Proteins for DDX54 Gene

  • Protein details for DDX54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDD1-DDX54_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX54
    Protein Accession:
    Q8TDD1
    Secondary Accessions:
    • Q86YT8
    • Q9BRZ1

    Protein attributes for DDX54 Gene

    Size:
    881 amino acids
    Molecular mass:
    98595 Da
    Quaternary structure:
    • Interacts in a hormone-dependent manner with nuclear receptors
    SequenceCaution:
    • Sequence=AAN59978.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX54 Gene

Proteomics data for DDX54 Gene at MOPED

Post-translational modifications for DDX54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX54 Gene

Domains for DDX54 Gene

Gene Families for DDX54 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX54_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q8TDD1
  • Contains 1 helicase C-terminal domain.:
    • Q8TDD1
Family:
  • Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.:
    • Q8TDD1
genes like me logo Genes that share domains with DDX54: view

Function for DDX54 Gene

Molecular function for DDX54 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.

Enzyme Numbers (IUBMB) for DDX54 Gene

Gene Ontology (GO) - Molecular Function for DDX54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003714 transcription corepressor activity IDA 12466272
GO:0003723 RNA binding --
GO:0004004 ATP-dependent RNA helicase activity IDA 12466272
genes like me logo Genes that share ontologies with DDX54: view

Phenotypes for DDX54 Gene

GenomeRNAi human phenotypes for DDX54:
genes like me logo Genes that share phenotypes with DDX54: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX54 Gene

Localization for DDX54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX54 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX54 Gene COMPARTMENTS Subcellular localization image for DDX54 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DDX54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12466272
GO:0005730 nucleolus IDA 12466272
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX54: view

Pathways for DDX54 Gene

SuperPathways for DDX54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing IDA 12466272
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX54: view

No data available for Pathways by source for DDX54 Gene

Transcripts for DDX54 Gene

Unigene Clusters for DDX54 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX54 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: -
SP2:
SP3: - -
SP4: -
SP5: - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:
SP14: -
SP15:
SP16:
SP17:

ExUns: 18c ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b · 23c · 23d · 23e
SP1:
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:
SP7: - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - -
SP12: -
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DDX54 Gene

GeneLoc Exon Structure for
DDX54
ECgene alternative splicing isoforms for
DDX54

Expression for DDX54 Gene

mRNA expression in normal human tissues for DDX54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX54 Gene

SOURCE GeneReport for Unigene cluster for DDX54 Gene Hs.506861

genes like me logo Genes that share expressions with DDX54: view

Orthologs for DDX54 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX54 36
  • 99.24 (n)
  • 99.09 (a)
DDX54 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX54 36
  • 88.75 (n)
  • 90.31 (a)
DDX54 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX54 36
  • 88.66 (n)
  • 88.1 (a)
DDX54 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx54 36
  • 83.16 (n)
  • 85.65 (a)
Ddx54 16
Ddx54 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX54 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX54 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx54 36
  • 82.34 (n)
  • 85.21 (a)
chicken
(Gallus gallus)
Aves DDX54 36
  • 74.02 (n)
  • 74.11 (a)
DDX54 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX54 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx54 36
  • 63.31 (n)
  • 66.83 (a)
Str.2961 36
zebrafish
(Danio rerio)
Actinopterygii ddx54 36
  • 65.06 (n)
  • 64.25 (a)
ddx54 37
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007511 36
  • 55.6 (n)
  • 50.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32344 36
  • 54.48 (n)
  • 48.06 (a)
CG32344 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y94H6A.5 36
  • 49.74 (n)
  • 46.31 (a)
Y94H6A.5 37
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL086W 36
  • 47.46 (n)
  • 42.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP10 36
  • 46.42 (n)
  • 41.75 (a)
DBP10 37
  • 31 (a)
OneToOne
DBP10 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24684g 36
  • 48.17 (n)
  • 47.75 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77030 36
  • 50.13 (n)
  • 47.84 (a)
rice
(Oryza sativa)
Liliopsida Os.21287 36
Os08g0416100 36
  • 51.41 (n)
  • 46.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07712 36
  • 55.56 (n)
  • 52.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp10 36
  • 47.97 (n)
  • 46.8 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3817 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for DDX54:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX54 Gene

ENSEMBL:
Gene Tree for DDX54 (if available)
TreeFam:
Gene Tree for DDX54 (if available)

Paralogs for DDX54 Gene

genes like me logo Genes that share paralogs with DDX54: view

No data available for Paralogs for DDX54 Gene

Variants for DDX54 Gene

Sequence variations from dbSNP and Humsavar for DDX54 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10354 - 113,162,992(+) CCAGG(A/G)CAGCG missense, reference
rs11564 - 113,163,135(+) ACCCC(C/T)GCTCG missense, reference
rs2290767 -- 113,161,697(+) TAGTT(C/G)GAGAT intron-variant
rs2305897 -- 113,180,229(-) TGTCT(C/T)ATGAC intron-variant
rs2305898 -- 113,179,591(-) GAGGA(C/G)TAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX54 Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680
nsv899527 CNV Loss 21882294
nsv899528 CNV Loss 21882294
nsv899530 CNV Gain 21882294
esv996809 CNV Deletion 20482838

Relevant External Links for DDX54 Gene

HapMap Linkage Disequilibrium report
DDX54

Disorders for DDX54 Gene

Relevant External Links for DDX54

Human Genome Epidemiology (HuGE) Navigator
DDX54
genes like me logo Genes that share disorders with DDX54: view

No data available for UniProtKB/Swiss-Prot for DDX54 Gene

Publications for DDX54 Gene

  1. Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97). (PMID: 12466272) Rajendran R.R. … Katzenellenbogen B.S. (J. Biol. Chem. 2003) 2 3 4 23
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Structural basis and specificity of human otubain 1-mediated deubiquitination. (PMID: 18954305) Edelmann M.J. … Kessler B.M. (Biochem. J. 2009) 3

Products for DDX54 Gene

Sources for DDX54 Gene

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