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Aliases for DDX54 Gene

Aliases for DDX54 Gene

  • DEAD-Box Helicase 54 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 54 2 3 5
  • ATP-Dependent RNA Helicase DP97 3 4
  • DEAD Box RNA Helicase 97 KDa 3 4
  • DEAD Box Protein 54 3 4
  • DEAD Box Helicase 97 KDa 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • DP97 3

External Ids for DDX54 Gene

Previous GeneCards Identifiers for DDX54 Gene

  • GC12M113377
  • GC12M112006
  • GC12M112057
  • GC12M113595
  • GC12M110607
  • GC12M113596
  • GC12M113598

Summaries for DDX54 Gene

Entrez Gene Summary for DDX54 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX54 Gene

DDX54 (DEAD-Box Helicase 54) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for DDX54 Gene

  • Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX54 Gene

Genomics for DDX54 Gene

Regulatory Elements for DDX54 Gene

Promoters for DDX54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX54 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX54 Gene

Chromosome:
12
Start:
113,157,173 bp from pter
End:
113,185,479 bp from pter
Size:
28,307 bases
Orientation:
Minus strand

Genomic View for DDX54 Gene

Genes around DDX54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX54 Gene

Proteins for DDX54 Gene

  • Protein details for DDX54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDD1-DDX54_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX54
    Protein Accession:
    Q8TDD1
    Secondary Accessions:
    • Q86YT8
    • Q9BRZ1

    Protein attributes for DDX54 Gene

    Size:
    881 amino acids
    Molecular mass:
    98595 Da
    Quaternary structure:
    • Interacts in a hormone-dependent manner with nuclear receptors.
    SequenceCaution:
    • Sequence=AAN59978.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX54 Gene

Proteomics data for DDX54 Gene at MOPED

Post-translational modifications for DDX54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX54 Gene

Antibody Products

Domains & Families for DDX54 Gene

Gene Families for DDX54 Gene

Suggested Antigen Peptide Sequences for DDX54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDD1

UniProtKB/Swiss-Prot:

DDX54_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
genes like me logo Genes that share domains with DDX54: view

Function for DDX54 Gene

Molecular function for DDX54 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.

Enzyme Numbers (IUBMB) for DDX54 Gene

Gene Ontology (GO) - Molecular Function for DDX54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 12466272
GO:0003723 RNA binding IEA --
GO:0005102 receptor binding IDA 12466272
GO:0005524 ATP binding IEA --
GO:0030331 estrogen receptor binding IDA 12466272
genes like me logo Genes that share ontologies with DDX54: view
genes like me logo Genes that share phenotypes with DDX54: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX54 Gene

Localization for DDX54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX54 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX54 Gene COMPARTMENTS Subcellular localization image for DDX54 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DDX54 Gene

Pathways & Interactions for DDX54 Gene

SuperPathways for DDX54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0030520 intracellular estrogen receptor signaling pathway TAS 12466272
GO:1903507 negative regulation of nucleic acid-templated transcription IDA 12466272
genes like me logo Genes that share ontologies with DDX54: view

No data available for Pathways by source and SIGNOR curated interactions for DDX54 Gene

Drugs & Compounds for DDX54 Gene

(1) Drugs for DDX54 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX54 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX54: view

Transcripts for DDX54 Gene

Unigene Clusters for DDX54 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX54 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: -
SP2:
SP3: - -
SP4: -
SP5: - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:
SP14: -
SP15:
SP16:
SP17:

ExUns: 18c ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b · 23c · 23d · 23e
SP1:
SP2:
SP3: - - - - -
SP4:
SP5:
SP6:
SP7: - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - -
SP12: -
SP13: -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DDX54 Gene

GeneLoc Exon Structure for
DDX54
ECgene alternative splicing isoforms for
DDX54

Expression for DDX54 Gene

mRNA expression in normal human tissues for DDX54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX54 Gene

This gene is overexpressed in CD8 Tcells (16.6), Peripheral blood mononuclear cells (14.9), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX54 Gene



SOURCE GeneReport for Unigene cluster for DDX54 Gene Hs.506861

genes like me logo Genes that share expression patterns with DDX54: view

Protein tissue co-expression partners for DDX54 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX54 Gene

Orthologs for DDX54 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX54 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX54 35
  • 88.75 (n)
  • 90.31 (a)
DDX54 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX54 35
  • 88.66 (n)
  • 88.1 (a)
DDX54 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx54 35
  • 83.16 (n)
  • 85.65 (a)
Ddx54 16
Ddx54 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX54 35
  • 99.24 (n)
  • 99.09 (a)
DDX54 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx54 35
  • 82.34 (n)
  • 85.21 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX54 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX54 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX54 35
  • 74.02 (n)
  • 74.11 (a)
DDX54 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX54 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx54 35
  • 63.31 (n)
  • 66.83 (a)
Str.2961 35
zebrafish
(Danio rerio)
Actinopterygii ddx54 35
  • 65.06 (n)
  • 64.25 (a)
ddx54 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007511 35
  • 55.6 (n)
  • 50.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32344 35
  • 54.48 (n)
  • 48.06 (a)
CG32344 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y94H6A.5 35
  • 49.74 (n)
  • 46.31 (a)
Y94H6A.5 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL086W 35
  • 47.46 (n)
  • 42.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24684g 35
  • 48.17 (n)
  • 47.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP10 35
  • 46.42 (n)
  • 41.75 (a)
DBP10 36
  • 31 (a)
OneToOne
DBP10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77030 35
  • 50.13 (n)
  • 47.84 (a)
rice
(Oryza sativa)
Liliopsida Os.21287 35
Os08g0416100 35
  • 51.41 (n)
  • 46.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3817 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07712 35
  • 55.56 (n)
  • 52.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp10 35
  • 47.97 (n)
  • 46.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for DDX54:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX54 Gene

ENSEMBL:
Gene Tree for DDX54 (if available)
TreeFam:
Gene Tree for DDX54 (if available)

Paralogs for DDX54 Gene

genes like me logo Genes that share paralogs with DDX54: view

No data available for Paralogs for DDX54 Gene

Variants for DDX54 Gene

Sequence variations from dbSNP and Humsavar for DDX54 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_033860 -
rs35519289 - 113,165,654(+) GGGAG(A/C/T)GGTAG reference, missense
rs11564 - 113,163,135(+) ACCCC(C/T)GCTCG reference, missense
rs10354 - 113,162,992(+) CCAGG(A/G)CAGCG reference, missense
rs2305897 -- 113,180,229(-) TGTCT(C/T)ATGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX54 Gene

Variant ID Type Subtype PubMed ID
nsv519540 CNV Gain+Loss 19592680
nsv899527 CNV Loss 21882294
nsv899528 CNV Loss 21882294
nsv899530 CNV Gain 21882294
esv996809 CNV Deletion 20482838

Variation tolerance for DDX54 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 82.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX54 Gene

HapMap Linkage Disequilibrium report
DDX54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX54 Gene

Disorders for DDX54 Gene

Relevant External Links for DDX54

Human Genome Epidemiology (HuGE) Navigator
DDX54
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX54

No disorders were found for DDX54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX54 Gene

Publications for DDX54 Gene

  1. Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97). (PMID: 12466272) Rajendran R.R. … Katzenellenbogen B.S. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3

Products for DDX54 Gene

Sources for DDX54 Gene

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