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DDX53 Gene

protein-coding   GIFtS: 50
GCID: GC0XP023018

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 53

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 531 2     Cancer Associated Gene1
Cancer/Testis Antigen 261 2 3     DEAD-Box Protein CAGE2
Cancer-Associated Gene Protein2 3     Probable ATP-Dependent RNA Helicase DDX532
CAGE2 3     EC 3.6.4.133
CT262 3     DEAD Box Protein CAGE3
DEAD Box Protein 532 3     EC 3.6.18

External Ids:    HGNC: 200831   Entrez Gene: 1684002   Ensembl: ENSG000001847357   UniProtKB: Q86TM33   

Export aliases for DDX53 gene to outside databases

Previous GC identifers: GC0XU900468 GC0XP022379 GC0XP022777 GC0XP022927 GC0XP020758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX53 Gene:
This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase
protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. (provided by
RefSeq, Sep 2011)

GeneCards Summary for DDX53 Gene:
DDX53 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 53) is a protein-coding gene. Diseases associated with DDX53 include peptic ulcer, and autism spectrum disorder. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX46.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX53 gene promoter:
         HOXA9B   HOXA9   STAT1   CUTL1   IRF-1   RORalpha2   Meis-1b   GATA-1   ATF   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DDX53

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.13

DDX53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX53 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP023018:  view genomic region     (about GC identifiers)

Start:
23,018,087 bp from pter      End:
23,020,206 bp from pter
Size:
2,120 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DDX53_HUMAN, Q86TM3 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX53  
Size: 631 amino acids; 71154 Da
1 PDB 3D structure from and Proteopedia for DDX53:
3IUY (3D)    
Secondary accessions: Q0D2N2 Q6NVV4

Explore the universe of human proteins at neXtProt for DDX53: NX_Q86TM3

Explore proteomics data for DDX53 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX53 (Q86TM3) (see all 7)
     TPTRELA  DEADKML  IATPGRL  IIATPGR 


    See DDX53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_874358.2  
    ENSEMBL proteins: 
     ENSP00000368667  

    DDX53 Human Recombinant Protein Products:

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    Novus Biologicals DDX53 Protein
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    Cloud-Clone Corp. Proteins for DDX53

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    Cloud-Clone Corp. CLIAs for DDX53


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 8):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR004087 KH_dom
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif

    Graphical View of Domain Structure for InterPro Entry Q86TM3

    ProtoNet protein and cluster: Q86TM3

    2 Blocks protein domains:
    IPB000629 ATP-dependent helicase
    IPB004087 KH domain


    UniProtKB/Swiss-Prot: DDX53_HUMAN, Q86TM3
    Similarity: Belongs to the DEAD box helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 KH domain


    DDX53 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX53_HUMAN, Q86TM3
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    DDX53 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DDX53:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX53
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX53_HUMAN, Q86TM3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DDX53 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX53
    Interactions:

        GeneGlobe Interaction Network for DDX53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for DDX53 (Q86TM33 ENSP000003686674) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    COPAENSP000003570484STRING: ENSP00000357048
    DHX15ENSP000003367414STRING: ENSP00000336741
    IBA57ENSP000003556724STRING: ENSP00000355672
    RBM15ENSP000003587994STRING: ENSP00000358799
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX53



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DDX53 gene: 
    NM_182699.3  

    Unigene Cluster for DDX53:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
    Hs.434416  [show with all ESTs]
    Unigene Representative Sequence: BC051703
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000327968(uc004daj.3)

    miRNA
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    GenScript: all cDNA clones in your preferred vector: DDX53 (NM_182699)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX53
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX53
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat DDX53

    Additional mRNA sequence: 

    AY039237.1 BC051703.1 BC067878.1 

    1 DOTS entry:

    DT.95152064 

    8 AceView cDNA sequences:

    CD557286 AY039237 NM_182699 BC067878 BI464283 BI560190 BI560451 AA781181 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DDX53 Expression
    About this image

    DDX53 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX53 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434416

    UniProtKB/Swiss-Prot: DDX53_HUMAN, Q86TM3
    Tissue specificity: Expressed in testis. Wide expression in various cancer tissues and cancer cell lines

        Custom PCR Arrays for DDX53
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDX53 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia DDX531 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 77.67(n)
    69.07(a)
      100683521  XM_005642476.1  XP_005642533.1 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    54(a)
    1 → many
    3(80944374-80961995)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    55(a)
    1 → many
    GL343341.1(166536-195687)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ066843.12   -- 76.61(n)    BJ066843.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddx436
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
    46(a)
    1 → many
    13(27556546-27577923) ENSDARG00000022614
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78786
    --
    39(a)
    1 → many
    3R(3948421-3950995)
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G11A.36
    Protein Y54G11A.3 (Y54G11A.3) mRNA, complete cds
    38(a)
    1 → many
    II(14276651-14283977) WBGene00013214
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP26
    Essential ATP-dependent RNA helicase of the DEAD-b...
    35(a)
    1 → many
    XIV(413639-416281) YNL112W


    ENSEMBL Gene Tree for DDX53 (if available)
    TreeFam Gene Tree for DDX53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX53 gene
    DDX462  DDX52  DDX172  DDX422  DDX432  
    15 SIMAP similar genes for DDX53 using alignment to 1 protein entry:     DDX53_HUMAN:
    DDX43    DDX17    DKFZp686J01190    DDX5    DDX3Y    DDX42
    DDX46    EIF4A2    DDX54    EIF4A1    DDX39B    EIF4A3
    DDX52    DDX6    DDX47

    DDX53 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DDX53
    PGOHUM00000241551


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX53 (see all 145)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480311901,2
    C--22930076(+) TCTTCA/CAATAG 1 -- us2k10--------
    rs42885111,2
    C,F,A,H--22930182(+) tgactA/Gaagag 1 -- us2k19Minor allele frequency- G:0.08NS EA NA CSA 559
    rs59709701,2
    C,F,A,H--22930502(+) GAGTAA/TTGCCA 1 -- us2k111Minor allele frequency- T:0.13NS EA NA 1260
    rs1415518201,2
    C--22930814(+) CTACT-/AAAAAT 1 -- us2k10--------
    rs1381947471,2
    C--22930861(+) AATCCC/TAGATA 1 -- us2k10--------
    rs1844335231,2
    --22930885(+) GGCAGA/GAGAAT 1 -- us2k10--------
    rs1439221121,2
    C--22930913(+) CCAAGA/GTTGCA 1 -- us2k10--------
    rs1872031201,2
    --22930935(+) TCATGC/TTATTG 1 -- us2k10--------
    rs1123120741,2
    F--22931641(+) TAAATA/GAACAC 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1472412731,2
    --22931736(+) GTATAC/TGGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDX53 (23018087 - 23020206 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DDX53: --
    Human Gene Mutation Database (HGMD): DDX53
    Locus Specific Mutation Databases (LSDB): DDX53

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX53
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX53

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    11 diseases for DDX53:    
    About MalaCards
    peptic ulcer    autism spectrum disorder    gastritis    tonsillitis
    hiv-1    prostate cancer    prostatitis    squamous cell carcinoma
    cerebritis    thyroiditis    endotheliitis


    DDX53 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): DDX53
    Human Genome Epidemiology (HuGE) Navigator: DDX53 (2 documents)

    Export disorders for DDX53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX53 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DDX53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative structural analysis of human DEAD-box RNA helicases. (PubMed id 20941364)1, 2 Schutz P.... Schuler H. (PLoS ONE 2010)
    2. Functional impact of global rare copy number variation in autism spectrum disorders. (PubMed id 20531469)1, 4 Pinto D....Betancur C. (Nature 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification and characterization of a novel cancer/testis antigen gene CAGE. (PubMed id 11922625)1, 2 Cho B.... Jeoung D.I. (Biochem. Biophys. Res. Commun. 2002)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)
    7. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    8. Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs. (PubMed id 20534591)1 Kim Y....Jeoung D. (J. Biol. Chem. 2010)
    9. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    10. Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility. (PubMed id 18388483)1 Kim Y. and Jeoung D. (J. Microbiol. Biotechnol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 168400 HGNC: 20083 AceView: DDX53 Ensembl:ENSG00000184735 euGenes: HUgn168400
    ECgene: DDX53 H-InvDB: DDX53

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDX53 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDX53 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX53 gene:
    Search GeneIP for patents involving DDX53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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