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Aliases for DDX53 Gene

Aliases for DDX53 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 53 2 3
  • Cancer/Testis Antigen 26 2 3 4
  • Cancer-Associated Gene Protein 3 4
  • DEAD Box Protein 53 3 4
  • CAGE 3 4
  • CT26 3 4
  • Probable ATP-Dependent RNA Helicase DDX53 3
  • Cancer Associated Gene 2
  • DEAD-Box Protein CAGE 3
  • DEAD Box Protein CAGE 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX53 Gene

Previous GeneCards Identifiers for DDX53 Gene

  • GC0XU900468
  • GC0XP022379
  • GC0XP022777
  • GC0XP022927
  • GC0XP020758

Summaries for DDX53 Gene

Entrez Gene Summary for DDX53 Gene

  • This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]

GeneCards Summary for DDX53 Gene

DDX53 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 53) is a Protein Coding gene. Diseases associated with DDX53 include autism spectrum disorder. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX43.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX53 Gene

Genomics for DDX53 Gene

Regulatory Elements for DDX53 Gene

Genomic Location for DDX53 Gene

Start:
22,999,961 bp from pter
End:
23,003,589 bp from pter
Size:
3,629 bases
Orientation:
Plus strand

Genomic View for DDX53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX53 Gene

Proteins for DDX53 Gene

  • Protein details for DDX53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TM3-DDX53_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX53
    Protein Accession:
    Q86TM3
    Secondary Accessions:
    • Q0D2N2
    • Q6NVV4

    Protein attributes for DDX53 Gene

    Size:
    631 amino acids
    Molecular mass:
    71154 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DDX53 Gene

neXtProt entry for DDX53 Gene

Proteomics data for DDX53 Gene at MOPED

Selected DME Specific Peptides for DDX53 Gene

Post-translational modifications for DDX53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX53 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DDX53 Gene

Gene Families for DDX53 Gene

HGNC:
  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TM3

UniProtKB/Swiss-Prot:

DDX53_HUMAN :
  • Q86TM3
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 KH domain.
Family:
  • Belongs to the DEAD box helicase family.
genes like me logo Genes that share domains with DDX53: view

Function for DDX53 Gene

Molecular function for DDX53 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX53 Gene

Gene Ontology (GO) - Molecular Function for DDX53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
genes like me logo Genes that share ontologies with DDX53: view

Phenotypes for DDX53 Gene

GenomeRNAi human phenotypes for DDX53:
genes like me logo Genes that share phenotypes with DDX53: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDX53 Gene

Localization for DDX53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX53 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX53 Gene COMPARTMENTS Subcellular localization image for DDX53 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX53: view

Pathways for DDX53 Gene

SuperPathways for DDX53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX53: view

No data available for Pathways by source for DDX53 Gene

Transcripts for DDX53 Gene

mRNA/cDNA for DDX53 Gene

(8) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDX53 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX53 Gene

No ASD Table

Relevant External Links for DDX53 Gene

GeneLoc Exon Structure for
DDX53
ECgene alternative splicing isoforms for
DDX53

Expression for DDX53 Gene

mRNA expression in normal human tissues for DDX53 Gene

mRNA differential expression in normal tissues according to GTEx for DDX53 Gene

This gene is overexpressed in Testis (51.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DDX53 Gene

SOURCE GeneReport for Unigene cluster for DDX53 Gene Hs.434416

mRNA Expression by UniProt/SwissProt for DDX53 Gene

Q86TM3-DDX53_HUMAN
Tissue specificity: Expressed in testis. Wide expression in various cancer tissues and cancer cell lines.
genes like me logo Genes that share expressions with DDX53: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DDX53 Gene

Orthologs for DDX53 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX53 35
  • 98.57 (n)
  • 96.51 (a)
DDX53 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX53 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX53 35
  • 77.67 (n)
  • 69.07 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddx43 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7878 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G11A.3 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 36
  • 35 (a)
OneToMany
Species with no ortholog for DDX53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DDX53 Gene

ENSEMBL:
Gene Tree for DDX53 (if available)
TreeFam:
Gene Tree for DDX53 (if available)

Paralogs for DDX53 Gene

Paralogs for DDX53 Gene

Selected SIMAP similar genes for DDX53 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DDX53 Gene

genes like me logo Genes that share paralogs with DDX53: view

Variants for DDX53 Gene

Sequence variations from dbSNP and Humsavar for DDX53 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_052168 -
VAR_052169 -
VAR_052170 -
VAR_064707 -

Relevant External Links for DDX53 Gene

HapMap Linkage Disequilibrium report
DDX53
Human Gene Mutation Database (HGMD)
DDX53
Locus Specific Mutation Databases (LSDB)
DDX53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DDX53 Gene

Disorders for DDX53 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DDX53 Gene including...

Search for DDX53 Gene in MalaCards »

Relevant External Links for DDX53

Genetic Association Database (GAD)
DDX53
Human Genome Epidemiology (HuGE) Navigator
DDX53
genes like me logo Genes that share disorders with DDX53: view

No data available for UniProtKB/Swiss-Prot for DDX53 Gene

Publications for DDX53 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Identification and characterization of a novel cancer/testis antigen gene CAGE. (PMID: 11922625) Cho B. … Jeoung D.I. (Biochem. Biophys. Res. Commun. 2002) 3 4
  3. Functional impact of global rare copy number variation in autism spectrum disorders. (PMID: 20531469) Pinto D. … Betancur C. (Nature 2010) 3 48
  4. Comparative structural analysis of human DEAD-box RNA helicases. (PMID: 20941364) Schutz P. … Schuler H. (PLoS ONE 2010) 3 4
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for DDX53 Gene

Sources for DDX53 Gene

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