DDX53 Gene
protein-coding GIFtS: 49
GCID: GC0XP023018
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DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
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Aliases
for DDX53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 531 2 | | DEAD-Box Protein CAGE2 | | CAGE1 2 3 | | Probable ATP-Dependent RNA Helicase DDX532 | | CT261 2 3 | | EC 3.6.4.133 | | Cancer-Associated Gene Protein2 3 | | DEAD Box Protein CAGE3 | | Cancer/Testis Antigen 262 3 | | EC 3.6.18 | | DEAD Box Protein 532 3 | | |
Export aliases for DDX53 gene to outside databasesPrevious GC identifers: GC0XU900468 GC0XP022379 GC0XP022777 GC0XP022927 GC0XP020758 |
Summaries
for DDX53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DDX53:
This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase proteinfamily. Other members of this protein family participate in ATP-dependent RNA unwinding. (provided by RefSeq, Sep2011)
|
Genomic Views
for DDX53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDX53 gene promoter:
HOXA9B HOXA9 STAT1 CUTL1 IRF-1 RORalpha2 Meis-1b GATA-1 ATF Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX53
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX53 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.11 Ensembl cytogenetic band: Xp22.11 HGNC cytogenetic band: Xp22.13DDX53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP023018: view genomic region
(about GC identifiers)
Start:
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23,018,087 bp from pter |
End:
|
23,020,206 bp from pter |
Size:
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2,120 bases |
Orientation:
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plus strand |
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Proteins
for DDX53 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDX53_HUMAN, Q86TM3 (See
protein sequence)Recommended Name: Probable ATP-dependent RNA helicase DDX53 Size: 631 amino acids; 71154 Da
Subcellular location: Nucleus
1 PDB 3D structure from  and Proteopedia  for DDX53:3IUY (3D)
Secondary accessions: Q0D2N2 Q6NVV4Explore the universe of human proteins at neXtProt for DDX53: NX_Q86TM3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86TM3
4/7 DME Specific Peptides for DDX53 (Q86TM3) (see all 7)
DDX53 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_874358.2
ENSEMBL proteins: ENSP00000368667
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
DDX53 for ontologies About GeneDecksing
DDX53 Antibody Products:
Assay Products for DDX53: |
Protein
Domains /
Families
for DDX53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX53 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q86TM3ProtoNet protein and cluster: Q86TM3 2 Blocks protein families: IPB000629 ATP-dependent helicase IPB004087 KH domain
UniProtKB/Swiss-Prot: DDX53_HUMAN, Q86TM3Similarity: Belongs to the DEAD box helicase familySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domainSimilarity: Contains 1 KH domain |
Function
for DDX53 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DDX53_HUMAN, Q86TM3Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX53
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX53 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
DDX53 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DDX53:
|
Pathways & Interactions
for DDX53 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDX53
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for DDX53 (Q86TM33 ENSP000003686674) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for DDX53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DDX53
Search CenterWatch for drugs/clinical trials and news about DDX53
|
Transcripts
for DDX53 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDX53 gene: NM_182699.3 Unigene Cluster for DDX53: DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 Hs.434416 [show with all ESTs]Unigene Representative Sequence: BC0517031 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000327968(uc004daj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX53
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX53
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDX53 (NM_182699) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX53 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX53 |
Additional cDNA sequence: AY039237.1 BC051703.1 BC067878.1 1 DOTS entry: DT.95152064 8 AceView cDNA sequences: CD557286 BC067878 BI464283 AY039237 NM_182699 BI560451 BI560190 AA781181
GeneLoc Exon Structure
|
Expression
for DDX53 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DDX53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX53
SOURCE GeneReport for Unigene cluster: Hs.434416
UniProtKB/Swiss-Prot: DDX53_HUMAN, Q86TM3Tissue specificity: Expressed in testis. Wide expression in various cancer tissues and cancer cell lines
SABiosciences Custom PCR Arrays for DDX53
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX53
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DDX53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX53 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX53 |
Orthologs
for DDX53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DDX53 gene from 8/19 species (see all 19) About this table
ENSEMBL Gene Tree for DDX53 (if available)
TreeFam Gene Tree for DDX53 (if available) |
Paralogs
for DDX53 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDX53 gene
- DDX12 DDX412 DDX52 DDX172 DDX432
16 SIMAP similar genes for DDX53 using alignment to 1 protein entry: DDX53_HUMAN:DDX43 DDX17 DDX4 DKFZp686J01190 DDX5 DDX3Y
DDX42 DDX46 EIF4A2 DDX54 EIF4A1 DDX39B
EIF4A3 DDX52 DDX6 DDX47
DDX53 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DDX53
PGOHUM00000241551
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Genomic Variants
for DDX53 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDX53 (23018087 - 23020206 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DDX53: --
Human Gene Mutation Database (HGMD): DDX53
Locus Specific Mutation Databases (LSDB): DDX53
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX53 |
|
Disorders
/ Diseases
for DDX53 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDX53 for disorders About GeneDecksing
7  diseases for DDX53: About MalaCardsautism spectrum disorder peptic ulcer squamous cell carcinoma gastritis
prostate cancer carcinoma prostatitis
Human Genome Epidemiology (HuGE) Navigator: DDX53 (2 documents)
Export disorders for DDX53 gene to outside databases
|
Publications
for DDX53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDX53 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with DDX53) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparative structural analysis of human DEAD-box RNA helicases. (PubMed id 20941364)1, 2 Schutz P.... Schuler H. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of a novel cancer/testis antigen gene CAGE. (PubMed id 11922625)1, 2 Cho B.... Jeoung D.I. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (2010)
- Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs. (PubMed id 20534591)1 Kim Y....Jeoung D. (2010)
- Functional impact of global rare copy number variatio n in autism spectrum disorders. (PubMed id 20531469)1 Pinto D....Betancur C. (2010)
- Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility. (PubMed id 18388483)1 Kim Y. and Jeoung D. (2008)
- Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK). (PubMed id 17028776)1 Shim H....Jeoung D. (2006)
|
External Searches for DDX53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DDX53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDX53 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDX53 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DDX53 gene:
Search GeneIP for patents involving DDX53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDX53 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX53 |
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