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Aliases for DDX52 Gene

Aliases for DDX52 Gene

  • DExD-Box Helicase 52 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 52 2 3
  • DEAD-Box Helicase 52 2 3
  • DEAD Box Protein 52 3 4
  • ROK1 3 4
  • Probable ATP-Dependent RNA Helicase DDX52 3
  • ATP-Dependent RNA Helicase ROK1-Like 4
  • EC 4
  • EC 3.6.1 58
  • HUSSY19 3

External Ids for DDX52 Gene

Previous GeneCards Identifiers for DDX52 Gene

  • GC17M035703
  • GC17M036168
  • GC17M036167
  • GC17M033047
  • GC17M035969
  • GC17M031909

Summaries for DDX52 Gene

GeneCards Summary for DDX52 Gene

DDX52 (DExD-Box Helicase 52) is a Protein Coding gene. Diseases associated with DDX52 include Chromosome 17Q12 Deletion Syndrome. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

Gene Wiki entry for DDX52 Gene

Additional gene information for DDX52 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX52 Gene

Genomics for DDX52 Gene

Regulatory Elements for DDX52 Gene

Enhancers for DDX52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H037603 1.4 Ensembl ENCODE 21.5 +36.0 36041 7.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SYNRG DDX52 GC17P037579
GH17H037670 1.2 Ensembl ENCODE dbSUPER 11.7 -28.2 -28233 2.8 GATAD2A FOXA2 SAP130 FOXA3 CEBPB KAT8 ZFHX2 JUND SCRT2 CEBPA DDX52 HNF1B GC17P037657 LOC105371754
GH17H037673 1.2 ENCODE dbSUPER 11.6 -32.4 -32366 4.7 FOXA2 ATF1 MLX ARID4B ZNF143 MXD4 REST KAT8 NFIL3 SSRP1 DDX52 HNF1B SYNRG GC17P037657 LOC105371754
GH17H037486 1.6 Ensembl ENCODE dbSUPER 8.6 +152.7 152704 8.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TADA2A DUSP14 ACACA DDX52 SYNRG MRPL45 GC17M037483 PIR41271
GH17H037688 1 ENCODE dbSUPER 10.9 -45.9 -45855 1.5 SOX13 FOXA2 ZKSCAN1 RERE NR2F6 CREM TCF7L2 GATAD2A HMG20B SP5 HNF1B DDX52 LOC105371754 GC17P037657
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX52 on UCSC Golden Path with GeneCards custom track

Promoters for DDX52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093678 264 1601 PKNOX1 ATF1 FOXA2 ZNF133 ARID4B SIN3A DMAP1 YY1 ZNF143 ATF7

Genomic Locations for DDX52 Gene

Genomic Locations for DDX52 Gene
33,726 bases
Minus strand

Genomic View for DDX52 Gene

Genes around DDX52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX52 Gene

Proteins for DDX52 Gene

  • Protein details for DDX52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX52
    Protein Accession:
    Secondary Accessions:
    • Q86YG1
    • Q8N213
    • Q9NVE0
    • Q9Y482

    Protein attributes for DDX52 Gene

    599 amino acids
    Molecular mass:
    67498 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD27766.1; Type=Frameshift; Positions=324, 327, 330, 350, 365, 377; Evidence={ECO:0000305}; Sequence=AK093661; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA91812.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=CAA09374.1; Type=Frameshift; Positions=355, 377; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX52 Gene

neXtProt entry for DDX52 Gene

Selected DME Specific Peptides for DDX52 Gene


Post-translational modifications for DDX52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX52 Gene

Gene Families for DDX52 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
  • Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
genes like me logo Genes that share domains with DDX52: view

Function for DDX52 Gene

Molecular function for DDX52 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX52 Gene

Phenotypes From GWAS Catalog for DDX52 Gene

Gene Ontology (GO) - Molecular Function for DDX52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX52: view
genes like me logo Genes that share phenotypes with DDX52: view

Animal Models for DDX52 Gene

MGI Knock Outs for DDX52:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX52 Gene

Localization for DDX52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX52 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX52 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX52: view

Pathways & Interactions for DDX52 Gene

genes like me logo Genes that share pathways with DDX52: view

Interacting Proteins for DDX52 Gene

Selected Interacting proteins: Q9Y2R4-DDX52_HUMAN for DDX52 Gene via IID

Gene Ontology (GO) - Biological Process for DDX52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS,IBA --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX52: view

No data available for SIGNOR curated interactions for DDX52 Gene

Drugs & Compounds for DDX52 Gene

(3) Drugs for DDX52 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DDX52 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX52: view

Transcripts for DDX52 Gene

Unigene Clusters for DDX52 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 52:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX52 Gene

No ASD Table

Relevant External Links for DDX52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX52 Gene

This gene is overexpressed in Lung (32.2) and Peripheral blood mononuclear cells (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DDX52 Gene

Protein tissue co-expression partners for DDX52 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX52 Gene:


SOURCE GeneReport for Unigene cluster for DDX52 Gene:


Evidence on tissue expression from TISSUES for DDX52 Gene

  • Liver(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with DDX52: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX52 Gene

Orthologs for DDX52 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX52 33
  • 99.72 (n)
(Canis familiaris)
Mammalia DDX52 33
  • 92.92 (n)
(Bos Taurus)
Mammalia DDX52 33
  • 91.55 (n)
(Mus musculus)
Mammalia Ddx52 33 16
  • 86.66 (n)
(Rattus norvegicus)
Mammalia Ddx52 33
  • 86.66 (n)
(Gallus gallus)
Aves DDX52 33
  • 72.07 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx52 33
  • 73.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5589 33
  • 56.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012358 33
  • 52.11 (n)
(Caenorhabditis elegans)
Secernentea R05D11.4 33
  • 51.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROK1 33
  • 53.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17424g 33
  • 53.23 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL024C 33
  • 50.9 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09720 33
  • 53.37 (n)
(Oryza sativa)
Liliopsida Os07g0647900 33
  • 53.25 (n)
Os.11258 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rok1 33
  • 53.44 (n)
Species where no ortholog for DDX52 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX52 Gene

Gene Tree for DDX52 (if available)
Gene Tree for DDX52 (if available)

Paralogs for DDX52 Gene

genes like me logo Genes that share paralogs with DDX52: view

No data available for Paralogs for DDX52 Gene

Variants for DDX52 Gene

Sequence variations from dbSNP and Humsavar for DDX52 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000086910 -- 37,641,364(+) ACCAC(G/T)GCACC intron-variant, upstream-variant-2KB
rs1000091160 -- 37,625,727(+) TACTC(C/T)AAAAT intron-variant
rs1000139010 -- 37,641,610(+) CACGC(A/T)CCTGT intron-variant, upstream-variant-2KB
rs1000290684 -- 37,635,733(+) AATAG(C/G)TGGGT intron-variant
rs1000343168 -- 37,612,047(+) TATCT(A/C)ATATA utr-variant-3-prime, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX52 Gene

Variant ID Type Subtype PubMed ID
nsv953887 CNV duplication 24416366
nsv833431 CNV gain 17160897
esv3640501 CNV gain 21293372
esv3640494 CNV gain 21293372

Variation tolerance for DDX52 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX52 Gene

Disorders for DDX52 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX52 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DDX52 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX52

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DDX52: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX52 Gene

Publications for DDX52 Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for DDX52 Gene

Sources for DDX52 Gene

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