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Aliases for DDX52 Gene

Aliases for DDX52 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 52 2 3
  • ROK1 3 4 6
  • DEAD Box Protein 52 3 4
  • HUSSY19 3 6
  • Probable ATP-Dependent RNA Helicase DDX52 3
  • ATP-Dependent RNA Helicase ROK1-Like 4
  • EC 4
  • EC 3.6.1 63

External Ids for DDX52 Gene

Previous GeneCards Identifiers for DDX52 Gene

  • GC17M035703
  • GC17M036168
  • GC17M036167
  • GC17M033047
  • GC17M035969
  • GC17M031909

Summaries for DDX52 Gene

GeneCards Summary for DDX52 Gene

DDX52 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 52) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

Gene Wiki entry for DDX52 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX52 Gene

Genomics for DDX52 Gene

Regulatory Elements for DDX52 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX52 Gene

37,609,739 bp from pter
37,643,464 bp from pter
33,726 bases
Minus strand

Genomic View for DDX52 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX52 Gene

Proteins for DDX52 Gene

  • Protein details for DDX52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX52
    Protein Accession:
    Secondary Accessions:
    • Q86YG1
    • Q8N213
    • Q9NVE0
    • Q9Y482

    Protein attributes for DDX52 Gene

    599 amino acids
    Molecular mass:
    67498 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD27766.1; Type=Frameshift; Positions=324, 327, 330, 350, 365, 377; Evidence={ECO:0000305}; Sequence=AK093661; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA91812.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305}; Sequence=CAA09374.1; Type=Frameshift; Positions=355, 377; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX52 Gene

neXtProt entry for DDX52 Gene

Proteomics data for DDX52 Gene at MOPED

Post-translational modifications for DDX52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX52 Gene

Domains for DDX52 Gene

Gene Families for DDX52 Gene

  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2R4
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
genes like me logo Genes that share domains with DDX52: view

Function for DDX52 Gene

Molecular function for DDX52 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX52 Gene

Gene Ontology (GO) - Molecular Function for DDX52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX52: view

Phenotypes for DDX52 Gene

genes like me logo Genes that share phenotypes with DDX52: view

Animal Model Products

CRISPR Products

miRNA for DDX52 Gene

miRTarBase miRNAs that target DDX52

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX52

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX52 Gene

Localization for DDX52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX52 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for DDX52 Gene COMPARTMENTS Subcellular localization image for DDX52 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX52: view

Pathways for DDX52 Gene

SuperPathways for DDX52 Gene

No Data Available

Interacting Proteins for DDX52 Gene

Selected Interacting proteins: Q9Y2R4-DDX52_HUMAN for DDX52 Gene via I2D

Gene Ontology (GO) - Biological Process for DDX52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IBA --
GO:0008152 metabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX52: view

No data available for Pathways by source for DDX52 Gene

Transcripts for DDX52 Gene

Unigene Clusters for DDX52 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 52:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX52

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX52 Gene

No ASD Table

Relevant External Links for DDX52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX52 Gene

mRNA expression in normal human tissues for DDX52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DDX52 Gene

SOURCE GeneReport for Unigene cluster for DDX52 Gene Hs.590937

genes like me logo Genes that share expressions with DDX52: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX52 Gene

Orthologs for DDX52 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX52 35
  • 99.72 (n)
  • 99.67 (a)
(Bos Taurus)
Mammalia DDX52 35
  • 91.55 (n)
  • 91.44 (a)
(Canis familiaris)
Mammalia DDX52 35
  • 92.92 (n)
  • 94.31 (a)
(Mus musculus)
Mammalia Ddx52 35
  • 86.66 (n)
  • 88.94 (a)
Ddx52 16
(Rattus norvegicus)
Mammalia Ddx52 35
  • 86.66 (n)
  • 88.44 (a)
(Gallus gallus)
Aves DDX52 35
  • 72.07 (n)
  • 75.69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx52 35
  • 73.85 (n)
  • 83.96 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012358 35
  • 52.11 (n)
  • 49.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5589 35
  • 56.07 (n)
  • 53.78 (a)
(Caenorhabditis elegans)
Secernentea R05D11.4 35
  • 51.37 (n)
  • 43.37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL024C 35
  • 50.9 (n)
  • 43.78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROK1 35
  • 53.67 (n)
  • 44.36 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17424g 35
  • 53.23 (n)
  • 44.77 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09720 35
  • 53.37 (n)
  • 44.89 (a)
(Oryza sativa)
Liliopsida Os.11258 35
Os07g0647900 35
  • 53.25 (n)
  • 46.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rok1 35
  • 53.44 (n)
  • 42.43 (a)
Species with no ortholog for DDX52:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDX52 Gene

Gene Tree for DDX52 (if available)
Gene Tree for DDX52 (if available)

Paralogs for DDX52 Gene

genes like me logo Genes that share paralogs with DDX52: view

No data available for Paralogs for DDX52 Gene

Variants for DDX52 Gene

Sequence variations from dbSNP and Humsavar for DDX52 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3813910 -- 37,643,330(-) AGGTA(C/T)TGTGC intron-variant
rs3813911 -- 37,643,246(-) CGCAC(A/T)TGGAC intron-variant
rs3813912 -- 37,643,034(-) TCTCC(A/G)AACCT intron-variant
rs4332783 -- 37,637,644(+) atctc(A/G)gctca intron-variant
rs4573978 -- 37,611,969(+) aaaaa(A/C)aaaac utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX52 Gene

Variant ID Type Subtype PubMed ID
nsv833431 CNV Gain 17160897

Relevant External Links for DDX52 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX52 Gene

Disorders for DDX52 Gene

(1) University of Copenhagen DISEASES for DDX52 Gene

Relevant External Links for DDX52

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with DDX52: view

No data available for UniProtKB/Swiss-Prot for DDX52 Gene

Publications for DDX52 Gene

  1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3

Products for DDX52 Gene

Sources for DDX52 Gene

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