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DDX52 Gene

protein-coding   GIFtS: 55
GCID: GC17M035969

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 52

  Search for DDX52
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 521 2     Probable ATP-Dependent RNA Helicase DDX522
ROK12 3 5     EC 3.6.4.133
DEAD Box Protein 522 3     ATP-Dependent RNA Helicase ROK1-Like3
HUSSY192 5     EC 3.6.18

External Ids:    HGNC: 200381   Entrez Gene: 110562   Ensembl: ENSG000001411417   OMIM: 6125005   UniProtKB: Q9Y2R43   

Export aliases for DDX52 gene to outside databases

Previous GC identifers: GC17M035703 GC17M036168 GC17M036167 GC17M033047 GC17M031909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDX52 Gene:
DDX52 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 52) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

Gene Wiki entry for DDX52 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX52 gene promoter:
         E2F-4   E2F-3a   ER-alpha   E2F-5   p53   E2F-2   POU2F1   E2F   E2F-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX52 promoter sequence
   Search Chromatin IP Primers for DDX52

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX52


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1

DDX52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX52 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M035969:  view genomic region     (about GC identifiers)

Start:
35,969,787 bp from pter      End:
36,003,493 bp from pter
Size:
33,707 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX52_HUMAN, Q9Y2R4 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX52  
Size: 599 amino acids; 67498 Da
Sequence caution: Sequence=AAD27766.1; Type=Frameshift; Positions=324, 327, 330, 350, 365, 377; Sequence=AK093661;
Type=Miscellaneous discrepancy; Note=Cloning artifact; Sequence=BAA91812.1; Type=Miscellaneous discrepancy;
Note=Cloning artifact; Sequence=CAA09374.1; Type=Frameshift; Positions=355, 377;
1 PDB 3D structure from and Proteopedia for DDX52:
3DKP (3D)    
Secondary accessions: Q86YG1 Q8N213 Q9NVE0 Q9Y482

Explore the universe of human proteins at neXtProt for DDX52: NX_Q9Y2R4

Explore proteomics data for DDX52 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX52 (Q9Y2R4) (see all 16)
     VIHAERT  PPVLVFV  VINYDFP  NVDVIHA 


    See DDX52 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008941.2  
    ENSEMBL proteins: 
     ENSP00000466534   ENSP00000268854   ENSP00000445989   ENSP00000443408   ENSP00000466128  
     ENSP00000377893  

    DDX52 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DDX52
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DDX52
    GenScript Custom Purified and Recombinant Proteins Services for DDX52
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX52

     
    Search eBioscience for Proteins for DDX52 

    DDX52 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals DDX52 Antibodies
    Abcam antibodies for DDX52
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    Search ThermoFisher Antibodies for DDX52
    LSBio Antibodies in human, mouse, rat for DDX52

    DDX52 Assay Products:

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    Cloud-Clone Corp. ELISAs for DDX52
    Cloud-Clone Corp. CLIAs for DDX52
    Search eBioscience for ELISAs for DDX52 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9Y2R4

    ProtoNet protein and cluster: Q9Y2R4

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX52_HUMAN, Q9Y2R4
    Similarity: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX52           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX52_HUMAN, Q9Y2R4
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003723RNA binding ----
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DDX52           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX52:
     Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ddx52):
     growth/size/body 

    Find genes that share phenotypes with DDX52           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX52
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDX52

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX52
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX52

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX52:
    hsa-mir-16-5p (MIRT031427)

    Block miRNA regulation of human, mouse, rat DDX52 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX52 (see all 26):
    hsa-miR-361-5p hsa-miR-4311 hsa-miR-607 hsa-miR-4251 hsa-miR-539 hsa-miR-3653 hsa-miR-520a-5p hsa-miR-197
    SwitchGear 3'UTR luciferase reporter plasmidDDX52 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDX52
    Predesigned siRNA for gene silencing in human, mouse, rat DDX52

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDX52

    Clone
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    OriGene clones in human, mouse for DDX52 (see all 12)
    OriGene ORF clones in mouse, rat for DDX52
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX52 (NM_007010)
    Sino Biological Human cDNA Clone for DDX52
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX52
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX52

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DDX52 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX52


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX52_HUMAN, Q9Y2R4: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with DDX52           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX52
    Interactions:

        Search GeneGlobe Interaction Network for DDX52

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX52 (Q9Y2R43 ENSP000002688544) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX52



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX52 gene (2 alternative transcripts): 
    NM_152300.2  NM_007010.3  

    Unigene Cluster for DDX52:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
    Hs.590937  [show with all ESTs]
    Unigene Representative Sequence: NM_007010
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591354 ENST00000349699(uc002hoi.2) ENST00000488402 ENST00000592520
    ENST00000460080 ENST00000589411 ENST00000587431 ENST00000491963(uc002hoj.1)
    ENST00000394367(uc002hoh.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDX52 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX52 (see all 26):
    hsa-miR-361-5p hsa-miR-4311 hsa-miR-607 hsa-miR-4251 hsa-miR-539 hsa-miR-3653 hsa-miR-520a-5p hsa-miR-197
    SwitchGear 3'UTR luciferase reporter plasmidDDX52 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDX52
    Predesigned siRNA for gene silencing in human, mouse, rat DDX52
    Clone
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    OriGene clones in human, mouse for DDX52 (see all 12)
    OriGene ORF clones in mouse, rat for DDX52
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX52 (NM_007010)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX52
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX52
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDX52
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX52
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX52
      QuantiTect SYBR Green Assays in human, mouse, rat DDX52
      QuantiFast Probe-based Assays in human, mouse, rat DDX52

    Additional mRNA sequence: 

    AB208938.1 AF077033.1 AJ010840.1 AK001245.1 AK001652.1 AK025721.1 AK027425.1 AK093661.1 
    BC006489.2 BC012557.1 BC041785.1 

    9 DOTS entries:

    DT.113614  DT.95270618  DT.120918398  DT.100778682  DT.422496  DT.120918407  DT.40131436  DT.100778684 
    DT.100778686 

    Selected AceView cDNA sequences (see all 207):

    AA806622 AA563590 BG286433 AU105495 BU902724 BE044119 BM784554 W20474 
    AA456419 BC041785 AA443492 AI201605 AI161405 AA947786 AJ709778 AL703638 
    BE349995 CR613865 BM550361 AA460140 AK025721 AA953554 AA313565 AI811496 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX52 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
    SP1:                    -     -                                                     -                                                   
    SP2:                          -                                                     -                                                   
    SP3:                    -     -                                                     -                                                   
    SP4:                    -                                                           -                                                   
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for DDX52

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX52 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTCCTG
    DDX52 Expression
    About this image


    DDX52 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    DDX52 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX52 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590937
        Custom PCR Arrays for DDX52
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DDX52
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX52

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX52 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx521 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 521, 5 86.66(n)1
    88.94(a)1
      11 (51.24 cM)5
    783941  NM_030096.21  NP_084372.21 
     839420625 
    chicken
    (Gallus gallus)
    Aves DDX521 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 72.07(n)
    75.69(a)
      417660  NM_001030725.2  NP_001025896.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX526
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
    72(a)
    1 ↔ 1
    GL345013.1(480-13720)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044017.12   -- 74.06(n)    BC044017.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI887111.12   -- 74.94(n)    BI887111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55891 CG5589 56.07(n)
    53.78(a)
      39979  NM_140752.3  NP_649009.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R05D11.41 R05D11.4 51.37(n)
    43.37(a)
      172651  NM_059925.4  NP_492326.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ROK1(YGL171W)4
    ROK11
    ATP-dependent RNA helicase of the DEAD box family; more4
    ROK11
    53.67(n)1
    44.36(a)1
      7(182390-184084)4
    8527041, 4  NP_011344.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G097201 AT3G09720 53.37(n)
    44.89(a)
      820129  NM_111806.6  NP_187583.2 
    rice
    (Oryza sativa)
    Liliopsida Os.112582 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.22(n)    AK063527.1 


    ENSEMBL Gene Tree for DDX52 (if available)
    TreeFam Gene Tree for DDX52 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX52 gene
    Selected SIMAP similar genes for DDX52 using alignment to 6 protein entries:     DDX52_HUMAN (see all proteins) (see all similar genes):
    DKFZp547B159    BAT1    DDX39B    DDX41    EIF4A1    DDX54
    EIF4A2    DDX59    EIF4A3    DDX3X    DDX27    DDX3Y
    DDX42    DDX53    E4-DBP    DDX17    DDX46    DDX47

    Find genes that share paralogs with DDX52           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX52 (see all 691)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889332511,2
    --35972009(+) AAAAAA/CAAAAC 1 -- ds50010--------
    rs45739781,2
    C--35972014(+) aaaaaA/Caaaac 1 -- ds50013Minor allele frequency- C:0.17NA WA CSA 6
    rs2005456641,2
    C--35972014(+) AAAAA-/CAAAAC 1 -- ds50010--------
    rs2014745581,2
    --35972019(+) AAAAC-/AAAAAC 1 -- ds50010--------
    rs129467001,2
    C--35972024(+) caaaaA/Caaaaa 1 -- ds50012Minor allele frequency- C:0.25NA WA 4
    rs1485201751,2
    C--35972119(+) TATAA-/TGTGTGT 1 -- ds50010--------
    rs1997078991,2
    --35972123(+) TGTGT-/GCGTGTG 1 -- ds50010--------
    rs579621761,2
    C,F--35972254(+) GTAGCC/TGGGAC 1 -- ds50014Minor allele frequency- T:0.30WA NA EA 360
    rs1929337941,2
    --35972255(+) TAGCCA/GGGACT 1 -- ds50010--------
    rs1169936351,2
    F--35972275(+) CACCCG/AGCTAA 1 -- ds50011Minor allele frequency- A:0.02EA 120

    HapMap Linkage Disequilibrium report for DDX52 (35969787 - 36003493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDX52:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833431CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX52
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX52

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612500    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DDX52:
    Congenital diaphragmatic hernia

    Find genes that share disorders with DDX52           About GenesLikeMe

    Genetic Association Database (GAD): DDX52

    Export disorders for DDX52 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX52 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with DDX52)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 3 Stanchi F.... Valle G. (Yeast 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    5. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11056 HGNC: 20038 AceView: DDX52 Ensembl:ENSG00000141141 euGenes: HUgn11056
    ECgene: DDX52 H-InvDB: DDX52

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX52 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX52 gene:
    Search GeneIP for patents involving DDX52

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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