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Aliases for DDX51 Gene

Aliases for DDX51 Gene

  • DEAD-Box Helicase 51 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 51 2 5
  • DEAD Box Protein 51 4
  • EC 4
  • EC 3.6.1 63

External Ids for DDX51 Gene

Previous GeneCards Identifiers for DDX51 Gene

  • GC12M132503
  • GC12M131117
  • GC12M131289
  • GC12M132621
  • GC12M129506

Summaries for DDX51 Gene

GeneCards Summary for DDX51 Gene

DDX51 (DEAD-Box Helicase 51) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for DDX51 Gene

  • ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX51 Gene

Genomics for DDX51 Gene

Regulatory Elements for DDX51 Gene

Enhancers for DDX51 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX51 on UCSC Golden Path with GeneCards custom track

Promoters for DDX51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX51 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX51 Gene

132,136,594 bp from pter
132,144,335 bp from pter
7,742 bases
Minus strand

Genomic View for DDX51 Gene

Genes around DDX51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX51 Gene

Proteins for DDX51 Gene

  • Protein details for DDX51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX51
    Protein Accession:
    Secondary Accessions:
    • A8MPT9
    • Q5CZ71
    • Q8IXK5
    • Q96ED1

    Protein attributes for DDX51 Gene

    666 amino acids
    Molecular mass:
    72457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDX51 Gene

Proteomics data for DDX51 Gene at MOPED

Selected DME Specific Peptides for DDX51 Gene

Post-translational modifications for DDX51 Gene

  • Ubiquitination at Lys 211
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX51 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DDX51 Gene

Gene Families for DDX51 Gene

Suggested Antigen Peptide Sequences for DDX51 Gene

Graphical View of Domain Structure for InterPro Entry



  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
genes like me logo Genes that share domains with DDX51: view

Function for DDX51 Gene

Molecular function for DDX51 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

Enzyme Numbers (IUBMB) for DDX51 Gene

Gene Ontology (GO) - Molecular Function for DDX51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX51: view
genes like me logo Genes that share phenotypes with DDX51: view

Animal Models for DDX51 Gene

MGI Knock Outs for DDX51:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX51 Gene

Localization for DDX51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX51 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for DDX51 Gene COMPARTMENTS Subcellular localization image for DDX51 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DDX51 Gene

Pathways & Interactions for DDX51 Gene

SuperPathways for DDX51 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX51 Gene


No data available for Pathways by source and SIGNOR curated interactions for DDX51 Gene

Drugs & Compounds for DDX51 Gene

(1) Drugs for DDX51 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX51 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX51: view

Transcripts for DDX51 Gene

Unigene Clusters for DDX51 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 51:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX51 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP5: -

Relevant External Links for DDX51 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX51 Gene

mRNA expression in normal human tissues for DDX51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX51 Gene

This gene is overexpressed in Lung (17.7), CD8 Tcells (12.9), Pancreas (10.7), and Blymphocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX51 Gene

SOURCE GeneReport for Unigene cluster for DDX51 Gene Hs.445168

genes like me logo Genes that share expression patterns with DDX51: view

Protein tissue co-expression partners for DDX51 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX51 Gene

Orthologs for DDX51 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX51 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX51 35
  • 82.34 (n)
  • 83.3 (a)
DDX51 36
  • 82 (a)
(Canis familiaris)
Mammalia DDX51 35
  • 80.02 (n)
  • 77.11 (a)
DDX51 36
  • 76 (a)
(Mus musculus)
Mammalia Ddx51 35
  • 80 (n)
  • 80 (a)
Ddx51 16
Ddx51 36
  • 76 (a)
(Pan troglodytes)
Mammalia DDX51 35
  • 99.12 (n)
  • 98.99 (a)
DDX51 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ddx51 35
  • 79.5 (n)
  • 77.67 (a)
(Monodelphis domestica)
Mammalia DDX51 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia DDX51 36
  • 62 (a)
(Gallus gallus)
Aves DDX51 35
  • 62.38 (n)
  • 60.78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx51 35
  • 56.45 (n)
  • 54.8 (a)
Str.12327 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13840 35
(Danio rerio)
Actinopterygii ddx51 35
  • 56.98 (n)
  • 51.82 (a)
Dr.4368 35
ddx51 36
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11218 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006941 35
  • 45.64 (n)
  • 36.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbp73D 35
  • 48.74 (n)
  • 44.29 (a)
Dbp73D 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea ZK686.2 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP6 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH1 35
  • 47.15 (n)
  • 42.34 (a)
(Oryza sativa)
Liliopsida Os02g0795900 35
  • 47.93 (n)
  • 42.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5286 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2296 36
  • 37 (a)
Species with no ortholog for DDX51:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX51 Gene

Gene Tree for DDX51 (if available)
Gene Tree for DDX51 (if available)

Paralogs for DDX51 Gene

(1) SIMAP similar genes for DDX51 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DDX51: view

No data available for Paralogs for DDX51 Gene

Variants for DDX51 Gene

Sequence variations from dbSNP and Humsavar for DDX51 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_055299 -
VAR_055300 -
VAR_055301 -
rs17857213 - 132,142,347(+) CGCTA(A/G)GCCGG reference, missense
rs1133690 - 132,142,123(-) GGCCC(A/G)GCAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DDX51 Gene

Variant ID Type Subtype PubMed ID
nsv899699 CNV Gain 21882294
dgv1519n71 CNV Loss 21882294
dgv1520n71 CNV Loss 21882294
nsv899720 CNV Loss 21882294
dgv1521n71 CNV Loss 21882294
nsv428285 CNV Gain 18775914
dgv1522n71 CNV Loss 21882294
dgv1523n71 CNV Loss 21882294
dgv1524n71 CNV Loss 21882294
nsv509493 CNV Insertion 20534489
nsv470333 CNV Loss 18288195
dgv103n21 CNV Loss 19592680
nsv826563 CNV Gain 20364138
nsv899739 CNV Loss 21882294
nsv899740 CNV Loss 21882294
dgv1525n71 CNV Loss 21882294
nsv899743 CNV Loss 21882294
nsv899744 CNV Loss 21882294
nsv944 CNV Insertion 18451855
nsv899745 CNV Loss 21882294

Variation tolerance for DDX51 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDX51 Gene

Disorders for DDX51 Gene

Relevant External Links for DDX51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX51 Gene

Publications for DDX51 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DDX51 Gene

Sources for DDX51 Gene