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Aliases for DDX51 Gene

Aliases for DDX51 Gene

  • DEAD-Box Helicase 51 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 51 2
  • DEAD Box Protein 51 4
  • EC 3.6.4.13 4
  • EC 3.6.1 61

External Ids for DDX51 Gene

Previous GeneCards Identifiers for DDX51 Gene

  • GC12M132503
  • GC12M131117
  • GC12M131289
  • GC12M132621
  • GC12M129506

Summaries for DDX51 Gene

GeneCards Summary for DDX51 Gene

DDX51 (DEAD-Box Helicase 51) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for DDX51 Gene

  • ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX51 Gene

Genomics for DDX51 Gene

Regulatory Elements for DDX51 Gene

Enhancers for DDX51 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F132069 1 Ensembl ENCODE 44.1 +72.9 72948 2.9 HDGF CTCF KLF1 ESRRA MXI1 ZIC2 RAD21 ZFHX2 EGR1 POLR2A DDX51 SNORA49 EP400NL ENSG00000257000
GH12F132083 0.2 ENCODE 41.4 +59.7 59659 2.2 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 FOS SP3 SP5 EP400NL DDX51 ENSG00000279640
GH12F132153 0.8 Ensembl ENCODE 35.5 -9.7 -9705 1.5 KLF17 ARID4B SIN3A ZNF48 ZSCAN9 ZNF2 RAD21 ZNF121 GLIS2 ZNF143 DDX51 RPS6P21 RPS6P20 EP400NL GC12P132155 NOC4L
GH12F131864 0.5 ENCODE 34.3 +279.0 278955 1.2 ATF1 PKNOX1 ZNF133 SIN3A YBX1 PLRG1 RAD21 ZNF155 ZNF302 SMARCC2 EP400 GOLGA3 SFSWAP DDX51 ENSG00000255933 FBRSL1 NOC4L EP400NL RNU6-1017P MMP17
GH12F132162 1.5 FANTOM5 Ensembl ENCODE 28.1 -18.6 -18566 1.8 CTCF KLF1 KLF17 MAX ZIC2 HIC1 ZNF664 ZNF23 ZNF316 GLIS2 DDX51 EP400NL ULK1 FBRSL1 SFSWAP LOC105370090 GC12P132155
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DDX51 on UCSC Golden Path with GeneCards custom track

Promoters for DDX51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000439592 135 2001 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143

Genomic Location for DDX51 Gene

Chromosome:
12
Start:
132,136,594 bp from pter
End:
132,144,335 bp from pter
Size:
7,742 bases
Orientation:
Minus strand

Genomic View for DDX51 Gene

Genes around DDX51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX51 Gene

Proteins for DDX51 Gene

  • Protein details for DDX51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8A6-DDX51_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX51
    Protein Accession:
    Q8N8A6
    Secondary Accessions:
    • A8MPT9
    • Q5CZ71
    • Q8IXK5
    • Q96ED1

    Protein attributes for DDX51 Gene

    Size:
    666 amino acids
    Molecular mass:
    72457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDX51 Gene

Selected DME Specific Peptides for DDX51 Gene

Post-translational modifications for DDX51 Gene

  • Ubiquitination at Lys 211
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX51 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DDX51 Gene

Gene Families for DDX51 Gene

Suggested Antigen Peptide Sequences for DDX51 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8A6

UniProtKB/Swiss-Prot:

DDX51_HUMAN :
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
Domain:
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
genes like me logo Genes that share domains with DDX51: view

Function for DDX51 Gene

Molecular function for DDX51 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

Enzyme Numbers (IUBMB) for DDX51 Gene

Gene Ontology (GO) - Molecular Function for DDX51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX51: view
genes like me logo Genes that share phenotypes with DDX51: view

Animal Models for DDX51 Gene

MGI Knock Outs for DDX51:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX51 Gene

Localization for DDX51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX51 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX51 Gene COMPARTMENTS Subcellular localization image for DDX51 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DDX51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX51: view

Pathways & Interactions for DDX51 Gene

SuperPathways for DDX51 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with DDX51: view

No data available for Pathways by source and SIGNOR curated interactions for DDX51 Gene

Drugs & Compounds for DDX51 Gene

(3) Drugs for DDX51 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX51 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX51: view

Transcripts for DDX51 Gene

Unigene Clusters for DDX51 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 51:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX51 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for DDX51 Gene

GeneLoc Exon Structure for
DDX51
ECgene alternative splicing isoforms for
DDX51

Expression for DDX51 Gene

mRNA expression in normal human tissues for DDX51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX51 Gene

This gene is overexpressed in Lung (17.7), CD8 Tcells (12.9), Pancreas (10.7), and Blymphocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX51 Gene



Protein tissue co-expression partners for DDX51 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX51 Gene:

DDX51

SOURCE GeneReport for Unigene cluster for DDX51 Gene:

Hs.445168
genes like me logo Genes that share expression patterns with DDX51: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX51 Gene

Orthologs for DDX51 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX51 34 35
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia DDX51 34 35
  • 82.34 (n)
dog
(Canis familiaris)
Mammalia DDX51 34 35
  • 80.02 (n)
mouse
(Mus musculus)
Mammalia Ddx51 34 16 35
  • 80 (n)
rat
(Rattus norvegicus)
Mammalia Ddx51 34
  • 79.5 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX51 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX51 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX51 34
  • 62.38 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx51 34
  • 56.45 (n)
Str.12327 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13840 34
zebrafish
(Danio rerio)
Actinopterygii ddx51 34 35
  • 56.98 (n)
Dr.4368 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11218 34
fruit fly
(Drosophila melanogaster)
Insecta Dbp73D 34 35
  • 48.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006941 34
  • 45.64 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK686.2 35
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP6 35
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons RH1 34
  • 47.15 (n)
rice
(Oryza sativa)
Liliopsida Os02g0795900 34
  • 47.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2296 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5286 34
Species where no ortholog for DDX51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX51 Gene

ENSEMBL:
Gene Tree for DDX51 (if available)
TreeFam:
Gene Tree for DDX51 (if available)

Paralogs for DDX51 Gene

(1) SIMAP similar genes for DDX51 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DDX51: view

No data available for Paralogs for DDX51 Gene

Variants for DDX51 Gene

Sequence variations from dbSNP and Humsavar for DDX51 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10128884 -- 132,137,079(+) tttct(A/G)tcagA utr-variant-3-prime
rs10128885 -- 132,137,209(+) GGGAC(A/G)GGAAT utr-variant-3-prime
rs10794454 -- 132,146,277(+) GGCTT(C/T)TTCCA intron-variant, upstream-variant-2KB
rs10902498 -- 132,145,355(+) GTCCT(G/T)GGGTA intron-variant, upstream-variant-2KB
rs111226738 -- 132,140,817(+) CACAC(A/G)GTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX51 Gene

Variant ID Type Subtype PubMed ID
dgv103n21 CNV loss 19592680
nsv1041402 CNV gain 25217958
nsv1070571 CNV deletion 25765185
nsv428285 CNV gain 18775914
nsv470333 CNV loss 18288195
nsv509493 CNV insertion 20534489
nsv560935 CNV loss 21841781
nsv826563 CNV gain 20364138
nsv944 CNV insertion 18451855
nsv952511 CNV deletion 24416366

Variation tolerance for DDX51 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX51 Gene

Disorders for DDX51 Gene

Relevant External Links for DDX51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX51

No disorders were found for DDX51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX51 Gene

Publications for DDX51 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for DDX51 Gene

Sources for DDX51 Gene

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