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Aliases for DDX51 Gene

Aliases for DDX51 Gene

  • DEAD-Box Helicase 51 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 51 2
  • DEAD Box Protein 51 4
  • EC 3.6.4.13 4
  • EC 3.6.1 56

External Ids for DDX51 Gene

Previous GeneCards Identifiers for DDX51 Gene

  • GC12M132503
  • GC12M131117
  • GC12M131289
  • GC12M132621
  • GC12M129506

Summaries for DDX51 Gene

GeneCards Summary for DDX51 Gene

DDX51 (DEAD-Box Helicase 51) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for DDX51 Gene

  • ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

Additional gene information for DDX51 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX51 Gene

Genomics for DDX51 Gene

GeneHancer (GH) Regulatory Elements for DDX51 Gene

Promoters and enhancers for DDX51 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I132142 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.5 0.0 -11 2.7 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 DDX51 NOC4L EP400P1 GALNT9 ZNF605 ZNF84 LINC02361
GH12I132597 Enhancer 1.2 Ensembl ENCODE 96.4 -454.0 -453979 1.8 HDGF ARNT YBX1 ZNF2 ZNF143 ZNF548 SP3 ZNF662 REST ZNF592 ZNF140 EP400 ZNF84 ZNF268 ZNF891 ZNF26 GOLGA3 ZNF605 ANKLE2 DDX51
GH12I132083 Promoter/Enhancer 1.6 Ensembl ENCODE 41.4 +59.7 59659 2.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 POLR2B EP400P1 ENSG00000274670 DDX51 ENSG00000279640
GH12I131709 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.8 +433.0 432955 2.8 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 SFSWAP EP400 NOC4L DDX51 EP400P1 FBRSL1 PUS1 ENSG00000255933
GH12I133129 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.8 -986.2 -986166 2.6 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF891 ZNF10 ENSG00000256825 ZNF84 DDX51 ZNF605 ZNF268 ZNF140 CHFR ENSG00000250790
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DDX51 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDX51 gene promoter:

Genomic Locations for DDX51 Gene

Genomic Locations for DDX51 Gene
chr12:132,136,594-132,144,335
(GRCh38/hg38)
Size:
7,742 bases
Orientation:
Minus strand
chr12:132,621,139-132,628,880
(GRCh37/hg19)

Genomic View for DDX51 Gene

Genes around DDX51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX51 Gene

Proteins for DDX51 Gene

  • Protein details for DDX51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8A6-DDX51_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX51
    Protein Accession:
    Q8N8A6
    Secondary Accessions:
    • A8MPT9
    • Q5CZ71
    • Q8IXK5
    • Q96ED1

    Protein attributes for DDX51 Gene

    Size:
    666 amino acids
    Molecular mass:
    72457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDX51 Gene

Selected DME Specific Peptides for DDX51 Gene

Q8N8A6:
  • RVGRTAR
  • TGSGKTLA
  • APTGSGKT
  • ATPGRLVD
  • DEADRMID
  • TPGRLVDH
  • YVHRVGRT
  • VATPGRL
  • IVVATPGR

Post-translational modifications for DDX51 Gene

Other Protein References for DDX51 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DDX51 Gene

Gene Families for DDX51 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX51 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8A6

UniProtKB/Swiss-Prot:

DDX51_HUMAN :
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
  • Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
Domain:
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Family:
  • Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
genes like me logo Genes that share domains with DDX51: view

Function for DDX51 Gene

Molecular function for DDX51 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.

Enzyme Numbers (IUBMB) for DDX51 Gene

Phenotypes From GWAS Catalog for DDX51 Gene

Gene Ontology (GO) - Molecular Function for DDX51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX51: view
genes like me logo Genes that share phenotypes with DDX51: view

Animal Models for DDX51 Gene

MGI Knock Outs for DDX51:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX51 Gene

Localization for DDX51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX51 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX51 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with DDX51: view

Pathways & Interactions for DDX51 Gene

SuperPathways for DDX51 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with DDX51: view

No data available for Pathways by source and SIGNOR curated interactions for DDX51 Gene

Drugs & Compounds for DDX51 Gene

(3) Drugs for DDX51 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for DDX51 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX51: view

Transcripts for DDX51 Gene

Unigene Clusters for DDX51 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 51:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX51 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:
SP3:
SP4:
SP5: -

Relevant External Links for DDX51 Gene

GeneLoc Exon Structure for
DDX51
ECgene alternative splicing isoforms for
DDX51

Expression for DDX51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX51 Gene

This gene is overexpressed in Lung (17.7), CD8 Tcells (12.9), Pancreas (10.7), and Blymphocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX51 Gene



Protein tissue co-expression partners for DDX51 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX51 Gene:

DDX51

SOURCE GeneReport for Unigene cluster for DDX51 Gene:

Hs.445168

Evidence on tissue expression from TISSUES for DDX51 Gene

  • Eye(4.6)
  • Intestine(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with DDX51: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX51 Gene

Orthologs for DDX51 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX51 33 34
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia DDX51 33 34
  • 82.34 (n)
dog
(Canis familiaris)
Mammalia DDX51 33 34
  • 80.02 (n)
mouse
(Mus musculus)
Mammalia Ddx51 33 16 34
  • 80 (n)
rat
(Rattus norvegicus)
Mammalia Ddx51 33
  • 79.5 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX51 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX51 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX51 33
  • 62.38 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx51 33
  • 56.45 (n)
Str.12327 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13840 33
zebrafish
(Danio rerio)
Actinopterygii ddx51 33 34
  • 56.98 (n)
Dr.4368 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11218 33
fruit fly
(Drosophila melanogaster)
Insecta Dbp73D 33 34
  • 48.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006941 33
  • 45.64 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK686.2 34
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP6 34
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons RH1 33
  • 47.15 (n)
rice
(Oryza sativa)
Liliopsida Os02g0795900 33
  • 47.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2296 34
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5286 33
Species where no ortholog for DDX51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX51 Gene

ENSEMBL:
Gene Tree for DDX51 (if available)
TreeFam:
Gene Tree for DDX51 (if available)

Paralogs for DDX51 Gene

(1) SIMAP similar genes for DDX51 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DDX51: view

No data available for Paralogs for DDX51 Gene

Variants for DDX51 Gene

Sequence variations from dbSNP and Humsavar for DDX51 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000269617 -- 132,142,812(-) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1000521431 -- 132,143,414(-) C/G intron_variant
rs1000575013 -- 132,140,616(-) T/C intron_variant
rs1000819124 -- 132,143,415(-) G/A intron_variant
rs1000922669 -- 132,136,931(-) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DDX51 Gene

Variant ID Type Subtype PubMed ID
dgv103n21 CNV loss 19592680
nsv1041402 CNV gain 25217958
nsv1070571 CNV deletion 25765185
nsv428285 CNV gain 18775914
nsv470333 CNV loss 18288195
nsv509493 CNV insertion 20534489
nsv560935 CNV loss 21841781
nsv826563 CNV gain 20364138
nsv944 CNV insertion 18451855
nsv952511 CNV deletion 24416366

Variation tolerance for DDX51 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.22; 90.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDX51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX51 Gene

Disorders for DDX51 Gene

Additional Disease Information for DDX51

No disorders were found for DDX51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX51 Gene

Publications for DDX51 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for DDX51 Gene

Sources for DDX51 Gene

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