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Aliases for DDX50 Gene

Aliases for DDX50 Gene

  • DExD-Box Helicase 50 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50 2 3
  • DEAD-Box Helicase 50 2 3
  • DEAD Box Protein 50 3 4
  • Gu-Beta 3 4
  • Malignant Cell Derived RNA Helicase 3
  • ATP-Dependent RNA Helicase DDX50 3
  • RNA Helicase II/Gu Beta 3
  • Nucleolar Protein GU2 3
  • Nucleolar Protein Gu2 4
  • EC 4
  • RH-II/GuB 3
  • EC 3.6.1 61
  • Mcdrh 3
  • GU2 3
  • GUB 3

External Ids for DDX50 Gene

Previous GeneCards Identifiers for DDX50 Gene

  • GC10P070553
  • GC10P070005
  • GC10P070331
  • GC10P070661
  • GC10P064662

Summaries for DDX50 Gene

Entrez Gene Summary for DDX50 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX50 Gene

DDX50 (DExD-Box Helicase 50) is a Protein Coding gene. Diseases associated with DDX50 include Rectal Disease. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX21.

Gene Wiki entry for DDX50 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX50 Gene

Genomics for DDX50 Gene

Regulatory Elements for DDX50 Gene

Enhancers for DDX50 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F069179 1.2 ENCODE 71.7 +281.7 281688 3.3 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 DDX50 CCAR1 DDX21 TYSND1 MIR1254-1 HKDC1 SUPV3L1 LOC101928994 VPS26A
GH10F069085 1.5 FANTOM5 ENCODE 40.9 +191.0 191047 8.7 HDGF PKNOX1 ARNT WRNIP1 SIN3A ZNF2 YY1 CBX5 ZNF207 ZNF263 DDX50 DDX21 CCAR1 SRGN RUFY2 MIR1254-1 SUPV3L1 HKDC1 PBLD LOC101928994
GH10F068526 1.2 ENCODE 40.2 -371.7 -371677 2.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DDX50 DNA2 CCAR1 SUPV3L1 SIRT1 MIR1254-1 DDX21 RPL12P8 SLC25A16 ENSG00000207438
GH10F068954 1.2 ENCODE 30.1 +57.5 57538 3.8 MLX CREB3L1 YBX1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 DDX50 DDX21 CCAR1 KIF1BP MIR1254-1 STOX1 GC10P068966
GH10F068091 1.4 FANTOM5 Ensembl ENCODE 25.4 -804.8 -804765 4.8 TBP ESRRA TAF1 DDX20 JUN SIN3A MAX RFX5 ZKSCAN1 GTF3C2 CCAR1 DDX50 SIRT1 ATOH7 ENSG00000233590 HNRNPH3 PBLD MIR1254-1 RPL12P8 DDX21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX50 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX50 Gene

68,898,972 bp from pter
68,946,847 bp from pter
47,876 bases
Plus strand

Genomic View for DDX50 Gene

Genes around DDX50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX50 Gene

Proteins for DDX50 Gene

  • Protein details for DDX50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX50
    Protein Accession:
    Secondary Accessions:
    • Q5VX37
    • Q8WV76
    • Q9BWI8

    Protein attributes for DDX50 Gene

    737 amino acids
    Molecular mass:
    82565 Da
    Quaternary structure:
    • Interacts with C1QBP.

    Three dimensional structures from OCA and Proteopedia for DDX50 Gene

neXtProt entry for DDX50 Gene

Selected DME Specific Peptides for DDX50 Gene


Post-translational modifications for DDX50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for DDX50 Gene

Gene Families for DDX50 Gene

Suggested Antigen Peptide Sequences for DDX50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
genes like me logo Genes that share domains with DDX50: view

Function for DDX50 Gene

Molecular function for DDX50 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX50 Gene

Gene Ontology (GO) - Molecular Function for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX50: view
genes like me logo Genes that share phenotypes with DDX50: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX50

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX50 Gene

Localization for DDX50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX50 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX50 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX50: view

Pathways & Interactions for DDX50 Gene

SuperPathways for DDX50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX50: view

No data available for Pathways by source and SIGNOR curated interactions for DDX50 Gene

Drugs & Compounds for DDX50 Gene

(3) Drugs for DDX50 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX50 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX50: view

Transcripts for DDX50 Gene

Unigene Clusters for DDX50 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 50:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX50 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP2: -
SP5: - -

Relevant External Links for DDX50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX50 Gene

Protein differential expression in normal tissues from HIPED for DDX50 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9) and Stomach (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX50 Gene

Protein tissue co-expression partners for DDX50 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX50 Gene:


SOURCE GeneReport for Unigene cluster for DDX50 Gene:

genes like me logo Genes that share expression patterns with DDX50: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX50 Gene

Orthologs for DDX50 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX50 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX50 34 35
  • 99.91 (n)
(Canis familiaris)
Mammalia DDX50 34 35
  • 95.65 (n)
(Bos Taurus)
Mammalia DDX50 34 35
  • 94.84 (n)
(Mus musculus)
Mammalia Ddx50 34 16 35
  • 92.74 (n)
(Rattus norvegicus)
Mammalia Ddx50 34
  • 92.3 (n)
(Monodelphis domestica)
Mammalia DDX50 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia DDX50 35
  • 57 (a)
(Gallus gallus)
Aves -- 35
  • 63 (a)
-- 35
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6015 34
(Danio rerio)
Actinopterygii ddx21 35
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TIF1 35
  • 32 (a)
TIF2 35
  • 32 (a)
DBP3 35
  • 31 (a)
MRH4 37
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1138 34
  • 49.73 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7087 34
(Oryza sativa)
Liliopsida Os03g0827700 34
  • 51.26 (n)
(Zea mays)
Liliopsida Zm.12927 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2984 35
  • 47 (a)
Species where no ortholog for DDX50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX50 Gene

Gene Tree for DDX50 (if available)
Gene Tree for DDX50 (if available)

Paralogs for DDX50 Gene

Paralogs for DDX50 Gene

(6) SIMAP similar genes for DDX50 Gene using alignment to 3 proteins: Pseudogenes for DDX50 Gene

genes like me logo Genes that share paralogs with DDX50: view

Variants for DDX50 Gene

Sequence variations from dbSNP and Humsavar for DDX50 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs374203626 Uncertain significance 68,906,745(+) TGACT(C/T)GGATG reference, missense, utr-variant-5-prime
rs10128256 -- 68,920,659(+) AATAT(A/C)TTTTG intron-variant
rs10400179 -- 68,931,860(+) TTTCA(C/G)TCTGT intron-variant
rs10509307 -- 68,950,602(+) AAAGT(G/T)ATTGG intron-variant
rs10509308 -- 68,937,355(+) AAGTC(C/T)GTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX50 Gene

Variant ID Type Subtype PubMed ID
esv2579637 CNV insertion 19546169
nsv519999 CNV loss 19592680
nsv831907 CNV gain 17160897

Variation tolerance for DDX50 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX50 Gene

Disorders for DDX50 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX50 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rectal disease
  • rectal disorders
- elite association - COSMIC cancer census association via MalaCards
Search DDX50 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX50

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DDX50: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX50 Gene

Publications for DDX50 Gene

  1. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. (PMID: 11891046) Valdez B.C. … Sequitin A.M. (Gene 2002) 2 3 4 22 64
  2. Solution structure of the GUCT domain from human RNA helicase II/Gu beta reveals the RRM fold, but implausible RNA interactions. (PMID: 18615715) Ohnishi S. … Yokoyama S. (Proteins 2009) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64

Products for DDX50 Gene

Sources for DDX50 Gene

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