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Aliases for DDX50 Gene

Aliases for DDX50 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50 2 3
  • DEAD Box Protein 50 3 4
  • Gu-Beta 3 4
  • GUB 3 6
  • Malignant Cell Derived RNA Helicase 3
  • ATP-Dependent RNA Helicase DDX50 3
  • RNA Helicase II/Gu Beta 3
  • Nucleolar Protein GU2 3
  • Nucleolar Protein Gu2 4
  • EC 3.6.4.13 4
  • RH-II/GuB 3
  • EC 3.6.1 64
  • Mcdrh 3
  • GU2 3

External Ids for DDX50 Gene

Summaries for DDX50 Gene

Entrez Gene Summary for DDX50 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX50 Gene

DDX50 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX21.

Gene Wiki entry for DDX50 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX50 Gene

Genomics for DDX50 Gene

Genomic Location for DDX50 Gene

Start:
68,901,278 bp from pter
End:
68,946,847 bp from pter
Size:
45,570 bases
Orientation:
Plus strand

Genomic View for DDX50 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX50 Gene

Regulatory Elements for DDX50 Gene

Proteins for DDX50 Gene

  • Protein details for DDX50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ39-DDX50_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX50
    Protein Accession:
    Q9BQ39
    Secondary Accessions:
    • Q5VX37
    • Q8WV76
    • Q9BWI8

    Protein attributes for DDX50 Gene

    Size:
    737 amino acids
    Molecular mass:
    82565 Da
    Quaternary structure:
    • Interacts with C1QBP.

    Three dimensional structures from OCA and Proteopedia for DDX50 Gene

neXtProt entry for DDX50 Gene

Proteomics data for DDX50 Gene at MOPED

Post-translational modifications for DDX50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX50 Gene

Domains for DDX50 Gene

Gene Families for DDX50 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX50_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q9BQ39
  • Contains 1 helicase C-terminal domain.:
    • Q9BQ39
Family:
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.:
    • Q9BQ39
genes like me logo Genes that share domains with DDX50: view

Function for DDX50 Gene

Molecular function for DDX50 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX50 Gene

Gene Ontology (GO) - Molecular Function for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003723 RNA binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
genes like me logo Genes that share ontologies with DDX50: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX50 Gene

Localization for DDX50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX50 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX50 Gene COMPARTMENTS Subcellular localization image for DDX50 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX50: view

Pathways for DDX50 Gene

SuperPathways for DDX50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX50: view

No data available for Pathways by source for DDX50 Gene

Transcripts for DDX50 Gene

Unigene Clusters for DDX50 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX50 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for DDX50 Gene

GeneLoc Exon Structure for
DDX50
ECgene alternative splicing isoforms for
DDX50

Expression for DDX50 Gene

mRNA expression in normal human tissues for DDX50 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX50 Gene

SOURCE GeneReport for Unigene cluster for DDX50 Gene Hs.522984

genes like me logo Genes that share expressions with DDX50: view

Orthologs for DDX50 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX50 36
  • 99.91 (n)
  • 99.86 (a)
DDX50 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX50 36
  • 94.84 (n)
  • 97.42 (a)
DDX50 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX50 36
  • 95.65 (n)
  • 97.95 (a)
DDX50 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx50 36
  • 92.74 (n)
  • 96 (a)
Ddx50 16
Ddx50 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX50 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX50 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx50 36
  • 92.3 (n)
  • 95.41 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6015 36
zebrafish
(Danio rerio)
Actinopterygii ddx21 37
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP3 37
  • 31 (a)
ManyToMany
MRH4 39
TIF1 37
  • 32 (a)
ManyToMany
TIF2 37
  • 32 (a)
ManyToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7087 36
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1138 36
  • 49.73 (n)
  • 41.68 (a)
corn
(Zea mays)
Liliopsida Zm.12927 36
rice
(Oryza sativa)
Liliopsida Os03g0827700 36
  • 51.26 (n)
  • 44.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2984 37
  • 47 (a)
OneToMany
Species with no ortholog for DDX50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX50 Gene

ENSEMBL:
Gene Tree for DDX50 (if available)
TreeFam:
Gene Tree for DDX50 (if available)

Paralogs for DDX50 Gene

Paralogs for DDX50 Gene

Selected SIMAP similar genes for DDX50 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DDX50 Gene

genes like me logo Genes that share paralogs with DDX50: view

Variants for DDX50 Gene

Sequence variations from dbSNP and Humsavar for DDX50 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs955413 -- 68,943,097(+) AGTTA(C/T)TTTTT intron-variant
rs1055599 -- 68,906,786(-) CAGGT(A/C)ATCTG reference, missense, utr-variant-5-prime
rs1055600 -- 68,906,731(-) TGGTG(C/G)CTTGA missense, reference, utr-variant-5-prime
rs1539166 -- 68,937,152(+) CATAG(G/T)AAATA intron-variant
rs1547806 -- 68,946,118(-) AATTA(A/C)ATGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX50 Gene

Variant ID Type Subtype PubMed ID
nsv831907 CNV Gain 17160897
esv2579637 CNV Insertion 19546169
nsv519999 CNV Loss 19592680

Relevant External Links for DDX50 Gene

HapMap Linkage Disequilibrium report
DDX50

Disorders for DDX50 Gene

Relevant External Links for DDX50

Genetic Association Database (GAD)
DDX50
genes like me logo Genes that share disorders with DDX50: view

No data available for UniProtKB/Swiss-Prot for DDX50 Gene

Publications for DDX50 Gene

  1. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. (PMID: 11891046) Valdez B.C. … Sequitin A.M. (Gene 2002) 2 3 4 23
  2. Solution structure of the GUCT domain from human RNA helicase II/Gu beta reveals the RRM fold, but implausible RNA interactions. (PMID: 18615715) Ohnishi S. … Yokoyama S. (Proteins 2009) 3 4 23
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3

Products for DDX50 Gene

Sources for DDX50 Gene

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