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Aliases for DDX50 Gene

Aliases for DDX50 Gene

  • DEAD-Box Helicase 50 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 50 2 3 5
  • DEAD Box Protein 50 3 4
  • Gu-Beta 3 4
  • Malignant Cell Derived RNA Helicase 3
  • RNA Helicase II/Gu Beta 3
  • Nucleolar Protein GU2 3
  • Nucleolar Protein Gu2 4
  • EC 3.6.4.13 4
  • RH-II/GuB 3
  • EC 3.6.1 63
  • Mcdrh 3
  • GU2 3
  • GUB 3

External Ids for DDX50 Gene

Previous GeneCards Identifiers for DDX50 Gene

  • GC10P070553
  • GC10P070005
  • GC10P070331
  • GC10P070661
  • GC10P064662

Summaries for DDX50 Gene

Entrez Gene Summary for DDX50 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box enzyme that may be involved in ribosomal RNA synthesis or processing. This gene and DDX21, also called RH-II/GuA, have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. This gene has pseudogenes on chromosomes 2, 3 and 4. Alternative splicing of this gene generates multiple transcript variants, but the full length nature of all the other variants but one has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX50 Gene

DDX50 (DEAD-Box Helicase 50) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX21.

Gene Wiki entry for DDX50 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX50 Gene

Genomics for DDX50 Gene

Regulatory Elements for DDX50 Gene

Enhancers for DDX50 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX50 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX50 Gene

Chromosome:
10
Start:
68,898,972 bp from pter
End:
68,946,847 bp from pter
Size:
47,876 bases
Orientation:
Plus strand

Genomic View for DDX50 Gene

Genes around DDX50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX50 Gene

Proteins for DDX50 Gene

  • Protein details for DDX50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ39-DDX50_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX50
    Protein Accession:
    Q9BQ39
    Secondary Accessions:
    • Q5VX37
    • Q8WV76
    • Q9BWI8

    Protein attributes for DDX50 Gene

    Size:
    737 amino acids
    Molecular mass:
    82565 Da
    Quaternary structure:
    • Interacts with C1QBP.

    Three dimensional structures from OCA and Proteopedia for DDX50 Gene

neXtProt entry for DDX50 Gene

Proteomics data for DDX50 Gene at MOPED

Post-translational modifications for DDX50 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX50 Gene

Domains & Families for DDX50 Gene

Gene Families for DDX50 Gene

Suggested Antigen Peptide Sequences for DDX50 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ39

UniProtKB/Swiss-Prot:

DDX50_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
genes like me logo Genes that share domains with DDX50: view

Function for DDX50 Gene

Molecular function for DDX50 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX50 Gene

Gene Ontology (GO) - Molecular Function for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX50: view
genes like me logo Genes that share phenotypes with DDX50: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX50

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX50 Gene

Localization for DDX50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX50 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX50 Gene COMPARTMENTS Subcellular localization image for DDX50 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with DDX50: view

Pathways & Interactions for DDX50 Gene

SuperPathways for DDX50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX50 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DDX50 Gene

Drugs & Compounds for DDX50 Gene

(1) Drugs for DDX50 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX50 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX50: view

Transcripts for DDX50 Gene

Unigene Clusters for DDX50 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX50 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2: -
SP3:
SP4:
SP5: - -

Relevant External Links for DDX50 Gene

GeneLoc Exon Structure for
DDX50
ECgene alternative splicing isoforms for
DDX50

Expression for DDX50 Gene

mRNA expression in normal human tissues for DDX50 Gene

Protein differential expression in normal tissues from HIPED for DDX50 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.9) and Stomach (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX50 Gene



SOURCE GeneReport for Unigene cluster for DDX50 Gene Hs.522984

genes like me logo Genes that share expression patterns with DDX50: view

Protein tissue co-expression partners for DDX50 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX50 Gene

Orthologs for DDX50 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX50 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX50 35
  • 94.84 (n)
  • 97.42 (a)
DDX50 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX50 35
  • 95.65 (n)
  • 97.95 (a)
DDX50 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx50 35
  • 92.74 (n)
  • 96 (a)
Ddx50 16
Ddx50 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX50 35
  • 99.91 (n)
  • 99.86 (a)
DDX50 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx50 35
  • 92.3 (n)
  • 95.41 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX50 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX50 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 61 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6015 35
zebrafish
(Danio rerio)
Actinopterygii ddx21 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP3 36
  • 31 (a)
ManyToMany
TIF1 36
  • 32 (a)
ManyToMany
TIF2 36
  • 32 (a)
ManyToMany
MRH4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1138 35
  • 49.73 (n)
  • 41.68 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7087 35
rice
(Oryza sativa)
Liliopsida Os03g0827700 35
  • 51.26 (n)
  • 44.67 (a)
corn
(Zea mays)
Liliopsida Zm.12927 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2984 36
  • 47 (a)
OneToMany
Species with no ortholog for DDX50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX50 Gene

ENSEMBL:
Gene Tree for DDX50 (if available)
TreeFam:
Gene Tree for DDX50 (if available)

Paralogs for DDX50 Gene

Paralogs for DDX50 Gene

(6) SIMAP similar genes for DDX50 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DDX50 Gene

genes like me logo Genes that share paralogs with DDX50: view

Variants for DDX50 Gene

Sequence variations from dbSNP and Humsavar for DDX50 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1539166 -- 68,937,152(+) CATAG(G/T)AAATA intron-variant
rs1547806 -- 68,946,118(-) AATTA(A/C)ATGTA intron-variant
rs3085755 -- 68,902,211(+) AAAAA(-/A/AA)GGAAA intron-variant
rs3085757 -- 68,930,563(-) GGCTA(-/GAGGCTA)CACCA intron-variant
rs3086395 -- 68,935,193(+) TTAGT(-/CCAGCATT)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX50 Gene

Variant ID Type Subtype PubMed ID
nsv831907 CNV Gain 17160897
esv2579637 CNV Insertion 19546169
nsv519999 CNV Loss 19592680

Variation tolerance for DDX50 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDX50 Gene

Disorders for DDX50 Gene

Relevant External Links for DDX50

Genetic Association Database (GAD)
DDX50
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX50

No disorders were found for DDX50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX50 Gene

Publications for DDX50 Gene

  1. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. (PMID: 11891046) Valdez B.C. … Sequitin A.M. (Gene 2002) 2 3 4 23 67
  2. Solution structure of the GUCT domain from human RNA helicase II/Gu beta reveals the RRM fold, but implausible RNA interactions. (PMID: 18615715) Ohnishi S. … Yokoyama S. (Proteins 2009) 3 23
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DDX50 Gene

Sources for DDX50 Gene

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