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DDX5 Gene

protein-coding   GIFtS: 68
GCID: GC17M062494

DEAD (Asp-Glu-Ala-Asp) Box Helicase 5

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase,...)
(Previous symbols: HLR1, G17P1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 51 2     ATP-Dependent RNA Helicase DDX52
G17P11 2 3 5     DEAD Box-52
HLR11 2 3 5     p682
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 51 2     Probable ATP-Dependent RNA Helicase DDX52
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 5 (RNA Helicase, 68kD)1 2     EC 3.6.4.133
DEAD Box Protein 52 3     HELR3
RNA Helicase P682 3     EC 3.6.18
HUMP682     

External Ids:    HGNC: 27461   Entrez Gene: 16552   Ensembl: ENSG000001086547   OMIM: 1806305   UniProtKB: P178443   

Export aliases for DDX5 gene to outside databases

Previous GC identifers: GC17M065876 GC17P068976 GC17M062913 GC17M063045 GC17M059926 GC17M057943


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX5 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also
a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This
gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been
detected, but no isoforms encoded by these transcripts have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX5 Gene:
DDX5 (DEAD (Asp-Glu-Ala-Asp) box helicase 5) is a protein-coding gene. GO annotations related to this gene include calmodulin binding and enzyme binding. An important paralog of this gene is DDX46.

UniProtKB/Swiss-Prot: DDX5_HUMAN, P17844
Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for
increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the
stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.
Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional
coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated
transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and
SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation.
Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and
p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast
differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves
association with histone deacetylases, such as HDAC1

Gene Wiki entry for DDX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX5 gene promoter:
         E2F-3a   E2F-4   E2F-5   p53   E2F-2   E47   Evi-1   C/EBPalpha   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): DDX5 promoter sequence
   Search Chromatin IP Primers for DDX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q21

DDX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M062494:  view genomic region     (about GC identifiers)

Start:
62,494,374 bp from pter      End:
62,504,317 bp from pter
Size:
9,944 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003315947 302,103-310,213     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX5_HUMAN, P17844 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX5  
Size: 614 amino acids; 69148 Da
Subunit: Interacts with BRDT (By similarity). Identified in the spliceosome C complex. Interacts with RBM4; the
interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1; the
interaction is enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300,
CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17
2 PDB 3D structures from and Proteopedia for DDX5:
3FE2 (3D)        4A4D (3D)    
Secondary accessions: B5BU21 D3DU32 O75681 Q53Y61

Explore the universe of human proteins at neXtProt for DDX5: NX_P17844

Explore proteomics data for DDX5 at MOPED

Post-translational modifications: 

  • Arg-502 is dimethylated, probably to asymmetric dimethylarginine1
  • Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression
    activity. Sumoylation also significantly increases stability, and reduces polyubiquitination1
  • Polyubiquitinated, leading to proteasomal degradation1
  • Ubiquitination2 at Lys56, Lys91, Lys197, Lys207, Lys236, Lys284, Lys340, Lys351, Lys375, Lys388,
                                 Lys411, Lys437, Lys451, Lys470, Lys529
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX5 (P17844) (see all 37)
     DMGFEPQ  LAPTREL  YGGAPKG  DEADRML 


    See DDX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004387.1  
    ENSEMBL proteins: 
     ENSP00000440276   ENSP00000464566   ENSP00000225792   ENSP00000403085   ENSP00000462885  
     ENSP00000464659   ENSP00000462222   ENSP00000463975   ENSP00000464337   ENSP00000464304  
     ENSP00000464064   ENSP00000463541   ENSP00000463101   ENSP00000464587   ENSP00000465791  
     ENSP00000462206   ENSP00000463903   ENSP00000463168  

    DDX5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DDX5
    OriGene Protein Over-expression Lysate for DDX5
    OriGene MassSpec for DDX5
    OriGene Custom Protein Services for DDX5
    GenScript Custom Purified and Recombinant Proteins Services for DDX5
    Novus Biologicals DDX5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX5

     
    Search eBioscience for Proteins for DDX5 

    DDX5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DDX5
    R&D Systems Antibodies for DDX5
    Cell Signaling Technology (CST) Antibodies for DDX5 
    OriGene Antibodies for DDX5
    OriGene Custom Antibody Services for DDX5
    Novus Biologicals DDX5 Antibodies
    Abcam antibodies for DDX5
    Cloud-Clone Corp. Antibodies for DDX5
    ThermoFisher Antibody for DDX5
    LSBio Antibodies in human, mouse, rat for DDX5

    DDX5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDX5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDX5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX5
    Cloud-Clone Corp. CLIAs for DDX5
    Search eBioscience for ELISAs for DDX5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR012587 P68HR
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif

    Graphical View of Domain Structure for InterPro Entry P17844

    ProtoNet protein and cluster: P17844

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX5_HUMAN, P17844
    Similarity: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX5_HUMAN, P17844
    Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for
    increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the
    stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.
    Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional
    coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated
    transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and
    SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation.
    Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and
    p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast
    differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves
    association with histone deacetylases, such as HDAC1
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for DDX5:
    DEAD/H box protein 5,putative RNA helicase

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003712transcription cofactor activity ----
    GO:0003713transcription coactivator activity IDA--
    GO:0003724RNA helicase activity NAS1996094
    GO:0004004ATP-dependent RNA helicase activity IEA--
         
    Find genes that share ontologies with DDX5           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DDX5:
     Actin fiber cells  Cell division defect  Increased mitotic index  Nuclear pre-40S maturation def 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ddx5):
     cardiovascular system  cellular  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with DDX5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDX5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX5

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX5:
    hsa-mir-20a-5p (MIRT050507), hsa-mir-340-5p (MIRT019588), hsa-mir-92a-3p (MIRT049294), hsa-mir-93-5p (MIRT028078), hsa-mir-130b-3p (MIRT020195), hsa-mir-23a-3p (MIRT050394), hsa-mir-18a-5p (MIRT050662), hsa-mir-15b-5p (MIRT046459), hsa-mir-24-3p (MIRT050373), hsa-mir-1 (MIRT002799), hsa-mir-205-5p (MIRT003236)

    Block miRNA regulation of human, mouse, rat DDX5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX5 (see all 98):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-106a hsa-miR-200a hsa-miR-519a hsa-miR-208b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidDDX5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDX5
    Predesigned siRNA for gene silencing in human, mouse, rat DDX5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDX5

    Clone
    Products:
         
    OriGene clones in human, mouse for DDX5 (see all 6)
    OriGene ORF clones in mouse, rat for DDX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX5 (NM_004396)
    Sino Biological Human cDNA Clone for DDX5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDX5
    Browse ESI BIO Cell Lines and PureStem Progenitors for DDX5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX5_HUMAN, P17844: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS2451786
    GO:0005730NOT nucleolus IDA--
    GO:0030529ribonucleoprotein complex IDA18809582
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with DDX5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDX5 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2Translational Control
    Translational Control
    3Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    4Spliceosome
    Spliceosome
    5Proteoglycans in cancer
    Proteoglycans in cancer


    Find genes that share SuperPaths with DDX5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DDX5
        Wnt / Hedgehog / Notch
    Translational Control

    1 BioSystems Pathway for DDX5
        Direct p53 effectors



    3 Kegg Pathways  (Kegg details for DDX5):
        Spliceosome
    Transcriptional misregulation in cancer
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including DDX5: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DDX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX5 (P178441, 2, 3 ENSP000002257924) via UniProtKB, MINT, STRING, and/or I2D (see all 1169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15298701
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA--
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-templated IEA--

    Find genes that share ontologies with DDX5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX5

    4 Novoseek inferred chemical compound relationships for DDX5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    11beta-hydroxysteroid 38.2 2 10658678 (1), 10720702 (1)
    tyrosine 7.38 4 15927448 (2), 17384675 (1), 17412694 (1)
    threonine 4.58 2 15927448 (1), 15972854 (1)
    serine 1.26 1 15972854 (1)



    Find genes that share compounds with DDX5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX5 gene: 
    NM_004396.3  

    Unigene Cluster for DDX5:

    DEAD (Asp-Glu-Ala-Asp) box helicase 5
    Hs.279806  [show with all ESTs]
    Unigene Representative Sequence: NM_004396
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000540698 ENST00000581693 ENST00000581230 ENST00000225792(uc010deh.2 uc002jek.2 uc002jej.2 uc010wqa.1)
    ENST00000450599 ENST00000578804 ENST00000580026 ENST00000578758 ENST00000581237
    ENST00000578491 ENST00000579461 ENST00000585317 ENST00000579996(uc002jel.1)
    ENST00000577787 ENST00000584549 ENST00000581551 ENST00000583201 ENST00000582326

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDX5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX5 (see all 98):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-106a hsa-miR-200a hsa-miR-519a hsa-miR-208b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidDDX5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDX5
    Predesigned siRNA for gene silencing in human, mouse, rat DDX5
    Clone
    Products:
         
    OriGene clones in human, mouse for DDX5 (see all 6)
    OriGene ORF clones in mouse, rat for DDX5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX5 (NM_004396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDX5
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX5
      QuantiTect SYBR Green Assays in human, mouse, rat DDX5
      QuantiFast Probe-based Assays in human, mouse, rat DDX5

    Additional mRNA sequence: 

    AB451257.1 AB451382.1 AK297192.1 AK297753.1 AK297905.1 AK310318.1 AL133585.1 AL359063.1 
    BC016027.1 BT006943.1 X15729.1 X52104.1 

    Selected DOTS entries (see all 101):

    DT.100703567  DT.95199726  DT.75113073  DT.98131836  DT.95234003  DT.120897923  DT.100703552  DT.97786061 
    DT.95234056  DT.91653854  DT.100703570  DT.95178067  DT.100868661  DT.450903  DT.100703579  DT.120897959 
    DT.95234009  DT.99991508  DT.120898189  DT.99947863  DT.100703551  DT.100703566  DT.100045368  DT.100703573 

    Selected AceView cDNA sequences (see all 324):

    BQ434152 AU136177 AW513576 BQ421687 CD695215 BM836344 BQ212768 BQ898214 
    CB139236 AL557857 AU280687 CB153299 BU159921 BM310898 CB163795 AA371223 
    BG678498 BU521301 AU140496 BM449583 BM464769 BM849764 CD708780 BU158441 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX5 (see all 19)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ·
    SP1:                    -     -     -                                                                             -                                             
    SP2:                                                                                                                                                            
    SP3:                    -     -     -                                                                                                                           
    SP4:                    -     -     -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 12d · 12e · 12f ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c · 17d ^ 18a · 18b · 18c · 18d
    SP1:        -     -           -           -           -     -     -     -     -     -                                       
    SP2:        -     -           -           -           -     -     -     -     -                                             
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for DDX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DDX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTCCAAT
    DDX5 Expression
    About this image


    DDX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    DDX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279806
        Pathway & Disease-focused RT2 Profiler PCR Array including DDX5: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDX5
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    QuantiFast Probe-based Assays in human, mouse, rat DDX5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX5 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx51 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51, 5 94.08(n)1
    98.7(a)1
      11 (70.01 cM)5
    132071  NM_007840.31  NP_031866.21 
     1067803555 
    chicken
    (Gallus gallus)
    Aves DDX51 DEAD (Asp-Glu-Ala-Asp) box helicase 5 83.11(n)
    90.88(a)
      395629  NM_204827.1  NP_990158.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    89(a)
    82(a)
    1 ↔ many
    1 ↔ many
    GL343250.1(1330131-1338692)
    GL343540.1(276359-279076)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6482 Xenopus laevis p68 RNA helicase mRNA, complete cds 79.59(n)    AF218580.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.284202 Danio rerio DEAD (Asp-Glu-Ala-Asp) box polypeptide more 77.05(n)    AY391418.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100771 , 3 RNA helicase3
    CG100771
    67(a)
    (best of 4)3
    59.93(n)1
    65.16(a)1
      387561  NM_139805.21  NP_648062.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F58E10.33 ATP-dependent helicase (DEAD box) 59(a)
    (best of 2)
      V(14011697-14014413)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP2(YNL112W)4
    DBP21
    Essential ATP-dependent RNA helicase of the DEAD-box more4
    DBP21
    57.99(n)1
    56.75(a)1
      14(413639-416281)4
    8556111, 4  NP_014287.31  NP_014287.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G551501 AT1G55150 60.09(n)
    59.23(a)
      841958  NM_104388.3  NP_175911.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.91452 Transcribed sequence with moderate similarity to protein more 77.44(n)    CA013267.1 


    ENSEMBL Gene Tree for DDX5 (if available)
    TreeFam Gene Tree for DDX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX5 gene
    DDX462  DDX172  DDX422  DDX432  DDX532  
    Selected SIMAP similar genes for DDX5 using alignment to 17 protein entries:     DDX5_HUMAN (see all proteins) (see all similar genes):
    DKFZp686J01190    DDX17    DDX23    DDX46    DDX43    DDX53
    DDX56    DKFZp547B159    EIF4A1    DDX42    DDX41    DDX39B
    DDX59    EIF4A2    DDX4    EIF4A3    mcdrh    DDX3Y

    Find genes that share paralogs with DDX5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DDX5
    PGOHUM00000237867


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX5 (see all 167)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429722761,2
    --62495211(+) AAGGAA/GACTCA 1 -- ut310--------
    rs796332901,2
    C--62495352(+) TTAAA-/TT    
       ATAAA
    CTTTG
    1 -- ut310--------
    rs1995303511,2
    C--62495610(+) CAAAT-/TAAA  
            
    TAAAA
    1 -- ut310--------
    rs1502537211,2
    --62495618(+) ATAAAA/GAGGAA 1 -- ut310--------
    rs2019487961,2
    --62495650(+) AAAAA-/AAACC 
            
    AAACA
    1 -- ut310--------
    rs2001796821,2
    --62495652(+) AAAAA-/ACCAAAC 1 -- ut310--------
    rs596491751,2
    C--62495653(+) AAAAA-/CCAAAC 1 -- ut310--------
    rs606475271,2
    --62495653(+) AAAAAC/ACAAAC 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs65042361,2
    C,F,A,H--62495667(+) AACAAA/GAAAAA 1 -- ut312Minor allele frequency- G:0.09NS WA 236
    rs1854589981,2
    --62495675(+) AAAAAA/CCAGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DDX5 (62494374 - 62504317 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DDX5: --
    Human Gene Mutation Database (HGMD): DDX5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX5
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 180630    OMIM disorders: --


    Find genes that share disorders with DDX5           About GenesLikeMe

    3 Novoseek inferred disease relationships for DDX5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 4.17 6 19995069 (2), 12527917 (1), 15927448 (1), 17699760 (1)
    necrosis 0 1 15927448 (1)
    cancer 0 3 18698352 (1), 15972854 (1), 11753651 (1)

    Genetic Association Database (GAD): DDX5
    Human Genome Epidemiology (HuGE) Navigator: DDX5 (4 documents)

    Export disorders for DDX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX5 gene, integrated from 10 sources (see all 201):
    (articles sorted by number of sources associating them with DDX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PubMed id 19995069)1, 2, 9 Mooney S.M.... Janknecht R. (Biochemistry 2010)
    2. Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. (PubMed id 12527917)1, 2, 9 Rossow K.L. and Janknecht R. (Oncogene 2003)
    3. P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras. (PubMed id 18698352)1, 3, 9 Camats M....Bach-Elias M. (PLoS ONE 2008)
    4. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. (PubMed id 15660129)1, 2, 9 Bates G.J.... Fuller-Pace F.V. (EMBO J. 2005)
    5. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. (PubMed id 15298701)1, 2, 9 Wilson B.J....Fuller-Pace F.V. (BMC Mol. Biol. 2004)
    6. Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. (PubMed id 10409727)1, 2, 9 Endoh H.... Kato S. (Mol. Cell. Biol. 1999)
    7. SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. (PubMed id 17369852)1, 2, 9 Jacobs A.M....Fuller-Pace F.V. (Oncogene 2007)
    8. Structure and expression of the human p68 RNA helicase gene. (PubMed id 10648785)1, 2, 9 Roessler O.G.... Stahl H. (Nucleic Acids Res. 2000)
    9. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. (PubMed id 19718048)1, 2, 9 Wortham N.C.... Fuller-Pace F.V. (Oncogene 2009)
    10. p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts. (PubMed id 1996094)1, 2, 9 Iggo R.D....Lane D.P. (Mol. Cell. Biol. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1655 HGNC: 2746 AceView: DDX5 Ensembl:ENSG00000108654 euGenes: HUgn1655
    ECgene: DDX5 Kegg: 1655 H-InvDB: DDX5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDX5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX5 gene:
    Search GeneIP for patents involving DDX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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