DDX5 Gene
protein-coding GIFtS: 66
GCID: GC17M062494
|
|
DEAD (Asp-Glu-Ala-Asp) box helicase 5(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase,...)
(Previous symbols: HLR1, G17P1)
| |
Aliases
for DDX5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DEAD (Asp-Glu-Ala-Asp) Box Helicase 51 2 | | HUMP682 | | G17P11 2 3 5 | | ATP-Dependent RNA Helicase DDX52 | | HLR11 2 3 5 | | DEAD Box-52 | | DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 51 2 | | Probable ATP-Dependent RNA Helicase DDX52 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 5 (RNA Helicase, 68kD)1 2 | | EC 3.6.4.133 | | P681 | | HELR3 | | DEAD Box Protein 52 3 | | EC 3.6.18 | | RNA Helicase P682 3 | | |
Export aliases for DDX5 gene to outside databasesPrevious GC identifers: GC17M065876 GC17P068976 GC17M062913 GC17M063045 GC17M059926 GC17M057943 |
Summaries
for DDX5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DDX5:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alteration of RNA secondary structure, such as translationinitiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distributionpatterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellulargrowth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also aproliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This geneconsists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected,but no isoforms encoded by these transcripts have been identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DDX5_HUMAN, P17844Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary forincreasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loopregion downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved intranscriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator forestrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 andAF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 andinvolved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptionalcoactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in apromoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1
Gene Wiki entry for DDX5
|
Genomic Views
for DDX5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDX5 gene promoter:
E2F-3a E2F-4 E2F-5 p53 E2F-2 E47 Evi-1 C/EBPalpha E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q21DDX5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M062494: view genomic region
(about GC identifiers)
Start:
|
62,494,374 bp from pter |
End:
|
62,504,317 bp from pter |
Size:
|
9,944 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17-,PATCHES 62,534,995-62,543,105 |
|
Proteins
for DDX5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDX5_HUMAN, P17844 (See
protein sequence)Recommended Name: Probable ATP-dependent RNA helicase DDX5 Size: 614 amino acids; 69148 Da
Subunit: Interacts with BRDT (By similarity). Identified in the spliceosome C complex. Interacts with RBM4; theinteraction occurs in a RNA-independent manner. Interacts with EIF2C1 and EIF2C2. Interacts with ESR1; the interactionis enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300, CREBBP, POLR2A,TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17
Subcellular location: Nucleus, nucleolus
2 PDB 3D structures from  and Proteopedia  for DDX5:3FE2 (3D)
4A4D (3D)
Secondary accessions: B5BU21 D3DU32 O75681 Q53Y61Explore the universe of human proteins at neXtProt for DDX5: NX_P17844
Post-translational modifications:
Arg-502 is dimethylated, probably to asymmetric dimethylarginine1
Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity.Sumoylation also significantly increases stability, and reduces polyubiquitination1
Polyubiquitinated, leading to proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17844
4/37 DME Specific Peptides for DDX5 (P17844) (see all 37)
DDX5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004387.1
ENSEMBL proteins: ENSP00000440276 ENSP00000464566 ENSP00000225792 ENSP00000403085 ENSP00000462885 ENSP00000464659 ENSP00000462222 ENSP00000463975 ENSP00000464337 ENSP00000464304 ENSP00000464064 ENSP00000463541 ENSP00000463101 ENSP00000464587 ENSP00000465791 ENSP00000462206 ENSP00000463903 ENSP00000463168
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DDX5 for ontologies About GeneDecksing
DDX5 Antibody Products:
Assay Products for DDX5: |
Protein
Domains /
Families
for DDX5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX5 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P17844ProtoNet protein and cluster: P17844 1 Blocks protein family: IPB000629 ATP-dependent helicase
UniProtKB/Swiss-Prot: DDX5_HUMAN, P17844Similarity: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamilySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Function
for DDX5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DDX5_HUMAN, P17844Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary forincreasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loopregion downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved intranscriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator forestrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 andAF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 andinvolved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptionalcoactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in apromoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1Catalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for DDX5:DEAD/H box protein 5,putative RNA helicase
Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DDX5 (NM_004396) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX5 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
DDX5 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for DDX5:
Animal Models:
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ddx5):
DDX5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DDX5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Wnt / Hedgehog / Notch | | | 2 | Direct p53 effectors | | | 3 | Translational Control | | | 4 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for DDX5
1  BioSystems Pathway for DDX5
1 
Kegg Pathway (Kegg details for DDX5):
DDX5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDX5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1033 Interacting proteins for DDX5 (P178441, 2, 3 ENSP000002257924) via UniProtKB, MINT, STRING, and/or I2D (see all 1033)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IDA | 15298701 | | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
IDA | -- | | GO:0000398 | mRNA splicing, via spliceosome |
IC | 11991638 | | GO:0001701 | in utero embryonic development |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- |
DDX5 for ontologies About GeneDecksing
|
Drugs & Compounds
for DDX5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DDX5 for compounds About GeneDecksing
 Browse Tocris compounds for DDX5
4 Novoseek chemical compound relationships for DDX5 gene About this table
Search CenterWatch for drugs/clinical trials and news about DDX5
|
Transcripts
for DDX5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDX5 gene: NM_004396.3 Unigene Cluster for DDX5: DEAD (Asp-Glu-Ala-Asp) box helicase 5 Hs.279806 [show with all ESTs]Unigene Representative Sequence: NM_00439618/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34): ENST00000540698 ENST00000581693 ENST00000581230 ENST00000225792(uc010deh.2 uc002jek.2 uc002jej.2 uc010wqa.1)
ENST00000450599 ENST00000578804 ENST00000580026 ENST00000578758 ENST00000581237
ENST00000578491 ENST00000579461 ENST00000585317 ENST00000579996(uc002jel.1)
ENST00000577787 ENST00000584549 ENST00000581551 ENST00000583201 ENST00000582326
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDX5 (NM_004396) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX5 |
Additional cDNA sequence: AB451257.1 AB451382.1 AK297192.1 AK297753.1 AK297905.1 AK310318.1 AL133585.1 AL359063.1 BC016027.1 BT006943.1 X15729.1 X52104.1 24/101 DOTS entries (see all 101): DT.100703567 DT.95199726 DT.75113073 DT.98131836 DT.95234003 DT.120897923 DT.100703552 DT.97786061 DT.95234056 DT.91653854 DT.100703570 DT.95178067 DT.100868661 DT.450903 DT.100703579 DT.120897959 DT.95234009 DT.99991508 DT.120898189 DT.99947863 DT.100703551 DT.100703566 DT.100045368 DT.100703573 24/324 AceView cDNA sequences (see all 324): F11307 AL540302 BQ221770 BE327780 AU131075 AA361125 BQ921964 CD722279 AU134481 BP359218 AU123487 BM697547 AU137934 AA331853 CD172029 AA360500 BU509756 BI914380 CB216716 AV708455 AL534775 BQ431929 BM799417 BM759860
GeneLoc Exon Structure
5/19 Alternative Splicing Database (ASD) splice patterns (SP) for DDX5 (see all 19) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12d | · | 12e | · | 12f | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d | · | 14e | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d | ^ | 18a | · | 18b | · | 18c | · | 18d |
|---|
|
| SP1: | | | - | | - | | | | - | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | - | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DDX5
|
Expression
for DDX5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTCCAAT
About this image
See DDX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX5
SOURCE GeneReport for Unigene cluster: Hs.279806
SABiosciences Expression via Pathway-Focused PCR Array including DDX5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX5 |
Orthologs
for DDX5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DDX5 gene from 9/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DDX51 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 |
83.22(n)
91.22(a) |
|
395629 NM_204827.1 NP_990158.1 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
84(a)82(a) |
1 ↔ many1 ↔ many |
GL343250.1(1330017-1338007) GL343540.1(276359-279076) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.6482 |
Xenopus laevis p68 RNA helicase mRNA, complete cds |
79.59(n) |
|
AF218580.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.284202 |
Danio rerio DEAD (Asp-Glu-Ala-Asp) box polypeptide more |
77.05(n) |
|
AY391418.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG100771 , 3 |
RNA helicase3
CG100771 |
67(a)
(best of 4)3
56.62(n)1
59.75(a)1 |
|
387561 NM_139805.21 NP_648062.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
F58E10.31 , 3 |
ATP-dependent helicase (DEAD box)3
Protein F58E10.31 |
59(a)
(best of 2)3
57.69(n)1
56.44(a)1 |
|
V(14011697-14014413)3
1798971 NM_001047669.21 NP_001041134.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
DBP2(YNL112W)4
DBP21 |
Essential ATP-dependent RNA helicase of the DEAD-box more4
Dbp2p1 |
58.78(n)1
58.25(a)1 |
|
14(413639-416281)4
8556111, 4 NP_014287.31 NP_014287.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G551506AT5G631206 |
DEAD-box ATP-dependent RNA helicase 30 |
54(a)45(a) |
many ↔ manymany ↔ many |
1(20574480-20577320) 5(25318752-25322265) |
rice
(Oryza sativa) |
Liliopsida |
---- |
DEAD-box ATP-dependent RNA helicase, putative, exp...DEAD-box ATP-dependent RNA helicase 30, putative, ... |
57(a)41(a) |
many ↔ manymany ↔ many |
1(5245503-5250192) 1(39687217-39692116) |
ENSEMBL Gene Tree for DDX5 (if available)
TreeFam Gene Tree for DDX5 (if available) |
Paralogs
for DDX5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDX5 gene
- DDX12 DDX412 DDX172 DDX432 DDX532
18/27 SIMAP similar genes for DDX5 using alignment to 17 protein entries: DDX5_HUMAN (see all proteins)
(see all similar genes):DKFZp686J01190 DDX17 DDX23 DDX46 DDX43 DDX53
BAT1 DDX56 DKFZp547B159 EIF4A1 DDX42 DDX41
DDX4 DDX59 EIF4A2 DDX39B EIF4A3 mcdrh
DDX5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DDX5
PGOHUM00000237867
|
Genomic Variants
for DDX5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDX5 (62494374 - 62504317 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DDX5: --
Human Gene Mutation Database (HGMD): DDX5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX5 |
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Disorders
/ Diseases
for DDX5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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DDX5 for disorders About GeneDecksing
OMIM gene information: 180630
OMIM disorders: --
13  diseases for DDX5: About MalaCardssquamous cell carcinoma multiple myeloma hepatitis c myeloma
colon cancer prostate cancer breast cancer hepatitis
sarcoma fibrosis prostatitis carcinoma
malaria
3 Novoseek disease relationships for DDX5 gene About this table
Human Genome Epidemiology (HuGE) Navigator: DDX5 (4 documents)
Export disorders for DDX5 gene to outside databases
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Publications
for DDX5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for DDX5 gene, integrated from 9 sources (see all 175):
(articles sorted by number of sources associating them with DDX5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sumoylation of p68 and p72 RNA helicases affects prot ein stability and transactivation potential. (PubMed id 19995069)1, 2, 9 Mooney S.M....Janknecht R. (2010)
- Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. (PubMed id 12527917)1, 2, 9 Rossow K.L. and Janknecht R. (2003)
- P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras. (PubMed id 18698352)1, 3, 9 Camats M....Bach-Elias M. (2008)
- The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. (PubMed id 15660129)1, 2, 9 Bates G.J....Fuller-Pace F.V. (2005)
- The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. (PubMed id 15298701)1, 2, 9 Wilson B.J....Fuller-Pace F.V. (2004)
- Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. (PubMed id 10409727)1, 2, 9 Endoh H....Kato S. (1999)
- SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. (PubMed id 17369852)1, 2, 9 Jacobs A.M....Fuller-Pace F.V. (2007)
- Structure and expression of the human p68 RNA helicase gene. (PubMed id 10648785)1, 2, 9 Roessler O.G.... Stahl H. (2000)
- The DEAD-box protein p72 regulates ERalpha-/oestrogen -dependent transcription and cell growth, and is associated with improved survi val in ERalpha-positive breast cancer. (PubMed id 19718048)1, 2, 9 Wortham N.C....Fuller-Pace F.V. (2009)
- p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts. (PubMed id 1996094)1, 2, 9 Iggo R.D....Lane D.P. (1991)
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External Searches for DDX5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DDX5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DDX5 gene
(According to HUGE)
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| -- |
Specialized Databases showing DDX5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
About This Section
| Patent Information for DDX5 gene:
Search GeneIP for patents involving DDX5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDX5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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| | |  | OriGene Antibodies for DDX5 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX5 | | | OriGene Protein Over-expression Lysate for DDX5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDX5 | | OriGene 3'-UTR Clone for DDX5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DDX5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX5 |
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