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Aliases for DDX49 Gene

Aliases for DDX49 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 49 2 3
  • DEAD Box Protein 49 3 4
  • Probable ATP-Dependent RNA Helicase DDX49 3
  • EC 3.6.4.13 4
  • R27090_2 3
  • EC 3.6.1 64

External Ids for DDX49 Gene

Summaries for DDX49 Gene

GeneCards Summary for DDX49 Gene

DDX49 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 49) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX49 Gene

Genomics for DDX49 Gene

Genomic Location for DDX49 Gene

Start:
18,919,675 bp from pter
End:
18,928,633 bp from pter
Size:
8,959 bases
Orientation:
Plus strand

Genomic View for DDX49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX49 Gene

Regulatory Elements for DDX49 Gene

Proteins for DDX49 Gene

  • Protein details for DDX49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6V7-DDX49_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX49
    Protein Accession:
    Q9Y6V7
    Secondary Accessions:
    • E7ENA0
    • Q53FJ1
    • Q9BVQ8

    Protein attributes for DDX49 Gene

    Size:
    483 amino acids
    Molecular mass:
    54226 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX49 Gene

Proteomics data for DDX49 Gene at MOPED

Post-translational modifications for DDX49 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys23

Other Protein References for DDX49 Gene

Domains for DDX49 Gene

Gene Families for DDX49 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX49_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q9Y6V7
  • Contains 1 helicase C-terminal domain.:
    • Q9Y6V7
Family:
  • Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.:
    • Q9Y6V7
genes like me logo Genes that share domains with DDX49: view

Function for DDX49 Gene

Molecular function for DDX49 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX49 Gene

Gene Ontology (GO) - Molecular Function for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX49: view

Phenotypes for DDX49 Gene

genes like me logo Genes that share phenotypes with DDX49: view

miRNA for DDX49 Gene

miRTarBase miRNAs that target DDX49

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX49 Gene

Localization for DDX49 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX49 Gene COMPARTMENTS Subcellular localization image for DDX49 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX49: view

Pathways for DDX49 Gene

SuperPathways for DDX49 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX49: view

No data available for Pathways by source for DDX49 Gene

Transcripts for DDX49 Gene

Unigene Clusters for DDX49 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 49:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX49 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: - - - - - - -
SP8: - - -

Relevant External Links for DDX49 Gene

GeneLoc Exon Structure for
DDX49
ECgene alternative splicing isoforms for
DDX49

Expression for DDX49 Gene

mRNA expression in normal human tissues for DDX49 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX49 Gene

SOURCE GeneReport for Unigene cluster for DDX49 Gene Hs.143187

genes like me logo Genes that share expressions with DDX49: view

Orthologs for DDX49 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX49 36
  • 99.79 (n)
  • 100 (a)
DDX49 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX49 36
  • 90.56 (n)
  • 93.11 (a)
DDX49 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX49 36
  • 90.3 (n)
  • 95.01 (a)
DDX49 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx49 36
  • 85.4 (n)
  • 92.52 (a)
Ddx49 16
Ddx49 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX49 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddx49 36
  • 85.94 (n)
  • 91.65 (a)
chicken
(Gallus gallus)
Aves DDX49 36
  • 76.66 (n)
  • 84.89 (a)
DDX49 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ddx49-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx49 36
  • 70.5 (n)
  • 81.17 (a)
zebrafish
(Danio rerio)
Actinopterygii ddx49 36
  • 69.6 (n)
  • 77.36 (a)
ddx49 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005130 36
  • 55.75 (n)
  • 51.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbp45A 36
  • 55.33 (n)
  • 51.03 (a)
Dbp45A 37
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H20J04.4 36
  • 51.45 (n)
  • 51.23 (a)
H20J04.4 37
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER301C 36
  • 53.51 (n)
  • 46.57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP8 36
  • 50.57 (n)
  • 49.76 (a)
DBP8 37
  • 48 (a)
OneToOne
DBP8 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05203g 36
  • 50.2 (n)
  • 47.42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH36 36
  • 51.83 (n)
  • 47.92 (a)
rice
(Oryza sativa)
Liliopsida Os07g0633500 36
  • 52.94 (n)
  • 50.98 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06418 36
  • 53.42 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp8 36
  • 48.35 (n)
  • 48.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3519 37
  • 55 (a)
OneToOne
Species with no ortholog for DDX49:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX49 Gene

ENSEMBL:
Gene Tree for DDX49 (if available)
TreeFam:
Gene Tree for DDX49 (if available)

Paralogs for DDX49 Gene

genes like me logo Genes that share paralogs with DDX49: view

No data available for Paralogs for DDX49 Gene

Variants for DDX49 Gene

Sequence variations from dbSNP and Humsavar for DDX49 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7497 -- 18,928,489(-) AAGGG(A/G)CCAGC utr-variant-3-prime, nc-transcript-variant
rs739577 -- 18,927,262(-) ACTAC(A/G)GGCGT intron-variant
rs999453 -- 18,924,608(-) GTTGG(A/G)AAGAA intron-variant
rs999454 -- 18,923,749(-) CCCTC(C/T)CTGGA intron-variant
rs1056038 -- 18,928,313(+) CTGGT(C/T)TGAGC reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX49 Gene

Variant ID Type Subtype PubMed ID
dgv3786n71 CNV Loss 21882294
nsv833777 CNV Loss 17160897
dgv3787n71 CNV Loss 21882294
nsv470132 CNV Loss 18288195
dgv3788n71 CNV Loss 21882294
nsv833778 CNV Loss 17160897

Relevant External Links for DDX49 Gene

HapMap Linkage Disequilibrium report
DDX49

Disorders for DDX49 Gene

No disorders were found for DDX49 Gene.

No data available for UniProtKB/Swiss-Prot for DDX49 Gene

Publications for DDX49 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  5. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen J.S. … Lamond A.I. (Curr. Biol. 2002) 3

Products for DDX49 Gene

Sources for DDX49 Gene

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