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Aliases for DDX49 Gene

Aliases for DDX49 Gene

  • DEAD-Box Helicase 49 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 49 2 3 5
  • DEAD Box Protein 49 3 4
  • EC 4
  • R27090_2 3
  • EC 3.6.1 63

External Ids for DDX49 Gene

Previous GeneCards Identifiers for DDX49 Gene

  • GC19P018875
  • GC19P018891
  • GC19P019030
  • GC19P018594

Summaries for DDX49 Gene

GeneCards Summary for DDX49 Gene

DDX49 (DEAD-Box Helicase 49) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX49 Gene

Genomics for DDX49 Gene

Regulatory Elements for DDX49 Gene

Enhancers for DDX49 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX49 on UCSC Golden Path with GeneCards custom track

Promoters for DDX49 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX49 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX49 Gene

18,919,675 bp from pter
18,928,633 bp from pter
8,959 bases
Plus strand

Genomic View for DDX49 Gene

Genes around DDX49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX49 Gene

Proteins for DDX49 Gene

  • Protein details for DDX49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX49
    Protein Accession:
    Secondary Accessions:
    • E7ENA0
    • Q53FJ1
    • Q9BVQ8

    Protein attributes for DDX49 Gene

    483 amino acids
    Molecular mass:
    54226 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX49 Gene


neXtProt entry for DDX49 Gene

Proteomics data for DDX49 Gene at MOPED

Post-translational modifications for DDX49 Gene

  • Ubiquitination at Lys 23
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX49 Gene

Domains & Families for DDX49 Gene

Gene Families for DDX49 Gene

Suggested Antigen Peptide Sequences for DDX49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
genes like me logo Genes that share domains with DDX49: view

Function for DDX49 Gene

Molecular function for DDX49 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX49 Gene

Gene Ontology (GO) - Molecular Function for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX49: view
genes like me logo Genes that share phenotypes with DDX49: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX49

miRNA for DDX49 Gene

miRTarBase miRNAs that target DDX49

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX49 Gene

Localization for DDX49 Gene

Subcellular locations from

Jensen Localization Image for DDX49 Gene COMPARTMENTS Subcellular localization image for DDX49 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX49 Gene

Pathways & Interactions for DDX49 Gene

genes like me logo Genes that share pathways with DDX49: view

Pathways by source for DDX49 Gene

Gene Ontology (GO) - Biological Process for DDX49 Gene


No data available for SIGNOR curated interactions for DDX49 Gene

Drugs & Compounds for DDX49 Gene

(1) Drugs for DDX49 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX49 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX49: view

Transcripts for DDX49 Gene

Unigene Clusters for DDX49 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 49:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX49 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP3: - -
SP4: - - -
SP7: - - - - - - -
SP8: - - -

Relevant External Links for DDX49 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX49 Gene

mRNA expression in normal human tissues for DDX49 Gene

Protein differential expression in normal tissues from HIPED for DDX49 Gene

This gene is overexpressed in CD4 Tcells (23.8), Lung (16.5), and Placenta (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX49 Gene

SOURCE GeneReport for Unigene cluster for DDX49 Gene Hs.143187

genes like me logo Genes that share expression patterns with DDX49: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DDX49 Gene

Orthologs for DDX49 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX49 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX49 35
  • 90.56 (n)
  • 93.11 (a)
DDX49 36
  • 93 (a)
(Canis familiaris)
Mammalia DDX49 35
  • 90.3 (n)
  • 95.01 (a)
DDX49 36
  • 94 (a)
(Mus musculus)
Mammalia Ddx49 35
  • 85.4 (n)
  • 92.52 (a)
Ddx49 16
Ddx49 36
  • 90 (a)
(Pan troglodytes)
Mammalia DDX49 35
  • 99.79 (n)
  • 100 (a)
DDX49 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx49 35
  • 85.94 (n)
  • 91.65 (a)
(Monodelphis domestica)
Mammalia DDX49 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 88 (a)
-- 36
  • 67 (a)
(Gallus gallus)
Aves DDX49 35
  • 76.66 (n)
  • 84.89 (a)
DDX49 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx49 35
  • 70.5 (n)
  • 81.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia ddx49-A-prov 35
(Danio rerio)
Actinopterygii ddx49 35
  • 69.6 (n)
  • 77.36 (a)
ddx49 36
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005130 35
  • 55.75 (n)
  • 51.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbp45A 35
  • 55.33 (n)
  • 51.03 (a)
Dbp45A 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea H20J04.4 35
  • 51.45 (n)
  • 51.23 (a)
H20J04.4 36
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER301C 35
  • 53.51 (n)
  • 46.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05203g 35
  • 50.2 (n)
  • 47.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP8 35
  • 50.57 (n)
  • 49.76 (a)
DBP8 36
  • 48 (a)
DBP8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RH36 35
  • 51.83 (n)
  • 47.92 (a)
(Oryza sativa)
Liliopsida Os07g0633500 35
  • 52.94 (n)
  • 50.98 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06418 35
  • 53.42 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp8 35
  • 48.35 (n)
  • 48.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3519 36
  • 55 (a)
Species with no ortholog for DDX49:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX49 Gene

Gene Tree for DDX49 (if available)
Gene Tree for DDX49 (if available)

Paralogs for DDX49 Gene

genes like me logo Genes that share paralogs with DDX49: view

No data available for Paralogs for DDX49 Gene

Variants for DDX49 Gene

Sequence variations from dbSNP and Humsavar for DDX49 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35802425 - 18,922,633(+) CCAGC(A/G)CTACC nc-transcript-variant, reference, missense
rs35614860 - 18,924,656(+) TCAAG(G/T)CCAGC nc-transcript-variant, reference, missense
rs16995781 - 18,928,010(+) ACAAA(C/T)GGAAG nc-transcript-variant, reference, missense
rs12985985 -- 18,924,031(+) ttgaa(C/T)tcctg intron-variant
rs8105981 -- 18,921,510(+) CACAA(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX49 Gene

Variant ID Type Subtype PubMed ID
dgv3786n71 CNV Loss 21882294
nsv833777 CNV Loss 17160897
dgv3787n71 CNV Loss 21882294
nsv470132 CNV Loss 18288195
dgv3788n71 CNV Loss 21882294
nsv833778 CNV Loss 17160897

Variation tolerance for DDX49 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDX49 Gene

Disorders for DDX49 Gene

Relevant External Links for DDX49

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX49 Gene

Publications for DDX49 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3
  5. Human CCAAT/enhancer-binding protein I^ interacts with chromatin remodeling complexes of the imitation switch subfamily. (PMID: 22242598) Steinberg X.P. … GutiAcrrez J.L. (Biochemistry 2012) 3

Products for DDX49 Gene

Sources for DDX49 Gene