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Aliases for DDX49 Gene

Aliases for DDX49 Gene

  • DEAD-Box Helicase 49 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 49 2 3
  • DEAD Box Protein 49 3 4
  • Probable ATP-Dependent RNA Helicase DDX49 3
  • EC 3.6.4.13 4
  • R27090_2 3
  • EC 3.6.1 58
  • Dbp8 3

External Ids for DDX49 Gene

Previous GeneCards Identifiers for DDX49 Gene

  • GC19P018875
  • GC19P018891
  • GC19P019030
  • GC19P018594

Summaries for DDX49 Gene

GeneCards Summary for DDX49 Gene

DDX49 (DEAD-Box Helicase 49) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

Additional gene information for DDX49 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX49 Gene

Genomics for DDX49 Gene

Regulatory Elements for DDX49 Gene

Enhancers for DDX49 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H018300 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -615.2 -615170 8 HDGF PKNOX1 FOXA2 ARNT SIN3A ARID4B DMAP1 ZBTB7B YY1 SLC30A9 ENSG00000268030 UPF1 KIAA1683 ENSG00000268938 NR2C2AP MEF2B JUND LSM4 COLGALT1 ENSG00000269191
GH19H018372 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -538.6 -538575 17 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC NR2C2AP ENSG00000268030 UPF1 ENSG00000268938 KIAA1683 MEF2B COLGALT1 SUGP2 MVB12A MAU2
GH19H018289 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -627.4 -627439 6 YBX1 DMAP1 YY1 ZNF143 ZNF548 SP3 MEF2D GLIS1 RCOR2 NBN ENSG00000268030 NR2C2AP KIAA1683 UPF1 SUGP2 ENSG00000268938 MVB12A COLGALT1 GTPBP3 LOC100507551
GH19H018436 1.6 Ensembl ENCODE dbSUPER 10.7 -480.2 -480173 6 HDGF PKNOX1 ZFP64 SIN3A FEZF1 ZNF2 ZBTB7B ZNF766 SP3 SP5 ENSG00000268030 NR2C2AP UPF1 KIAA1683 ENSG00000268938 MEF2B SSBP4 KXD1 ENSG00000268199 GATAD2A
GH19H019031 1.5 FANTOM5 ENCODE 2 +113.7 113702 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 FOS TMEM161A ATP13A1 MEF2B RFXANK BORCS8 BORCS8-MEF2B SLC25A42 ARMC6 SUGP2 SUGP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX49 on UCSC Golden Path with GeneCards custom track

Promoters for DDX49 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108169 -375 2201 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 SLC30A9

Genomic Location for DDX49 Gene

Chromosome:
19
Start:
18,919,675 bp from pter
End:
18,928,633 bp from pter
Size:
8,959 bases
Orientation:
Plus strand

Genomic View for DDX49 Gene

Genes around DDX49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX49 Gene

Proteins for DDX49 Gene

  • Protein details for DDX49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6V7-DDX49_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX49
    Protein Accession:
    Q9Y6V7
    Secondary Accessions:
    • E7ENA0
    • Q53FJ1
    • Q9BVQ8

    Protein attributes for DDX49 Gene

    Size:
    483 amino acids
    Molecular mass:
    54226 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX49 Gene

Selected DME Specific Peptides for DDX49 Gene

Q9Y6V7:
  • RVGRTAR
  • DEADRLL
  • VASRGLD
  • AKTGSGKT
  • VLTPTREL
  • TDVASRG
  • TPTRELA
  • VIATPGR
  • GRTARAGR
  • TGSGKTAAF
  • LVMDEADR
  • ILIATDVA
  • RQTLLFSAT
  • YIHRVGR
  • ATPGRLADH
  • RELAYQI
  • IATPGRL

Post-translational modifications for DDX49 Gene

  • Ubiquitination at posLast=2323
  • Modification sites at PhosphoSitePlus

Domains & Families for DDX49 Gene

Gene Families for DDX49 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6V7

UniProtKB/Swiss-Prot:

DDX49_HUMAN :
  • Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
genes like me logo Genes that share domains with DDX49: view

Function for DDX49 Gene

Molecular function for DDX49 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DDX49 Gene

Phenotypes From GWAS Catalog for DDX49 Gene

Gene Ontology (GO) - Molecular Function for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX49: view
genes like me logo Genes that share phenotypes with DDX49: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX49

CRISPR Products

miRNA for DDX49 Gene

miRTarBase miRNAs that target DDX49

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DDX49
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX49 Gene

Localization for DDX49 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX49 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX49: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX49 Gene

Pathways & Interactions for DDX49 Gene

genes like me logo Genes that share pathways with DDX49: view

Gene Ontology (GO) - Biological Process for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX49: view

No data available for SIGNOR curated interactions for DDX49 Gene

Drugs & Compounds for DDX49 Gene

(3) Drugs for DDX49 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DDX49 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX49: view

Transcripts for DDX49 Gene

Unigene Clusters for DDX49 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 49:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DDX49
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DDX49 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: - - - - - - -
SP8: - - -

Relevant External Links for DDX49 Gene

GeneLoc Exon Structure for
DDX49
ECgene alternative splicing isoforms for
DDX49

Expression for DDX49 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX49 Gene

Protein differential expression in normal tissues from HIPED for DDX49 Gene

This gene is overexpressed in CD4 Tcells (23.8), Lung (16.5), and Placenta (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX49 Gene



NURSA nuclear receptor signaling pathways regulating expression of DDX49 Gene:

DDX49

SOURCE GeneReport for Unigene cluster for DDX49 Gene:

Hs.143187

Evidence on tissue expression from TISSUES for DDX49 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with DDX49: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX49 Gene

Orthologs for DDX49 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX49 33 34
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia DDX49 33 34
  • 90.56 (n)
dog
(Canis familiaris)
Mammalia DDX49 33 34
  • 90.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddx49 33
  • 85.94 (n)
mouse
(Mus musculus)
Mammalia Ddx49 33 16 34
  • 85.4 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX49 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX49 33 34
  • 76.66 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx49 33
  • 70.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia ddx49-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii ddx49 33 34
  • 69.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005130 33
  • 55.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dbp45A 33 34
  • 55.33 (n)
worm
(Caenorhabditis elegans)
Secernentea H20J04.4 33 34
  • 51.45 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER301C 33
  • 53.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP8 33 34 36
  • 50.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05203g 33
  • 50.2 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH36 33
  • 51.83 (n)
rice
(Oryza sativa)
Liliopsida Os07g0633500 33
  • 52.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3519 34
  • 55 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06418 33
  • 53.42 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp8 33
  • 48.35 (n)
Species where no ortholog for DDX49 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX49 Gene

ENSEMBL:
Gene Tree for DDX49 (if available)
TreeFam:
Gene Tree for DDX49 (if available)

Paralogs for DDX49 Gene

genes like me logo Genes that share paralogs with DDX49: view

No data available for Paralogs for DDX49 Gene

Variants for DDX49 Gene

Sequence variations from dbSNP and Humsavar for DDX49 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000062098 -- 18,928,985(+) TTTGG(A/C)CAGAC downstream-variant-500B
rs1000140536 -- 18,925,571(+) ATAAA(C/T)TAAAA intron-variant
rs1000244 -- 18,919,658(+) GGAAG(A/G)TTTTT upstream-variant-2KB
rs1000245 -- 18,920,278(+) AGTTT(C/G)GCCAT intron-variant, upstream-variant-2KB
rs1000453351 -- 18,918,589(+) CCGCC(A/C)CCACG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DDX49 Gene

Variant ID Type Subtype PubMed ID
nsv1151217 CNV deletion 26484159
nsv470132 CNV loss 18288195
nsv833777 CNV loss 17160897
nsv833778 CNV loss 17160897
nsv952423 CNV deletion 24416366

Variation tolerance for DDX49 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX49 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX49 Gene

Disorders for DDX49 Gene

Relevant External Links for DDX49

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX49

No disorders were found for DDX49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX49 Gene

Publications for DDX49 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 60
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60

Products for DDX49 Gene

Sources for DDX49 Gene

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