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Aliases for DDX49 Gene

Aliases for DDX49 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 49 2 3
  • DEAD Box Protein 49 3 4
  • EC 3.6.4.13 4
  • R27090_2 3
  • EC 3.6.1 63

External Ids for DDX49 Gene

Previous GeneCards Identifiers for DDX49 Gene

  • GC19P018875
  • GC19P018891
  • GC19P019030
  • GC19P018594

Summaries for DDX49 Gene

GeneCards Summary for DDX49 Gene

DDX49 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 49) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX49 Gene

Genomics for DDX49 Gene

Regulatory Elements for DDX49 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX49 Gene

Chromosome:
19
Start:
18,919,675 bp from pter
End:
18,928,633 bp from pter
Size:
8,959 bases
Orientation:
Plus strand

Genomic View for DDX49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX49 Gene

Proteins for DDX49 Gene

  • Protein details for DDX49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6V7-DDX49_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX49
    Protein Accession:
    Q9Y6V7
    Secondary Accessions:
    • E7ENA0
    • Q53FJ1
    • Q9BVQ8

    Protein attributes for DDX49 Gene

    Size:
    483 amino acids
    Molecular mass:
    54226 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX49 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX49 Gene

Proteomics data for DDX49 Gene at MOPED

Post-translational modifications for DDX49 Gene

  • Ubiquitination at Lys 23
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX49 Gene

Domains & Families for DDX49 Gene

Gene Families for DDX49 Gene

Suggested Antigen Peptide Sequences for DDX49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6V7

UniProtKB/Swiss-Prot:

DDX49_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
genes like me logo Genes that share domains with DDX49: view

Function for DDX49 Gene

Molecular function for DDX49 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX49 Gene

Gene Ontology (GO) - Molecular Function for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX49: view
genes like me logo Genes that share phenotypes with DDX49: view

Animal Model Products

miRNA for DDX49 Gene

miRTarBase miRNAs that target DDX49

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX49

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX49 Gene

Localization for DDX49 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX49 Gene COMPARTMENTS Subcellular localization image for DDX49 gene
Compartment Confidence
mitochondrion 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX49 Gene

Pathways & Interactions for DDX49 Gene

SuperPathways for DDX49 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX49: view

No data available for Pathways by source and SIGNOR curated interactions for DDX49 Gene

Drugs & Compounds for DDX49 Gene

(1) Drugs for DDX49 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX49 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX49: view

Transcripts for DDX49 Gene

Unigene Clusters for DDX49 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 49:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX49

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX49 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: - - - - - - -
SP8: - - -

Relevant External Links for DDX49 Gene

GeneLoc Exon Structure for
DDX49
ECgene alternative splicing isoforms for
DDX49

Expression for DDX49 Gene

mRNA expression in normal human tissues for DDX49 Gene

Protein differential expression in normal tissues from HIPED for DDX49 Gene

This gene is overexpressed in CD4 Tcells (23.8), Lung (16.5), and Placenta (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX49 Gene



SOURCE GeneReport for Unigene cluster for DDX49 Gene Hs.143187

genes like me logo Genes that share expression patterns with DDX49: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DDX49 Gene

Orthologs for DDX49 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX49 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX49 35
  • 90.56 (n)
  • 93.11 (a)
DDX49 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX49 35
  • 90.3 (n)
  • 95.01 (a)
DDX49 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx49 35
  • 85.4 (n)
  • 92.52 (a)
Ddx49 16
Ddx49 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX49 35
  • 99.79 (n)
  • 100 (a)
DDX49 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx49 35
  • 85.94 (n)
  • 91.65 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX49 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX49 35
  • 76.66 (n)
  • 84.89 (a)
DDX49 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx49 35
  • 70.5 (n)
  • 81.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia ddx49-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii ddx49 35
  • 69.6 (n)
  • 77.36 (a)
ddx49 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005130 35
  • 55.75 (n)
  • 51.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbp45A 35
  • 55.33 (n)
  • 51.03 (a)
Dbp45A 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea H20J04.4 35
  • 51.45 (n)
  • 51.23 (a)
H20J04.4 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER301C 35
  • 53.51 (n)
  • 46.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05203g 35
  • 50.2 (n)
  • 47.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP8 35
  • 50.57 (n)
  • 49.76 (a)
DBP8 36
  • 48 (a)
OneToOne
DBP8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RH36 35
  • 51.83 (n)
  • 47.92 (a)
rice
(Oryza sativa)
Liliopsida Os07g0633500 35
  • 52.94 (n)
  • 50.98 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06418 35
  • 53.42 (n)
  • 45.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp8 35
  • 48.35 (n)
  • 48.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3519 36
  • 55 (a)
OneToOne
Species with no ortholog for DDX49:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX49 Gene

ENSEMBL:
Gene Tree for DDX49 (if available)
TreeFam:
Gene Tree for DDX49 (if available)

Paralogs for DDX49 Gene

genes like me logo Genes that share paralogs with DDX49: view

No data available for Paralogs for DDX49 Gene

Variants for DDX49 Gene

Sequence variations from dbSNP and Humsavar for DDX49 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7497 -- 18,928,489(-) AAGGG(A/G)CCAGC utr-variant-3-prime, nc-transcript-variant
rs739577 -- 18,927,262(-) ACTAC(A/G)GGCGT intron-variant
rs999453 -- 18,924,608(-) GTTGG(A/G)AAGAA intron-variant
rs999454 -- 18,923,749(-) CCCTC(C/T)CTGGA intron-variant
rs1056038 -- 18,928,313(+) CTGGT(C/G/T)TGAGC reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX49 Gene

Variant ID Type Subtype PubMed ID
dgv3786n71 CNV Loss 21882294
nsv833777 CNV Loss 17160897
dgv3787n71 CNV Loss 21882294
nsv470132 CNV Loss 18288195
dgv3788n71 CNV Loss 21882294
nsv833778 CNV Loss 17160897

Variation tolerance for DDX49 Gene

Residual Variation Intolerance Score: 61.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX49 Gene

HapMap Linkage Disequilibrium report
DDX49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX49 Gene

Disorders for DDX49 Gene

Relevant External Links for DDX49

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX49
genes like me logo Genes that share disorders with DDX49: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX49 Gene

Publications for DDX49 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  4. Human CCAAT/enhancer-binding protein I^ interacts with chromatin remodeling complexes of the imitation switch subfamily. (PMID: 22242598) Steinberg X.P. … GutiAcrrez J.L. (Biochemistry 2012) 67
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 67

Products for DDX49 Gene

Sources for DDX49 Gene

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