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Aliases for DDX47 Gene

Aliases for DDX47 Gene

  • DEAD-Box Helicase 47 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 47 2 3 5
  • DEAD Box Protein 47 3 4
  • DEAD Box Polypeptide 47 3
  • E4-DEAD Box Protein 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • MSTP162 3
  • E4-DBP 3
  • HQ0256 3
  • RRP3 3

External Ids for DDX47 Gene

Previous GeneCards Identifiers for DDX47 Gene

  • GC12P012866
  • GC12P012857
  • GC12P012771
  • GC12P012966

Summaries for DDX47 Gene

Entrez Gene Summary for DDX47 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX47 Gene

DDX47 (DEAD-Box Helicase 47) is a Protein Coding gene. Diseases associated with DDX47 include anterior horn cell disease. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX28.

UniProtKB/Swiss-Prot for DDX47 Gene

  • Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.

Gene Wiki entry for DDX47 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX47 Gene

Genomics for DDX47 Gene

Regulatory Elements for DDX47 Gene

Promoters for DDX47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX47 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX47 Gene

Chromosome:
12
Start:
12,813,316 bp from pter
End:
12,829,981 bp from pter
Size:
16,666 bases
Orientation:
Plus strand

Genomic View for DDX47 Gene

Genes around DDX47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX47 Gene

Proteins for DDX47 Gene

  • Protein details for DDX47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0S4-DDX47_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX47
    Protein Accession:
    Q9H0S4
    Secondary Accessions:
    • B3KXP4
    • G5E955
    • Q96GM0
    • Q96NV8
    • Q9UI98

    Protein attributes for DDX47 Gene

    Size:
    455 amino acids
    Molecular mass:
    50647 Da
    Quaternary structure:
    • Interacts with AGO1 and AGO2. Interacts with GABARAP. Interacts with NOL8; the interaction is RNA-dependent.
    SequenceCaution:
    • Sequence=AAF23354.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX47 Gene

    Alternative splice isoforms for DDX47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX47 Gene

Proteomics data for DDX47 Gene at MOPED

Post-translational modifications for DDX47 Gene

  • Ubiquitination at Lys 161 and Lys 345
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX47 Gene

Domains & Families for DDX47 Gene

Gene Families for DDX47 Gene

Suggested Antigen Peptide Sequences for DDX47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0S4

UniProtKB/Swiss-Prot:

DDX47_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
genes like me logo Genes that share domains with DDX47: view

Function for DDX47 Gene

Molecular function for DDX47 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.

Enzyme Numbers (IUBMB) for DDX47 Gene

genes like me logo Genes that share phenotypes with DDX47: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX47

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX47 Gene

Localization for DDX47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX47 Gene

Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX47 Gene COMPARTMENTS Subcellular localization image for DDX47 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DDX47 Gene

Pathways & Interactions for DDX47 Gene

genes like me logo Genes that share pathways with DDX47: view

Pathways by source for DDX47 Gene

Gene Ontology (GO) - Biological Process for DDX47 Gene

None

No data available for SIGNOR curated interactions for DDX47 Gene

Drugs & Compounds for DDX47 Gene

(1) Drugs for DDX47 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX47 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX47: view

Transcripts for DDX47 Gene

Unigene Clusters for DDX47 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX47 Gene

No ASD Table

Relevant External Links for DDX47 Gene

GeneLoc Exon Structure for
DDX47
ECgene alternative splicing isoforms for
DDX47

Expression for DDX47 Gene

mRNA expression in normal human tissues for DDX47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX47 Gene

This gene is overexpressed in Lung (31.7) and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX47 Gene



SOURCE GeneReport for Unigene cluster for DDX47 Gene Hs.719938

genes like me logo Genes that share expression patterns with DDX47: view

Protein tissue co-expression partners for DDX47 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX47 Gene

Orthologs for DDX47 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX47 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX47 35
  • 89.45 (n)
  • 96.92 (a)
DDX47 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX47 35
  • 91.61 (n)
  • 97.75 (a)
DDX47 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx47 35
  • 87.55 (n)
  • 96.04 (a)
Ddx47 16
Ddx47 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX47 35
  • 99.71 (n)
  • 99.56 (a)
DDX47 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx47 35
  • 87.11 (n)
  • 96.48 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX47 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX47 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX47 35
  • 79.72 (n)
  • 92.63 (a)
DDX47 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX47 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx47 35
  • 76.62 (n)
  • 89.37 (a)
LOC394710 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8006 35
zebrafish
(Danio rerio)
Actinopterygii ddx47 35
  • 69.6 (n)
  • 78.85 (a)
Dr.14725 35
ddx47 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009808 35
  • 62.25 (n)
  • 71.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9253 35
  • 64.56 (n)
  • 71.85 (a)
CG9253 36
  • 62 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_T26G10.1 35
  • 61.76 (n)
  • 65.29 (a)
T26G10.1 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL041C 35
  • 56.66 (n)
  • 55.43 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14608g 35
  • 56.04 (n)
  • 56.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP3 35
  • 57.58 (n)
  • 57 (a)
RRP3 36
  • 46 (a)
OneToMany
RRP3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60990 35
  • 62.01 (n)
  • 60.64 (a)
rice
(Oryza sativa)
Liliopsida Os.5421 35
Os03g0669000 35
  • 61.28 (n)
  • 57.85 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.10537 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2700 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04504 35
  • 59.37 (n)
  • 61.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC823.08c 35
  • 62.9 (n)
  • 65.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
ManyToMany
Species with no ortholog for DDX47:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX47 Gene

ENSEMBL:
Gene Tree for DDX47 (if available)
TreeFam:
Gene Tree for DDX47 (if available)

Paralogs for DDX47 Gene

Paralogs for DDX47 Gene

genes like me logo Genes that share paralogs with DDX47: view

Variants for DDX47 Gene

Sequence variations from dbSNP and Humsavar for DDX47 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs960892 -- 12,814,508(+) CATCA(A/G)TGGGC intron-variant
rs1051374 -- 12,814,193(+) AAGAT(C/T)CAGAT reference, synonymous-codon
rs1010878 -- 12,824,466(-) AAACA(C/T)GAGAA intron-variant
rs2302604 -- 12,813,217(+) GCGCC(C/T)ATATT upstream-variant-2KB
rs2058609 -- 12,817,858(+) GCTGT(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX47 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073

Variation tolerance for DDX47 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX47 Gene

HapMap Linkage Disequilibrium report
DDX47
Human Gene Mutation Database (HGMD)
DDX47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX47 Gene

Disorders for DDX47 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DDX47 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anterior horn cell disease
- elite association - COSMIC cancer census association via MalaCards
Search DDX47 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX47

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX47
genes like me logo Genes that share disorders with DDX47: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX47 Gene

Publications for DDX47 Gene

  1. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PMID: 17932509) Hoeck J. … Meister G. (EMBO Rep. 2007) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for DDX47 Gene

Sources for DDX47 Gene

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