Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX46 Gene

Aliases for DDX46 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 46 2 3
  • DEAD Box Protein 46 3 4
  • PRP5 Homolog 3 4
  • Prp5-Like DEAD-Box Protein 3
  • RNA Helicase 3
  • EC 3.6.4.13 4
  • KIAA0801 4
  • EC 3.6.1 63
  • PRPF5 3
  • Prp5 3

External Ids for DDX46 Gene

Previous GeneCards Identifiers for DDX46 Gene

  • GC05P134125
  • GC05P134170
  • GC05P134122
  • GC05P134094
  • GC05P129280

Summaries for DDX46 Gene

Entrez Gene Summary for DDX46 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for DDX46 Gene

DDX46 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 46) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX53.

UniProtKB/Swiss-Prot for DDX46 Gene

  • Plays an essential role in splicing, either prior to, or during splicing A complex formation.

Gene Wiki entry for DDX46 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX46 Gene

Genomics for DDX46 Gene

Regulatory Elements for DDX46 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX46 Gene

Chromosome:
5
Start:
134,758,734 bp from pter
End:
134,855,133 bp from pter
Size:
96,400 bases
Orientation:
Plus strand

Genomic View for DDX46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX46 Gene

Proteins for DDX46 Gene

  • Protein details for DDX46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L014-DDX46_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX46
    Protein Accession:
    Q7L014
    Secondary Accessions:
    • O94894
    • Q96EI0
    • Q9Y658

    Protein attributes for DDX46 Gene

    Size:
    1031 amino acids
    Molecular mass:
    117362 Da
    Quaternary structure:
    • Integral component of the 17S U2 snRNP.
    SequenceCaution:
    • Sequence=BAA34521.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DDX46 Gene

Proteomics data for DDX46 Gene at MOPED

Post-translational modifications for DDX46 Gene

  • Ubiquitination at Lys 422, Lys 493, Lys 686, Lys 716, Lys 894, Lys 907, and Lys 1025
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX46 Gene

Antibody Products

Domains & Families for DDX46 Gene

Gene Families for DDX46 Gene

Suggested Antigen Peptide Sequences for DDX46 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L014

UniProtKB/Swiss-Prot:

DDX46_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
genes like me logo Genes that share domains with DDX46: view

Function for DDX46 Gene

Molecular function for DDX46 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Plays an essential role in splicing, either prior to, or during splicing A complex formation.

Enzyme Numbers (IUBMB) for DDX46 Gene

Gene Ontology (GO) - Molecular Function for DDX46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with DDX46: view
genes like me logo Genes that share phenotypes with DDX46: view

Animal Model Products

miRNA for DDX46 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX46

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX46 Gene

Localization for DDX46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX46 Gene

Nucleus speckle. Nucleus, Cajal body. Note=Present in Cajal bodies (CBs) and nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX46 Gene COMPARTMENTS Subcellular localization image for DDX46 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DDX46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16791210
GO:0015030 Cajal body IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with DDX46: view

Pathways & Interactions for DDX46 Gene

SuperPathways for DDX46 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with DDX46: view

Pathways by source for DDX46 Gene

1 KEGG pathway for DDX46 Gene

Gene Ontology (GO) - Biological Process for DDX46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0010468 regulation of gene expression IBA --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX46: view

No data available for SIGNOR curated interactions for DDX46 Gene

Drugs & Compounds for DDX46 Gene

(1) Drugs for DDX46 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX46 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX46: view

Transcripts for DDX46 Gene

Unigene Clusters for DDX46 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX46

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX46 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - - -
SP2: -
SP3: - - - - -
SP4: - - -
SP5:
SP6: - -
SP7:
SP8: - - -
SP9:
SP10:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DDX46 Gene

GeneLoc Exon Structure for
DDX46
ECgene alternative splicing isoforms for
DDX46

Expression for DDX46 Gene

mRNA expression in normal human tissues for DDX46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX46 Gene

This gene is overexpressed in Nasal epithelium (10.3), Lymph node (10.2), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX46 Gene



SOURCE GeneReport for Unigene cluster for DDX46 Gene Hs.406549

genes like me logo Genes that share expression patterns with DDX46: view

Protein tissue co-expression partners for DDX46 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX46 Gene

Orthologs for DDX46 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX46 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DDX46 35
  • 94.15 (n)
  • 99.81 (a)
DDX46 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx46 35
  • 89.48 (n)
  • 98.81 (a)
Ddx46 16
Ddx46 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX46 35
  • 99.74 (n)
  • 100 (a)
DDX46 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx46 35
  • 88.47 (n)
  • 98.59 (a)
cow
(Bos Taurus)
Mammalia DDX46 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX46 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX46 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX46 35
  • 82.99 (n)
  • 93.72 (a)
DDX46 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX46 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx46 35
  • 78.82 (n)
  • 90.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13242 35
zebrafish
(Danio rerio)
Actinopterygii ddx46 35
  • 72.5 (n)
  • 84.9 (a)
Dr.25491 35
ddx46 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010656 35
  • 46.33 (n)
  • 41.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6227 35
  • 60.08 (n)
  • 66.62 (a)
CG6227 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F53H1.1 35
  • 56.34 (n)
  • 52.68 (a)
F53H1.1 36
  • 50 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 36
  • 38 (a)
OneToMany
PRP5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G20920 35
  • 56.23 (n)
  • 51.49 (a)
rice
(Oryza sativa)
Liliopsida Os.24620 35
Os08g0159900 35
  • 55.43 (n)
  • 50.61 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5602 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02696 35
  • 53.46 (n)
  • 51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp11 35
  • 56.49 (n)
  • 54.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4221 36
  • 62 (a)
OneToOne
Species with no ortholog for DDX46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX46 Gene

ENSEMBL:
Gene Tree for DDX46 (if available)
TreeFam:
Gene Tree for DDX46 (if available)

Paralogs for DDX46 Gene

Paralogs for DDX46 Gene

genes like me logo Genes that share paralogs with DDX46: view

Variants for DDX46 Gene

Sequence variations from dbSNP and Humsavar for DDX46 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_028079 -

Structural Variations from Database of Genomic Variants (DGV) for DDX46 Gene

Variant ID Type Subtype PubMed ID
nsv830493 CNV Loss 17160897
nsv512860 CNV Insertion 21212237
nsv523937 CNV Gain 19592680
nsv830494 CNV Gain+Loss 17160897

Variation tolerance for DDX46 Gene

Residual Variation Intolerance Score: 5.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX46 Gene

HapMap Linkage Disequilibrium report
DDX46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX46 Gene

Disorders for DDX46 Gene

Relevant External Links for DDX46

Genetic Association Database (GAD)
DDX46
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX46
genes like me logo Genes that share disorders with DDX46: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX46 Gene

Publications for DDX46 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 67
  5. Lentiviral DDX46 knockdown inhibits growth and induces apoptosis in human colorectal cancer cells. (PMID: 25680556) Li M. … Cao J. (Gene 2015) 67

Products for DDX46 Gene

Sources for DDX46 Gene

Back to Top

Content