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Aliases for DDX43 Gene

Aliases for DDX43 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 43 2 3
  • Cancer/Testis Antigen 13 2 3 4
  • HAGE 3 4 6
  • DEAD Box Protein HAGE 3 4
  • DEAD Box Protein 43 3 4
  • Helical Antigen 3 4
  • CT13 3 4
  • Probable ATP-Dependent RNA Helicase DDX43 3
  • DEAD-Box Protein 43 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64

External Ids for DDX43 Gene

Summaries for DDX43 Gene

Entrez Gene Summary for DDX43 Gene

  • The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX43 Gene

DDX43 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 43) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX53.

Gene Wiki entry for DDX43 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX43 Gene

Genomics for DDX43 Gene

Genomic Location for DDX43 Gene

Start:
73,394,562 bp from pter
End:
73,417,569 bp from pter
Size:
23,008 bases
Orientation:
Plus strand

Genomic View for DDX43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX43 Gene

Regulatory Elements for DDX43 Gene

Transcription factor binding sites by QIAGEN in the DDX43 gene promoter:

Proteins for DDX43 Gene

  • Protein details for DDX43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXZ2-DDX43_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX43
    Protein Accession:
    Q9NXZ2
    Secondary Accessions:
    • B4E0C8
    • Q6NXR1

    Protein attributes for DDX43 Gene

    Size:
    648 amino acids
    Molecular mass:
    72844 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX43 Gene

Proteomics data for DDX43 Gene at MOPED

Selected DME Specific Peptides for DDX43 Gene

Post-translational modifications for DDX43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX43 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DDX43 Gene

Gene Families for DDX43 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX43_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q9NXZ2
  • Contains 1 helicase C-terminal domain.:
    • Q9NXZ2
  • Contains 1 KH domain.:
    • Q9NXZ2
Family:
  • Belongs to the DEAD box helicase family.:
    • Q9NXZ2
genes like me logo Genes that share domains with DDX43: view

Function for DDX43 Gene

Molecular function for DDX43 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX43 Gene

Gene Ontology (GO) - Molecular Function for DDX43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity TAS 10919659
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX43: view

Phenotypes for DDX43 Gene

GenomeRNAi human phenotypes for DDX43:
genes like me logo Genes that share phenotypes with DDX43: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDX43 Gene

Localization for DDX43 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX43 Gene COMPARTMENTS Subcellular localization image for DDX43 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DDX43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX43: view

Pathways for DDX43 Gene

SuperPathways for DDX43 Gene

No Data Available

Interacting Proteins for DDX43 Gene

Gene Ontology (GO) - Biological Process for DDX43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX43: view

No data available for Pathways by source for DDX43 Gene

Transcripts for DDX43 Gene

Unigene Clusters for DDX43 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX43 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - -
SP3:

Relevant External Links for DDX43 Gene

GeneLoc Exon Structure for
DDX43
ECgene alternative splicing isoforms for
DDX43

Expression for DDX43 Gene

mRNA expression in normal human tissues for DDX43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDX43 Gene

This gene is overexpressed in Testis (14.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX43 Gene

SOURCE GeneReport for Unigene cluster for DDX43 Gene Hs.125507

mRNA Expression by UniProt/SwissProt for DDX43 Gene

Q9NXZ2-DDX43_HUMAN
Tissue specificity: Expressed in testis. Expressed in many tumors of various histological types at a level that is 100-fold higher than the level observed in normal tissues except testis.
genes like me logo Genes that share expressions with DDX43: view

Orthologs for DDX43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX43 36
  • 99.54 (n)
  • 99.07 (a)
DDX43 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX43 36
  • 76.18 (n)
  • 72.23 (a)
DDX43 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102151353 36
  • 77.96 (n)
  • 77.96 (a)
mouse
(Mus musculus)
Mammalia Ddx43 36
  • 79.66 (n)
  • 77.64 (a)
Ddx43 16
Ddx43 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
ManyToMany
-- 37
  • 58 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 68 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ddx43 36
  • 79.28 (n)
  • 77.21 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 58 (a)
OneToMany
DDX43 36
  • 63.33 (n)
  • 61.71 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx43 36
  • 63.13 (n)
  • 61.78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6611 36
zebrafish
(Danio rerio)
Actinopterygii ddx43 37
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004351 36
  • 54.81 (n)
  • 57.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7878 36
  • 52.82 (n)
  • 51.76 (a)
CG7878 37
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.3 36
  • 48.88 (n)
  • 45.57 (a)
Y54G11A.3 37
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 37
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14598 36
Species with no ortholog for DDX43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX43 Gene

ENSEMBL:
Gene Tree for DDX43 (if available)
TreeFam:
Gene Tree for DDX43 (if available)

Paralogs for DDX43 Gene

Paralogs for DDX43 Gene

Selected SIMAP similar genes for DDX43 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DDX43 Gene

genes like me logo Genes that share paralogs with DDX43: view

Variants for DDX43 Gene

Sequence variations from dbSNP and Humsavar for DDX43 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs311687 -- 73,415,334(-) ATGAT(A/G)GTACC intron-variant
rs311688 -- 73,412,680(-) CACAC(A/G)CGCGC intron-variant
rs499173 -- 73,412,669(+) GTGTG(C/T)GCGCG intron-variant
rs504194 -- 73,395,733(+) GCTTA(G/T)AACAG intron-variant
rs504218 -- 73,395,739(+) AACAG(A/G)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX43 Gene

Variant ID Type Subtype PubMed ID
nsv830693 CNV Loss 17160897
nsv518515 CNV Loss 19592680
nsv886158 CNV Gain 21882294

Relevant External Links for DDX43 Gene

HapMap Linkage Disequilibrium report
DDX43

Disorders for DDX43 Gene

No disorders were found for DDX43 Gene.

No data available for UniProtKB/Swiss-Prot for DDX43 Gene

Publications for DDX43 Gene

  1. Identification on a human sarcoma of two new genes with tumor- specific expression. (PMID: 10919659) Martelange V.M.F. … Boon T. (Cancer Res. 2000) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DDX43 Gene

Sources for DDX43 Gene

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