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Aliases for DDX43 Gene

Aliases for DDX43 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 43 2 3
  • Cancer/Testis Antigen 13 2 3 4
  • HAGE 3 4 6
  • DEAD Box Protein HAGE 3 4
  • DEAD Box Protein 43 3 4
  • Helical Antigen 3 4
  • CT13 3 4
  • Probable ATP-Dependent RNA Helicase DDX43 3
  • DEAD-Box Protein 43 3
  • EC 4
  • EC 3.6.1 63

External Ids for DDX43 Gene

Previous GeneCards Identifiers for DDX43 Gene

  • GC06P074054
  • GC06P074100
  • GC06P074161
  • GC06P071302
  • GC06P074104

Summaries for DDX43 Gene

Entrez Gene Summary for DDX43 Gene

  • The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX43 Gene

DDX43 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 43) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX53.

Gene Wiki entry for DDX43 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX43 Gene

Genomics for DDX43 Gene

Regulatory Elements for DDX43 Gene

Transcription factor binding sites by QIAGEN in the DDX43 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX43 Gene

73,394,562 bp from pter
73,417,569 bp from pter
23,008 bases
Plus strand

Genomic View for DDX43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX43 Gene

Proteins for DDX43 Gene

  • Protein details for DDX43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX43
    Protein Accession:
    Secondary Accessions:
    • B4E0C8
    • Q6NXR1

    Protein attributes for DDX43 Gene

    648 amino acids
    Molecular mass:
    72844 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX43 Gene


neXtProt entry for DDX43 Gene

Proteomics data for DDX43 Gene at MOPED

Selected DME Specific Peptides for DDX43 Gene

Post-translational modifications for DDX43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX43 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for DDX43 Gene

Gene Families for DDX43 Gene

  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX43 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NXZ2
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 KH domain.
  • Belongs to the DEAD box helicase family.
genes like me logo Genes that share domains with DDX43: view

Function for DDX43 Gene

Molecular function for DDX43 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for DDX43 Gene

Gene Ontology (GO) - Molecular Function for DDX43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity TAS 10919659
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX43: view

Phenotypes for DDX43 Gene

GenomeRNAi human phenotypes for DDX43:
genes like me logo Genes that share phenotypes with DDX43: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX43

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDX43 Gene

Localization for DDX43 Gene

Subcellular locations from

Jensen Localization Image for DDX43 Gene COMPARTMENTS Subcellular localization image for DDX43 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DDX43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX43: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX43 Gene

Pathways for DDX43 Gene

SuperPathways for DDX43 Gene

No Data Available

Interacting Proteins for DDX43 Gene

Gene Ontology (GO) - Biological Process for DDX43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX43: view

No data available for Pathways by source for DDX43 Gene

Transcripts for DDX43 Gene

Unigene Clusters for DDX43 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 43:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX43

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX43 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2: - -

Relevant External Links for DDX43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX43 Gene

mRNA expression in normal human tissues for DDX43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDX43 Gene

This gene is overexpressed in Testis (14.8).

Protein differential expression in normal tissues for DDX43 Gene

This gene is overexpressed in Testis (39.7), Ovary (18.4), and Lung (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX43 Gene

SOURCE GeneReport for Unigene cluster for DDX43 Gene Hs.125507

mRNA Expression by UniProt/SwissProt for DDX43 Gene

Tissue specificity: Expressed in testis. Expressed in many tumors of various histological types at a level that is 100-fold higher than the level observed in normal tissues except testis.
genes like me logo Genes that share expressions with DDX43: view

Expression partners for DDX43 Gene

In Situ Assay Products

Orthologs for DDX43 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX43 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX43 35
  • 76.18 (n)
  • 72.23 (a)
DDX43 36
  • 71 (a)
(Canis familiaris)
Mammalia LOC102151353 35
  • 77.96 (n)
  • 77.96 (a)
(Mus musculus)
Mammalia Ddx43 35
  • 79.66 (n)
  • 77.64 (a)
Ddx43 16
Ddx43 36
  • 77 (a)
(Pan troglodytes)
Mammalia DDX43 35
  • 99.54 (n)
  • 99.07 (a)
DDX43 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ddx43 35
  • 79.28 (n)
  • 77.21 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
-- 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
-- 36
  • 63 (a)
(Gallus gallus)
Aves DDX43 35
  • 63.33 (n)
  • 61.71 (a)
-- 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx43 35
  • 63.13 (n)
  • 61.78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6611 35
(Danio rerio)
Actinopterygii ddx43 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004351 35
  • 54.81 (n)
  • 57.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7878 35
  • 52.82 (n)
  • 51.76 (a)
CG7878 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.3 35
  • 48.88 (n)
  • 45.57 (a)
Y54G11A.3 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 36
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14598 35
Species with no ortholog for DDX43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX43 Gene

Gene Tree for DDX43 (if available)
Gene Tree for DDX43 (if available)

Paralogs for DDX43 Gene

Paralogs for DDX43 Gene

Selected SIMAP similar genes for DDX43 Gene using alignment to 2 proteins: Pseudogenes for DDX43 Gene

genes like me logo Genes that share paralogs with DDX43: view

Variants for DDX43 Gene

Sequence variations from dbSNP and Humsavar for DDX43 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs311687 -- 73,415,334(-) ATGAT(A/G)GTACC intron-variant
rs311688 -- 73,412,680(-) CACAC(A/G)CGCGC intron-variant
rs499173 -- 73,412,669(+) GTGTG(C/T)GCGCG intron-variant
rs504194 -- 73,395,733(+) GCTTA(G/T)AACAG intron-variant
rs504218 -- 73,395,739(+) AACAG(A/G)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX43 Gene

Variant ID Type Subtype PubMed ID
nsv830693 CNV Loss 17160897
nsv518515 CNV Loss 19592680
nsv886158 CNV Gain 21882294

Relevant External Links for DDX43 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX43 Gene

Disorders for DDX43 Gene

No disorders were found for DDX43 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DDX43 Gene

Publications for DDX43 Gene

  1. Identification on a human sarcoma of two new genes with tumor- specific expression. (PMID: 10919659) Martelange V.M.F. … Boon T. (Cancer Res. 2000) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DDX43 Gene

Sources for DDX43 Gene

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