DDX43 Gene
protein-coding GIFtS : 49
GCID: GC06 P074104
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
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Aliasesfor DDX43 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 43 1 2 DEAD Box Protein HAGE2 3 HAGE1 2 3 5 DKFZp434H21141 CT131 2 3 DEAD-Box Protein 432 Cancer/Testis Antigen 132 3 Probable ATP-Dependent RNA Helicase DDX432 Helical Antigen2 3 EC 3.6.4.133 DEAD Box Protein 432 3 EC 3.6.18
Export aliases for DDX43 gene to outside databases Previous GC identifers: GC06P074054 GC06P074100 GC06P074161 GC06P071302
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Summariesfor DDX43 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DDX43 : The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. (provided by RefSeq, Jul 2008) Gene Wiki entry for DDX43
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Genomic Viewsfor DDX43 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007299.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DDX43 gene promoter: ER-alpha AML1a Other transcription factors Search SABiosciences Chromatin IP Primers for DDX43 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DDX43
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q12-q13 Ensembl cytogenetic band: 6q13 HGNC cytogenetic band: 6q12-q13 DDX43 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P074104: view genomic region
(about GC identifiers )
Start:
74,104,285 bp from pter
End:
74,127,292 bp from pter
Size:
23,008 bases
Orientation:
plus strand
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Proteinsfor DDX43 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DDX43_HUMAN, Q9NXZ2 (See
protein sequence )Recommended Name: Probable ATP-dependent RNA helicase DDX43 Size : 648 amino acids; 72844 Da
Secondary accessions : Q6NXR1Explore the universe of human proteins at neXtProt for DDX43: NX_Q9NXZ2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NXZ2 4/11 DME Specific Peptides for DDX43 (Q9NXZ2 ) (see all 11 )DDX43 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_061135.2 ENSEMBL proteins: ENSP00000359361 ENSP00000441636 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IDA --
DDX43 for ontologies About GeneDecksing DDX43 Antibody Products: Assay Products for DDX43:
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Protein
Domains / Familiesfor DDX43 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DDX43 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q9NXZ2 ProtoNet protein and cluster: Q9NXZ2
2 Blocks protein families : IPB000629 ATP-dependent helicase IPB004087 KH domain UniProtKB/Swiss-Prot: DDX43_HUMAN, Q9NXZ2 Similarity : Belongs to the DEAD box helicase familySimilarity : Contains 1 helicase ATP-binding domainSimilarity : Contains 1 helicase C-terminal domainSimilarity : Contains 1 KH domain
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Functionfor DDX43 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DDX43_HUMAN, Q9NXZ2 Catalytic activity : ATP + H(2)O = ADP + phosphateEnzyme Numbers (IUBMB): EC 3.6.1 2 EC 3.6.4.13 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDX43 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDX43OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DDX43 (NM_018665 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX43 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDX43
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX43
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
DDX43 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for DDX43 :
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Pathways & Interactionsfor DDX43 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX43 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for DDX43 (ENSP00000359361 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor DDX43 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DDX43 Search CenterWatch for drugs/clinical trials and news about DDX43
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Transcriptsfor DDX43 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DDX43 gene: NM_018665.2 Unigene Cluster for DDX43:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 Hs.125507 [show with all ESTs ] Unigene Representative Sequence: NM_018665 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000370336 (uc011dyn.1 uc003pgw.3 ) ENST00000464221 ENST00000479773 ENST00000539829 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDX43 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDX43OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DDX43 (NM_018665 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX43 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDX43
Additional cDNA sequence: AJ278110.1 AK303324.1 AK313686.1 AL136751.1 BC056879.1 BC066938.1
3 DOTS entries : DT.400485 DT.121355947
DT.121355885 24/29 AceView cDNA sequences (see all 29 ):
AI521173 BC056879 BQ020439 CB114540 BU171821 BC066938 BX281294 AA948168 AW593728 BV205400 AI637624 BG772793 AI638049 BE144935 AL043701 AI378017 BV205399 BX646425 BQ023352 AL136751 NM_018665 AA883800 BG724057 BE907039 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for DDX43 About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 SP1 :         -                                   SP2 :         -     -                               SP3 :                                          
ECgene alternative splicing isoforms for DDX43
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Expression for DDX43 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DDX43 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image DDX43 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DDX43 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DDX43 SOURCE GeneReport for Unigene cluster: Hs.125507 UniProtKB/Swiss-Prot: DDX43_HUMAN, Q9NXZ2 Tissue specificity : Expressed in testis. Expressed in many tumors of various histological types at a level that is100-fold higher than the level observed in normal tissues except testis SABiosciences Custom PCR Arrays for DDX43 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDX43Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat DDX43 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDX43 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDX43 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX43
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Orthologsfor DDX43 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for DDX43 gene from 7/22 species (see all 22 ) About this table
ENSEMBL Gene Tree for DDX43 (if available)TreeFam Gene Tree for DDX43 (if available)
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Paralogsfor DDX43 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DDX43 gene DDX1 2 DDX41 2 DDX5 2 DDX17 2 DDX53 2 12 SIMAP similar genes for DDX43 using alignment to 2 protein entries: DDX43_HUMAN (see all proteins ):DDX53 DDX5 DDX17 DDX4 DDX46 DKFZp686J01190 EIF4A2 DDX23 DDX42 DDX41 DDX3Y DDX3X
DDX43 for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for DDX43 PGOHUM00000235363 PGOHUM00000232685 PGOHUM00000232903
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Genomic Variantsfor DDX43 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DDX43 (74104285 - 74127292 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DDX43: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DDX43
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Disorders
/ Diseasesfor DDX43 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DDX43 for disorders About GeneDecksing
OMIM gene information: 606286
OMIM disorders : --5 diseases for DDX43 : About MalaCards chronic myeloid leukemia myeloid leukemia leukemia sarcoma melanoma Export disorders for DDX43 gene to outside databases
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Publicationsfor DDX43 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DDX43 gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with DDX43) Utopia : connect your pdf to the dynamic world of online information
Identification on a human sarcoma of two new genes with tumor- specific expression. (PubMed id 10919659) 1 , 2 , 3, 9 Martelange V.M.F.... Boon T. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) Aberrant hypomethylation of DDX43 promoter in myelodys plastic syndrome. (PubMed id 22563673) 1 Chen Q....Li Y. (2012) The helicase HAGE expressed by malignant melanoma-init iating cells is required for tumor cell proliferation in vivo. (PubMed id 22393060) 1 Linley A.J....Regad T. (2012) Gene expression of helicase antigen in patients with a cute and chronic myeloid leukemia. (PubMed id 22040965) 1 Chen Q....Xiao G.F. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) HAGE, a cancer/testis antigen expressed at the protei n level in a variety of cancers. (PubMed id 20058853) 1 Mathieu M.G....McArdle S.E. (2010) Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia. (PubMed id 17296563) 1 Roman-Gomez J....Torres A. (2007) HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides. (PubMed id 17487488) 1 Mathieu M.G....McArdle S.E. (2007)
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External Searches for DDX43 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DDX43 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DDX43 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DDX43 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DDX43 gene: Search GeneIP for patents involving DDX43 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DDX43 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DDX43 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DDX43 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDX43 OriGene Protein Over-expression Lysate for DDX43 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DDX43 OriGene 3'-UTR Clone for DDX43 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDX43 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDX43 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DDX43 OriGene Custom Protein Services for DDX43 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX43 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DDX43 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DDX43 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DDX43 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDX43 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDX43
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DDX43 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX43
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDX43
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Aliases for DDX43
Databases for DDX43
Disorders / Diseases for DDX43
Domains / Families for DDX43
Drugs / Compounds for DDX43
Expression for DDX43
Function for DDX43
Genomic Views for DDX43
Intellectual Property for DDX43
Orthologs for DDX43
Paralogs for DDX43
Pathways / Interactions for DDX43
Products for DDX43
Proteins for DDX43
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Search Box for DDX43
Summaries for DDX43
Transcripts for DDX43
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