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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX42 Gene

protein-coding   GIFtS: 54
GCID: GC17P061851

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
 Explore 6 diseases affiliated with
DDX42 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDX42    

Aliases
for DDX42 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 421 2     RNA Helicase-Related Protein2 3
RHELP1 2 3 5     SF3b DEAD Box Protein2 3
RNAHP1 2 3     ATP-Dependent RNA Helicase DDX422
SF3b1251 2 3     SF3b125 DEAD-Box Protein2
Splicing Factor 3B-Associated 125 KDa Protein2 3     EC 3.6.4.133
DEAD Box Protein 422 3     EC 3.6.18
RNA Helicase-Like Protein2 3     

External Ids:    HGNC: 186761   Entrez Gene: 113252   Ensembl: ENSG000001982317   OMIM: 6133695   UniProtKB: Q86XP33   

Export aliases for DDX42 gene to outside databases

Previous GC identifers: GC17P062192 GC17P062337 GC17P059205 GC17P057219


Summaries
for DDX42 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDX42:
This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are
putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary
structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and
division. Two transcript variants encoding the same protein have been identified for this gene. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3
Function: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary
structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex
formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and
hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of
complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the
apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm

Gene Wiki entry for DDX42


Genomic Views
for DDX42 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX42 gene promoter:
         TBP   GR   Elk-1   AML1a   GR-beta   AREB6   HNF-1   GR-alpha   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX42 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23

DDX42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX42 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P061851:  view genomic region     (about GC identifiers)

Start:
 61,850,963 bp from pter      End:
 61,896,677 bp from pter
Size:
 45,715 bases      Orientation:
 plus strand

Proteins
for DDX42 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX42  
Size: 938 amino acids; 102975 Da
Subunit: Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155,
SF3B2/SAP145/SF3B155, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. Interacts
(via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is independent of
p53/TP53
Subcellular location: Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies (CBs)
and nuclear speckles
Sequence caution: Sequence=AAC32396.1; Type=Frameshift; Positions=818;
Secondary accessions: A6NML1 A8KA43 O75619 Q68G51 Q96BK1 Q96HR7 Q9Y3V8
Alternative splicing: 2 isoforms:  Q86XP3-1   Q86XP3-2   

Explore the universe of human proteins at neXtProt for DDX42: NX_Q86XP3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86XP3

    • 4/30 DME Specific Peptides for DDX42 (Q86XP3) (see all 30)
     AFQSQYK  GAMGDRL  QSERNKV  TPGRLID 

    DDX42 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_031398.2  NP_987095.1  

    ENSEMBL proteins: 
     ENSP00000464232   ENSP00000464050   ENSP00000463561   ENSP00000352308   ENSP00000463038  
     ENSP00000462174   ENSP00000461957   ENSP00000374574   ENSP00000390121  

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    Novus Biologicals DDX42 Protein
    Novus Biologicals DDX42 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DDX42

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015030Cajal body IEA--
    GO:0016607nuclear speck IEA--


    DDX42 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DDX42

    Protein Domains /
    Families
    for DDX42 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDX42 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q86XP3

    ProtoNet protein and cluster: Q86XP3

    1 Blocks protein family: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3
    Similarity: Belongs to the DEAD box helicase family. DDX42 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for DDX42 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3
    Function: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary
    structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex
    formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and
    hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of
    complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the
    apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm
    Catalytic activity: ATP + H(2)O = ADP + phosphate

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

    miRNA
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    hsa-miR-549 hsa-miR-125a-5p hsa-miR-3133 hsa-miR-340 hsa-miR-125b hsa-miR-186 hsa-miR-205* hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmid: DDX42 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19377511
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--


    DDX42 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for DDX42:
     Increased gamma-H2AX phosphory  Low eccentricity cells  Synthetic lethal with Ras 


    Pathways & Interactions
    for DDX42 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		Spliceosome0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for DDX42):
        Spliceosome


    DDX42 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/749 Interacting proteins for DDX42 (Q86XP32, 3 ENSP000003523084) via UniProtKB, MINT, STRING, and/or I2D (see all 749)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205620 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000221413
    SF3B1O755332, 3, ENSP000003353214MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000335321
    RECQL5O947622, 3MINT-63238 I2D: score=5 
    RUVBL1Q9Y2652, 3, ENSP000003182974MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000318297
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization IDA19377511
    GO:0045767regulation of anti-apoptosis ----


    DDX42 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDX42 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX42
    Search CenterWatch for drugs/clinical trials and news about DDX42 

    Transcripts
    for DDX42 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDX42 gene (2 alternative transcripts): 
    NM_007372.2  NM_203499.1  

    Unigene Cluster for DDX42:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
    Hs.702010  [show with all ESTs]
    Unigene Representative Sequence: NM_007372
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000581135 ENST00000578681(uc002jbu.3) ENST00000583590(uc002jbv.3 uc010wps.2)
    ENST00000359353(uc002jbw.1) ENST00000580108 ENST00000578137 ENST00000584261
    ENST00000577940 ENST00000579511 ENST00000577978 ENST00000584010(uc002jbx.3)
    ENST00000581477 ENST00000578593(uc002jby.3) ENST00000584951 ENST00000579539
    ENST00000582985 ENST00000581767 ENST00000389924

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX42
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX42 (see all 19):
    hsa-miR-549 hsa-miR-125a-5p hsa-miR-3133 hsa-miR-340 hsa-miR-125b hsa-miR-186 hsa-miR-205* hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmid: DDX42 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB036090.1 AF083255.1 AF147429.1 AK001964.1 AK095772.1 AK096751.1 AK122737.1 AK126480.1 
    AK292908.1 AL050096.1 BC008208.1 BC015505.1 BC078667.1 BC093081.1 

    24 DOTS entries:

    DT.101964800  DT.452278  DT.100823349  DT.100745450  DT.100823348  DT.101977643  DT.121007436  DT.100823342 
    DT.121007394  DT.100823351  DT.86837221  DT.91983138  DT.97801238  DT.107162  DT.102838777  DT.100823345 
    DT.121007307  DT.95173866  DT.97762171  DT.100823347  DT.102838776  DT.91941760  DT.92447108  DT.95173850 

    24/300 AceView cDNA sequences (see all 300):

    CF143527 AL602757 CR606414 AW009662 AI678965 BE388910 BM550220 BQ213215 
    BQ232108 CD516379 NM_203499 BE886138 CA446920 AW500358 BM564503 BQ431901 
    BU185874 BC015505 BM462117 AA677736 BQ478265 BQ226877 AA838742 CD244617 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DDX42 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                                -                             -                 -     -                     
    SP2:                                                                                -                             -                 -     -                     
    SP3:                                                                                                              -                 -     -                     
    SP4:                                            -     -                                                                                                         
    SP5:                                            -           -                                                                                                   

    ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b · 22c · 22d · 22e
    SP1:              -     -                                       
    SP2:              -     -                                       
    SP3:              -     -                                       
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DDX42

    Expression
    for DDX42 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGAAACAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DDX42 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX42

    SOURCE GeneReport for Unigene cluster: Hs.702010

    UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3
    Tissue specificity: Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus,
    muscle and pancreatic islets

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    In Situ
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    Orthologs
    for DDX42 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX42 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DDX421 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 77.33(n)
    88.24(a)    		   419959  NM_001030926.1  NP_001026097.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DDX426
    		 --
    		 86(a)
    		 1 ↔ 1
    		 6(78562376-78579605)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC043977.12   -- 76.19(n)    BC043977.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ddx421 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 69.01(n)
    75.75(a)    		   503932  NM_001037805.2  NP_001032894.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG64181 CG6418 58.1(n)
    56.28(a)    		   39218  NM_140156.2  NP_648413.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C46F11.41 Protein C46F11.4 57.86(n)
    56.69(a)    		   175469  NM_065342.3  NP_497743.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G473301 DEAD-box ATP-dependent RNA helicase 24 52.83(n)
    47.36(a)    		   819346  NM_130301.4  NP_566099.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g03085001 hypothetical protein 52.57(n)
    49.03(a)    		   4332617  NM_001056439.1  NP_001049904.1 


    ENSEMBL Gene Tree for DDX42 (if available)
    TreeFam Gene Tree for DDX42 (if available) 

    Paralogs
    for DDX42 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX42 gene
    DDX592  DDX462  
    17 SIMAP similar genes for DDX42 using alignment to 5 protein entries:     DDX42_HUMAN (see all proteins):
    DDX46    DDX47    DDX53    DDX54    DDX3X    DDX5
    EIF4A2    EIF4A1    DDX17    DDX43    DDX49    EIF4A3
    DDX3Y    DDX39B    DDX52    DDX39A    DDX41

    DDX42 for paralogs           About GeneDecksing



    Genomic Variants
    for DDX42 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/892 NCBI SNPs in DDX42 are shown (see all 892)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs786741111,2
    		--61849933(+) ACTCTT/AAAAAC 3 -- int1 us2k11Minor allele frequency- A:0.50CSA 2
    rs1447835511,2
    		C,--61849939(+) AAAAC-/TTTTTT 3 -- int1 us2k10--------
    rs1895020471,2
    		--61849976(+) CACCGA/GAACAG 3 -- int1 us2k10--------
    rs1436528371,2
    		--61850133(+) CATTTC/TTACCT 3 -- int1 us2k10--------
    rs733319491,2
    		C,--61850159(+) GAAGTC/TTCCGC 3 -- int1 us2k12Minor allele frequency- T:0.04WA 120
    rs1471837671,2
    		--61850288(+) ATTATC/TTTCTG 3 -- int1 us2k10--------
    rs80767171,2
    		C,F,A,H,--61850301(+) AGCTCA/GTCCAA 3 -- int1 us2k125Minor allele frequency- G:0.18NS EA NA CSA WA 2948
    rs562950111,2
    		C,F,--61850359(+) AGGCCA/GTCATT 3 -- int1 us2k15Minor allele frequency- G:0.34NA CSA WA EA 362
    rs1811455321,2
    		--61850372(+) TTGTTA/GTCATT 3 -- int1 us2k10--------
    rs80770131,2
    		C,F,A,--61850392(+) GTCTTT/CCTGAC 3 -- us2k1 int19Minor allele frequency- C:0.28WA NA CSA EA 368

    HapMap Linkage Disequilibrium report for DDX42 (61850963 - 61896677 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DDX42: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX42
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX42

    Disorders / Diseases
    for DDX42 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDX42 for disorders           About GeneDecksing

    OMIM gene information: 613369    OMIM disorders: --

    6 diseases for DDX42:    About MalaCards
    japanese encephalitis    fanconi's anemia    encephalitis    tonsillitis
    anemia    pancreatitis


    Export disorders for DDX42 gene to outside databases

    Publications
    for DDX42 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX42 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with DDX42)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human member of the DEAD box protein family. (PubMed id 10727850)1, 2, 3, 9 Suk K.... Lee M.-S. (2000)
    2. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2, 9 Will C.L....Luhrmann R. (2002)
    3. The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. (PubMed id 19377511)1, 2 Uhlmann-Schiffler H....Stahl H. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Ddx42p -- a human DEAD box protein with RNA chaperone activities. (PubMed id 16397294)1, 2 Uhlmann-Schiffler H.... Stahl H. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for DDX42 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDX42 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11325 HGNC: 18676 AceView: DDX42 Ensembl:ENSG00000198231 euGenes: HUgn11325
    ECgene: DDX42 Kegg: 11325 H-InvDB: DDX42

    Other Databases showing DDX42 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDX42 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX42 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDX42 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDX42 gene:
    Search GeneIP for patents involving DDX42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DDX42 gene

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    About This Section

     
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