Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX42 Gene

protein-coding   GIFtS: 54
GCID: GC17P061851

DEAD (Asp-Glu-Ala-Asp) Box Helicase 42

(Previous name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 42)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 421 2     DDX42P2
RHELP2 3 5     ATP-Dependent RNA Helicase DDX422
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 421 2     EC 3.6.4.133
Splicing Factor 3B-Associated 125 KDa Protein2 3     DEAD Box Protein 423
RNAHP2 3     RNA Helicase-Like Protein3
SF3b1252 3     RNA Helicase-Related Protein3
SF3b DEAD Box Protein2 3     EC 3.6.18

External Ids:    HGNC: 186761   Entrez Gene: 113252   Ensembl: ENSG000001982317   OMIM: 6133695   UniProtKB: Q86XP33   

Export aliases for DDX42 gene to outside databases

Previous GC identifers: GC17P062192 GC17P062337 GC17P059205 GC17P057219


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDX42 Gene:
This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are
putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA
secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and
spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and
cellular growth and division. Two transcript variants encoding the same protein have been identified for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX42 Gene: 
DDX42 (DEAD (Asp-Glu-Ala-Asp) box helicase 42) is a protein-coding gene. Diseases associated with DDX42 include japanese encephalitis, and encephalitis, and among its related super-pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX21.

UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3
Function: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA
secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA
duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP
binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein
triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2
and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm

Gene Wiki entry for DDX42 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX42 gene promoter:
         TBP   GR   Elk-1   AML1a   GR-beta   AREB6   HNF-1   GR-alpha   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX42 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23

DDX42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX42 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P061851:  view genomic region     (about GC identifiers)

Start:
61,850,963 bp from pter      End:
61,896,677 bp from pter
Size:
45,715 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX42  
Size: 938 amino acids; 102975 Da
Subunit: Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155,
SF3B2/SAP145/SF3B155, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125.
Interacts (via the C-terminus) with TP53BP2; the interaction is not inhibitied by TP53BP2 ubiquitination and is
independent of p53/TP53
Subcellular location: Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies
(CBs) and nuclear speckles
Sequence caution: Sequence=AAC32396.1; Type=Frameshift; Positions=818;
Secondary accessions: A6NML1 A8KA43 O75619 Q68G51 Q96BK1 Q96HR7 Q9Y3V8
Alternative splicing: 2 isoforms:  Q86XP3-1   Q86XP3-2   

Explore the universe of human proteins at neXtProt for DDX42: NX_Q86XP3

Explore proteomics data for DDX42 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86XP3

  • 4/30 DME Specific Peptides for DDX42 (Q86XP3) (see all 30)
     AFQSQYK  GAMGDRL  QSERNKV  TPGRLID 

    DDX42 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDX42 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_031398.2  NP_987095.1  

    ENSEMBL proteins: 
     ENSP00000464232   ENSP00000464050   ENSP00000463561   ENSP00000352308   ENSP00000463038  
     ENSP00000462174   ENSP00000461957   ENSP00000374574   ENSP00000390121  

    Human Recombinant Protein Products for DDX42: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DDX42
    GenScript Custom Purified and Recombinant Proteins Services for DDX42
    Novus Biologicals DDX42 Protein
    Novus Biologicals DDX42 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX42 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015030Cajal body IEA--
    GO:0016607nuclear speck IEA--

    DDX42 for ontologies           About GeneDecksing



    DDX42 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DDX42
    GenScript Custom Superior Antibodies Services for DDX42
    Novus Biologicals DDX42 Antibodies
    Abcam antibodies for DDX42
    Cloud-Clone Corp. Antibodies for DDX42 
    Search ThermoFisher Antibodies for DDX42
    Search LSBio for Antibodies for DDX42 

    Assay Products for DDX42: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDX42
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDX42
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX42 
    Cloud-Clone Corp. CLIAs for DDX42


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    5/6 InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q86XP3

    ProtoNet protein and cluster: Q86XP3

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3
    Similarity: Belongs to the DEAD box helicase family. DDX42 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX42 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX42_HUMAN, Q86XP3
    Function: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA
    secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA
    duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP
    binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein
    triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2
    and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI19377511
    GO:0005524ATP binding IEA--
         
    DDX42 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DDX42:
     Increased gamma-H2AX phosphory  Low eccentricity cells  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX42 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDX42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX42 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX42 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX42
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX42 (see all 19):
    hsa-miR-549 hsa-miR-125a-5p hsa-miR-3133 hsa-miR-340 hsa-miR-125b hsa-miR-186 hsa-miR-205* hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidDDX42 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDX42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX42

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDX42
    Sirion Biotech Customized adenovirus for overexpression of DDX42

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DDX42 (see all 10)
    OriGene ORF clones in mouse, rat for DDX42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DDX42 (NM_203499)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX42
    Sirion Biotech Customized lentivirus for stable overexpression of DDX42 
                         Customized lentivirus expression plasmids for stable overexpression of DDX42 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDX42
    Search LifeMap BioReagents cell lines for DDX42
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX42


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DDX42 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for DDX42):
        Spliceosome


    DDX42 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/787 Interacting proteins for DDX42 (Q86XP32, 3 ENSP000003523084) via UniProtKB, MINT, STRING, and/or I2D (see all 787)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205620 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000221413
    SF3B1O755332, 3, ENSP000003353214MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000335321
    RECQL5O947622, 3MINT-63238 I2D: score=5 
    RUVBL1Q9Y2652, 3, ENSP000003182974MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000318297
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization IDA19377511

    DDX42 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX42

    Search CenterWatch for drugs/clinical trials and news about DDX42

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDX42 gene (2 alternative transcripts): 
    NM_007372.3  NM_203499.2  

    Unigene Cluster for DDX42:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
    Hs.702010  [show with all ESTs]
    Unigene Representative Sequence: NM_007372
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000581135 ENST00000578681(uc002jbu.3) ENST00000583590(uc002jbv.3 uc010wps.2)
    ENST00000359353(uc002jbw.1) ENST00000580108 ENST00000578137 ENST00000584261
    ENST00000577940 ENST00000579511 ENST00000577978 ENST00000584010(uc002jbx.3)
    ENST00000581477 ENST00000578593(uc002jby.3) ENST00000584951 ENST00000579539
    ENST00000582985 ENST00000581767 ENST00000389924
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX42
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX42 (see all 19):
    hsa-miR-549 hsa-miR-125a-5p hsa-miR-3133 hsa-miR-340 hsa-miR-125b hsa-miR-186 hsa-miR-205* hsa-miR-3174
    SwitchGear 3'UTR luciferase reporter plasmidDDX42 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDX42
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX42
    Clone
    Products:
         
    OriGene clones in human, mouse for DDX42 (see all 10)
    OriGene ORF clones in mouse, rat for DDX42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DDX42 (NM_203499)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX42
    Sirion Biotech Customized lentivirus for stable overexpression of DDX42 
                         Customized lentivirus expression plasmids for stable overexpression of DDX42 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX42
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX42
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX42
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX42

    Additional mRNA sequence: 

    AB036090.1 AF083255.1 AF147429.1 AK001964.1 AK095772.1 AK096751.1 AK122737.1 AK126480.1 
    AK292908.1 AL050096.1 BC008208.1 BC015505.1 BC078667.1 BC093081.1 

    24 DOTS entries:

    DT.101964800  DT.452278  DT.100823349  DT.100745450  DT.100823348  DT.101977643  DT.121007436  DT.100823342 
    DT.121007394  DT.100823351  DT.86837221  DT.91983138  DT.97801238  DT.107162  DT.102838777  DT.100823345 
    DT.121007307  DT.95173866  DT.97762171  DT.100823347  DT.102838776  DT.91941760  DT.92447108  DT.95173850 

    24/300 AceView cDNA sequences (see all 300):

    BE901178 CK300795 BM743670 CB215329 BM564503 AI199468 AI149108 BM550220 
    CD516379 BU185874 NM_007372 CA428921 AI678965 BQ478265 NM_203499 BE387686 
    BE388910 CA446920 AF083255 CF143527 BM462117 CR617579 CB128477 BC015505 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DDX42 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                                -                             -                 -     -                     
    SP2:                                                                                -                             -                 -     -                     
    SP3:                                                                                                              -                 -     -                     
    SP4:                                            -     -                                                                                                         
    SP5:                                            -           -                                                                                                   

    ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b · 22c · 22d · 22e
    SP1:              -     -                                       
    SP2:              -     -                                       
    SP3:              -     -                                       
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DDX42

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAAACAC
    DDX42 Expression
    About this image


    See DDX42 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX42

    SOURCE GeneReport for Unigene cluster: Hs.702010

    UniProtKB/Swiss-Prot: DDX42_HUMAN, Q86XP3
    Tissue specificity: Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus,
    muscle and pancreatic islets

        SABiosciences Custom PCR Arrays for DDX42
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX42
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX42
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX42
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX42
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX42 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx421 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 421, 5 90.8(n)1
    96.66(a)1
      11 (68.89 cM)5
    720471  NM_028074.41  NP_082350.31 
     1062169265 
    chicken
    (Gallus gallus)
    Aves DDX421 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 77.33(n)
    88.24(a)
      419959  NM_001030926.1  NP_001026097.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX426
    Uncharacterized protein
    84(a)
    1 ↔ 1
    6(78561336-78584418)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043977.12   -- 76.19(n)    BC043977.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddx421 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 69.01(n)
    75.75(a)
      503932  NM_001037805.2  NP_001032894.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64181 CG6418 58.1(n)
    56.28(a)
      39218  NM_140156.2  NP_648413.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C46F11.41 Protein C46F11.4 57.86(n)
    56.69(a)
      175469  NM_065342.3  NP_497743.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP56
    RNA helicase in the DEAD-box family, necessary for...
    22(a)
    1 → many
    II(691969-694518)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G473301 DEAD-box ATP-dependent RNA helicase 24 52.83(n)
    47.36(a)
      819346  NM_130301.4  NP_566099.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03085001 hypothetical protein 52.57(n)
    49.03(a)
      4332617  NM_001056439.1  NP_001049904.1 


    ENSEMBL Gene Tree for DDX42 (if available)
    TreeFam Gene Tree for DDX42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX42 gene
    DDX212  DDX462  DDX502  DDX52  DDX172  DDX432  DDX532  
    17 SIMAP similar genes for DDX42 using alignment to 5 protein entries:     DDX42_HUMAN (see all proteins):
    DDX46    DDX47    DDX53    DDX54    DDX3X    DDX5
    EIF4A2    EIF4A1    DDX17    DDX43    DDX49    EIF4A3
    DDX3Y    DDX39B    DDX52    DDX39A    DDX41

    DDX42 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/983 SNPs in DDX42 are shown (see all 983)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573795081,2
    C--61853126(+) AAAGCC/TTTTTA 2 -- int12Minor allele frequency- T:0.05WA 120
    rs1427996061,2
    --61853194(+) TATATC/TGTAAC 2 -- int10--------
    rs604240911,2
    C,F--61853195(+) ATATTG/TTAACA 2 -- int12Minor allele frequency- T:0.06WA 120
    rs1446429081,2
    --61853208(+) TTAATA/GTAAGA 2 -- int10--------
    rs1831894951,2
    --61853257(+) TAGTCA/GTATAA 2 -- int10--------
    rs1484754731,2
    --61853260(+) TCATAC/TAATCA 2 -- int10--------
    rs1878061531,2
    --61853266(+) AATCAG/TCTCTT 2 -- int10--------
    rs1926241171,2
    C--61853282(+) CTTTAA/CGCTGA 2 -- int10--------
    rs1856113031,2
    --61853295(+) GGAGAA/GGGGAT 2 -- int10--------
    rs116516931,2
    C,F,H--61853326(+) CTAGCA/GTTTAC 2 -- int18Minor allele frequency- G:0.39WA NA CSA EA 369

    HapMap Linkage Disequilibrium report for DDX42 (61850963 - 61896677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DDX42:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658528CNV Deletion23128226
    esv2716097CNV Deletion23290073
    nsv833510CNV Loss17160897
    nsv510720CNV Loss20534489
    nsv517272CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX42
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613369    OMIM disorders: --

    6 diseases for DDX42:    About MalaCards
    japanese encephalitis    encephalitis    tonsillitis    fanconi's anemia
    anemia    pancreatitis


    DDX42 for disorders           About GeneDecksing


    Export disorders for DDX42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX42 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with DDX42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human member of the DEAD box protein family. (PubMed id 10727850)1, 2, 3, 9 Suk K.... Lee M.-S. (2000)
    2. Ddx42p -- a human DEAD box protein with RNA chaperone activities. (PubMed id 16397294)1, 2, 3 Uhlmann-Schiffler H.... Stahl H. (2006)
    3. Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. (PubMed id 12234937)1, 2, 9 Will C.L....Luhrmann R. (2002)
    4. The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. (PubMed id 19377511)1, 2 Uhlmann-Schiffler H....Stahl H. (2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (2012)
    10. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11325 HGNC: 18676 AceView: DDX42 Ensembl:ENSG00000198231 euGenes: HUgn11325
    ECgene: DDX42 Kegg: 11325 H-InvDB: DDX42

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX42 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDX42 gene:
    Search GeneIP for patents involving DDX42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DDX42  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DDX42  
     OriGene qSTAR qPCR primer pairs in human, mouse for DDX42   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DDX42   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDX42   OriGene Custom Protein Services for DDX42  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX42
     QIAGEN SeqTarget long-range PCR primers for resequencing DDX42
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX42
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX42
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX42
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX42
     GenScript Custom Purified and Recombinant Proteins Services for DDX42 GenScript cDNA clones with any tag delivered in your preferred vector for DDX42
     GenScript Custom Assay Services for DDX42 GenScript Custom Superior Antibodies Services for DDX42
     GenScript Custom overexpressing Cell Line Services for DDX42 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DDX42 promoter
     Search Chromatin IP Primers for DDX42
     RT2 qPCR Primer Assay in human, mouse, rat DDX42
     Search GNC Networks for DDX42
     SABiosciences Custom PCR Arrays for DDX42
     Search Tocris compounds for DDX42
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DDX42 antibodies
     DDX42 proteins
     DDX42 lysates
     Antibodies for DDX42
     See all of Abcam's Antibodies, Kits and Proteins for DDX42
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DDX42
     Antibodies for DDX42
     ELISAs for DDX42
     CLIAs for DDX42
     Search LifeMap BioReagents cell lines for DDX42
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX42
     SwitchGear 3'UTR luciferase reporter plasmids for DDX42
     SwitchGear Promoter luciferase reporter plasmids for DDX42
     Search ThermoFisher Antibodies for DDX42
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX42
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX42
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDX42
    Customized:
     lentivirus for stable overexpression of DDX42
     lentivirus expression plasmids for stable overexpression of DDX42
     adenovirus for overexpression of DDX42
     Search LSBio for Antibodies for DDX42
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DDX42 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4