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Aliases for DDX41 Gene

Aliases for DDX41 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41 2 3
  • DEAD Box Protein Abstrakt Homolog 3 4
  • DEAD Box Protein 41 3 4
  • ABS 3 4
  • DEAD-Box Protein Abstrakt 3
  • Putative RNA Helicase 3
  • 2900024F02Rik 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX41 Gene

Previous GeneCards Identifiers for DDX41 Gene

  • GC05M176869
  • GC05M176919
  • GC05M176871
  • GC05M176938
  • GC05M171859

Summaries for DDX41 Gene

Entrez Gene Summary for DDX41 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX41 Gene

DDX41 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41) is a Protein Coding gene. Diseases associated with DDX41 include von economo's disease and cd3gamma deficiency. Among its related pathways are Immune System and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include nucleic acid binding and helicase activity.

UniProtKB/Swiss-Prot for DDX41 Gene

  • Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing

Gene Wiki entry for DDX41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX41 Gene

Genomics for DDX41 Gene

Regulatory Elements for DDX41 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX41 Gene

Chromosome:
5
Start:
177,511,577 bp from pter
End:
177,517,469 bp from pter
Size:
5,893 bases
Orientation:
Minus strand

Genomic View for DDX41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX41 Gene

Proteins for DDX41 Gene

  • Protein details for DDX41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJV9-DDX41_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX41
    Protein Accession:
    Q9UJV9
    Secondary Accessions:
    • B2RDC8
    • Q96BK6
    • Q96K05
    • Q9NT96
    • Q9NW04

    Protein attributes for DDX41 Gene

    Size:
    622 amino acids
    Molecular mass:
    69838 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    SequenceCaution:
    • Sequence=CAE46035.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX41 Gene

neXtProt entry for DDX41 Gene

Proteomics data for DDX41 Gene at MOPED

Post-translational modifications for DDX41 Gene

  • Ubiquitination at Lys 49 and Lys 538
  • Modification sites at PhosphoSitePlus

Domains & Families for DDX41 Gene

Gene Families for DDX41 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJV9

UniProtKB/Swiss-Prot:

DDX41_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX41 subfamily.
  • Contains 1 CCHC-type zinc finger.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX41 subfamily.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with DDX41: view

Function for DDX41 Gene

Molecular function for DDX41 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for DDX41 Gene

Gene Ontology (GO) - Molecular Function for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005515 protein binding IPI 22365833
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX41: view
genes like me logo Genes that share phenotypes with DDX41: view

Animal Model Products

miRNA for DDX41 Gene

miRTarBase miRNAs that target DDX41

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX41

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX41 Gene

Localization for DDX41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX41 Gene COMPARTMENTS Subcellular localization image for DDX41 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
lysosome 2
plasma membrane 2
vacuole 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with DDX41: view

Pathways & Interactions for DDX41 Gene

genes like me logo Genes that share pathways with DDX41: view

Gene Ontology (GO) - Biological Process for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006396 RNA processing TAS 10607561
GO:0006915 apoptotic process TAS 10607561
GO:0007275 multicellular organismal development TAS 10607561
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX41: view

No data available for SIGNOR curated interactions for DDX41 Gene

Drugs & Compounds for DDX41 Gene

(1) Drugs for DDX41 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for DDX41 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
retinoic acid
302-79-4
genes like me logo Genes that share compounds with DDX41: view

Transcripts for DDX41 Gene

Unigene Clusters for DDX41 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 41:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX41

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX41 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - - - - -
SP17:
SP18:
SP19: - -
SP20: - - -
SP21: - - - -
SP22: - - - - - - -
SP23: -
SP24: -
SP25:

ExUns: 10d ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -

Relevant External Links for DDX41 Gene

GeneLoc Exon Structure for
DDX41
ECgene alternative splicing isoforms for
DDX41

Expression for DDX41 Gene

mRNA expression in normal human tissues for DDX41 Gene

Protein differential expression in normal tissues from HIPED for DDX41 Gene

This gene is overexpressed in Lung (33.6), Bone (12.6), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX41 Gene



SOURCE GeneReport for Unigene cluster for DDX41 Gene Hs.484288

genes like me logo Genes that share expression patterns with DDX41: view

Protein tissue co-expression partners for DDX41 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX41 Gene

Orthologs for DDX41 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX41 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX41 35
  • 90.94 (n)
  • 99.2 (a)
DDX41 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX41 35
  • 91.21 (n)
  • 99.2 (a)
DDX41 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx41 35
  • 89.39 (n)
  • 98.87 (a)
Ddx41 16
Ddx41 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX41 35
  • 99.46 (n)
  • 100 (a)
DDX41 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx41 35
  • 89.82 (n)
  • 99.04 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX41 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX41 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859810 35
  • 84.21 (n)
  • 96.57 (a)
-- 36
  • 93 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DDX41 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx41 35
  • 75.2 (n)
  • 90.21 (a)
Str.11810 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24533 35
zebrafish
(Danio rerio)
Actinopterygii ddx41 35
  • 72.9 (n)
  • 77.7 (a)
Dr.12223 35
CABZ01074913.1 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004711 35
  • 61.9 (n)
  • 69.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta abs 35
  • 65.25 (n)
  • 67.4 (a)
abs 36
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sacy-1 35
  • 57.32 (n)
  • 60.23 (a)
sacy-1 36
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP1 36
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51280 35
  • 61.16 (n)
  • 65.46 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10608 35
rice
(Oryza sativa)
Liliopsida Os.26998 35
Os02g0150100 35
  • 64.8 (n)
  • 68.23 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4791 35
corn
(Zea mays)
Liliopsida Zm.3965 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7836 35
Species with no ortholog for DDX41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX41 Gene

ENSEMBL:
Gene Tree for DDX41 (if available)
TreeFam:
Gene Tree for DDX41 (if available)

Paralogs for DDX41 Gene

genes like me logo Genes that share paralogs with DDX41: view

No data available for Paralogs for DDX41 Gene

Variants for DDX41 Gene

Structural Variations from Database of Genomic Variants (DGV) for DDX41 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv6381n71 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv883177 CNV Loss 21882294
nsv5147 CNV Loss 18451855
esv1002656 CNV Deletion 20482838

Variation tolerance for DDX41 Gene

Residual Variation Intolerance Score: 3.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX41 Gene

HapMap Linkage Disequilibrium report
DDX41
Human Gene Mutation Database (HGMD)
DDX41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DDX41 Gene

Disorders for DDX41 Gene

MalaCards: The human disease database

(10) MalaCards diseases for DDX41 Gene - From: ClinVar and DISEASES

Disorder Aliases PubMed IDs
von economo's disease
  • encephalitis lethargica
cd3gamma deficiency
eumycotic mycetoma
  • mycotic mycetoma
cercarial dermatitis
  • cutaneous schistosomiasis
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association
Search DDX41 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX41
genes like me logo Genes that share disorders with DDX41: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX41 Gene

Publications for DDX41 Gene

  1. Retinoic acid-inducible gene-I (RIG-I) is induced by IFN-{gamma} in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis. (PMID: 20167631) Imaizumi T. … Ito E. (Lupus 2010) 23 67
  2. A role for DEAD box 1 at DNA double-strand breaks. (PMID: 18710941) Li L. … Godbout R. (Mol. Cell. Biol. 2008) 23 67
  3. Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes. (PMID: 17182220) Kitamura H. … Hanada K. (J. Dermatol. Sci. 2007) 23 67
  4. Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline. (PMID: 16452506) Savitsky M. … Gvozdev V. (Genes Dev. 2006) 23 67
  5. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. (PMID: 16959245) Alli Z. … Abdelhaleem M. (Exp. Mol. Pathol. 2006) 23 67

Products for DDX41 Gene

Sources for DDX41 Gene

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