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Aliases for DDX41 Gene

Aliases for DDX41 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41 2 3
  • ABS 3 4 6
  • DEAD Box Protein Abstrakt Homolog 3 4
  • DEAD Box Protein 41 3 4
  • Probable ATP-Dependent RNA Helicase DDX41 3
  • DEAD-Box Protein Abstrakt 3
  • Putative RNA Helicase 3
  • 2900024F02Rik 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64

External Ids for DDX41 Gene

Summaries for DDX41 Gene

Entrez Gene Summary for DDX41 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX41 Gene

DDX41 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for DDX41 Gene

  • Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing

Gene Wiki entry for DDX41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX41 Gene

Genomics for DDX41 Gene

Genomic Location for DDX41 Gene

Start:
177,511,577 bp from pter
End:
177,517,469 bp from pter
Size:
5,893 bases
Orientation:
Minus strand

Genomic View for DDX41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX41 Gene

Regulatory Elements for DDX41 Gene

Proteins for DDX41 Gene

  • Protein details for DDX41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJV9-DDX41_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX41
    Protein Accession:
    Q9UJV9
    Secondary Accessions:
    • B2RDC8
    • Q96BK6
    • Q96K05
    • Q9NT96
    • Q9NW04

    Protein attributes for DDX41 Gene

    Size:
    622 amino acids
    Molecular mass:
    69838 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    SequenceCaution:
    • Sequence=CAE46035.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX41 Gene

neXtProt entry for DDX41 Gene

Proteomics data for DDX41 Gene at MOPED

Post-translational modifications for DDX41 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys49 and Lys538

Other Protein References for DDX41 Gene

Domains for DDX41 Gene

Gene Families for DDX41 Gene

HGNC:
  • DDX :DEAD-boxes

UniProtKB/Swiss-Prot:

DDX41_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q9UJV9
  • Contains 1 helicase C-terminal domain.:
    • Q9UJV9
Family:
  • Belongs to the DEAD box helicase family. DDX41 subfamily.:
    • Q9UJV9
Similarity:
  • Contains 1 CCHC-type zinc finger.:
    • Q9UJV9
genes like me logo Genes that share domains with DDX41: view

Function for DDX41 Gene

Molecular function for DDX41 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing

Enzyme Numbers (IUBMB) for DDX41 Gene

Gene Ontology (GO) - Molecular Function for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with DDX41: view
genes like me logo Genes that share phenotypes with DDX41: view

miRNA for DDX41 Gene

miRTarBase miRNAs that target DDX41

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX41 Gene

Localization for DDX41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX41 Gene COMPARTMENTS Subcellular localization image for DDX41 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DDX41: view

Pathways for DDX41 Gene

genes like me logo Genes that share pathways with DDX41: view

Gene Ontology (GO) - Biological Process for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006396 RNA processing TAS 10607561
GO:0006915 apoptotic process TAS 10607561
GO:0007275 multicellular organismal development TAS 10607561
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with DDX41: view

Compounds for DDX41 Gene

(1) Novoseek inferred chemical compound relationships for DDX41 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 6.04 1
genes like me logo Genes that share compounds with DDX41: view

Transcripts for DDX41 Gene

Unigene Clusters for DDX41 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX41 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - - - - -
SP17:
SP18:
SP19: - -
SP20: - - -
SP21: - - - -
SP22: - - - - - - -
SP23: -
SP24: -
SP25:

ExUns: 10d ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -

Relevant External Links for DDX41 Gene

GeneLoc Exon Structure for
DDX41
ECgene alternative splicing isoforms for
DDX41

Expression for DDX41 Gene

mRNA expression in normal human tissues for DDX41 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX41 Gene

SOURCE GeneReport for Unigene cluster for DDX41 Gene Hs.484288

genes like me logo Genes that share expressions with DDX41: view

Orthologs for DDX41 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX41 36
  • 99.46 (n)
  • 100 (a)
DDX41 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX41 36
  • 90.94 (n)
  • 99.2 (a)
DDX41 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX41 36
  • 91.21 (n)
  • 99.2 (a)
DDX41 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx41 36
  • 89.39 (n)
  • 98.87 (a)
Ddx41 16
Ddx41 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX41 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX41 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx41 36
  • 89.82 (n)
  • 99.04 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 93 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
LOC100859810 36
  • 84.21 (n)
  • 96.57 (a)
lizard
(Anolis carolinensis)
Reptilia DDX41 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24533 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx41 36
  • 75.2 (n)
  • 90.21 (a)
Str.11810 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01074913.1 37
  • 68 (a)
OneToOne
ddx41 36
  • 72.9 (n)
  • 77.7 (a)
Dr.12223 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004711 36
  • 61.9 (n)
  • 69.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta abs 36
  • 65.25 (n)
  • 67.4 (a)
abs 37
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sacy-1 36
  • 57.32 (n)
  • 60.23 (a)
sacy-1 37
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP1 37
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51280 36
  • 61.16 (n)
  • 65.46 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10608 36
corn
(Zea mays)
Liliopsida Zm.3965 36
rice
(Oryza sativa)
Liliopsida Os.26998 36
Os02g0150100 36
  • 64.8 (n)
  • 68.23 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4791 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7836 36
Species with no ortholog for DDX41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX41 Gene

ENSEMBL:
Gene Tree for DDX41 (if available)
TreeFam:
Gene Tree for DDX41 (if available)

Paralogs for DDX41 Gene

genes like me logo Genes that share paralogs with DDX41: view

No data available for Paralogs for DDX41 Gene

Variants for DDX41 Gene

Sequence variations from dbSNP and Humsavar for DDX41 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs335436 -- 177,512,734(+) AAAGC(A/G)CTGCT intron-variant
rs335437 -- 177,513,273(-) GAGCC(A/G)GGGGT intron-variant
rs335438 -- 177,513,383(-) GGGCG(C/T)GCTGG reference, synonymous-codon
rs335439 -- 177,513,870(-) AACCT(C/G)AGGGT intron-variant
rs335440 -- 177,516,246(-) AGCTG(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX41 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv6381n71 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv883177 CNV Loss 21882294
nsv5147 CNV Loss 18451855
esv1002656 CNV Deletion 20482838

Relevant External Links for DDX41 Gene

HapMap Linkage Disequilibrium report
DDX41

Disorders for DDX41 Gene

(2) Novoseek inferred disease relationships for DDX41 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 45.1 2
tumors 0 1
genes like me logo Genes that share disorders with DDX41: view

No data available for UniProtKB/Swiss-Prot for DDX41 Gene

Publications for DDX41 Gene

  1. Developmental and cell biological functions of the Drosophila DEAD- box protein abstrakt. (PMID: 10607561) Irion U. … Leptin M. (Curr. Biol. 1999) 2 3 4
  2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3

Products for DDX41 Gene

Sources for DDX41 Gene

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