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DDX41 Gene

protein-coding   GIFtS: 56
GCID: GC05M176938

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 411 2     DEAD-Box Protein Abstrakt2
ABS2 3 5     Probable ATP-Dependent RNA Helicase DDX412
DEAD Box Protein 412 3     Putative RNA Helicase2
DEAD Box Protein Abstrakt Homolog2 3     EC 3.6.4.133
2900024F02Rik2     EC 3.6.18

External Ids:    HGNC: 186741   Entrez Gene: 514282   Ensembl: ENSG000001832587   OMIM: 6081705   UniProtKB: Q9UJV93   

Export aliases for DDX41 gene to outside databases

Previous GC identifers: GC05M176869 GC05M176919 GC05M176871 GC05M171859


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX41 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of
this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during
post-transcriptional gene expression. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX41 Gene:
DDX41 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 41) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot: DDX41_HUMAN, Q9UJV9
Function: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be
involved in pre-mRNA splicing

Gene Wiki entry for DDX41 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX41 gene promoter:
         E2F-3a   AP-1   ATF-2   E2F-2   IRF-1   E2F   E2F-1   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDX41 promoter sequence
   Search Chromatin IP Primers for DDX41

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

DDX41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX41 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176938:  view genomic region     (about GC identifiers)

Start:
176,938,578 bp from pter      End:
176,944,470 bp from pter
Size:
5,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX41_HUMAN, Q9UJV9 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX41  
Size: 622 amino acids; 69838 Da
Subunit: Identified in the spliceosome C complex
Sequence caution: Sequence=CAE46035.1; Type=Miscellaneous discrepancy; Note=Intron retention;
1 PDB 3D structure from and Proteopedia for DDX41:
2P6N (3D)    
Secondary accessions: B2RDC8 Q96BK6 Q96K05 Q9NT96 Q9NW04

Explore the universe of human proteins at neXtProt for DDX41: NX_Q9UJV9

Explore proteomics data for DDX41 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys49, Lys538
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX41 (Q9UJV9) (see all 15)
     GNTGIAT  TPGRLMD  VATPGRL  IHGGKDQ 


    See DDX41 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057306.2  
    ENSEMBL proteins: 
     ENSP00000330349   ENSP00000422753   ENSP00000421460   ENSP00000425739   ENSP00000426330  
     ENSP00000427082  
    Reactome Protein details: Q9UJV9

    DDX41 Human Recombinant Protein Products:

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    Novus Biologicals DDX41 Proteins
    Novus Biologicals DDX41 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DDX41

     
    Search eBioscience for Proteins for DDX41 

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    Search eBioscience for ELISAs for DDX41 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9UJV9

    ProtoNet protein and cluster: Q9UJV9

    2 Blocks protein domains:
    IPB000629 ATP-dependent helicase
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: DDX41_HUMAN, Q9UJV9
    Similarity: Belongs to the DEAD box helicase family. DDX41 subfamily
    Similarity: Contains 1 CCHC-type zinc finger
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX41           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX41_HUMAN, Q9UJV9
    Function: Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be
    involved in pre-mRNA splicing
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding ----
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with DDX41           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for DDX41:
     Cell cycle / mitosis defect  Cell division defect  Increased S DNA content, incre  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce 

         1 MGI phenotypic allele for Ddx41 (no phenotypes)

    Find genes that share phenotypes with DDX41           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX41
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    miRNA
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    miRTarBase miRNAs that target DDX41:
    hsa-mir-484 (MIRT041875), hsa-mir-16-5p (MIRT031540), hsa-let-7b-5p (MIRT032281)

    Block miRNA regulation of human, mouse, rat DDX41 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DDX41:
    hsa-miR-432
    SwitchGear 3'UTR luciferase reporter plasmidDDX41 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX41

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX41_HUMAN, Q9UJV9: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol TAS--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with DDX41           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDX41 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    STING mediated induction of host immune responses0.00
    Regulation of innate immune responses to cytosolic DNA0.00
    IRF3-mediated induction of type I IFN0.00


    Find genes that share SuperPaths with DDX41           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for DDX41
        STING mediated induction of host immune responses
    Regulation of innate immune responses to cytosolic DNA
    IRF3-mediated induction of type I IFN


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX41
    Interactions:

        GeneGlobe Interaction Network for DDX41

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX41 (Q9UJV91, 2, 3 ENSP000003303494) via UniProtKB, MINT, STRING, and/or I2D (see all 814)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNB1P146352, 3MINT-7945693 MINT-7947479 I2D: score=4 
    NKAPQ8N5F71, 2, ENSP000003604644EBI-1046350,EBI-721539 MINT-8337673 MINT-8331403 STRING: ENSP00000360464
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SART1O432902, ENSP000003104484MINT-7945693 MINT-7947479 STRING: ENSP00000310448
    SNRNP70P086212, ENSP000002214484MINT-7945693 MINT-7947479 STRING: ENSP00000221448
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006396RNA processing TAS10607561
    GO:0006915apoptotic process TAS10607561
    GO:0007275multicellular organismal development TAS10607561
    GO:0032479regulation of type I interferon production TAS--

    Find genes that share ontologies with DDX41           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX41

    1 Novoseek inferred chemical compound relationship for DDX41 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 6.04 1 8065313 (1)



    Find genes that share compounds with DDX41           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX41 gene: 
    NM_016222.2  

    Unigene Cluster for DDX41:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
    Hs.484288  [show with all ESTs]
    Unigene Representative Sequence: AK091545
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512334 ENST00000330503(uc003mhn.3) ENST00000507955(uc003mho.3)
    ENST00000505081(uc003mhq.1) ENST00000503078(uc003mhp.3) ENST00000507900
    ENST00000504807 ENST00000512027 ENST00000511040 ENST00000508279 ENST00000513562
    ENST00000512431 ENST00000504781 ENST00000509576 ENST00000506965 ENST00000515562
    ENST00000510171
    miRNA
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    Block miRNA regulation of human, mouse, rat DDX41 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DDX41:
    hsa-miR-432
    SwitchGear 3'UTR luciferase reporter plasmidDDX41 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX41
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    GenScript: all cDNA clones in your preferred vector: DDX41 (NM_016222)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX41
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX41
      QuantiTect SYBR Green Assays in human, mouse, rat DDX41
      QuantiFast Probe-based Assays in human, mouse, rat DDX41

    Additional mRNA sequence: 

    AF195417.1 AK001255.1 AK026117.1 AK027768.1 AK091545.1 AK091774.1 AK092585.1 AK222598.1 
    AK310525.1 AK315491.1 AL137455.1 BC015476.1 BC067902.1 BX641072.1 

    Selected DOTS entries (see all 37):

    DT.100847188  DT.85101027  DT.120867314  DT.120867280  DT.100847193  DT.100847194  DT.97768327  DT.92057283 
    DT.120867293  DT.120867276  DT.120867306  DT.100847199  DT.120867223  DT.95094554  DT.100847198  DT.120867264 
    DT.120867238  DT.120867247  DT.100847181  DT.100847183  DT.100847202  DT.120867251  DT.120867283  DT.120867295 

    Selected AceView cDNA sequences (see all 579):

    BQ673063 CR606489 BM771965 BC015476 CF141789 BM772478 AL537856 CB155838 
    BM471314 BU169225 CR618460 BM765542 BQ723518 CA394362 BM746029 BM016003 
    BM766224 BM765872 BQ681315 CR614266 BX358294 BU839315 BM476239 BQ710793 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX41 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ·
    SP1:                    -           -     -                                   -           -     -                             -     -     -                     
    SP2:                    -                                                     -           -     -                             -     -     -                     
    SP3:                    -           -     -           -     -     -           -           -     -                             -     -     -                     
    SP4:                    -           -     -                                   -           -     -                 -     -     -     -     -                     
    SP5:                    -           -     -                                   -           -     -                             -     -                           

    ExUns: 10d ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                  -                                                               
    SP2:                                                  -                                                               
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for DDX41

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCTGAG
    DDX41 Expression
    About this image

    DDX41 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX41 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484288
        Custom PCR Arrays for DDX41
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX41

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX41 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx411 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 411, 5 89.39(n)1
    98.87(a)1
      13 (30.06 cM)5
    729351  NM_134059.21  NP_598820.21 
     555304105 
    chicken
    (Gallus gallus)
    Aves LOC1008598101 probable ATP-dependent RNA helicase DDX41-like 84.21(n)
    96.57(a)
      100859810  XM_003643675.2  XP_003643723.2 
    lizard
    (Anolis carolinensis)
    Reptilia DDX416
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
    91(a)
    1 ↔ 1
    2(145602905-145621319)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245332 Xenopus laevis transcribed sequence with weak similarity more 76.94(n)    CB198425.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.122232 Transcribed sequence with weak similarity to protein more 81.07(n)    BQ617609.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta abs1 abstrakt 65.25(n)
    67.4(a)
      40530  NM_079496.4  NP_524220.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sacy-11 sacy-1 57.32(n)
    60.23(a)
      172413  NM_059561.4  NP_491962.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP16
    Putative ATP-dependent RNA helicase of the DEAD-bo...
    30(a)
    1 ↔ 1
    XVI(324411-326264) YPL119C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G512801 AT5G51280 61.16(n)
    65.46(a)
      835202  NM_124507.4  NP_199941.1 
    rice
    (Oryza sativa)
    Liliopsida Os.269982 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.53(n)    AK060595.1 


    ENSEMBL Gene Tree for DDX41 (if available)
    TreeFam Gene Tree for DDX41 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX41 gene
    Selected SIMAP similar genes for DDX41 using alignment to 7 protein entries:     DDX41_HUMAN (see all proteins) (see all similar genes):
    DDX23    MST162    DDX56    DKFZp547B159    DDX54    DDX5
    DDX3X    EIF4A2    DDX52    DDX59    DKFZp686J01190    DDX17
    DDX3Y    DDX43    DDX18    DDX39B    DDX47    DDX49

    Find genes that share paralogs with DDX41           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for DDX41 (see all 286)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764888701,2
    C,F--171858666(+) GTCAAC/TGGAAT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1837920081,2
    --171858725(+) CCTGAA/GGCAAG 1 -- ds50010--------
    rs1506152991,2
    --171858799(+) GGGCCA/TGAGAG 1 -- ds50010--------
    rs1399548821,2
    C--171858837(+) GAATCC/GAAGCA 1 -- ds50010--------
    rs1864127481,2
    --171858856(+) TGGCCC/TGCCAA 1 -- ds50010--------
    rs26307581,2
    C,F,O,H--171858861(-) CCACAT/CTGGCG 1 -- ds500121Minor allele frequency- C:0.43NS EA NA WA 2346
    rs1904657571,2
    --171858896(+) ACAACA/CCAGTG 1 -- ds50010--------
    rs1830548201,2
    --171858937(+) CAGCTC/TGGTGG 1 -- ds50010--------
    rs1439145341,2
    C--171859051(+) TCCAGA/GAACCA 1 -- ds50010--------
    rs286955781,2
    C,F--171859199(+) CCCATA/C/TCCAGG 2 -- ut31 ese313NA WA CSA EA 379

    HapMap Linkage Disequilibrium report for DDX41 (176938578 - 176944470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DDX41:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002656CNV Deletion20482838
    nsv5147CNV Loss18451855
    dgv6379n71CNV Loss21882294
    nsv883177CNV Loss21882294
    dgv6383n71CNV Loss21882294
    dgv6381n71CNV Loss21882294
    nsv883164CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DDX41
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX41

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608170    OMIM disorders: --


    Find genes that share disorders with DDX41           About GenesLikeMe

    2 Novoseek inferred disease relationships for DDX41 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 45.1 2 8834177 (1), 9694872 (1)
    tumors 0 1 9694872 (1)


    Export disorders for DDX41 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX41 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with DDX41)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Developmental and cell biological functions of the Drosophila DEAD- box protein abstrakt. (PubMed id 10607561)1, 2, 3 Irion U. and Leptin M. (Curr. Biol. 1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    10. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. (PubMed id 23142775)1 Parvatiyar K....Cheng G. (Nat. Immunol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51428 HGNC: 18674 AceView: DDX41 Ensembl:ENSG00000183258 euGenes: HUgn51428
    ECgene: DDX41 H-InvDB: DDX41

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX41 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX41 gene:
    Search GeneIP for patents involving DDX41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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