Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX41 Gene

Aliases for DDX41 Gene

  • DEAD-Box Helicase 41 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41 2 3 5
  • DEAD Box Protein Abstrakt Homolog 3 4
  • DEAD Box Protein 41 3 4
  • ABS 3 4
  • DEAD-Box Protein Abstrakt 3
  • Putative RNA Helicase 3
  • 2900024F02Rik 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • MPLPF 3

External Ids for DDX41 Gene

Previous GeneCards Identifiers for DDX41 Gene

  • GC05M176869
  • GC05M176919
  • GC05M176871
  • GC05M176938
  • GC05M171859

Summaries for DDX41 Gene

Entrez Gene Summary for DDX41 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX41 Gene

DDX41 (DEAD-Box Helicase 41) is a Protein Coding gene. Diseases associated with DDX41 include acute myeloblastic leukemia with maturation and acute myeloid leukemia, flt3-related. Among its related pathways are Immune System and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DDX23.

UniProtKB/Swiss-Prot for DDX41 Gene

  • Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.

Gene Wiki entry for DDX41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX41 Gene

Genomics for DDX41 Gene

Regulatory Elements for DDX41 Gene

Promoters for DDX41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX41 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX41 Gene

Chromosome:
5
Start:
177,511,577 bp from pter
End:
177,517,469 bp from pter
Size:
5,893 bases
Orientation:
Minus strand

Genomic View for DDX41 Gene

Genes around DDX41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX41 Gene

Proteins for DDX41 Gene

  • Protein details for DDX41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJV9-DDX41_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX41
    Protein Accession:
    Q9UJV9
    Secondary Accessions:
    • B2RDC8
    • Q96BK6
    • Q96K05
    • Q9NT96
    • Q9NW04

    Protein attributes for DDX41 Gene

    Size:
    622 amino acids
    Molecular mass:
    69838 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    SequenceCaution:
    • Sequence=CAE46035.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX41 Gene

neXtProt entry for DDX41 Gene

Proteomics data for DDX41 Gene at MOPED

Post-translational modifications for DDX41 Gene

  • Ubiquitination at Lys 49 and Lys 538
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DDX41 (DDX41)

Domains & Families for DDX41 Gene

Gene Families for DDX41 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJV9

UniProtKB/Swiss-Prot:

DDX41_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX41 subfamily.
  • Contains 1 CCHC-type zinc finger.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX41 subfamily.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with DDX41: view

Function for DDX41 Gene

Molecular function for DDX41 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing.

Enzyme Numbers (IUBMB) for DDX41 Gene

Gene Ontology (GO) - Molecular Function for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DDX41: view
genes like me logo Genes that share phenotypes with DDX41: view

Animal Models for DDX41 Gene

MGI Knock Outs for DDX41:

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX41

miRNA for DDX41 Gene

miRTarBase miRNAs that target DDX41

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX41 Gene

Localization for DDX41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX41 Gene COMPARTMENTS Subcellular localization image for DDX41 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 3
plasma membrane 3
cytoskeleton 2
extracellular 2
lysosome 2
mitochondrion 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DDX41: view

Pathways & Interactions for DDX41 Gene

genes like me logo Genes that share pathways with DDX41: view

Gene Ontology (GO) - Biological Process for DDX41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10607561
GO:0008152 metabolic process IEA --
GO:0032479 regulation of type I interferon production TAS --
GO:0045087 innate immune response TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with DDX41: view

No data available for SIGNOR curated interactions for DDX41 Gene

Drugs & Compounds for DDX41 Gene

(1) Drugs for DDX41 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for DDX41 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX41: view

Transcripts for DDX41 Gene

Unigene Clusters for DDX41 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX41 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - -
SP16: - - - - - - - - - -
SP17:
SP18:
SP19: - -
SP20: - - -
SP21: - - - -
SP22: - - - - - - -
SP23: -
SP24: -
SP25:

ExUns: 10d ^ 11 ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - -
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -

Relevant External Links for DDX41 Gene

GeneLoc Exon Structure for
DDX41
ECgene alternative splicing isoforms for
DDX41

Expression for DDX41 Gene

mRNA expression in normal human tissues for DDX41 Gene

Protein differential expression in normal tissues from HIPED for DDX41 Gene

This gene is overexpressed in Lung (33.6), Bone (12.6), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX41 Gene



SOURCE GeneReport for Unigene cluster for DDX41 Gene Hs.484288

genes like me logo Genes that share expression patterns with DDX41: view

Protein tissue co-expression partners for DDX41 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX41 Gene

Orthologs for DDX41 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX41 36
  • 100 (a)
OneToOne
DDX41 35
  • 99.46 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia DDX41 36
  • 99 (a)
OneToOne
DDX41 35
  • 90.94 (n)
  • 99.2 (a)
dog
(Canis familiaris)
Mammalia DDX41 35
  • 91.21 (n)
  • 99.2 (a)
DDX41 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx41 16
Ddx41 36
  • 99 (a)
OneToOne
Ddx41 35
  • 89.39 (n)
  • 98.87 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX41 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX41 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx41 35
  • 89.82 (n)
  • 99.04 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 93 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
LOC100859810 35
  • 84.21 (n)
  • 96.57 (a)
lizard
(Anolis carolinensis)
Reptilia DDX41 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24533 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx41 35
  • 75.2 (n)
  • 90.21 (a)
Str.11810 35
zebrafish
(Danio rerio)
Actinopterygii ddx41 35
  • 72.9 (n)
  • 77.7 (a)
Dr.12223 35
CABZ01074913.1 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004711 35
  • 61.9 (n)
  • 69.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta abs 36
  • 64 (a)
OneToOne
abs 35
  • 65.25 (n)
  • 67.4 (a)
worm
(Caenorhabditis elegans)
Secernentea sacy-1 36
  • 53 (a)
OneToOne
sacy-1 35
  • 57.32 (n)
  • 60.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP1 36
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51280 35
  • 61.16 (n)
  • 65.46 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10608 35
corn
(Zea mays)
Liliopsida Zm.3965 35
rice
(Oryza sativa)
Liliopsida Os.26998 35
Os02g0150100 35
  • 64.8 (n)
  • 68.23 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4791 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7836 35
Species with no ortholog for DDX41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX41 Gene

ENSEMBL:
Gene Tree for DDX41 (if available)
TreeFam:
Gene Tree for DDX41 (if available)

Paralogs for DDX41 Gene

Paralogs for DDX41 Gene

genes like me logo Genes that share paralogs with DDX41: view

Variants for DDX41 Gene

Sequence variations from dbSNP and Humsavar for DDX41 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs335438 -- 177,513,383(-) GGGCG(C/T)GCTGG reference, synonymous-codon
rs2112182 -- 177,516,674(+) GCCCC(A/C/T)TGCGA intron-variant
rs11555632 -- 177,516,385(-) AGCGG(C/T)AGTGA reference, synonymous-codon, utr-variant-5-prime
rs34567318 -- 177,515,203(-) CAGAT(-/G)CCAGG reference, frameshift-variant
rs73334195 -- 177,514,296(+) GAAAG(G/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX41 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv6381n71 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv883177 CNV Loss 21882294
nsv5147 CNV Loss 18451855
esv1002656 CNV Deletion 20482838

Variation tolerance for DDX41 Gene

Residual Variation Intolerance Score: 3.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX41 Gene

HapMap Linkage Disequilibrium report
DDX41
Human Gene Mutation Database (HGMD)
DDX41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX41 Gene

Disorders for DDX41 Gene

MalaCards: The human disease database

(18) MalaCards diseases for DDX41 Gene - From: ClinVar, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
acute myeloblastic leukemia with maturation
  • acute myeloblastic leukemia m2
acute myeloid leukemia, flt3-related
  • aml
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
thrombocytopenia 5
  • thc5
von economo's disease
  • encephalitis lethargica
- elite association - COSMIC cancer census association via MalaCards
Search DDX41 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX41
genes like me logo Genes that share disorders with DDX41: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX41 Gene

Publications for DDX41 Gene

  1. Developmental and cell biological functions of the Drosophila DEAD- box protein abstrakt. (PMID: 10607561) Irion U. … Leptin M. (Curr. Biol. 1999) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms. (PMID: 25920683) Polprasert C. … Maciejewski J.P. (Cancer Cell 2015) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for DDX41 Gene

Sources for DDX41 Gene

Back to Top

Content