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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX4 Gene

protein-coding   GIFtS: 55
GCID: GC05P055069

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4 )
 Explore 12 diseases affiliated with
DDX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDX4    

Aliases
for DDX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41 2     DEAD Box Protein 42 3
VASA1 2 3 5     Probable ATP-Dependent RNA Helicase DDX42
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 41 2     EC 3.6.4.133
Vasa Homolog2 3     EC 3.6.18

External Ids:    HGNC: 187001   Entrez Gene: 545142   Ensembl: ENSG000001526707   OMIM: 6052815   UniProtKB: Q9NQI03   

Export aliases for DDX4 gene to outside databases

Previous GC identifers: GC05P055195 GC05P056462 GC05P055004 GC05P055049 GC05P055050 GC05P052007


Summaries
for DDX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDX4:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation
initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution
patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular
growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and
several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ
cell development. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: DDX4_HUMAN, Q9NQI0
Function: May play a role in germ cell development. May play a role in sperm motility




Genomic Views
for DDX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX4 gene promoter:
         ER-alpha   MEF-2A   FOXF2   POU3F2 (N-Oct-5a)   aMEF-2   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2-p13.1   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5p15.2-p13.1

DDX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P055069:  view genomic region     (about GC identifiers)

Start:
 55,033,845 bp from pter      End:
 55,112,985 bp from pter
Size:
 79,141 bases      Orientation:
 plus strand

Proteins
for DDX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDX4_HUMAN, Q9NQI0 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX4  
Size: 724 amino acids; 79308 Da
Subunit: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9.
Interacts with PIWIL2 and MAEL (By similarity)
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region (By similarity)
Secondary accessions: A8K8Q2 B3KSF4 E9PCD8 Q5M7Z3 Q86VX0 Q9NT92 Q9NYB1
Alternative splicing: 3 isoforms:  Q9NQI0-1   Q9NQI0-2   Q9NQI0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX4: NX_Q9NQI0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQI0

    • 4/24 DME Specific Peptides for DDX4 (Q9NQI0) (see all 24)
     GGYRDGN  NVQHVIN  GINFDKY  DEADRML 

    DDX4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001136021.1  NP_001160005.1  NP_001160006.1  NP_077726.1  

    ENSEMBL proteins: 
     ENSP00000424838   ENSP00000427167   ENSP00000424779   ENSP00000421960   ENSP00000424112  
     ENSP00000347087   ENSP00000427522   ENSP00000423102   ENSP00000423123   ENSP00000430431  
     ENSP00000334167   ENSP00000425359  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): DDX4
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    Novus Biologicals DDX4 Proteins
    Novus Biologicals DDX4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DDX4

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0030529ribonucleoprotein complex ----
    GO:0033391chromatoid body IEA--
    GO:0044464cell part ----


    DDX4 for ontologies           About GeneDecksing



    DDX4 Antibody Products: 
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    Uscn ELISAs and CLIAs for DDX4

    Protein Domains /
    Families
    for DDX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDX4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9NQI0

    ProtoNet protein and cluster: Q9NQI0

    1 Blocks protein family: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX4_HUMAN, Q9NQI0
    Similarity: Belongs to the DEAD box helicase family. DDX4/VASA subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for DDX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DDX4_HUMAN, Q9NQI0
    Function: May play a role in germ cell development. May play a role in sperm motility
    Catalytic activity: ATP + H(2)O = ADP + phosphate

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX4
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX4:
    hsa-miR-21* hsa-miR-656 hsa-miR-1323 hsa-miR-708* hsa-miR-548o hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmid: DDX4 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DDX4
    OriGene siRNA: DDX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DDX4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX4 (see all 8)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX4 

    Cell Line
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    Search LifeMap BioReagents cell lines for DDX4

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--


    DDX4 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ddx4):
     cellular  endocrine/exocrine gland  reproductive system 

    DDX4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DDX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translational Control
    		Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DDX4
        Translational Control



    DDX4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/18 Interacting proteins for DDX4 (Q9NQI02, 3 ENSP000003470874) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRCP129312, 3, ENSP000003509414MINT-7302740 I2D: score=1 STRING: ENSP00000350941
    MAELQ96JY03, ENSP000003568464I2D: score=1 STRING: ENSP00000356846
    RANBP9Q96S593, ENSP000000116194I2D: score=1 STRING: ENSP00000011619
    PIWIL2Q8TC593, ENSP000003492084I2D: score=1 STRING: ENSP00000349208
    FDPSP143243I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000237leptotene IEA--
    GO:0007141male meiosis I IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030317sperm motility IMP--


    DDX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDX4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX4
    2 Novoseek chemical compound relationships for DDX4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vas-a 92.6 91 18088417 (11), 20123973 (8), 18805576 (7), 11850529 (6) (see all 20)
    atp 1.67 2 16630807 (1), 14747711 (1)

    Search CenterWatch for drugs/clinical trials and news about DDX4 

    Transcripts
    for DDX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDX4 gene (5 alternative transcripts): 
    NM_019039.1  NM_001142549.1  NM_001166533.1  NM_001166534.1  NM_024415.2  

    Unigene Cluster for DDX4:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
    Hs.223581  [show with all ESTs]
    Unigene Representative Sequence: NM_024415
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505374(uc003jqg.4 uc010ivz.3) ENST00000506511 ENST00000508580
    ENST00000515709 ENST00000506848 ENST00000514679 ENST00000354991 ENST00000511491
    ENST00000503129 ENST00000511853 ENST00000507645 ENST00000509312 ENST00000353507(uc003jqh.4 uc003jqj.3)
    ENST00000514278

    miRNA
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    hsa-miR-21* hsa-miR-656 hsa-miR-1323 hsa-miR-708* hsa-miR-548o hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmid: DDX4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX4 (see all 7)
    OriGene shRNA RFP: DDX4
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DDX4 (NM_014829)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX4

    Additional cDNA sequence: 

    AK093439.1 AK292417.1 AK308300.1 AL137462.1 AY004154.1 BC030638.1 BC047455.1 BC088362.1 

    7 DOTS entries:

    DT.120851717  DT.99927731  DT.95167229  DT.95167231  DT.75179347  DT.120851772  DT.120851718 

    24/59 AceView cDNA sequences (see all 59):

    AI337133 AA758412 AI969018 BX282689 AA383535 BE550448 AL137462 AI953070 
    CD358073 AF262962 NM_019039 BE550307 NM_024415 CD557160 CD557531 BG718634 
    BC047455 AI654417 BG717110 BG719449 BI464267 CD251828 AK093439 AA398976 

    GeneLoc Exon Structure


    Expression
    for DDX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGATTAAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DDX4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    Reproductive SystemEarly GonadPrimordial Germ CellsGerm Cells
    TestisTestis CordXY Germ CellsGerm Cells, Male Gametocytes
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    TestisSeminiferous TubulesPrimary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    Ovarian tissue-dissociated cells (Primary Cell)Reproductive System
    Ovarian tissue-dissociated cells (human) (Primary Cell)Ovary, Reproductive System
    human Fetal Gonadal Stromal Cell (Primary Cell)Reproductive System
    Embryoid bodies (Derivation of post-m...)
    Primordial-like germ cells (cKIT+ SSEA1+ VASA+) (Derivation of primor...)
    Primordial germ cell-like cells (Reconstitution of mo...)
    Ddx4-positive cells (Oocyte formation by ...)
    Human oogonial stem cells (Oocyte formation by ...)
    Oocytes (Oocyte formation by ...)
    Oocytes (Oocyte formation by ...)

    See DDX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX4

    SOURCE GeneReport for Unigene cluster: Hs.223581

    UniProtKB/Swiss-Prot: DDX4_HUMAN, Q9NQI0
    Tissue specificity: Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of
    the gonadal ridge in both sexes

        SABiosciences Expression via Pathway-Focused PCR Array including DDX4: 
              Embryonic Stem Cells in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for DDX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DDX4 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 69.18(n)
    66.92(a)    		   395447  NM_204708.1  NP_990039.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DDX46
    		 --
    		 73(a)
    		 1 ↔ 1
    		 2(2337238-2354101)
    African clawed frog
    (Xenopus laevis)    		 Amphibia VLG12 DEAD box protein 77.43(n)    AF046043.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii vasa2 vasa homolog 74.39(n)   30263  Y12007.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta vas1 , 3 dorsal appendage formation ATP dependent
    helicase3
    vasa1    		 51(a)3
    51.52(n)1
    47.51(a)1    		   35C13
    348841  NM_165103.21  NP_723899.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea vbh-13
    glh-11    		 Protein GLH-11 47(a)
    (best of 7)3
    49.97(n)1
    41.2(a)1    		   I(3159765-3162284)3
    1724141  NM_059562.41  NP_491963.11 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria rhlE6
    rhlB6
    		 ATP-dependent RNA helicase
    		 34(a)
    29(a)
    		 many ↔ many
    many ↔ many
    		 Chromosome(830095-831459)
    Chromosome(3962388-3963653)


    ENSEMBL Gene Tree for DDX4 (if available)
    TreeFam Gene Tree for DDX4 (if available) 

    Paralogs
    for DDX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX4 gene
    DDX3X2  DDX3Y2  
    18/24 SIMAP similar genes for DDX4 using alignment to 9 protein entries:     DDX4_HUMAN (see all proteins) (see all similar genes):
    DKFZp686J01190    DDX59    DDX43    DDX53    DDX39B    DDX56
    DDX54    EIF4A2    DDX5    DDX3X    EIF4A1    DDX52
    E4-DBP    DDX17    DDX3Y    BAT1    DDX47    DDX49

    DDX4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DDX4
    PGOHUM00000235728


    Genomic Variants
    for DDX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1372 NCBI SNPs in DDX4 are shown (see all 1372)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1904439671,2
    		--55031929(+) TTTTTA/TAAAAA 3 -- us2k10--------
    rs573351491,2
    		--55032014(+) AGGAGG/TTTGAG 3 -- us2k14Minor allele frequency- T:0.18CSA WA NA EA 360
    rs1808882191,2
    		--55032103(+) ATAAAC/TAAAAA 3 -- us2k10--------
    rs1141031681,2
    		F,--55032107(+) ATAAAA/TAATAT 3 -- us2k11Minor allele frequency- T:0.04WA 118
    rs752184121,2
    		F,--55032243(+) TTTATC/ACTTTA 3 -- us2k11Minor allele frequency- A:0.02NA 120
    rs566647191,2
    		--55032432(+) GATCTC/TGGCTC 3 -- us2k10--------
    rs1896984981,2
    		--55032619(+) GGCCTC/TCCCAA 3 -- us2k10--------
    rs1488948391,2
    		--55032640(+) TACAGA/GCAGAC 3 -- us2k10--------
    rs753038551,2
    		--55032679(+) CTACAC/TTTTTA 3 -- us2k13Minor allele frequency- T:0.10CSA WA NA 240
    rs1434552801,2
    		--55032682(+) CACTTC/TTAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDX4 (55033845 - 55112985 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for DDX4
         2 CNVs: 31233 2578

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    Disorders / Diseases
    for DDX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDX4 for disorders           About GeneDecksing

    OMIM gene information: 605281    OMIM disorders: --

    12 diseases for DDX4:    About MalaCards
    aortitis    spermatocele    male infertility    epithelial ovarian cancer
    diabetic neuropathy    polyneuropathy    ovarian cancer    infertility
    azoospermia    neuropathy    hermaphroditism    malaria

    2 diseases from the University of Copenhagen DISEASES database for DDX4:
    Male infertility     Infertility

    Export disorders for DDX4 gene to outside databases

    Publications
    for DDX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX4 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with DDX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human VASA gene is specifically expressed in the germ cell lineage. (PubMed id 10920202)1, 2, 3, 9 Castrillon D.H.... Crum C.P. (2000)
    2. VASA is a specific marker for both normal and malignant human germ cells. (PubMed id 11850529)1, 3, 9 Zeeman A.M....Looijenga L.H. (2002)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint. (PubMed id 18805576)1, 9 Hashimoto H....Nishimura R. (2008)
    6. Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis. (PubMed id 19629140)1, 9 Sugimoto K....Namiki M. (2009)
    7. Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro. (PubMed id 22162380)1 Medrano J.V....Reijo Pera R.A. (2012)
    8. NANOS3 function in human germ cell development. (PubMed id 21421998)2 Julaton V.T. and Reijo Pera R.A. (2011)
    9. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)

    External Searches for DDX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54514 HGNC: 18700 AceView: DDX4 Ensembl:ENSG00000152670 euGenes: HUgn54514
    ECgene: DDX4 H-InvDB: DDX4

    Other Databases showing DDX4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDX4 gene:
    Search GeneIP for patents involving DDX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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