Aliases for DDX4 Gene
External Ids for DDX4 Gene
Previous GeneCards Identifiers for DDX4 Gene
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for DDX4 Gene
DDX4 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 4) is a Protein Coding gene. Diseases associated with DDX4 include bladder calculus and cardiovascular syphilis. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DDX1.
UniProtKB/Swiss-Prot for DDX4 Gene
May play a role in germ cell development. May play a role in sperm motility.