Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX4 Gene

Aliases for DDX4 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 4 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 4 2 3
  • DEAD Box Protein 4 3 4
  • Vasa Homolog 3 4
  • VASA 3 4
  • EC 4
  • EC 3.6.1 63

External Ids for DDX4 Gene

Previous GeneCards Identifiers for DDX4 Gene

  • GC05P055195
  • GC05P056462
  • GC05P055004
  • GC05P055049
  • GC05P055050
  • GC05P055069
  • GC05P052007

Summaries for DDX4 Gene

Entrez Gene Summary for DDX4 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for DDX4 Gene

DDX4 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 4) is a Protein Coding gene. Diseases associated with DDX4 include bladder calculus and cardiovascular syphilis. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DDX1.

UniProtKB/Swiss-Prot for DDX4 Gene

  • May play a role in germ cell development. May play a role in sperm motility.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX4 Gene

Genomics for DDX4 Gene

Regulatory Elements for DDX4 Gene

Genomic Location for DDX4 Gene

55,737,995 bp from pter
55,817,157 bp from pter
79,163 bases
Plus strand

Genomic View for DDX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX4 Gene

Proteins for DDX4 Gene

  • Protein details for DDX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX4
    Protein Accession:
    Secondary Accessions:
    • A8K8Q2
    • B3KSF4
    • D6RDK4
    • E9PCD8
    • Q5M7Z3
    • Q86VX0
    • Q9NT92
    • Q9NYB1

    Protein attributes for DDX4 Gene

    724 amino acids
    Molecular mass:
    79308 Da
    Quaternary structure:
    • Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL. Interacts with ARNTL/BMAL1 and CLOCK (By similarity).

    Alternative splice isoforms for DDX4 Gene


neXtProt entry for DDX4 Gene

Proteomics data for DDX4 Gene at MOPED

Post-translational modifications for DDX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DDX4 (DDX4)

Domains & Families for DDX4 Gene

Gene Families for DDX4 Gene

Suggested Antigen Peptide Sequences for DDX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
genes like me logo Genes that share domains with DDX4: view

Function for DDX4 Gene

Molecular function for DDX4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
May play a role in germ cell development. May play a role in sperm motility.

Enzyme Numbers (IUBMB) for DDX4 Gene

Gene Ontology (GO) - Molecular Function for DDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX4: view

Phenotypes for DDX4 Gene

genes like me logo Genes that share phenotypes with DDX4: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX4 Gene

Localization for DDX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX4 Gene

Cytoplasm. Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for DDX4 Gene COMPARTMENTS Subcellular localization image for DDX4 gene
Compartment Confidence
cytoskeleton 2
extracellular 2
nucleus 2
plasma membrane 2
cytosol 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 21421998
GO:0030529 ribonucleoprotein complex --
GO:0033391 chromatoid body IEA --
GO:0043186 P granule IBA --
genes like me logo Genes that share ontologies with DDX4: view

Pathways & Interactions for DDX4 Gene

genes like me logo Genes that share pathways with DDX4: view

Pathways by source for DDX4 Gene

1 Cell Signaling Technology pathway for DDX4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007141 male meiosis I IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0010467 gene expression TAS --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX4: view

No data available for SIGNOR curated interactions for DDX4 Gene

Drugs & Compounds for DDX4 Gene

(2) Drugs for DDX4 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
ATP Pharma Activator 0

(4) Additional Compounds for DDX4 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX4: view

Transcripts for DDX4 Gene

Unigene Clusters for DDX4 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX4 Gene

No ASD Table

Relevant External Links for DDX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX4 Gene

mRNA expression in normal human tissues for DDX4 Gene

mRNA differential expression in normal tissues according to GTEx for DDX4 Gene

This gene is overexpressed in Testis (x50.2).

Protein differential expression in normal tissues from HIPED for DDX4 Gene

This gene is overexpressed in Ovary (34.8) and Testis (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX4 Gene

SOURCE GeneReport for Unigene cluster for DDX4 Gene Hs.223581

mRNA Expression by UniProt/SwissProt for DDX4 Gene

Tissue specificity: Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
genes like me logo Genes that share expression patterns with DDX4: view

Protein tissue co-expression partners for DDX4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for DDX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX4 35
  • 92.45 (n)
  • 91.71 (a)
DDX4 36
  • 91 (a)
(Canis familiaris)
Mammalia DDX4 35
  • 92.39 (n)
  • 93.08 (a)
DDX4 36
  • 92 (a)
(Mus musculus)
Mammalia Ddx4 35
  • 87.98 (n)
  • 89.6 (a)
Ddx4 16
Ddx4 36
  • 89 (a)
(Pan troglodytes)
Mammalia DDX4 35
  • 99.68 (n)
  • 99.86 (a)
DDX4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx4 35
  • 87.46 (n)
  • 88.12 (a)
(Monodelphis domestica)
Mammalia DDX4 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia DDX4 36
  • 82 (a)
(Gallus gallus)
Aves DDX4 35
  • 71.37 (n)
  • 69.71 (a)
DDX4 36
  • 55 (a)
(Anolis carolinensis)
Reptilia DDX4 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx4 35
  • 63.91 (n)
  • 62.31 (a)
Str.4894 35
African clawed frog
(Xenopus laevis)
Amphibia VLG1 35
(Danio rerio)
Actinopterygii vasa 35
  • 63.81 (n)
  • 64.46 (a)
vasa 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.190 35
fruit fly
(Drosophila melanogaster)
Insecta vas 37
  • 51 (a)
vas 35
  • 54.39 (n)
  • 53.1 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008578 35
  • 52.31 (n)
  • 55.32 (a)
(Caenorhabditis elegans)
Secernentea F58G11.2 37
  • 33 (a)
glh-1 37
  • 42 (a)
glh-2 37
  • 43 (a)
glh-3 37
  • 37 (a)
glh-4 37
  • 36 (a)
T08D2.3 37
  • 34 (a)
vbh-1 37
  • 47 (a)
F58G11.2 36
  • 21 (a)
vbh-1 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED1 36
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8121 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for DDX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX4 Gene

Gene Tree for DDX4 (if available)
Gene Tree for DDX4 (if available)

Paralogs for DDX4 Gene

Paralogs for DDX4 Gene Pseudogenes for DDX4 Gene

genes like me logo Genes that share paralogs with DDX4: view

Variants for DDX4 Gene

Sequence variations from dbSNP and Humsavar for DDX4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_019574 -
VAR_052159 -

Structural Variations from Database of Genomic Variants (DGV) for DDX4 Gene

Variant ID Type Subtype PubMed ID
nsv830305 CNV Loss 17160897
nsv881699 CNV Loss 21882294
nsv830306 CNV Gain 17160897
dgv1799e1 CNV Complex 17122850
nsv525146 CNV Loss 19592680
nsv4835 CNV Insertion 18451855
nsv10698 CNV Gain 18304495

Variation tolerance for DDX4 Gene

Residual Variation Intolerance Score: 24.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX4 Gene

Disorders for DDX4 Gene

MalaCards: The human disease database

(19) MalaCards diseases for DDX4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bladder calculus
  • urinary bladder calculi
cardiovascular syphilis
  • syphilis, cardiovascular
lower urinary tract calculus
  • calculus of lower urinary tract
retroperitoneal leiomyosarcoma
- elite association
Search DDX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DDX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX4 Gene

Publications for DDX4 Gene

  1. VASA is a specific marker for both normal and malignant human germ cells. (PMID: 11850529) Zeeman A.M. … Looijenga L.H. (Lab. Invest. 2002) 2 23 67
  2. The human VASA gene is specifically expressed in the germ cell lineage. (PMID: 10920202) Castrillon D.H. … Crum C.P. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 23 67
  3. Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. (PMID: 20123973) Kugler J.M. … Lasko P. (Mol. Cell. Biol. 2010) 23 67
  4. A marsupial, Trichosurus vulpecula, DDX4/VASAGene (TvDDX4) of the DEAD box protein family: molecular conservation and germline expression. (PMID: 20016130) Cui S. … Selwood L. (Cytogenet. Genome Res. 2009) 23 67
  5. Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis. (PMID: 19629140) Sugimoto K. … Namiki M. (J. Hum. Genet. 2009) 23 67

Products for DDX4 Gene

Sources for DDX4 Gene

Back to Top