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Aliases for DDX4 Gene

Aliases for DDX4 Gene

  • DEAD-Box Helicase 4 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 4 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 4 2 3
  • DEAD Box Protein 4 3 4
  • Vasa Homolog 3 4
  • VASA 3 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX4 Gene

Previous GeneCards Identifiers for DDX4 Gene

  • GC05P055195
  • GC05P056462
  • GC05P055004
  • GC05P055049
  • GC05P055050
  • GC05P055069
  • GC05P052007

Summaries for DDX4 Gene

Entrez Gene Summary for DDX4 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for DDX4 Gene

DDX4 (DEAD-Box Helicase 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DDX1.

UniProtKB/Swiss-Prot for DDX4 Gene

  • Probable ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX4 Gene

Genomics for DDX4 Gene

Regulatory Elements for DDX4 Gene

Genomic Location for DDX4 Gene

Chromosome:
5
Start:
55,737,995 bp from pter
End:
55,817,157 bp from pter
Size:
79,163 bases
Orientation:
Plus strand

Genomic View for DDX4 Gene

Genes around DDX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX4 Gene

Proteins for DDX4 Gene

  • Protein details for DDX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQI0-DDX4_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX4
    Protein Accession:
    Q9NQI0
    Secondary Accessions:
    • A8K8Q2
    • B3KSF4
    • D6RDK4
    • E9PCD8
    • Q5M7Z3
    • Q86VX0
    • Q9NT92
    • Q9NYB1

    Protein attributes for DDX4 Gene

    Size:
    724 amino acids
    Molecular mass:
    79308 Da
    Quaternary structure:
    • Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL. Interacts with ARNTL/BMAL1 and CLOCK.

    Alternative splice isoforms for DDX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX4 Gene

Proteomics data for DDX4 Gene at MOPED

Post-translational modifications for DDX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DDX4 (DDX4)

Domains & Families for DDX4 Gene

Gene Families for DDX4 Gene

Suggested Antigen Peptide Sequences for DDX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQI0

UniProtKB/Swiss-Prot:

DDX4_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
genes like me logo Genes that share domains with DDX4: view

Function for DDX4 Gene

Molecular function for DDX4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity).

Enzyme Numbers (IUBMB) for DDX4 Gene

genes like me logo Genes that share phenotypes with DDX4: view

Animal Models for DDX4 Gene

MGI Knock Outs for DDX4:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX4 Gene

Localization for DDX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX4 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q61496}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX4 Gene COMPARTMENTS Subcellular localization image for DDX4 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071546 pi-body ISS --
genes like me logo Genes that share ontologies with DDX4: view

Pathways & Interactions for DDX4 Gene

genes like me logo Genes that share pathways with DDX4: view

Pathways by source for DDX4 Gene

Gene Ontology (GO) - Biological Process for DDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007140 male meiosis ISS --
GO:0007283 spermatogenesis ISS --
GO:0008152 metabolic process IEA --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0031047 gene silencing by RNA IEA,TAS --
genes like me logo Genes that share ontologies with DDX4: view

No data available for SIGNOR curated interactions for DDX4 Gene

Drugs & Compounds for DDX4 Gene

(2) Drugs for DDX4 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for DDX4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX4: view

Transcripts for DDX4 Gene

Unigene Clusters for DDX4 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX4 Gene

No ASD Table

Relevant External Links for DDX4 Gene

GeneLoc Exon Structure for
DDX4
ECgene alternative splicing isoforms for
DDX4

Expression for DDX4 Gene

mRNA expression in normal human tissues for DDX4 Gene

mRNA differential expression in normal tissues according to GTEx for DDX4 Gene

This gene is overexpressed in Testis (x50.2).

Protein differential expression in normal tissues from HIPED for DDX4 Gene

This gene is overexpressed in Ovary (34.8) and Testis (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX4 Gene



SOURCE GeneReport for Unigene cluster for DDX4 Gene Hs.223581

mRNA Expression by UniProt/SwissProt for DDX4 Gene

Q9NQI0-DDX4_HUMAN
Tissue specificity: Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
genes like me logo Genes that share expression patterns with DDX4: view

Protein tissue co-expression partners for DDX4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for DDX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX4 35
  • 92.45 (n)
  • 91.71 (a)
DDX4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX4 35
  • 92.39 (n)
  • 93.08 (a)
DDX4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx4 35
  • 87.98 (n)
  • 89.6 (a)
Ddx4 16
Ddx4 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX4 35
  • 99.68 (n)
  • 99.86 (a)
DDX4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx4 35
  • 87.46 (n)
  • 88.12 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX4 35
  • 71.37 (n)
  • 69.71 (a)
DDX4 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX4 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx4 35
  • 63.91 (n)
  • 62.31 (a)
Str.4894 35
African clawed frog
(Xenopus laevis)
Amphibia VLG1 35
zebrafish
(Danio rerio)
Actinopterygii vasa 35
  • 63.81 (n)
  • 64.46 (a)
vasa 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.190 35
fruit fly
(Drosophila melanogaster)
Insecta vas 37
  • 51 (a)
vas 35
  • 54.39 (n)
  • 53.1 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008578 35
  • 52.31 (n)
  • 55.32 (a)
worm
(Caenorhabditis elegans)
Secernentea F58G11.2 37
  • 33 (a)
glh-1 37
  • 42 (a)
glh-2 37
  • 43 (a)
glh-3 37
  • 37 (a)
glh-4 37
  • 36 (a)
T08D2.3 37
  • 34 (a)
vbh-1 37
  • 47 (a)
F58G11.2 36
  • 21 (a)
ManyToMany
vbh-1 36
  • 37 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED1 36
  • 41 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8121 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for DDX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX4 Gene

ENSEMBL:
Gene Tree for DDX4 (if available)
TreeFam:
Gene Tree for DDX4 (if available)

Paralogs for DDX4 Gene

Paralogs for DDX4 Gene

Pseudogenes.org Pseudogenes for DDX4 Gene

genes like me logo Genes that share paralogs with DDX4: view

Variants for DDX4 Gene

Sequence variations from dbSNP and Humsavar for DDX4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2306259 - 55,780,012(-) TTCCA(C/T)CTCTT intron-variant, reference, missense
rs2305123 - 55,785,866(-) CAGAA(C/T)TGCTG reference, missense
rs153509 -- 55,807,215(+) gtgtg(G/T)ctctg intron-variant
rs187737 -- 55,804,930(+) tttca(C/T)gatat intron-variant
rs162090 -- 55,812,287(-) accgc(A/G)cccgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX4 Gene

Variant ID Type Subtype PubMed ID
nsv830305 CNV Loss 17160897
nsv881699 CNV Loss 21882294
nsv830306 CNV Gain 17160897
dgv1799e1 CNV Complex 17122850
nsv525146 CNV Loss 19592680
nsv4835 CNV Insertion 18451855
nsv10698 CNV Gain 18304495

Variation tolerance for DDX4 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.72; 73.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX4 Gene

HapMap Linkage Disequilibrium report
DDX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX4 Gene

Disorders for DDX4 Gene

Relevant External Links for DDX4

Genetic Association Database (GAD)
DDX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX4

No disorders were found for DDX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX4 Gene

Publications for DDX4 Gene

  1. The human VASA gene is specifically expressed in the germ cell lineage. (PMID: 10920202) Castrillon D.H. … Crum C.P. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23 67
  2. VASA is a specific marker for both normal and malignant human germ cells. (PMID: 11850529) Zeeman A.M. … Looijenga L.H. (Lab. Invest. 2002) 2 3 23
  3. Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis. (PMID: 19629140) Sugimoto K. … Namiki M. (J. Hum. Genet. 2009) 3 23
  4. Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint. (PMID: 18805576) Hashimoto H. … Nishimura R. (Gynecol. Oncol. 2008) 3 23
  5. Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles. (PMID: 25747659) Nott T.J. … Baldwin A.J. (Mol. Cell 2015) 3

Products for DDX4 Gene

Sources for DDX4 Gene

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