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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX3Y Gene

protein-coding   GIFtS: 61
GCID: GC0YP015016

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome...)
(Previous symbol: DBY)
 Explore 14 diseases affiliated with
DDX3Y via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDX3Y    

Aliases
for DDX3Y gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, Y-Linked1 2     ATP-Dependent RNA Helicase DDX3Y2
DBY1 2 3 5     EC 3.6.4.133
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide, Y Chromosome1 2     EC 3.6.18
DEAD Box Protein 3, Y-Chromosomal2 3     

External Ids:    HGNC: 26991   Entrez Gene: 86532   Ensembl: ENSG000000670487   OMIM: 4000105   UniProtKB: O155233   

Export aliases for DDX3Y gene to outside databases

Previous GC identifers: GC0YP014327 GC0YP014024 GC0YP014025 GC0YP013454 GC0YP013526 GC0YP009668


Summaries
for DDX3Y gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDX3Y:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation
initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution
patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular
growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. The gene mutation
causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a
key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been
identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
Function: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis

Gene Wiki entry for DDX3Y


Genomic Views
for DDX3Y gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000024.9  NT_011875.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX3Y gene promoter:
         AREB6   AP-1   PPAR-gamma2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX3Y promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX3Y

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX3Y


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11   Ensembl cytogenetic band:  Yq11.21   HGNC cytogenetic band: Yq11

DDX3Y Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX3Y gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP015016:  view genomic region     (about GC identifiers)

Start:
 15,016,019 bp from pter      End:
 15,032,390 bp from pter
Size:
 16,372 bases      Orientation:
 plus strand

Proteins
for DDX3Y gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX3Y  
Size: 660 amino acids; 73154 Da
Subunit: May interact with TDRD3
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent
manner
Secondary accessions: Q8IYV7

Explore the universe of human proteins at neXtProt for DDX3Y: NX_O15523

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15523

    • 4/38 DME Specific Peptides for DDX3Y (O15523) (see all 38)
     DMGFEPQ  YIPPHLR  LAPTREL  DEADRML 

    DDX3Y Protein expression data from MOPED and PaxDb:    About this image 
    DDX3Y Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116137.1  NP_004651.2  

    ENSEMBL proteins: 
     ENSP00000353284   ENSP00000336725   ENSP00000398953   ENSP00000400377   ENSP00000443710  

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    Novus Biologicals DDX3Y Proteins
    Novus Biologicals DDX3Y Lysates
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    Uscn Proteins for DDX3Y

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    DDX3Y for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DDX3Y gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDX3Y for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry O15523

    ProtoNet protein and cluster: O15523

    1 Blocks protein family: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
    Similarity: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for DDX3Y gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX3Y_HUMAN, O15523
    Function: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    DDX3Y for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    hsa-miR-4272 hsa-miR-15a hsa-miR-519a hsa-miR-4325 hsa-miR-3613-3p hsa-miR-200b hsa-miR-92b hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DDX3Y 3' UTR sequence
    Inhib. RNA
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    Clone
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for DDX3Y gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    		RIG-I-like receptor signaling pathway0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for DDX3Y):
        RIG-I-like receptor signaling pathway


    DDX3Y for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX3Y

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/37 Interacting proteins for DDX3Y (O155232, 3 ENSP000003367254) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPAP1Q9BWH63, ENSP000003061234I2D: score=1 STRING: ENSP00000306123
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    POT1Q9NUX53, ENSP000003502494I2D: score=1 STRING: ENSP00000350249
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    About this table

    Drugs & Compounds
    for DDX3Y gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX3Y
    Search CenterWatch for drugs/clinical trials and news about DDX3Y 

    Transcripts
    for DDX3Y gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDX3Y gene (2 alternative transcripts): 
    NM_001122665.1  NM_004660.3  

    Unigene Cluster for DDX3Y:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
    Hs.99120  [show with all ESTs]
    Unigene Representative Sequence: NM_001122665
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360160 ENST00000493363 ENST00000336079(uc004fsu.1 uc010nwv.1 uc011naq.1 uc004fsv.2 uc010nww.1 uc011nar.1)
    ENST00000454054 ENST00000440554 ENST00000469101 ENST00000463199 ENST00000495478
    ENST00000472510 ENST00000537441

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX3Y
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX3Y (see all 64):
    hsa-miR-4272 hsa-miR-15a hsa-miR-519a hsa-miR-4325 hsa-miR-3613-3p hsa-miR-200b hsa-miR-92b hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmid: DDX3Y 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX3Y (see all 4)
    OriGene shRNA RFP: DDX3Y
    OriGene siRNA: DDX3Y
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX3Y
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    Additional cDNA sequence: 

    AF000984.1 AF000985.1 AK296366.1 AK302172.1 AK303176.1 AK303638.1 AK307884.1 AK310382.1 
    BC011022.1 BC034942.2 

    11 DOTS entries:

    DT.75122010  DT.100662033  DT.120653361  DT.75182652  DT.100720496  DT.87079201  DT.91653447  DT.95260035 
    DT.120653365  DT.95260036  DT.95260037 

    24/119 AceView cDNA sequences (see all 119):

    BM828395 BM955866 CD557228 BQ427895 CB160793 BM835031 BM723220 CD358766 
    BQ009351 BC034942 AA447588 AL046792 BP361097 AA806363 AA811802 AU279665 
    AA629589 AL046798 BQ003181 CD358163 CN480253 BQ006257 BQ718381 CD251965 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DDX3Y (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
    SP1:              -     -     -     -     -           -                 -                                                     -                                 
    SP2:                                                  -                 -                                                     -                                 
    SP3:                                                                    -                                                                                       
    SP4:              -     -                             -                 -                                                                                       
    SP5:                                                  -                 -                       -     -     -     -           -                                 

    ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for DDX3Y

    Expression
    for DDX3Y gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX3Y expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTCTGTTT
    DDX3Y Expression
    About this image

    DDX3Y expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    HeartMyocardiumCardiac FibroblastsEpicardium
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium

    See DDX3Y Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX3Y

    SOURCE GeneReport for Unigene cluster: Hs.99120

    UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
    Tissue specificity: Testis-specific. Expressed predominantly in spermatogonia

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    In Situ
    Assay Products:     
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    Orthologs
    for DDX3Y gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for DDX3Y gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NIX1_CHICK6
    		 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3
    		 89(a)
    		 1 → many
    		 1(115609204-115624062)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 85(a)
    		 1 → many
    		 3(134104469-134122006)
    zebrafish
    (Danio rerio)    		 Actinopterygii pl106
    ddx36
    		 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3
    		 75(a)
    71(a)
    		 many ↔ many
    many ↔ many
    		 6(59558999-59576600)
    9(34367809-34388046)
    fruit fly
    (Drosophila melanogaster)    		 Insecta bel6
    		 belle
    		 47(a)
    		 1 → many
    		 3R(4481309-4486483)
    worm
    (Caenorhabditis elegans)    		 Secernentea laf-16
    vbh-16
    		 Protein LAF-1
    Vasa- and Belle-like Helicase family member (vbh-1...
    		 46(a)
    45(a)
    		 many ↔ many
    many ↔ many
    		 III(2770498-2779045)
    I(3158516-3162378)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DED1(YOR204W)4
    DED11    		 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, more4
    Ded1p1    		 55.97(n)1
    54.84(a)1    		   15(722911-724725)4
    8543791, 4  NP_014847.31  NP_014847.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G585106
    AT3G585706
    (see all 3)    		 DEAD-box ATP-dependent RNA helicase 52
    (see all 3)    		 45(a)
    44(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 3(21639978-21643795)
    3(21656504-21660532)
    rice
    (Oryza sativa)    		 Liliopsida Os11g05995001 hypothetical protein 52.89(n)
    54.89(a)    		   4350856  NM_001074753.1  NP_001068221.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria rhlE6
    rhlB6
    		 ATP-dependent RNA helicase
    		 35(a)
    31(a)
    		 many ↔ many
    many ↔ many
    		 Chromosome(830095-831459)
    Chromosome(3962388-3963653)


    ENSEMBL Gene Tree for DDX3Y (if available)
    TreeFam Gene Tree for DDX3Y (if available) 

    Paralogs
    for DDX3Y gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX3Y gene
    DDX42  DDX3X2  
    18/25 SIMAP similar genes for DDX3Y using alignment to 5 protein entries:     DDX3Y_HUMAN (see all proteins) (see all similar genes):
    DDX3X    DDX53    DDX46    DDX54    DDX41    EIF4A2
    DDX5    DDX43    DDX59    EIF4A1    DDX4    DDX42
    DKFZp547B159    DDX17    DDX52    DKFZp686J01190    EIF4A3    E4-DBP

    DDX3Y for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DDX3Y
    PGOHUM00000246016 PGOHUM00000241852


    Genomic Variants
    for DDX3Y gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/71 NCBI SNPs in DDX3Y are shown (see all 71)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr Y posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs20326621,2
    		C,F--15014262(+) GATCCC/TTTGAG 1 -- us2k13Minor allele frequency- T:0.07NA CSA 74
    rs20326771,2
    		C--15014550(+) TTTTTT/CTTCCC 1 -- us2k1 tfbs3 trp32Minor allele frequency- C:0.01NA 73
    rs133049921,2
    		C--15015396(+) GTTACG/AAACGT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs93068361,2
    		C--15016438(+) GGAGGG/CAGCGG 2 -- int1 us2k1 trp31Minor allele frequency- C:0.01NS 109
    rs20326801,2
    		C,F,H--15016536(+) GCATTA/GGGAGA 2 -- int1 us2k17Minor allele frequency- G:0.01NA EA NS 389
    rs93412851,2
    		C--15017505(+) CGTAAC/TAAGTA 2 -- int12Minor allele frequency- T:0.01NS NA 111
    rs81790221,2
    		C,F--15018459(+) AGATGG/ACAAGA 2 -- int13Minor allele frequency- A:0.02NS NA 194
    rs81790211,2
    		C,F--15018582(+) GTGCTC/TTTGGC 2 -- int12Minor allele frequency- T:0.07NS 192
    rs93412861,2
    		F--15019092(+) TGTCAT/CTGGGA 2 -- int12Minor allele frequency- C:0.07NS CSA 110
    rs93412871,2
    		F--15019124(+) AGCTAA/CATTGG 2 -- int12Minor allele frequency- C:0.03NS CSA 110

    HapMap Linkage Disequilibrium report for DDX3Y (15016019 - 15032390 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DDX3Y: --
    Human Gene Mutation Database (HGMD): DDX3Y

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX3Y
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX3Y

    Disorders / Diseases
    for DDX3Y gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDX3Y for disorders           About GeneDecksing

    OMIM gene information: 400010    OMIM disorders: --

    UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
  • Note=DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli
    • cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading
    to azoospermia

    14 diseases for DDX3Y:    About MalaCards
    sertoli cell-only syndrome    male infertility    infertility    graft versus host disease
    y chromosome infertility    spermatocytoma    azoospermia    astigmatism
    hypercalcemia    huntington's disease    meningioma    malaria
    prostatitis    spermatogenic failure

    3 diseases from the University of Copenhagen DISEASES database for DDX3Y:
    Azoospermia     Sertoli cell-only syndrome     Spermatocytoma

    4 Novoseek disease relationships for DDX3Y gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 80.4 3 11097428 (1), 15383328 (1), 14751364 (1)
    oligozoospermia 71.7 1 15383328 (1)
    infertility male 61.1 1 11294825 (1)
    graft-versus-host disease 45.6 1 11929796 (1)

    GeneTests: DDX3Y
    Y Chromosome Infertility


    Export disorders for DDX3Y gene to outside databases

    Publications
    for DDX3Y gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX3Y gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with DDX3Y)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2, 3 Lahn B.T. and Page D.C. (1997)
    2. The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control. (PubMed id 15294876)1, 2, 9 Ditton H.J.... Vogt P.H. (2004)
    3. Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. (PubMed id 15383328)1, 2, 9 Sekiguchi T.... Nishimoto T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis. (PubMed id 17881721)1, 9 Lardone M.C....Castro A. (2007)
    6. DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. (PubMed id 18299450)1, 9 Rosinski K.V....Warren E.H. (2008)
    7. Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation. (PubMed id 15096539)1, 9 Zorn E....Ritz J. (2004)
    8. The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease. (PubMed id 11929796)1, 9 Vogt M.H....Falkenburg J.H. (2002)
    9. AZFa protein DDX3Y is differentially expressed in huma n male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells. (PubMed id 22466863)1 Gueler B....Vogt P.H. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for DDX3Y gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDX3Y gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8653 HGNC: 2699 AceView: DDX3Y Ensembl:ENSG00000067048 euGenes: HUgn8653
    ECgene: DDX3Y Kegg: 8653 H-InvDB: DDX3Y

    Other Databases showing DDX3Y gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDX3Y gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX3Y Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DDX3Y

    Intellectual Property
    for DDX3Y gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDX3Y gene:
    Search GeneIP for patents involving DDX3Y

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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