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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX3Y Gene

protein-coding   GIFtS: 61
GCID: GC0YP015016

DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, Y-Linked

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome,...)
(Previous symbol: DBY)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, Y-Linked1 2     DEAD Box Protein 3, Y-Chromosomal2 3
DBY1 2 3 5     ATP-Dependent RNA Helicase DDX3Y2
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, Y-Linked1 2     EC 3.6.4.133
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide, Y Chromosome1 2     EC 3.6.18

External Ids:    HGNC: 26991   Entrez Gene: 86532   Ensembl: ENSG000000670487   OMIM: 4000105   UniProtKB: O155233   

Export aliases for DDX3Y gene to outside databases

Previous GC identifers: GC0YP014327 GC0YP014024 GC0YP014025 GC0YP013454 GC0YP013526 GC0YP009668


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDX3Y Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome.
The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting
that this gene plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same
protein, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX3Y Gene: 
DDX3Y (DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked) is a protein-coding gene. Diseases associated with DDX3Y include spermatocytoma, and infertility, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Toll-like receptor signaling pathway. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX3X.

UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
Function: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis

Gene Wiki entry for DDX3Y Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000024.9  NT_011875.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX3Y gene promoter:
         AREB6   AP-1   PPAR-gamma2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX3Y promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX3Y

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX3Y


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11   Ensembl cytogenetic band:  Yq11.21   HGNC cytogenetic band: Yq11

DDX3Y Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX3Y gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP015016:  view genomic region     (about GC identifiers)

Start:
15,016,019 bp from pter      End:
15,032,390 bp from pter
Size:
16,372 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX3Y  
Size: 660 amino acids; 73154 Da
Subunit: May interact with TDRD3
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent
manner
Secondary accessions: Q8IYV7

Explore the universe of human proteins at neXtProt for DDX3Y: NX_O15523

Explore proteomics data for DDX3Y at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15523

  • 4/38 DME Specific Peptides for DDX3Y (O15523) (see all 38)
     DMGFEPQ  YIPPHLR  LAPTREL  DEADRML 

    DDX3Y Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDX3Y Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116137.1  NP_004651.2  

    ENSEMBL proteins: 
     ENSP00000353284   ENSP00000398953   ENSP00000336725   ENSP00000400377  

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    Novus Biologicals DDX3Y Proteins
    Novus Biologicals DDX3Y Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX3Y 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    DDX3Y for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    5/6 InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry O15523

    ProtoNet protein and cluster: O15523

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
    Similarity: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX3Y for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX3Y_HUMAN, O15523
    Function: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
         
    DDX3Y for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidDDX3Y 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX3Y


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DDX3Y About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.52
    2Toll-like receptor signaling pathway
    Hepatitis B0.31
    3Viral carcinogenesis
    Viral carcinogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for DDX3Y):
        RIG-I-like receptor signaling pathway
    Hepatitis B
    Viral carcinogenesis


    DDX3Y for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX3Y

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/42 Interacting proteins for DDX3Y (O155232, 3 ENSP000003367254) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000172850Q9Y3333I2D: score=4 
    ENSG00000224979Q9Y3333I2D: score=4 
    ENSG00000225998Q9Y3333I2D: score=4 
    ENSG00000231502Q9Y3333I2D: score=4 
    ENSG00000236826Q9Y3333I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX3Y

    Search CenterWatch for drugs/clinical trials and news about DDX3Y

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDX3Y gene (2 alternative transcripts): 
    NM_001122665.1  NM_004660.3  

    Unigene Cluster for DDX3Y:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
    Hs.99120  [show with all ESTs]
    Unigene Representative Sequence: NM_001122665
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360160 ENST00000454054 ENST00000336079(uc004fsu.1 uc010nwv.1 uc011naq.1 uc004fsv.2 uc010nww.1 uc011nar.1)
    ENST00000493363 ENST00000440554 ENST00000469101 ENST00000472510 ENST00000463199
    ENST00000495478
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX3Y
    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX3Y (see all 64):
    hsa-miR-4272 hsa-miR-15a hsa-miR-519a hsa-miR-4325 hsa-miR-3613-3p hsa-miR-200b hsa-miR-92b hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDX3Y 3' UTR sequence
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX3Y
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX3Y
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX3Y
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    Additional mRNA sequence: 

    AF000984.1 AF000985.1 AK296366.1 AK302172.1 AK303176.1 AK303638.1 AK307884.1 AK310382.1 
    BC011022.1 BC034942.2 

    11 DOTS entries:

    DT.75122010  DT.100662033  DT.120653361  DT.75182652  DT.100720496  DT.87079201  DT.91653447  DT.95260035 
    DT.120653365  DT.95260036  DT.95260037 

    24/119 AceView cDNA sequences (see all 119):

    BQ427895 BM955866 AU279665 BQ006257 CD358163 BQ009351 AA447588 BQ718381 
    BQ003181 AA806363 BC034942 BM723220 BP361097 BM828395 AA811802 CN480253 
    BM835031 CD358766 CD557228 AA629589 AL046792 AL046798 CB160793 BX479935 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DDX3Y (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
    SP1:              -     -     -     -     -           -                 -                                                     -                                 
    SP2:                                                  -                 -                                                     -                                 
    SP3:                                                                    -                                                                                       
    SP4:              -     -                             -                 -                                                                                       
    SP5:                                                  -                 -                       -     -     -     -           -                                 

    ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for DDX3Y

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX3Y expression in normal human tissues (normalized intensities)      DDX3Y embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTCTGTTT
    DDX3Y Expression
    About this image


    DDX3Y expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Human umbilical vein endothelial cells (HUVEC)
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             neutrophils   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived endothelial progenitor cells
             stem cells (umbilical cord cd34+)   

    See DDX3Y Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX3Y

    SOURCE GeneReport for Unigene cluster: Hs.99120

    UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
    Tissue specificity: Testis-specific. Expressed predominantly in spermatogonia

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX3Y

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX3Y gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx3y5
    D1Pas11
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked5
    DNA segment, Chr 1, Pasteur Institute 11
    82.5(n)1
    89.65(a)1
      Y5
    1109571  NM_033077.21  NP_149068.11 
     12607155 
    chicken
    (Gallus gallus)
    Aves DDX3X6
    ATP-dependent RNA helicase DDX3X
    87(a)
    1 → many
    1(111360104-111377529)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    78(a)
    1 → many
    3(134104469-134125049)
    zebrafish
    (Danio rerio)
    Actinopterygii pl106
    ddx36
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3
    74(a)
    70(a)
    many ↔ many
    many ↔ many
    6(59558999-59576600)
    9(34367809-34388046)
    fruit fly
    (Drosophila melanogaster)
    Insecta bel6
    belle
    46(a)
    1 → many
    3R(4481309-4486483)
    worm
    (Caenorhabditis elegans)
    Secernentea laf-16
    vbh-16
    Protein VBH-1, isoform a
    45(a)
    45(a)
    many ↔ many
    many ↔ many
    III(2769358-2779053)
    I(3158514-3162376)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DED1(YOR204W)4
    DED11
    ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, more4
    Ded1p1
    55.97(n)1
    54.84(a)1
      15(722911-724725)4
    8543791, 4  NP_014847.31  NP_014847.14 
    rice
    (Oryza sativa)
    Liliopsida Os11g05995001 hypothetical protein 52.89(n)
    54.89(a)
      4350856  NM_001074753.1  NP_001068221.1 


    ENSEMBL Gene Tree for DDX3Y (if available)
    TreeFam Gene Tree for DDX3Y (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX3Y gene
    DDX3X2  DDX42  
    18/21 SIMAP similar genes for DDX3Y using alignment to 5 protein entries:     DDX3Y_HUMAN (see all proteins) (see all similar genes):
    DDX3X    DDX53    DDX46    DDX54    DDX41    EIF4A2
    DDX5    DDX43    DDX59    EIF4A1    DDX42    DKFZp547B159
    DDX4    DDX17    DDX52    DKFZp686J01190    EIF4A3    E4-DBP

    DDX3Y for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DDX3Y
    PGOHUM00000246016 PGOHUM00000241852


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/204 SNPs in DDX3Y are shown (see all 204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20326621,2
    C,F--15014262(+) gatccC/Tttgag 1 -- us2k13Minor allele frequency- T:0.07NA CSA 74
    rs20326771,2
    C--15014550(+) TTTTTT/CTTCCC 1 -- us2k1 tfbs3 trp32Minor allele frequency- C:0.01NA 73
    rs133049921,2
    C--15015396(+) GTTACG/AAACGT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs93068361,2
    C--15016438(+) GGAGGG/CAGCGG 2 -- int1 us2k1 trp31Minor allele frequency- C:0.01NS 109
    rs20326801,2
    C,F,H--15016536(+) GCATTA/GGGAGA 2 -- int1 us2k17Minor allele frequency- G:0.01NA EA NS 389
    rs93412851,2
    C--15017505(+) CGTAAC/TAAGTA 2 -- int12Minor allele frequency- T:0.01NS NA 111
    rs81790221,2
    C,F--15018459(+) AGATGG/ACAAGA 2 -- int13Minor allele frequency- A:0.02NS NA 194
    rs81790211,2
    C,F--15018582(+) GTGCTC/TTTGGC 2 -- int12Minor allele frequency- T:0.07NS 192
    rs93412861,2
    C,F--15019092(+) TGTCAT/CTGGGA 2 -- int12Minor allele frequency- C:0.07NS CSA 110
    rs93412871,2
    F--15019124(+) AGCTAA/CATTGG 2 -- int12Minor allele frequency- C:0.03NS CSA 110

    HapMap Linkage Disequilibrium report for DDX3Y (15016019 - 15032390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDX3Y:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740672CNV Deletion23290073


    Human Gene Mutation Database (HGMD): DDX3Y
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX3Y
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX3Y

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 400010    OMIM disorders: --

    UniProtKB/Swiss-Prot: DDX3Y_HUMAN, O15523
  • Note=DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in
    Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous
    tubules leading to azoospermia

  • 11 diseases for DDX3Y:    About MalaCards
    spermatocytoma    infertility    male infertility    sertoli cell-only syndrome
    y chromosome infertility    astigmatism    azoospermia    graft versus host disease
    hypercalcemia    meningioma    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for DDX3Y:
    Azoospermia     Sertoli cell-only syndrome

    DDX3Y for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for DDX3Y gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 80.4 3 11097428 (1), 15383328 (1), 14751364 (1)
    oligozoospermia 71.7 1 15383328 (1)
    infertility male 61.1 1 11294825 (1)
    graft-versus-host disease 45.6 1 11929796 (1)

    GeneTests: DDX3Y
    GeneReviews: DDX3Y

    Export disorders for DDX3Y gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX3Y gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with DDX3Y)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2, 3 Lahn B.T. and Page D.C. (1997)
    2. The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control. (PubMed id 15294876)1, 2, 9 Ditton H.J.... Vogt P.H. (2004)
    3. Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. (PubMed id 15383328)1, 2, 9 Sekiguchi T.... Nishimoto T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis. (PubMed id 17881721)1, 9 Lardone M.C....Castro A. (2007)
    6. DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. (PubMed id 18299450)1, 9 Rosinski K.V....Warren E.H. (2008)
    7. Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation. (PubMed id 15096539)1, 9 Zorn E....Ritz J. (2004)
    8. The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease. (PubMed id 11929796)1, 9 Vogt M.H....Falkenburg J.H. (2002)
    9. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    10. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8653 HGNC: 2699 AceView: DDX3Y Ensembl:ENSG00000067048 euGenes: HUgn8653
    ECgene: DDX3Y Kegg: 8653 H-InvDB: DDX3Y

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX3Y Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DDX3Y

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDX3Y gene:
    Search GeneIP for patents involving DDX3Y

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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