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Aliases for DDX3Y Gene

Aliases for DDX3Y Gene

  • DEAD-Box Helicase 3, Y-Linked 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, Y-Linked 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide, Y Chromosome 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, Y-Linked 2 3
  • DEAD Box Protein 3, Y-Chromosomal 3 4
  • DBY 3 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX3Y Gene

Previous HGNC Symbols for DDX3Y Gene

  • DBY

Previous GeneCards Identifiers for DDX3Y Gene

  • GC0YP014327
  • GC0YP014024
  • GC0YP014025
  • GC0YP013454
  • GC0YP013526
  • GC0YP015016
  • GC0YP009668

Summaries for DDX3Y Gene

Entrez Gene Summary for DDX3Y Gene

  • The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for DDX3Y Gene

DDX3Y (DEAD-Box Helicase 3, Y-Linked) is a Protein Coding gene. Diseases associated with DDX3Y include Male Infertility and Sertoli Cell-Only Syndrome. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX4.

UniProtKB/Swiss-Prot for DDX3Y Gene

  • Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.

Gene Wiki entry for DDX3Y Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX3Y Gene

Genomics for DDX3Y Gene

Regulatory Elements for DDX3Y Gene

Enhancers for DDX3Y Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX3Y on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX3Y Gene

Chromosome:
Y
Start:
12,904,108 bp from pter
End:
12,920,478 bp from pter
Size:
16,371 bases
Orientation:
Plus strand

Genomic View for DDX3Y Gene

Genes around DDX3Y on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX3Y Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX3Y Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX3Y Gene

Proteins for DDX3Y Gene

  • Protein details for DDX3Y Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15523-DDX3Y_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX3Y
    Protein Accession:
    O15523
    Secondary Accessions:
    • B4DK29
    • B4DXX7
    • Q8IYV7

    Protein attributes for DDX3Y Gene

    Size:
    660 amino acids
    Molecular mass:
    73154 Da
    Quaternary structure:
    • May interact with TDRD3.

    Alternative splice isoforms for DDX3Y Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX3Y Gene

Proteomics data for DDX3Y Gene at MOPED

Post-translational modifications for DDX3Y Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX3Y Gene

Domains & Families for DDX3Y Gene

Graphical View of Domain Structure for InterPro Entry

O15523

UniProtKB/Swiss-Prot:

DDX3Y_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
genes like me logo Genes that share domains with DDX3Y: view

Function for DDX3Y Gene

Molecular function for DDX3Y Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.

Enzyme Numbers (IUBMB) for DDX3Y Gene

Gene Ontology (GO) - Molecular Function for DDX3Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX3Y: view
genes like me logo Genes that share phenotypes with DDX3Y: view

Human Phenotype Ontology for DDX3Y Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX3Y Gene

Localization for DDX3Y Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX3Y Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX3Y Gene COMPARTMENTS Subcellular localization image for DDX3Y gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DDX3Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036464 cytoplasmic ribonucleoprotein granule IBA --
genes like me logo Genes that share ontologies with DDX3Y: view

Pathways & Interactions for DDX3Y Gene

SuperPathways for DDX3Y Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX3Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IBA --
genes like me logo Genes that share ontologies with DDX3Y: view

No data available for Pathways by source and SIGNOR curated interactions for DDX3Y Gene

Drugs & Compounds for DDX3Y Gene

(1) Drugs for DDX3Y Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX3Y Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX3Y: view

Transcripts for DDX3Y Gene

Unigene Clusters for DDX3Y Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX3Y Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - - - - - - - -
SP9: -
SP10:
SP11:
SP12: -

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11:
SP12:

Relevant External Links for DDX3Y Gene

GeneLoc Exon Structure for
DDX3Y
ECgene alternative splicing isoforms for
DDX3Y

Expression for DDX3Y Gene

mRNA expression in normal human tissues for DDX3Y Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX3Y Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.9) and Ovary (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX3Y Gene



SOURCE GeneReport for Unigene cluster for DDX3Y Gene Hs.99120

mRNA Expression by UniProt/SwissProt for DDX3Y Gene

O15523-DDX3Y_HUMAN
Tissue specificity: Testis-specific. Expressed predominantly in spermatogonia.
genes like me logo Genes that share expression patterns with DDX3Y: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DDX3Y Gene

Orthologs for DDX3Y Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX3Y Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX3Y 35
  • 88.8 (n)
  • 89.97 (a)
DDX3Y 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx3y 35
  • 87.32 (n)
  • 88.43 (a)
Ddx3y 16
Ddx3y 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX3Y 35
  • 99.24 (n)
  • 98.33 (a)
DDX3Y 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX3X 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddx3 36
  • 71 (a)
ManyToMany
pl10 36
  • 74 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta bel 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vbh-1 35
  • 56.71 (n)
  • 57.68 (a)
ZC317.1 36
  • 26 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL273C 35
  • 56.3 (n)
  • 57.82 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01034g 35
  • 55.28 (n)
  • 56.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED1 35
  • 57.38 (n)
  • 57.01 (a)
DED1 36
  • 54 (a)
OneToMany
DED1 38
rice
(Oryza sativa)
Liliopsida Os11g0599500 35
  • 53.26 (n)
  • 56.27 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01369 35
  • 53.17 (n)
  • 56.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sum3 35
  • 56.48 (n)
  • 55.82 (a)
Species with no ortholog for DDX3Y:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DDX3Y Gene

ENSEMBL:
Gene Tree for DDX3Y (if available)
TreeFam:
Gene Tree for DDX3Y (if available)

Paralogs for DDX3Y Gene

Paralogs for DDX3Y Gene

Pseudogenes.org Pseudogenes for DDX3Y Gene

genes like me logo Genes that share paralogs with DDX3Y: view

Variants for DDX3Y Gene

Sequence variations from dbSNP and Humsavar for DDX3Y Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs2020857 -- 12,918,840(+) AAGAG(C/T)TCTTT downstream-variant-500B, utr-variant-3-prime
rs2032589 -- 12,919,198(+) ACTTG(-/G)CAGAC utr-variant-3-prime
rs2032590 -- 12,907,702(+) GACTA(G/T)ATGAA intron-variant
rs2032591 -- 12,918,770(+) ACTTA(C/G)ACTCT downstream-variant-500B, utr-variant-3-prime
rs2032592 -- 12,919,473(+) TTGAC(A/G)AAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX3Y Gene

Variant ID Type Subtype PubMed ID
esv2740672 CNV Deletion 23290073

Variation tolerance for DDX3Y Gene

Gene Damage Index Score: 0.30; 6.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX3Y Gene

Human Gene Mutation Database (HGMD)
DDX3Y

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX3Y Gene

Disorders for DDX3Y Gene

MalaCards: The human disease database

(7) MalaCards diseases for DDX3Y Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
sertoli cell-only syndrome
  • del castillo syndrome
azoospermia
  • spermatogenic failure
y chromosome infertility
  • y chromosome-related azoospermia
partial deletion of y
  • partial deletion of chromosome y
- elite association - COSMIC cancer census association via MalaCards
Search DDX3Y in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DDX3Y_HUMAN
  • Note=DDX3Y is located in the azoospermia factor a (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.

Relevant External Links for DDX3Y

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX3Y
genes like me logo Genes that share disorders with DDX3Y: view

No data available for Genatlas for DDX3Y Gene

Publications for DDX3Y Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3 4 67
  2. DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. (PMID: 18299450) Rosinski K.V. … Warren E.H. (Blood 2008) 3 23
  3. Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis. (PMID: 17881721) Lardone M.C. … Castro A. (Mol. Hum. Reprod. 2007) 3 23
  4. The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays. (PMID: 17979704) Rosner A. … Rinkevich B. (Curr. Med. Chem. 2007) 3 23
  5. Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation. (PMID: 15096539) Zorn E. … Ritz J. (J. Exp. Med. 2004) 3 23

Products for DDX3Y Gene

Sources for DDX3Y Gene

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