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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX3X Gene

protein-coding   GIFtS: 63
GCID: GC0XP041192

DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, X-Linked

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, DEAD (Asp-Glu-Ala-Asp)...)
(Previous symbol: DDX3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, X-Linked1 2     DEAD Box, X Isoform2 3
DDX31 2 3 5     CAP-Rf2
DBX2 3 5     DDX142
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked1 2     ATP-Dependent RNA Helicase DDX3X2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 31 2     DEAD/H Box-32
Helicase-Like Protein 22 3     Helicase Like Protein 22
HLP22 3     EC 3.6.4.133
DEAD Box Protein 3, X-Chromosomal2 3     EC 3.6.18

External Ids:    HGNC: 27451   Entrez Gene: 16542   Ensembl: ENSG000002153017   OMIM: 3001605   UniProtKB: O005713   

Export aliases for DDX3X gene to outside databases

Previous GC identifers: GC0XP040037 GC0XP040223 GC0XP040948 GC0XP041077 GC0XP038924


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDX3X Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with
hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in
the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the
Y-linked homolog. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jul 2010)

GeneCards Summary for DDX3X Gene: 
DDX3X (DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked) is a protein-coding gene. Diseases associated with DDX3X include hepatitis c, and hepatitis, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and DNA Damage. GO annotations related to this gene include RNA binding and ATPase activity. An important paralog of this gene is DDX4.

UniProtKB/Swiss-Prot: DDX3X_HUMAN, O00571
Function: Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and
deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded
DNA with a preference for 5'-single stranded DNA overhangs. Is involved in several steps of gene expression, such
as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and
some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance
transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin
promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation.
Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of
mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase
activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal
stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal
scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the
40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S
ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is
independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive
interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress
response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve
association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via
interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with
spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in
splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location.
Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta);
proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and
IKBKE-dependent IRF3 activation leading to IFN-beta induction. Also found associated with IFN-beta promoters; the
function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is
thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required
for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an
antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex;
activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition.
May be involved in mitotic chromosome segregation. Appears to be a prime target for viral manipulations.
Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFN-beta induction
probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the
function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function
in viral RNA sensing and may switch the function from a INF-beta inducing to a HCV replication mode. Involved in
HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs

Gene Wiki entry for DDX3X Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX3X gene promoter:
         p53   Sp1   SREBP-1c   C/EBPalpha   SREBP-1b   CREB   CHOP-10   SREBP-1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDX3X promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX3X

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX3X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3-p11.23   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11.3-p11.23

DDX3X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX3X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP041192:  view genomic region     (about GC identifiers)

Start:
41,192,651 bp from pter      End:
41,223,725 bp from pter
Size:
31,075 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDX3X_HUMAN, O00571 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX3X  
Size: 662 amino acids; 73243 Da
Subunit: Interacts with XPO1, TDRD3, PABPC1, NXF1, EIF3C, MAVS, DDX58 and NCAPH. Interacts with DDX5; the
interaction is regulated by the phosphorylation status of both proteins. Interacts with EIF4E; DDX3X competes
with EIF4G1/EIF4G3 for interaction with EIF4E. Interacts with IKBKE; the interaction is found to be induced upon
virus infection and to be inhibited by HBV polymerase. Interacts with TBK1; the interaction is inhibited by HBV
polymerase. Associates with the eukaryotic translation initiation factor 3 (eIF-3) complex. Associates with the
40S ribosome. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3,
PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with HCV core protein. Interacts with vaccinia
virus (VACV) protein K7. Found in a complex with HIV-1 Rev and XPO1
Subcellular location: Nucleus speckle. Cytoplasm. Mitochondrion outer membrane. Note=Located predominantly in
nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore
complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1 and may be also in a NFX1-dependent
manner. Associated with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus
during G(0) phase and in the cytoplasm during G1/S phase
3 PDB 3D structures from and Proteopedia for DDX3X:
2I4I (3D)        2JGN (3D)        3JRV (3D)    
Secondary accessions: A8K538 B4E3E8 O15536
Alternative splicing: 2 isoforms:  O00571-1   O00571-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX3X: NX_O00571

Explore proteomics data for DDX3X at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by TBK1; the phosphorylation is required to synergize with TBK1 in IFN-beta induction. Probably
    also phosphorylated by IKBKE. The cytoplasmic form is highly phosphorylated in the G1/S phase and much lower
    phosphorylated in G2/M
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00571

  • 4/39 DME Specific Peptides for DDX3X (O00571) (see all 39)
     DMGFEPQ  YIPPHLR  LAPTREL  DEADRML 

    DDX3X Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDX3X Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180345.1  NP_001180346.1  NP_001347.3  

    ENSEMBL proteins: 
     ENSP00000382840   ENSP00000392494   ENSP00000414281   ENSP00000439799  

    Human Recombinant Protein Products for DDX3X: 
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    GenScript Custom Purified and Recombinant Proteins Services for DDX3X
    Novus Biologicals DDX3X Proteins
    Novus Biologicals DDX3X Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX3X 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10329544
    GO:0005737cytoplasm IDA--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005852colocalizes with eukaryotic translation initiation factor 3 complex IDA18628297
    GO:0010494cytoplasmic stress granule IDA18596238

    DDX3X for ontologies           About GeneDecksing



    DDX3X Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DDX3X
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DDX3X  (DDX3)
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    GenScript Custom Superior Antibodies Services for DDX3X
    Novus Biologicals DDX3X Antibodies
    Abcam antibodies for DDX3X
    Cloud-Clone Corp. Antibodies for DDX3X 
    ThermoFisher Antibody for DDX3X
    LSBio Antibodies in human, mouse, rat for DDX3X 

    Assay Products for DDX3X: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DDX3X
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX3X 
    Cloud-Clone Corp. CLIAs for DDX3X


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    5/6 InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry O00571

    ProtoNet protein and cluster: O00571

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX3X_HUMAN, O00571
    Similarity: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX3X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX3X_HUMAN, O00571
    Function: Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and
    deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double stranded
    DNA with a preference for 5'-single stranded DNA overhangs. Is involved in several steps of gene expression, such
    as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and
    some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance
    transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin
    promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation.
    Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of
    mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase
    activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal
    stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal
    scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the
    40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S
    ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is
    independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive
    interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress
    response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve
    association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via
    interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with
    spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in
    splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location.
    Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta);
    proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and
    IKBKE-dependent IRF3 activation leading to IFN-beta induction. Also found associated with IFN-beta promoters; the
    function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is
    thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required
    for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an
    antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex;
    activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition.
    May be involved in mitotic chromosome segregation. Appears to be a prime target for viral manipulations.
    Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFN-beta induction
    probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the
    function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function
    in viral RNA sensing and may switch the function from a INF-beta inducing to a HCV replication mode. Involved in
    HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: Regulated by the cell cycle. Maximally expressed din the cytoplasm uring G1/S phase and decreased
    expression during G2/M phase

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA--
    GO:0003723RNA binding IDA--
    GO:0004003ATP-dependent DNA helicase activity IDA--
    GO:0004004ATP-dependent RNA helicase activity IDA--
         
    DDX3X for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX3X:
     Decreased p24 protein expressi  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX3X 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDX3X

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX3X 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX3X 

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX3X:
    hsa-mir-192 (MIRT004132)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX3X
    8/193 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX3X (see all 193):
    hsa-miR-194* hsa-miR-361-5p hsa-miR-520f hsa-miR-138-2* hsa-miR-342-3p hsa-miR-3921 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidDDX3X 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDX3X
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX3X

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DDX3X
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DDX3X (NM_001193416)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX3X


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DDX3X About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.52
    2DNA Damage
    Cell Cycle / Checkpoint Control0.32
    3Toll-like receptor signaling pathway
    Hepatitis B0.31
    4Viral carcinogenesis
    Viral carcinogenesis
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DDX3X
        Translational Control
    Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for DDX3X
        TNF-alpha/NF-kB Signaling Pathway


    3         Kegg Pathways  (Kegg details for DDX3X):
        RIG-I-like receptor signaling pathway
    Hepatitis B
    Viral carcinogenesis


    DDX3X for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDX3X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/918 Interacting proteins for DDX3X (O005711, 2, 3 ENSP000003828404) via UniProtKB, MINT, STRING, and/or I2D (see all 918)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3BP558841, 2, 3, ENSP000003541254EBI-353779,EBI-366696 MINT-7947479 I2D: score=1 STRING: ENSP00000354125
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    NXF1Q9UBU91, 2, ENSP000002941724EBI-353779,EBI-398874 MINT-7234837 MINT-7234858 STRING: ENSP00000294172
    NFKB2Q006532, 3MINT-47916 MINT-48749 I2D: score=5 
    TBK1Q9UHD22, 3, ENSP000003299674MINT-6948107 I2D: score=2 STRING: ENSP00000329967
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007059chromosome segregation IMP--
    GO:0007243intracellular protein kinase cascade IDA18636090
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IMP18846110

    DDX3X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX3X

    Search CenterWatch for drugs/clinical trials and news about DDX3X

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDX3X gene (4 alternative transcripts): 
    NM_001193416.1  NM_001193417.1  NM_001356.3  NM_024005.1  

    Unigene Cluster for DDX3X:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
    Hs.743263  [show with all ESTs]
    Unigene Representative Sequence: NM_001356
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399959(uc004dfe.3 uc011mks.2 uc004dff.3 uc011mkq.2 uc011mkr.2)
    ENST00000478993(uc010nhf.1 uc004dfg.3) ENST00000480592(uc004dfd.1)
    ENST00000457138 ENST00000441189 ENST00000542215(uc011mkt.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-194* hsa-miR-361-5p hsa-miR-520f hsa-miR-138-2* hsa-miR-342-3p hsa-miR-3921 hsa-miR-519a hsa-miR-4275
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    Additional mRNA sequence: 

    AB208983.1 AB451220.1 AB451343.1 AF000982.1 AF061337.1 AF086430.1 AK291153.1 AK296906.1 
    AK297159.1 AK304661.1 AK304689.1 AK310891.1 AY776161.1 BC007668.2 BC011819.2 BC055083.1 
    U50553.1 

    24/31 DOTS entries (see all 31):

    DT.100662030  DT.419467  DT.40232697  DT.121284236  DT.100662028  DT.100662025  DT.100662036  DT.91684372 
    DT.100874549  DT.100662026  DT.95158745  DT.100662034  DT.100723693  DT.91713065  DT.100662037  DT.121284191 
    DT.121284206  DT.121284228  DT.92455303  DT.95158742  DT.99972942  DT.100031006  DT.100662029  DT.121284194 

    24/564 AceView cDNA sequences (see all 564):

    AU124558 AI520772 BM712363 BE466848 AW055053 AL559965 T35361 BG696472 
    CD516959 BX445404 BF437164 BM720478 BP338092 BU509618 BQ225840 BX418853 
    AI079313 CB215360 AA481139 BP367525 AL698147 CD678781 CB216855 AA026343 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX3X expression in normal human tissues (normalized intensities)      DDX3X embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGTGCAT
    DDX3X Expression
    About this image


    DDX3X expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/midbrain   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Stem Bronchi
             trachea   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             plasma cells   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See DDX3X Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX3X

    SOURCE GeneReport for Unigene cluster: Hs.743263
        SABiosciences Expression via Pathway-Focused PCR Array including DDX3X: 
              Antiviral Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX3X gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx3x1 , 5 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked1, 5 92.25(n)1
    98.64(a)1
      X (8.17 cM)5
    132051  NM_010028.31  NP_034158.11 
     132809705 
    chicken
    (Gallus gallus)
    Aves DDX3X1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 82.61(n)
    93.67(a)
      418567  NM_001030800.1  NP_001025971.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    82(a)
    1 → many
    3(134104469-134125049)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044972.12   -- 84.23(n)    BC044972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059794.12   -- 79.85(n)   30116  BC059794.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bel1 belle 56.75(n)
    61.08(a)
      45826  NM_080522.3  NP_536783.1 
    worm
    (Caenorhabditis elegans)
    Secernentea laf-11 Protein LAF-1 55.52(n)
    54.88(a)
      190611  NM_065214.3  NP_497615.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP11 Dbp1p 56.17(n)
    54.33(a)
      855984   NP_015206.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G585701 DEAD-box ATP-dependent RNA helicase 52 55.4(n)
    54.82(a)
      825026  NM_115719.2  NP_191416.1 
    rice
    (Oryza sativa)
    Liliopsida AK066048.12   -- 73.62(n)    AK066048.1 


    ENSEMBL Gene Tree for DDX3X (if available)
    TreeFam Gene Tree for DDX3X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX3X gene
    DDX42  DDX3Y2  
    11 SIMAP similar genes for DDX3X using alignment to 4 protein entries:     DDX3X_HUMAN (see all proteins):
    DDX3Y    DDX42    DDX46    DDX41    EIF4A2    DDX4
    DDX43    DDX5    DDX17    DDX52    DDX47

    DDX3X for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DDX3X
    PGOHUM00000261804


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/336 SNPs in DDX3X are shown (see all 336)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358394
    A breast cancer sample4--see VAR_0358392 R T mis40--------
    rs1880206481,2
    --41108247(+) CAGTGC/TATCCC 3 -- us2k10--------
    rs1484403991,2
    C--41108412(+) ACCCTA/GATATC 3 -- us2k10--------
    rs1122271921,2
    C,F--41108699(+) ATGCAA/GGTACT 3 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs48272671,2
    C,F,A,H--41108895(+) GGCGGC/GATTTA 3 -- us2k15Minor allele frequency- G:0.29NS EA NA 419
    rs734665351,2
    C,F--41108951(+) GTTGAC/TAGATC 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1923977411,2
    --41108955(+) ACAGAA/TCATGT 3 -- us2k10--------
    rs589768781,2
    C--41109000(+) ATTTAA/GGTTTT 3 -- us2k13Minor allele frequency- G:0.00WA CSA 4
    rs1478572911,2
    --41109045(+) ATACTA/CGTTAT 3 -- us2k10--------
    rs1391904191,2
    --41109186(+) ATTTCA/CGTCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDX3X (41192651 - 41223725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDX3X:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33720CNV Loss17666407


    Human Gene Mutation Database (HGMD): DDX3X

    Locus Specific Mutation Databases (LSDB): DDX3X
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300160    OMIM disorders: --

    14 diseases for DDX3X:    About MalaCards
    hepatitis c    hepatitis    male infertility    infertility
    vaccinia    intrahepatic cholangiocarcinoma    cholangiocarcinoma    hepatitis b
    hypoxia    hepatocellular carcinoma    gastric cancer    prostate cancer
    prostatitis    breast cancer


    DDX3X for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DDX3X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 44.5 6 16301996 (1), 10329544 (1), 17979704 (1)

    Genetic Association Database (GAD): DDX3X
    Human Genome Epidemiology (HuGE) Navigator: DDX3X (1 document)

    Export disorders for DDX3X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX3X gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with DDX3X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2, 3 Lahn B.T. and Page D.C. (1997)
    2. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control. (PubMed id 16301996)1, 2, 9 Chang P.C....Wu Lee Y.H. (2006)
    3. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential. (PubMed id 20127681)1, 2, 9 Oshiumi H....Seya T. (2010)
    4. Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. (PubMed id 10329544)1, 2, 9 Owsianka A.M. and Patel A.H. (1999)
    5. Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. (PubMed id 15507209)1, 2, 9 Yedavalli V.S.... Jeang K.-T. (2004)
    6. Critical roles of RNA helicase DDX3 and its interacti ons with eIF4E/PABP1 in stress granule assembly and stress response. (PubMed id 21883093)1, 2 Shih J.W....Wu Lee Y.H. (2012)
    7. DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs. (PubMed id 22872150)1, 2 Soto-Rifo R....Ohlmann T. (2012)
    8. A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication. (PubMed id 21589879)1, 2 Garbelli A....Maga G. (2011)
    9. DEAD-box RNA helicase Belle/DDX3 and the RNA interfer ence pathway promote mitotic chromosome segregation. (PubMed id 21730191)1, 2 Pek J.W. and Kai T. (2011)
    10. DDX3 regulates cell growth through translational cont rol of cyclin E1. (PubMed id 20837705)1, 2 Lai M.C....Tarn W.Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1654 HGNC: 2745 AceView: DDX3X Ensembl:ENSG00000215301 euGenes: HUgn1654
    ECgene: DDX3X Kegg: 1654 H-InvDB: DDX3X

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX3X Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDX3X gene:
    Search GeneIP for patents involving DDX3X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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