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Aliases for DDX3X Gene

Aliases for DDX3X Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, X-Linked 2 3
  • DDX3 3 4 6
  • DBX 3 4 6
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 3 2 3
  • DEAD Box Protein 3, X-Chromosomal 3 4
  • Helicase-Like Protein 2 3 4
  • DEAD Box, X Isoform 3 4
  • HLP2 3 4
  • ATP-Dependent RNA Helicase DDX3X 3
  • DEAD/H Box-3 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • CAP-Rf 3
  • DDX14 3

External Ids for DDX3X Gene

Previous HGNC Symbols for DDX3X Gene

  • DDX3

Previous GeneCards Identifiers for DDX3X Gene

  • GC0XP040037
  • GC0XP040223
  • GC0XP040948
  • GC0XP041077
  • GC0XP041192
  • GC0XP038924

Summaries for DDX3X Gene

Entrez Gene Summary for DDX3X Gene

  • The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for DDX3X Gene

DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, X-Linked) is a Protein Coding gene. Diseases associated with DDX3X include hepatitis c and precursor t-cell acute lymphoblastic leukemia. Among its related pathways are Cell Cycle / Checkpoint Control and Translational Control. GO annotations related to this gene include RNA binding and ATPase activity. An important paralog of this gene is DDX4.

UniProtKB/Swiss-Prot for DDX3X Gene

  • Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5proximal stem-loop structure in their 5UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.

Gene Wiki entry for DDX3X Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX3X Gene

Genomics for DDX3X Gene

Regulatory Elements for DDX3X Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX3X Gene

Start:
41,333,348 bp from pter
End:
41,364,472 bp from pter
Size:
31,125 bases
Orientation:
Plus strand

Genomic View for DDX3X Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX3X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX3X Gene

Proteins for DDX3X Gene

  • Protein details for DDX3X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00571-DDX3X_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX3X
    Protein Accession:
    O00571
    Secondary Accessions:
    • A8K538
    • B4E3E8
    • O15536

    Protein attributes for DDX3X Gene

    Size:
    662 amino acids
    Molecular mass:
    73243 Da
    Quaternary structure:
    • Interacts with XPO1, TDRD3, PABPC1, NXF1, EIF3C, MAVS, DDX58 and NCAPH. Interacts with DDX5; the interaction is regulated by the phosphorylation status of both proteins. Interacts with EIF4E; DDX3X competes with EIF4G1/EIF4G3 for interaction with EIF4E. Interacts with IKBKE; the interaction is direct, found to be induced upon virus infection. Interacts (when phosphorylated at Ser-102) with IRF3; the interaction allows the phosphorylation and activation of IRF3 by IKBKE. Interacts with TBK1. Associates with the eukaryotic translation initiation factor 3 (eIF-3) complex. Associates with the 40S ribosome. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with HCV core protein. Interacts with vaccinia virus (VACV) protein K7. Found in a complex with HIV-1 Rev and XPO1. Interacts (when phosphorylated at Ser-102) with IRF3; the interaction allows the phosphorylation and activation of IRF3 by IKBKE.

    Three dimensional structures from OCA and Proteopedia for DDX3X Gene

    Alternative splice isoforms for DDX3X Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX3X Gene

Proteomics data for DDX3X Gene at MOPED

Post-translational modifications for DDX3X Gene

  • Phosphorylated by TBK1; the phosphorylation is required to synergize with TBK1 in IFNB induction. Phosphorylated by IKBKE at Ser-102 after ssRNA viral infection; enhances the induction of INFB promoter by IRF3. The cytoplasmic form is highly phosphorylated in the G1/S phase and much lower phosphorylated in G2/M.
  • Ubiquitination at Lys55, Lys208, Lys264, Lys342, Lys491, and Lys554
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DDX3X (DDX3)

Domains for DDX3X Gene

Gene Families for DDX3X Gene

HGNC:
  • DDX :DEAD-boxes

Graphical View of Domain Structure for InterPro Entry

O00571

UniProtKB/Swiss-Prot:

DDX3X_HUMAN :
  • O00571
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
genes like me logo Genes that share domains with DDX3X: view

Function for DDX3X Gene

Molecular function for DDX3X Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5proximal stem-loop structure in their 5UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.
UniProtKB/Swiss-Prot Induction: Regulated by the cell cycle. Maximally expressed din the cytoplasm uring G1/S phase and decreased expression during G2/M phase.

Enzyme Numbers (IUBMB) for DDX3X Gene

Gene Ontology (GO) - Molecular Function for DDX3X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IDA 21589879
GO:0003723 RNA binding IDA 21589879
GO:0003924 GTPase activity IDA 10074132
GO:0004003 ATP-dependent DNA helicase activity IDA 21589879
genes like me logo Genes that share ontologies with DDX3X: view

Phenotypes for DDX3X Gene

genes like me logo Genes that share phenotypes with DDX3X: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX3X

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX3X Gene

Localization for DDX3X Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX3X Gene

Nucleus speckle. Cytoplasm. Mitochondrion outer membrane. Note=Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1 and may be also in a NFX1-dependent manner. Associated with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus during G(0) phase and in the cytoplasm during G1/S phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX3X Gene COMPARTMENTS Subcellular localization image for DDX3X gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DDX3X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10074132
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IMP 10074132
GO:0005741 mitochondrial outer membrane IEA --
GO:0005852 colocalizes_with eukaryotic translation initiation factor 3 complex IDA 18628297
genes like me logo Genes that share ontologies with DDX3X: view

Pathways for DDX3X Gene

genes like me logo Genes that share pathways with DDX3X: view

Pathways by source for DDX3X Gene

2 Cell Signaling Technology pathways for DDX3X Gene
1 BioSystems pathway for DDX3X Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DDX3X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0007059 chromosome segregation IMP 21730191
GO:0008152 metabolic process --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IMP 18846110
genes like me logo Genes that share ontologies with DDX3X: view

Transcripts for DDX3X Gene

Unigene Clusters for DDX3X Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX3X

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX3X Gene

No ASD Table

Relevant External Links for DDX3X Gene

GeneLoc Exon Structure for
DDX3X
ECgene alternative splicing isoforms for
DDX3X

Expression for DDX3X Gene

mRNA expression in normal human tissues for DDX3X Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX3X Gene

SOURCE GeneReport for Unigene cluster for DDX3X Gene Hs.743263

genes like me logo Genes that share expressions with DDX3X: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX3X Gene

Orthologs for DDX3X Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX3X Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX3X 35
  • 93.64 (n)
  • 97.88 (a)
DDX3X 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX3X 35
  • 94.65 (n)
  • 99.85 (a)
DDX3X 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D1Pas1 36
  • 95 (a)
OneToMany
Ddx3x 35
  • 92.28 (n)
  • 98.64 (a)
Ddx3x 16
Ddx3x 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX3X 35
  • 81.76 (n)
  • 92.43 (a)
DDX3X 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx3x 35
  • 77.81 (n)
  • 87.42 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10835 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ddx3 36
  • 73 (a)
ManyToMany
pl10 36
  • 76 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta bel 35
  • 58.06 (n)
  • 63.23 (a)
bel 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea laf-1 35
  • 56.33 (n)
  • 55.75 (a)
laf-1 36
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED1 36
  • 54 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7412 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58570 35
  • 55.45 (n)
  • 55.89 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10750 35
rice
(Oryza sativa)
Liliopsida Os07g0202100 35
  • 55.7 (n)
  • 56.12 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.10226 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3988 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
Species with no ortholog for DDX3X:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX3X Gene

ENSEMBL:
Gene Tree for DDX3X (if available)
TreeFam:
Gene Tree for DDX3X (if available)

Paralogs for DDX3X Gene

Paralogs for DDX3X Gene

Selected SIMAP similar genes for DDX3X Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DDX3X Gene

genes like me logo Genes that share paralogs with DDX3X: view

Variants for DDX3X Gene

Sequence variations from dbSNP and Humsavar for DDX3X Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs14554 -- 41,350,031(+) AAGCA(A/T)TATTT utr-variant-3-prime
rs708452 -- 41,350,107(+) AAGTC(A/C)CTGTA utr-variant-3-prime
rs953114 -- 41,338,289(+) CTGGG(A/C)ACAAA intron-variant
rs1056357 -- 41,348,184(+) GATTC(A/G)TCCAT utr-variant-3-prime
rs1056358 -- 41,348,432(+) CAAAG(C/T)ACTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX3X Gene

Variant ID Type Subtype PubMed ID
esv33720 CNV Loss 17666407

Relevant External Links for DDX3X Gene

HapMap Linkage Disequilibrium report
DDX3X
Locus Specific Mutation Databases (LSDB)
DDX3X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX3X Gene

Disorders for DDX3X Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for DDX3X Gene including...

Search for DDX3X Gene in MalaCards »

(1) Novoseek inferred disease relationships for DDX3X Gene

Disease -log(P) Hits PubMed IDs
hepatitis c 44.5 3

Relevant External Links for DDX3X

Genetic Association Database (GAD)
DDX3X
Human Genome Epidemiology (HuGE) Navigator
DDX3X
genes like me logo Genes that share disorders with DDX3X: view

No data available for UniProtKB/Swiss-Prot for DDX3X Gene

Publications for DDX3X Gene

  1. Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. (PMID: 10329544) Owsianka A.M. … Patel A.H. (Virology 1999) 3 4 23
  2. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus- associated hepatocellular carcinoma and is involved in cell growth control. (PMID: 16301996) Chang P.C. … Wu Lee Y.H. (Oncogene 2006) 3 4 23
  3. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the DDX3 RNA helicase domain. (PMID: 17401195) Rodamilans B. … Montoya G. (Acta Crystallogr. F 2007) 3 4 23
  4. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up- regulate IFN-beta-inducing potential. (PMID: 20127681) Oshiumi H. … Seya T. (Eur. J. Immunol. 2010) 3 4 23
  5. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3 4

Products for DDX3X Gene

Sources for DDX3X Gene

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