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DDX3X Gene

protein-coding   GIFtS: 60
GCID: GC0XP041192

DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, X-Linked

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, DEAD (Asp-Glu-Ala-Asp)...)
(Previous symbol: DDX3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, X-Linked1 2     DEAD Box, X Isoform2 3
DDX31 2 3 5     CAP-Rf2
DBX2 3 5     DDX142
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked1 2     ATP-Dependent RNA Helicase DDX3X2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 31 2     DEAD/H Box-32
Helicase-Like Protein 22 3     Helicase Like Protein 22
HLP22 3     EC 3.6.4.133
DEAD Box Protein 3, X-Chromosomal2 3     EC 3.6.18

External Ids:    HGNC: 27451   Entrez Gene: 16542   Ensembl: ENSG000002153017   OMIM: 3001605   UniProtKB: O005713   

Export aliases for DDX3X gene to outside databases

Previous GC identifers: GC0XP040037 GC0XP040223 GC0XP040948 GC0XP041077 GC0XP038924


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX3X Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with
hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in
the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the
Y-linked homolog. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jul 2010)

GeneCards Summary for DDX3X Gene:
DDX3X (DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked) is a protein-coding gene. Diseases associated with DDX3X include hepatitis c, and hepatitis c virus. GO annotations related to this gene include RNA binding and ATPase activity. An important paralog of this gene is DDX1.

UniProtKB/Swiss-Prot: DDX3X_HUMAN, O00571
Function: Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and
deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded
DNA with a preference for 5'-single-stranded DNA overhangs. Is involved in several steps of gene expression, such
as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and
some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance
transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin
promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation.
Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of
mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase
activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal
stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal
scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the
40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S
ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is
independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive
interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress
response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve
association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via
interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with
spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in
splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location.
Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta);
proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and
IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE
and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent
of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling
in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the
intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through
association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors
promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic
chromosome segregation. Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase
and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or
IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core
protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function
from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for
XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs

Gene Wiki entry for DDX3X Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DDX3X gene promoter:
         p53   Sp1   SREBP-1c   C/EBPalpha   SREBP-1b   CREB   CHOP-10   SREBP-1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDX3X promoter sequence
   Search Chromatin IP Primers for DDX3X

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX3X


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3-p11.23   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11.3-p11.23

DDX3X Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX3X gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP041192:  view genomic region     (about GC identifiers)

Start:
41,192,651 bp from pter      End:
41,223,725 bp from pter
Size:
31,075 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DDX3X_HUMAN, O00571 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX3X  
Size: 662 amino acids; 73243 Da
Subunit: Interacts with XPO1, TDRD3, PABPC1, NXF1, EIF3C, MAVS, DDX58 and NCAPH. Interacts with DDX5; the
interaction is regulated by the phosphorylation status of both proteins. Interacts with EIF4E; DDX3X competes
with EIF4G1/EIF4G3 for interaction with EIF4E. Interacts with IKBKE; the interaction is direct, found to be
induced upon virus infection. Interacts (when phosphorylated at Ser-102) with IRF3; the interaction allows the
phosphorylation and activation of IRF3 by IKBKE. Interacts with TBK1. Associates with the eukaryotic translation
initiation factor 3 (eIF-3) complex. Associates with the 40S ribosome. Identified in a mRNP complex, at least
composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
Interacts with HCV core protein. Interacts with vaccinia virus (VACV) protein K7. Found in a complex with HIV-1
Rev and XPO1. Interacts (when phosphorylated at Ser-102) with IRF3; the interaction allows the phosphorylation
and activation of IRF3 by IKBKE
3 PDB 3D structures from and Proteopedia for DDX3X:
2I4I (3D)        2JGN (3D)        3JRV (3D)    
Secondary accessions: A8K538 B4E3E8 O15536
Alternative splicing: 2 isoforms:  O00571-1   O00571-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX3X: NX_O00571

Explore proteomics data for DDX3X at MOPED

Post-translational modifications: 

  • Phosphorylated by TBK1; the phosphorylation is required to synergize with TBK1 in IFNB induction. Phosphorylated
    by IKBKE at Ser-102 after ssRNA viral infection; enhances the induction of INFB promoter by IRF3. The cytoplasmic
    form is highly phosphorylated in the G1/S phase and much lower phosphorylated in G2/M1
  • Ubiquitination2 at Lys55, Lys208, Lys264, Lys342, Lys491, Lys554
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX3X (O00571) (see all 39)
     DMGFEPQ  YIPPHLR  LAPTREL  DEADRML 


    See DDX3X Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180345.1  NP_001180346.1  NP_001347.3  

    ENSEMBL proteins: 
     ENSP00000382840   ENSP00000392494   ENSP00000414281   ENSP00000439799  

    DDX3X Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DDX3X
    OriGene Protein Over-expression Lysate for DDX3X
    OriGene MassSpec for DDX3X
    OriGene Custom Protein Services for DDX3X
    GenScript Custom Purified and Recombinant Proteins Services for DDX3X
    Novus Biologicals DDX3X Proteins
    Novus Biologicals DDX3X Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX3X

    DDX3X Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DDX3X
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DDX3X  (DDX3)
    OriGene Antibodies for DDX3X
    OriGene Custom Antibody Services for DDX3X
    Novus Biologicals DDX3X Antibodies
    Abcam antibodies for DDX3X
    Cloud-Clone Corp. Antibodies for DDX3X
    ThermoFisher Antibody for DDX3X
    LSBio Antibodies in human, mouse, rat for DDX3X

    DDX3X Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDX3X
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDX3X
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX3X
    Cloud-Clone Corp. CLIAs for DDX3X


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry O00571

    ProtoNet protein and cluster: O00571

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX3X_HUMAN, O00571
    Similarity: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX3X for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX3X_HUMAN, O00571
    Function: Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and
    deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded
    DNA with a preference for 5'-single-stranded DNA overhangs. Is involved in several steps of gene expression, such
    as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and
    some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance
    transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin
    promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation.
    Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of
    mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase
    activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal
    stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal
    scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the
    40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S
    ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is
    independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive
    interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress
    response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve
    association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via
    interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with
    spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in
    splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location.
    Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta);
    proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and
    IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE
    and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent
    of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling
    in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the
    intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through
    association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors
    promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic
    chromosome segregation. Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase
    and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or
    IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core
    protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function
    from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for
    XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: Regulated by the cell cycle. Maximally expressed din the cytoplasm uring G1/S phase and decreased
    expression during G2/M phase

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA--
    GO:0003723RNA binding IDA--
    GO:0004003ATP-dependent DNA helicase activity IDA--
    GO:0004004ATP-dependent RNA helicase activity IDA--
         
    DDX3X for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX3X:
     Decreased p24 protein expressi  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX3X
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDX3X

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX3X
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX3X

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX3X:
    hsa-mir-99a-5p (MIRT048615), hsa-mir-21-5p (MIRT030902), hsa-mir-505-5p (MIRT037942), hsa-mir-130b-5p (MIRT038287), hsa-mir-124-3p (MIRT022863), hsa-mir-215-5p (MIRT024813), hsa-mir-421 (MIRT016125), hsa-mir-181a-5p (MIRT025200), hsa-mir-26b-5p (MIRT029833), hsa-mir-192-5p (MIRT004132), hsa-mir-92b-3p (MIRT040544), hsa-mir-629-3p (MIRT039582), hsa-mir-16-5p (MIRT031843)

    Block miRNA regulation of human, mouse, rat DDX3X using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX3X (see all 193):
    hsa-miR-194* hsa-miR-361-5p hsa-miR-520f hsa-miR-138-2* hsa-miR-342-3p hsa-miR-3921 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidDDX3X 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDX3X
    Predesigned siRNA for gene silencing in human, mouse, rat DDX3X

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDX3X

    Clone
    Products:
         
    OriGene clones in human, mouse for DDX3X (see all 12)
    OriGene ORF clones in mouse, rat for DDX3X
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DDX3X (NM_001193416)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX3X
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX3X

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDX3X
    Browse ESI BIO Cell Lines and PureStem Progenitors for DDX3X 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX3X


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX3X_HUMAN, O00571: Nucleus speckle. Cytoplasm. Mitochondrion outer membrane. Note=Located predominantly in
    nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore
    complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1 and may be also in a NFX1-dependent
    manner. Associated with polyadenylated mRNAs in the cytoplasm and the nucleus. Predominantly located in nucleus
    during G(0) phase and in the cytoplasm during G1/S phase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10329544
    GO:0005737cytoplasm IDA--
    GO:0005741mitochondrial outer membrane IEA--
    GO:0005852colocalizes with eukaryotic translation initiation factor 3 complex IDA18628297
    GO:0010494cytoplasmic stress granule IDA18596238

    DDX3X for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDX3X About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.47
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Toll-like receptor signaling pathway
    Hepatitis B0.31
    4Viral carcinogenesis
    Viral carcinogenesis
    5Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DDX3X
        Translational Control
    Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for DDX3X
        TNF-alpha/NF-kB Signaling Pathway


    3 Kegg Pathways  (Kegg details for DDX3X):
        RIG-I-like receptor signaling pathway
    Hepatitis B
    Viral carcinogenesis


    DDX3X for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DDX3X: 
              Antiviral Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DDX3X

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX3X (O005711, 2, 3 ENSP000003828404) via UniProtKB, MINT, STRING, and/or I2D (see all 1048)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    -Q99IB81, 2EBI-353779,EBI-6674379 MINT-8361022 MINT-8361063 MINT-8360971 MINT-8360947 MINT-8361004 MINT-8361079 MINT-8361102 MINT-8361045 MINT-8361121
    NXF1Q9UBU91, 2, ENSP000002941724EBI-353779,EBI-398874 MINT-7234837 MINT-7234858 STRING: ENSP00000294172
    NFKB2Q006532, 3MINT-47916 MINT-48749 I2D: score=5 
    SREK1Q8WXA92, 3, ENSP000003345384MINT-7947479 I2D: score=2 STRING: ENSP00000334538
    TBK1Q9UHD22, 3, ENSP000003299674MINT-6948107 I2D: score=2 STRING: ENSP00000329967
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process TAS9381176
    GO:0006351transcription, DNA-templated IEA--
    GO:0007059chromosome segregation IMP--
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors IMP18846110
    GO:0009615response to virus IDA18636090

    DDX3X for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX3X



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DDX3X gene (4 alternative transcripts): 
    NM_001193416.1  NM_001193417.1  NM_001356.3  NM_024005.1  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399959(uc004dfe.3 uc011mks.2 uc004dff.3 uc011mkq.2 uc011mkr.2)
    ENST00000478993(uc010nhf.1 uc004dfg.3) ENST00000480592(uc004dfd.1)
    ENST00000457138 ENST00000441189 ENST00000542215(uc011mkt.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DDX3X (see all 193):
    hsa-miR-194* hsa-miR-361-5p hsa-miR-520f hsa-miR-138-2* hsa-miR-342-3p hsa-miR-3921 hsa-miR-519a hsa-miR-4275
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      QuantiFast Probe-based Assays in human, mouse, rat DDX3X

    Selected AceView cDNA sequences (see all 564):

    BQ722942 AF086430 AA481219 BM456366 BQ225840 BG572307 BM712363 BE514080 
    BF437164 BG621868 CB959595 BM785448 AA481139 AU134371 BU663149 BQ680001 
    BM720478 AI079313 BQ441867 AA489825 CB215360 AA504995 AU122487 CD516959 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX3X expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGTGCAT
    DDX3X Expression
    About this image


    DDX3X expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    DDX3X Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX3X Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including DDX3X: 
              Antiviral Response in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX3X gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx3x1 , 5 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked1, 5 92.28(n)1
    98.64(a)1
      X (8.17 cM)5
    132051  NM_010028.31  NP_034158.11 
     132809705 
    chicken
    (Gallus gallus)
    Aves DDX3X1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 81.76(n)
    92.43(a)
      418567  NM_001030800.1  NP_001025971.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    1 → many
    3(134104469-134125049)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044972.12   -- 84.23(n)    BC044972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059794.12   -- 79.85(n)   30116  BC059794.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bel1 belle 58.06(n)
    63.23(a)
      45826  NM_080522.4  NP_536783.1 
    worm
    (Caenorhabditis elegans)
    Secernentea laf-11 laf-1 56.33(n)
    55.75(a)
      190611  NM_001267929.1  NP_001254858.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DED16
    ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helic...
    54(a)
    1 → many
    XV(722911-724725) YOR204W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G585701 AT3G58570 55.45(n)
    55.89(a)
      825026  NM_115719.2  NP_191416.1 
    rice
    (Oryza sativa)
    Liliopsida AK066048.12   -- 73.62(n)    AK066048.1 


    ENSEMBL Gene Tree for DDX3X (if available)
    TreeFam Gene Tree for DDX3X (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX3X gene
    DDX12  DDX42  DDX3Y2  
    11 SIMAP similar genes for DDX3X using alignment to 4 protein entries:     DDX3X_HUMAN (see all proteins):
    DDX3Y    DDX42    DDX46    DDX41    EIF4A2    DDX4
    DDX43    DDX5    DDX17    DDX52    DDX47

    DDX3X for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DDX3X
    PGOHUM00000261804


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX3X (see all 336)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358394
    A breast cancer sample4--see VAR_0358392 R T mis40--------
    rs1880206481,2
    --41108247(+) CAGTGC/TATCCC 3 -- us2k10--------
    rs1484403991,2
    C--41108412(+) ACCCTA/GATATC 3 -- us2k10--------
    rs1122271921,2
    C,F--41108699(+) ATGCAA/GGTACT 3 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs48272671,2
    C,F,A,H--41108895(+) GGCGGC/GATTTA 3 -- us2k15Minor allele frequency- G:0.29NS EA NA 419
    rs734665351,2
    C,F--41108951(+) GTTGAC/TAGATC 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1923977411,2
    --41108955(+) ACAGAA/TCATGT 3 -- us2k10--------
    rs589768781,2
    C--41109000(+) ATTTAA/GGTTTT 3 -- us2k13Minor allele frequency- G:0.00WA CSA 4
    rs1478572911,2
    --41109045(+) ATACTA/CGTTAT 3 -- us2k10--------
    rs1391904191,2
    --41109186(+) ATTTCA/CGTCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDX3X (41192651 - 41223725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDX3X:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33720CNV Loss17666407

    Human Gene Mutation Database (HGMD): DDX3X
    Locus Specific Mutation Databases (LSDB): DDX3X

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300160    OMIM disorders: --

    Selected diseases for DDX3X (see all 25):    
    About MalaCards
    hepatitis c    hepatitis c virus    precursor t-cell acute lymphoblastic leukemia    adenosquamous carcinoma
    hepatitis    vaccinia    male infertility    infertility
    hiv-1    intrahepatic cholangiocarcinoma    labyrinthitis    cholangiocarcinoma
    hepatitis b    breast and colorectal cancer    lymphoblastic leukemia    hypoxia
    hepatocellular carcinoma    prostatitis    prostate cancer    adenocarcinoma


    DDX3X for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for DDX3X gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 44.5 6 16301996 (1), 10329544 (1), 17979704 (1)

    Genetic Association Database (GAD): DDX3X
    Human Genome Epidemiology (HuGE) Navigator: DDX3X (1 document)

    Export disorders for DDX3X gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX3X gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with DDX3X)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2, 3 Lahn B.T. and Page D.C. (Science 1997)
    2. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus- associated hepatocellular carcinoma and is involved in cell growth control. (PubMed id 16301996)1, 2, 9 Chang P.C....Wu Lee Y.H. (Oncogene 2006)
    3. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up- regulate IFN-beta-inducing potential. (PubMed id 20127681)1, 2, 9 Oshiumi H.... Seya T. (Eur. J. Immunol. 2010)
    4. Hepatitis C virus core protein interacts with a human DEAD box protein DDX3. (PubMed id 10329544)1, 2, 9 Owsianka A.M. and Patel A.H. (Virology 1999)
    5. Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. (PubMed id 15507209)1, 2, 9 Yedavalli V.S.... Jeang K.-T. (Cell 2004)
    6. Human DEAD box helicase 3 couples II_B kinase I/ to interferon regulatory factor 3 activation. (PubMed id 23478265)1, 2 Gu L....SchrAPder M. (Mol. Cell. Biol. 2013)
    7. Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response. (PubMed id 21883093)1, 2 Shih J.W.... Wu Lee Y.H. (Biochem. J. 2012)
    8. DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs. (PubMed id 22872150)1, 2 Soto-Rifo R....Ohlmann T. (EMBO J. 2012)
    9. A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication. (PubMed id 21589879)1, 2 Garbelli A.... Maga G. (PLoS ONE 2011)
    10. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. (PubMed id 21730191)1, 2 Pek J.W. and Kai T. (Proc. Natl. Acad. Sci. U.S.A. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1654 HGNC: 2745 AceView: DDX3X Ensembl:ENSG00000215301 euGenes: HUgn1654
    ECgene: DDX3X Kegg: 1654 H-InvDB: DDX3X

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX3X Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX3X gene:
    Search GeneIP for patents involving DDX3X

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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