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DDX39A Gene

protein-coding   GIFtS: 50
GCID: GC19M014521

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39A

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 39, DEAD (Asp-Glu-Ala-Asp)...)
(Previous symbol: DDX39)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39A1 2     BAT12
DDX391 2 3     BAT1L2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 391 2     DDXL2
Nuclear RNA Helicase URH492 3     URH492
DEAD Box Protein 392 3     ATP-Dependent RNA Helicase DDX39A2
49 KDa1     Nuclear RNA Helicase, DECD Variant Of DEAD Box Family2
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 391     UAP56-Related Helicase, 49 KDa2
UAP56-Related Helicase1     EC 3.6.4.133

External Ids:    HGNC: 178211   Entrez Gene: 102122   Ensembl: ENSG000001231367   UniProtKB: O001483   

Export aliases for DDX39A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX39A Gene:
This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif
Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes
involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial
splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD
box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and
division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors.
A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript
variants. Additional alternatively spliced transcript variants of this gene have been described, but their
full-length nature is not known. (provided by RefSeq, Sep 2013)

GeneCards Summary for DDX39A Gene:
DDX39A (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A) is a protein-coding gene. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DDX39B.

UniProtKB/Swiss-Prot: DX39A_HUMAN, O00148
Function: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus

Gene Wiki entry for DDX39A (DDX39) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DDX39A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX39A promoter sequence
   Search Chromatin IP Primers for DDX39A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX39A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

DDX39A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX39A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014521:  view genomic region     (about GC identifiers)

Start:
14,519,610 bp from pter      End:
14,530,195 bp from pter
Size:
10,586 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DX39A_HUMAN, O00148 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX39A  
Size: 427 amino acids; 49130 Da
Subunit: Binds ALYREF/THOC4 and DDX39B/BAT1. Interacts with SARNP. Interacts with human cytomegalovirus/HHV-5
protein UL69. Interacts with MX1
Sequence caution: Sequence=BAB15509.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8N5M0 Q9BVP6 Q9H5W0
Alternative splicing: 2 isoforms:  O00148-1   O00148-2   

Explore the universe of human proteins at neXtProt for DDX39A: NX_O00148

Explore proteomics data for DDX39A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys35, Lys52, Lys89, Lys130, Lys221, Lys267, Lys333, Lys383
  • Modification sites at PhosphoSitePlus

  • See DDX39A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005795.2  
    ENSEMBL proteins: 
     ENSP00000322749   ENSP00000467862   ENSP00000242776   ENSP00000467911   ENSP00000467411  
     ENSP00000466810   ENSP00000464801   ENSP00000466754   ENSP00000465926   ENSP00000467040  
     ENSP00000392929  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for DDX39A (4 products) 

     
    antibodies-online peptides for DDX39A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry O00148

    ProtoNet protein and cluster: O00148

    UniProtKB/Swiss-Prot: DX39A_HUMAN, O00148
    Similarity: Belongs to the DEAD box helicase family. DECD subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX39A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DX39A_HUMAN, O00148
    Function: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: Up-regulated in proliferating cells. Present at low levels in quiescent cells

         Enzyme Number (IUBMB): EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI15047853
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DDX39A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX39A:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DDX39A

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    miRTarBase miRNAs that target DDX39A:
    hsa-mir-92a-3p (MIRT049339), hsa-mir-378a-3p (MIRT019655), hsa-mir-421 (MIRT016108), hsa-mir-99b-5p (MIRT044183), hsa-mir-652-3p (MIRT039528)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DX39A_HUMAN, O00148: Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737colocalizes with cytoplasm IDA--

    Find genes that share ontologies with DDX39A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DDX39A: 
              Hepatotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DDX39A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX39A (O001482, 3 ENSP000002427764) via UniProtKB, MINT, STRING, and/or I2D (see all 945)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000215425Q138382, 3MINT-62737 MINT-7945693 MINT-62639 MINT-62813 MINT-7947479 I2D: score=4 
    ENSG00000225859Q138382, 3MINT-62737 MINT-7945693 MINT-62639 MINT-62813 MINT-7947479 I2D: score=4 
    ENSG00000229496Q138382, 3MINT-62737 MINT-7945693 MINT-62639 MINT-62813 MINT-7947479 I2D: score=4 
    ENSG00000230624Q138382, 3MINT-62737 MINT-7945693 MINT-62639 MINT-62813 MINT-7947479 I2D: score=4 
    ENSG00000235439Q138382, 3MINT-62737 MINT-7945693 MINT-62639 MINT-62813 MINT-7947479 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IGI15047853
    GO:0006406mRNA export from nucleus IGI15047853

    Find genes that share ontologies with DDX39A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX39A (DX39A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX39A gene (3 alternative transcripts): 
    NM_005804.3  NM_001204057.1  NM_138998.1  

    Unigene Cluster for DDX39A:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
    Hs.311609  [show with all ESTs]
    Unigene Representative Sequence: NR_038336
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000587730 ENST00000324340 ENST00000589318 ENST00000588692 ENST00000242776(uc010xnp.2 uc002myo.3 uc010dzl.3)
    ENST00000592927 ENST00000592391 ENST00000588542 ENST00000589675 ENST00000593026
    ENST00000590315 ENST00000590556 ENST00000590260 ENST00000586558 ENST00000590239
    ENST00000586993 ENST00000592632 ENST00000593008
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    Additional mRNA sequence: 

    AB254849.1 AK301847.1 BC001009.2 NR_038336.1 NR_046366.1 U90426.1 

    22 DOTS entries:

    DT.100856632  DT.456269  DT.100856638  DT.92453764  DT.100801131  DT.100856631  DT.121468427  DT.100856636 
    DT.100856642  DT.92453760  DT.100856633  DT.100856639  DT.95168770  DT.95168785  DT.100856623  DT.100856630 
    DT.95168780  DT.100856621  DT.121468462  DT.91871049  DT.95168774  DT.97797893 

    Selected AceView cDNA sequences (see all 559):

    BM743897 NM_005804 BQ217549 BQ953614 BU187862 AW802212 CR597385 BI915035 
    BU158660 AW245062 BM792997 CR600064 BM553704 BX345174 BG819839 NM_138998 
    BQ021055 BE796043 CA427854 BM970172 CB161376 BX096628 BG675723 AW249803 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX39A (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c · 9d ^ 10 ^
    SP1:                          -     -     -     -     -     -     -     -     -           -     -     -                       -                       -     -   
    SP2:                          -     -     -     -     -     -     -     -     -           -     -     -                       -                       -     -   
    SP3:                          -     -     -     -     -     -     -     -     -           -     -     -                       -                       -     -   
    SP4:                          -     -     -     -     -     -     -     -     -           -     -     -                       -                       -     -   
    SP5:                          -     -     -     -     -     -     -     -     -           -     -                             -                       -     -   

    ExUns: 11a · 11b · 11c · 11d ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                    -     -     -     -                 -     -                                       
    SP2:                    -     -     -     -                 -     -                 -                     
    SP3:                    -     -     -     -                                                               
    SP4:                    -     -                                                                           
    SP5:                    -     -     -     -                                                               


    ECgene alternative splicing isoforms for DDX39A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DDX39A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTTCACC
    DDX39A Expression
    About this image


    DDX39A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    DDX39A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX39A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.311609

    UniProtKB/Swiss-Prot: DX39A_HUMAN, O00148
    Tissue specificity: Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary
    gland

        Pathway & Disease-focused RT2 Profiler PCR Array including DDX39A: 
              Hepatotoxicity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX39A gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx391 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 391, 5 88.91(n)1
    97.19(a)1
      8 (40.22 cM)5
    682781  NM_197982.31  NP_932099.21 
     837151775 
    lizard
    (Anolis carolinensis)
    Reptilia DDX39A6
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
    93(a)
    1 ↔ 1
    2(118795205-118817357)
    African clawed frog
    (Xenopus laevis)
    Amphibia ddx39-prov2 nuclear RNA helicase 82.1(n)    BC045125.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.11082 Danio rerio cDNA clone MGC55433 IMAGE2639515, complete more 79.64(n)    BC044169.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hel25E6
    Helicase at 25E
    83(a)
    1 → many
    2L(5539326-5542314)
    worm
    (Caenorhabditis elegans)
    Secernentea hel-11 hel-1 67.78(n)
    76.32(a)
      174333  NM_001026814.3  NP_001021985.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUB26
    Component of the TREX complex required for nuclear...
    60(a)
    1 → many
    IV(305237-306577) YDL084W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G112001 AT5G11200 65.99(n)
    73.74(a)
      830990  NM_001161234.1  NP_001154706.1 
    barley
    (Hordeum vulgare)
    Liliopsida BJ464871.12   -- 76.68(n)    BJ464871.1 


    ENSEMBL Gene Tree for DDX39A (if available)
    TreeFam Gene Tree for DDX39A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX39A gene
    DDX39B2  DDX202  
    Selected SIMAP similar genes for DDX39A using alignment to 8 protein entries:     DX39A_HUMAN (see all proteins) (see all similar genes):
    DKFZp547B159    DDX39    BAT1    DDX39B    STARD6    DDX56
    EIF4A2    DDX27    DDX54    EIF4A3    DDX47    DDX6
    E4-DBP    EIF4A1    DDX46    DDX25    DDX19A    DDX19L

    Find genes that share paralogs with DDX39A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DDX39A
    PGOHUM00000258701


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX39A (see all 298)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479230851,2
    Cuntested114459429(+) TGCTGA/G/TACTGC 4 V syn11NA 4542
    rs735178231,2
    C,F--14090177(+) CCACCG/ACCAGG 3 -- int15Minor allele frequency- A:0.04WA NA EU 1405
    rs1840154221,2
    C--14090199(+) TGCCCA/GTGAGG 3 -- int10--------
    rs1510914471,2
    C,F--14090231(+) GTGTCC/GGAGTC 4 S syn12Minor allele frequency- G:0.00NA EU 5765
    rs2018144561,2
    --14090249(+) ATGTCA/GTAGTT 4 Y syn10--------
    rs1410706191,2
    C,F--14090261(+) AAGACG/AATGTT 4 /I syn12Minor allele frequency- A:0.00NA EU 5759
    rs614063191,2
    C,F--14090285(+) TCCATC/TCCCCG 4 G syn14Minor allele frequency- T:0.02NS WA NA 4742
    rs1887174331,2
    C--14090322(+) TCCGCC/TGCTGG 4 Q R mis10--------
    rs1112337521,2
    C--14090359(+) CAGGCG/TGGGGT 3 -- spa10--------
    rs1385898181,2
    C--14090363(+) CTGGGG/ATGCAG 3 -- int11Minor allele frequency- A:0.00EU 1015

    HapMap Linkage Disequilibrium report for DDX39A (14519610 - 14530195 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DDX39A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911121CNV Loss21882294
    nsv911122CNV Loss21882294
    nsv833764CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX39A
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX39A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX39A gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with DDX39A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Intracellular characterization of DDX39, a novel growth-associated RNA helicase. (PubMed id 17196963)1, 2, 9 Sugiura T.... Nagano Y. (Exp. Cell Res. 2007)
    2. Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56. (PubMed id 15047853)1, 2, 9 Pryor A.... Johnson L.F. (Nucleic Acids Res. 2004)
    3. Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49. (PubMed id 21859714)1, 2 Wisskirchen C....Pavlovic J. (J. Biol. Chem. 2011)
    4. Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819)1, 2 Lehner B....Sanderson C.M. (Genomics 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family. (PubMed id 7601445)1, 3 Peelman L.... Spies T. (Genomics 1995)
    8. Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49. (PubMed id 16949217)1, 9 Kapadia F....Johnson L.F. (Gene 2006)
    9. The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA. (PubMed id 16478985)2, 9 Lischka P.... Stamminger T. (Mol. Cell. Biol. 2006)
    10. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. (PubMed id 24140708)1 Wu T....Zhang D.D. (amp 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10212 HGNC: 17821 AceView: DDX39 Ensembl:ENSG00000123136 euGenes: HUgn10212
    ECgene: DDX39A H-InvDB: DDX39A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX39A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX39A gene:
    Search GeneIP for patents involving DDX39A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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