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Aliases for DDX31 Gene

Aliases for DDX31 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 31 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 31 2 3
  • DEAD Box Protein 31 3 4
  • Helicain 3 4
  • Protein Phosphatase 1, Regulatory Subunit 25 3
  • Probable ATP-Dependent RNA Helicase DDX31 3
  • DEAD/DEXH Helicase DDX31 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 25 2
  • G2 Helicase 3
  • EC 4
  • EC 3.6.1 63
  • PPP1R25 3

External Ids for DDX31 Gene

Previous GeneCards Identifiers for DDX31 Gene

  • GC09M126494
  • GC09M127026
  • GC09M128823
  • GC09M130745
  • GC09M134458
  • GC09M135468
  • GC09M104963

Summaries for DDX31 Gene

Entrez Gene Summary for DDX31 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX31 Gene

DDX31 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 31) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for DDX31 Gene

  • Probable ATP-dependent RNA helicase.

Gene Wiki entry for DDX31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX31 Gene

Genomics for DDX31 Gene

Regulatory Elements for DDX31 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX31 Gene

132,592,997 bp from pter
132,670,401 bp from pter
77,405 bases
Minus strand

Genomic View for DDX31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX31 Gene

Proteins for DDX31 Gene

  • Protein details for DDX31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX31
    Protein Accession:
    Secondary Accessions:
    • Q5K6N2
    • Q5K6N3
    • Q5K6N4
    • Q5VZJ4
    • Q5VZJ9
    • Q96E91
    • Q96NY2
    • Q96SX5
    • Q9H5K6

    Protein attributes for DDX31 Gene

    851 amino acids
    Molecular mass:
    94087 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ14889.1; Type=Frameshift; Positions=816, 825; Evidence={ECO:0000305}; Sequence=AAQ14890.1; Type=Frameshift; Positions=816; Evidence={ECO:0000305}; Sequence=BAB14644.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15620.1; Type=Frameshift; Positions=141; Evidence={ECO:0000305}; Sequence=CAH70532.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16565.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX31 Gene


neXtProt entry for DDX31 Gene

Proteomics data for DDX31 Gene at MOPED

Post-translational modifications for DDX31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX31 Gene

Antibody Products

Domains for DDX31 Gene

Suggested Antigen Peptide Sequences for DDX31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
genes like me logo Genes that share domains with DDX31: view

Function for DDX31 Gene

Molecular function for DDX31 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase.

Enzyme Numbers (IUBMB) for DDX31 Gene

Gene Ontology (GO) - Molecular Function for DDX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX31: view
genes like me logo Genes that share phenotypes with DDX31: view

Animal Model Products

miRNA for DDX31 Gene

miRTarBase miRNAs that target DDX31

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX31 Gene

Localization for DDX31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX31 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for DDX31 Gene COMPARTMENTS Subcellular localization image for DDX31 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DDX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with DDX31: view

Pathways for DDX31 Gene

SuperPathways for DDX31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX31: view

No data available for Pathways by source for DDX31 Gene

Drugs for DDX31 Gene

(4) HMDB Compounds for DDX31 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide
genes like me logo Genes that share compounds with DDX31: view

Transcripts for DDX31 Gene

Unigene Clusters for DDX31 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX31 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: - -

ExUns: 21 ^ 22

Relevant External Links for DDX31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX31 Gene

mRNA expression in normal human tissues for DDX31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DDX31 Gene

This gene is overexpressed in Lung (27.9), Blymphocyte (13.6), and CD8 Tcells (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX31 Gene

SOURCE GeneReport for Unigene cluster for DDX31 Gene Hs.660767

genes like me logo Genes that share expressions with DDX31: view

Expression partners for DDX31 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX31 Gene

Orthologs for DDX31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX31 35
  • 83.29 (n)
  • 79.97 (a)
DDX31 36
  • 78 (a)
(Canis familiaris)
Mammalia DDX31 35
  • 85.71 (n)
  • 84.05 (a)
(Mus musculus)
Mammalia Ddx31 35
  • 83.28 (n)
  • 81.99 (a)
Ddx31 16
Ddx31 36
  • 80 (a)
(Pan troglodytes)
Mammalia DDX31 35
  • 99.26 (n)
  • 98.59 (a)
DDX31 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ddx31 35
  • 83.04 (n)
  • 82.64 (a)
(Monodelphis domestica)
Mammalia DDX31 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia DDX31 36
  • 75 (a)
(Gallus gallus)
Aves DDX31 35
  • 70.64 (n)
  • 67.73 (a)
DDX31 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx31 35
  • 64.87 (n)
  • 66.5 (a)
Str.11929 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15162 35
(Danio rerio)
Actinopterygii ddx31 35
  • 61.45 (n)
  • 62.02 (a)
Dr.7284 35
ddx31 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH02833 37
  • 40 (a)
CG8611 35
  • 49.75 (n)
  • 44.55 (a)
CG8611 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010670 35
  • 50.28 (n)
  • 44.21 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR082C 35
  • 44.83 (n)
  • 38.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13926g 35
  • 46.65 (n)
  • 37.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP7 35
  • 46.7 (n)
  • 39.21 (a)
DBP7 36
  • 29 (a)
DBP7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40700 35
  • 49.35 (n)
  • 44.53 (a)
(Oryza sativa)
Liliopsida Os.19569 35
Os05g0110500 35
  • 49.51 (n)
  • 43.57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06520 35
  • 46.16 (n)
  • 36.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp7 35
  • 47.42 (n)
  • 38.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for DDX31:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX31 Gene

Gene Tree for DDX31 (if available)
Gene Tree for DDX31 (if available)

Paralogs for DDX31 Gene

(6) SIMAP similar genes for DDX31 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDX31: view

No data available for Paralogs for DDX31 Gene

Variants for DDX31 Gene

Sequence variations from dbSNP and Humsavar for DDX31 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3433 -- 132,626,772(+) CTGAC(A/G)GCGAT intron-variant
rs184252 -- 132,647,620(+) AGACA(C/G)AAAAA intron-variant
rs184253 -- 132,627,970(+) ACTTT(C/G)CAGTC intron-variant
rs188631 -- 132,629,395(+) TAACA(A/C)CCTTG intron-variant
rs216682 -- 132,647,539(+) AACAT(A/G)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX31 Gene

Variant ID Type Subtype PubMed ID
nsv894023 CNV Gain 21882294
esv2661382 CNV Deletion 23128226

Relevant External Links for DDX31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX31 Gene

Disorders for DDX31 Gene

Relevant External Links for DDX31

Genetic Association Database (GAD)

No disorders were found for DDX31 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DDX31 Gene

Publications for DDX31 Gene

  1. The human DDX and DHX gene families of putative RNA helicases. (PMID: 12782131) Abdelhaleem M. … Wain H. (Genomics 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4

Products for DDX31 Gene

Sources for DDX31 Gene

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