Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX31 Gene

Aliases for DDX31 Gene

  • DEAD-Box Helicase 31 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 31 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 31 2 3
  • DEAD Box Protein 31 3 4
  • Helicain 3 4
  • Protein Phosphatase 1, Regulatory Subunit 25 3
  • DEAD/DEXH Helicase DDX31 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 25 2
  • G2 Helicase 3
  • EC 4
  • EC 3.6.1 63
  • PPP1R25 3

External Ids for DDX31 Gene

Previous GeneCards Identifiers for DDX31 Gene

  • GC09M126494
  • GC09M127026
  • GC09M128823
  • GC09M130745
  • GC09M134458
  • GC09M135468
  • GC09M104963

Summaries for DDX31 Gene

Entrez Gene Summary for DDX31 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]

GeneCards Summary for DDX31 Gene

DDX31 (DEAD-Box Helicase 31) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX31 Gene

  • Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224).

Gene Wiki entry for DDX31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX31 Gene

Genomics for DDX31 Gene

Regulatory Elements for DDX31 Gene

Enhancers for DDX31 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX31 on UCSC Golden Path with GeneCards custom track

Promoters for DDX31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX31 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX31 Gene

132,592,997 bp from pter
132,670,401 bp from pter
77,405 bases
Minus strand

Genomic View for DDX31 Gene

Genes around DDX31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX31 Gene

Proteins for DDX31 Gene

  • Protein details for DDX31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX31
    Protein Accession:
    Secondary Accessions:
    • Q5K6N2
    • Q5K6N3
    • Q5K6N4
    • Q5VZJ4
    • Q5VZJ9
    • Q96E91
    • Q96NY2
    • Q96SX5
    • Q9H5K6

    Protein attributes for DDX31 Gene

    851 amino acids
    Molecular mass:
    94087 Da
    Quaternary structure:
    • Interacts with NPM1; this interaction prevents interaction between NPM1 and HDM2.
    • Sequence=AAQ14889.1; Type=Frameshift; Positions=816, 825; Evidence={ECO:0000305}; Sequence=AAQ14890.1; Type=Frameshift; Positions=816; Evidence={ECO:0000305}; Sequence=BAB14644.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15620.1; Type=Frameshift; Positions=141; Evidence={ECO:0000305}; Sequence=CAH70532.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16565.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DDX31 Gene


neXtProt entry for DDX31 Gene

Proteomics data for DDX31 Gene at MOPED

Post-translational modifications for DDX31 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for DDX31

Domains & Families for DDX31 Gene

Suggested Antigen Peptide Sequences for DDX31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
genes like me logo Genes that share domains with DDX31: view

Function for DDX31 Gene

Molecular function for DDX31 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224).

Enzyme Numbers (IUBMB) for DDX31 Gene

Gene Ontology (GO) - Molecular Function for DDX31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX31: view
genes like me logo Genes that share phenotypes with DDX31: view

Animal Model Products

miRNA for DDX31 Gene

miRTarBase miRNAs that target DDX31

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX31 Gene

Localization for DDX31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX31 Gene

Nucleus, nucleolus. Note=Colocalized with NPM1 in the nucleoli. {ECO:0000269 PubMed:23019224}.

Subcellular locations from

Jensen Localization Image for DDX31 Gene COMPARTMENTS Subcellular localization image for DDX31 gene
Compartment Confidence
golgi apparatus 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DDX31 Gene

Pathways & Interactions for DDX31 Gene

SuperPathways for DDX31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX31 Gene


No data available for Pathways by source and SIGNOR curated interactions for DDX31 Gene

Drugs & Compounds for DDX31 Gene

(1) Drugs for DDX31 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX31 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX31: view

Transcripts for DDX31 Gene

Unigene Clusters for DDX31 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX31 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - -
SP2: - -

ExUns: 21 ^ 22

Relevant External Links for DDX31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX31 Gene

mRNA expression in normal human tissues for DDX31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX31 Gene

This gene is overexpressed in Lung (27.9), Blymphocyte (13.6), and CD8 Tcells (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX31 Gene

SOURCE GeneReport for Unigene cluster for DDX31 Gene Hs.660767

mRNA Expression by UniProt/SwissProt for DDX31 Gene

Tissue specificity: Weakly or undetectably expressed in normal organs. Up-regulated in renal cell carcinoma.
genes like me logo Genes that share expression patterns with DDX31: view

Protein tissue co-expression partners for DDX31 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DDX31 Gene

Orthologs for DDX31 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX31 35
  • 83.29 (n)
  • 79.97 (a)
DDX31 36
  • 78 (a)
(Canis familiaris)
Mammalia DDX31 35
  • 85.71 (n)
  • 84.05 (a)
(Mus musculus)
Mammalia Ddx31 35
  • 83.28 (n)
  • 81.99 (a)
Ddx31 16
Ddx31 36
  • 80 (a)
(Pan troglodytes)
Mammalia DDX31 35
  • 99.26 (n)
  • 98.59 (a)
DDX31 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ddx31 35
  • 83.04 (n)
  • 82.64 (a)
(Monodelphis domestica)
Mammalia DDX31 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia DDX31 36
  • 75 (a)
(Gallus gallus)
Aves DDX31 35
  • 70.64 (n)
  • 67.73 (a)
DDX31 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx31 35
  • 64.87 (n)
  • 66.5 (a)
Str.11929 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15162 35
(Danio rerio)
Actinopterygii ddx31 35
  • 61.45 (n)
  • 62.02 (a)
Dr.7284 35
ddx31 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH02833 37
  • 40 (a)
CG8611 35
  • 49.75 (n)
  • 44.55 (a)
CG8611 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010670 35
  • 50.28 (n)
  • 44.21 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR082C 35
  • 44.83 (n)
  • 38.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13926g 35
  • 46.65 (n)
  • 37.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP7 35
  • 46.7 (n)
  • 39.21 (a)
DBP7 36
  • 29 (a)
DBP7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40700 35
  • 49.35 (n)
  • 44.53 (a)
(Oryza sativa)
Liliopsida Os.19569 35
Os05g0110500 35
  • 49.51 (n)
  • 43.57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06520 35
  • 46.16 (n)
  • 36.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbp7 35
  • 47.42 (n)
  • 38.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for DDX31:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDX31 Gene

Gene Tree for DDX31 (if available)
Gene Tree for DDX31 (if available)

Paralogs for DDX31 Gene

(6) SIMAP similar genes for DDX31 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDX31: view

No data available for Paralogs for DDX31 Gene

Variants for DDX31 Gene

Sequence variations from dbSNP and Humsavar for DDX31 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs306547 - 132,595,027(+) GGCGA(C/T)GTCGG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs306548 - 132,594,894(+) TGTCC(C/T)GCTGT downstream-variant-500B, reference, missense
rs17402080 - 132,662,629(+) AGTTT(C/T)GTTCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs34246652 - 132,618,410(+) GCTCT(C/G/T)GGATT intron-variant, nc-transcript-variant, reference, synonymous-codon, missense
rs693559 -- 132,613,289(+) AATGT(G/T)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX31 Gene

Variant ID Type Subtype PubMed ID
nsv894023 CNV Gain 21882294
esv2661382 CNV Deletion 23128226

Variation tolerance for DDX31 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.98; 68.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDX31 Gene

Disorders for DDX31 Gene

Relevant External Links for DDX31

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX31 Gene

Publications for DDX31 Gene

  1. DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas. (PMID: 23019224) Fukawa T. … Katagiri T. (Cancer Res. 2012) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DDX31 Gene

Sources for DDX31 Gene