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DDX31 Gene

protein-coding   GIFtS: 53
GCID: GC09M135468

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 31

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 311 2     G2 Helicase2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 311 2     helicain2
DEAD Box Protein 312 3     Probable ATP-Dependent RNA Helicase DDX312
Protein Phosphatase 11     Protein Phosphatase 1, Regulatory Subunit 252
Regulatory Subunit 251     EC 3.6.4.133
PPP1R252     Helicain3
DEAD/DEXH Helicase DDX312     EC 3.6.18

External Ids:    HGNC: 167151   Entrez Gene: 647942   Ensembl: ENSG000001254857   UniProtKB: Q9H8H23   

Export aliases for DDX31 gene to outside databases

Previous GC identifers: GC09M126494 GC09M127026 GC09M128823 GC09M130745 GC09M132499 GC09M134458 GC09M104963


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX31 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of
this member has not been determined. Alternative splicing of this gene generates 2 transcript variants. (provided
by RefSeq, Jul 2008)

GeneCards Summary for DDX31 Gene:
DDX31 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 31) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot: DDX31_HUMAN, Q9H8H2
Function: Probable ATP-dependent RNA helicase (By similarity)

Gene Wiki entry for DDX31 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX31 gene promoter:
         RFX1   YY1   C/EBPalpha   E47   E2F   E2F-1   POU2F1   POU2F1a   Hand1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX31 promoter sequence
   Search Chromatin IP Primers for DDX31

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34.2

DDX31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX31 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M135468:  view genomic region     (about GC identifiers)

Start:
135,468,384 bp from pter      End:
135,545,788 bp from pter
Size:
77,405 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DDX31_HUMAN, Q9H8H2 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX31  
Size: 851 amino acids; 94087 Da
Sequence caution: Sequence=AAQ14889.1; Type=Frameshift; Positions=816, 825; Sequence=AAQ14890.1; Type=Frameshift;
Positions=816; Sequence=BAB14644.1; Type=Erroneous initiation; Sequence=BAB15620.1; Type=Frameshift;
Positions=141; Sequence=CAH70532.1; Type=Erroneous gene model prediction; Sequence=CAI16565.1; Type=Erroneous
gene model prediction;
Secondary accessions: Q5K6N2 Q5K6N3 Q5K6N4 Q5VZJ4 Q5VZJ9 Q96E91 Q96NY2 Q96SX5 Q9H5K6
Alternative splicing: 4 isoforms:  Q9H8H2-1   Q9H8H2-2   Q9H8H2-3   Q9H8H2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX31: NX_Q9H8H2

Explore proteomics data for DDX31 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX31 (Q9H8H2) (see all 12)
     LVPTREL  VPTRELA  AKSFGLR  DEADRIL 


    See DDX31 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_073616.6  NP_619526.1  

    ENSEMBL proteins: 
     ENSP00000361232   ENSP00000310539   ENSP00000361226   ENSP00000387730   ENSP00000442425  

    DDX31 Human Recombinant Protein Products:

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    Novus Biologicals DDX31 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX31

     
    Search eBioscience for Proteins for DDX31 

     
    antibodies-online proteins for DDX31 

     
    antibodies-online peptides for DDX31

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    antibodies-online antibodies for DDX31 (12 products) 

    DDX31 Assay Products:

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    antibodies-online kits for DDX31 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR025313 DUF4217
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif

    Graphical View of Domain Structure for InterPro Entry Q9H8H2

    ProtoNet protein and cluster: Q9H8H2

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX31_HUMAN, Q9H8H2
    Similarity: Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX31           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX31_HUMAN, Q9H8H2
    Function: Probable ATP-dependent RNA helicase (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DDX31           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DDX31:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DDX31

    miRNA
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    miRTarBase miRNAs that target DDX31:
    hsa-mir-877-3p (MIRT037156), hsa-mir-16-5p (MIRT031816)

    Block miRNA regulation of human, mouse, rat DDX31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX31 (see all 9):
    hsa-miR-221* hsa-miR-2355-5p hsa-miR-3150b-3p hsa-miR-3658 hsa-miR-765 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidDDX31 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX31

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    GenScript: all cDNA clones in your preferred vector (see all 2): DDX31 (NM_022779)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX31

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX31


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX31_HUMAN, Q9H8H2: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IEA--

    Find genes that share ontologies with DDX31           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX31
    Interactions:

        Search GeneGlobe Interaction Network for DDX31

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX31 (Q9H8H23 ENSP000003612324) via UniProtKB, MINT, STRING, and/or I2D (see all 133)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPF2Q9H7B23, ENSP000004023384I2D: score=4 STRING: ENSP00000402338
    DDX51Q8N8A63, ENSP000003804954I2D: score=2 STRING: ENSP00000380495
    NAA20P615993, ENSP000003356364I2D: score=2 STRING: ENSP00000335636
    NIP7Q9Y2213, ENSP000002549404I2D: score=2 STRING: ENSP00000254940
    BOP1Q141373, ENSP000003041514I2D: score=1 STRING: ENSP00000304151
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX31



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX31 gene (2 alternative transcripts): 
    NM_022779.7  NM_138620.1  

    Unigene Cluster for DDX31:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
    Hs.660767  [show with all ESTs]
    Unigene Representative Sequence: AF427339
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372155 ENST00000372159(uc004cbq.1) ENST00000310532(uc004cbr.1)
    ENST00000480876(uc004cbs.2) ENST00000482620 ENST00000372153(uc010mzu.1)
    ENST00000438527 ENST00000544003
    miRNA
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    Block miRNA regulation of human, mouse, rat DDX31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX31 (see all 9):
    hsa-miR-221* hsa-miR-2355-5p hsa-miR-3150b-3p hsa-miR-3658 hsa-miR-765 hsa-miR-3653 hsa-miR-548b-3p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidDDX31 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX31
    Clone
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    OriGene ORF clones in mouse, rat for DDX31
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DDX31 (NM_022779)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX31
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DDX31
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX31
      QuantiTect SYBR Green Assays in human, mouse, rat DDX31
      QuantiFast Probe-based Assays in human, mouse, rat DDX31

    Additional mRNA sequence: 

    AF335567.1 AF335568.1 AF335569.1 AF427339.1 AK023695.1 AK027002.1 AK027484.1 AK225121.1 
    AK225350.1 AK302670.1 AK304715.1 BC012726.2 

    10 DOTS entries:

    DT.411298  DT.75111957  DT.101978566  DT.97841365  DT.91714402  DT.101963499  DT.91807563  DT.92002888 
    DT.92423844  DT.102827625 

    Selected AceView cDNA sequences (see all 104):

    BE797061 AI214317 AA402462 BU180734 NM_138620 AF427339 NM_022779 BC012726 
    BX401058 AW474074 CD672604 AI703282 BE503800 BX331416 BU175522 AK023695 
    CR594429 BQ229587 AA928863 AA234394 AA234304 BM787297 AA570331 BF003062 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DDX31    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:              -                             -                 -                                   -                                                         
    SP2:              -                             -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DDX31

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX31 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTGTGA
    DDX31 Expression
    About this image


    DDX31 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
    DDX31 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX31 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660767
        Custom PCR Arrays for DDX31
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX31

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX31 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx311 , 5 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 311, 5 83.28(n)1
    81.99(a)1
      2 (19.38 cM)5
    2276741  NM_001033294.31  NP_001028466.21 
     288404065 
    chicken
    (Gallus gallus)
    Aves DDX311 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 70.64(n)
    67.73(a)
      427759  XM_425332.4  XP_425332.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151622 Xenopus laevis transcribed sequence with weak similarity more 74.25(n)    BX850995.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.72842 Danio rerio cDNA clone IMAGE6794757, partial cds 72.25(n)    BC056735.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH028333
    CG86111
    ATP dependent RNA helicase3
    CG86111
    40(a)3
    49.75(n)1
    44.55(a)1
      16A53
    327251  NM_176749.11  NP_788922.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP7(YKR024C)4
    DBP71
    Putative ATP-dependent RNA helicase of the DEAD-box more4
    DBP71
    46.7(n)1
    39.21(a)1
      11(487372-485144)4
    8538941, 4  NP_012949.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G407001 AT2G40700 49.35(n)
    44.53(a)
      818665  NM_129632.1  NP_181602.1 
    rice
    (Oryza sativa)
    Liliopsida Os.195692 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.78(n)    AK060179.1 


    ENSEMBL Gene Tree for DDX31 (if available)
    TreeFam Gene Tree for DDX31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX31 gene
    6 SIMAP similar genes for DDX31 using alignment to 3 protein entries:     DDX31_HUMAN (see all proteins):
    DDX56    DDX54    DDX47    E4-DBP    DDX18    DDX49

    Find genes that share paralogs with DDX31           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX31 (see all 1671)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405438711,2
    --135469277(+) GCCCAC/TAGGTG 1 -- ds50010--------
    rs22365171,2
    C,F,A--135469394(+) AAACAC/TAATGC 1 -- ds50018Minor allele frequency- T:0.20NA WA CSA EA 367
    rs3065511,2
    C,F,A--135469410(+) CAGGGC/TGGGGT 1 -- ds5001 ese31Minor allele frequency- T:0.07WA 118
    rs1871662681,2
    --135469490(+) GACAAA/GACAGG 1 -- ds50010--------
    rs735608471,2
    C,F--135469536(+) CTTTTG/TACTTC 1 -- ds50012Minor allele frequency- T:0.05WA 120
    rs1493229741,2
    C--135469765(+) AGTGAA/TAAATA 1 -- ut310--------
    rs3065501,2
    C,F,A,H--135469799(+) ATTCCA/GGTTTT 1 -- ut31 ese312Minor allele frequency- G:0.04NS EA NA WA 1388
    rs1905606711,2
    --135469918(+) TGACGC/TGCAGG 1 -- ut310--------
    rs735608501,2
    C,F--135469944(+) ATCCCG/AGGGTG 1 -- ut312Minor allele frequency- A:0.05WA 120
    rs1445755501,2
    C--135470032(+) CCTTCC/TGTCGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DDX31 (135468384 - 135545788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DDX31:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661382CNV Deletion23128226
    nsv894023CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX31
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX31

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with DDX31           About GenesLikeMe

    Genetic Association Database (GAD): DDX31

    Export disorders for DDX31 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX31 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DDX31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The human DDX and DHX gene families of putative RNA helicases. (PubMed id 12782131)1, 2 Abdelhaleem M.... Wain H. (Genomics 2003)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. DDX31 regulates the p53-HDM2 pathway and rRNA gene transcription through its interaction with NPM1 in renal cell carcinomas. (PubMed id 23019224)1 Fukawa T....Katagiri T. (Cancer Res. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64794 HGNC: 16715 AceView: DDX31 Ensembl:ENSG00000125485 euGenes: HUgn64794
    ECgene: DDX31 H-InvDB: DDX31

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDX31 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX31 gene:
    Search GeneIP for patents involving DDX31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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