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Aliases for DDX28 Gene

Aliases for DDX28 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 28 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 28 2 3
  • Mitochondrial DEAD Box Protein 28 3 4
  • MDDX28 3 4
  • Probable ATP-Dependent RNA Helicase DDX28 3
  • Mitochondrial DEAD-Box Polypeptide 28 3
  • EC 4
  • EC 3.6.1 63
  • M 6

External Ids for DDX28 Gene

Previous GeneCards Identifiers for DDX28 Gene

  • GC16M058750
  • GC16M068432
  • GC16M067790
  • GC16M067831
  • GC16M066612
  • GC16M068055
  • GC16M053928

Summaries for DDX28 Gene

Entrez Gene Summary for DDX28 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX28 Gene

DDX28 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 28) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX47.

UniProtKB/Swiss-Prot for DDX28 Gene

  • May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX28 Gene

Genomics for DDX28 Gene

Regulatory Elements for DDX28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX28 Gene

68,021,274 bp from pter
68,023,867 bp from pter
2,594 bases
Minus strand

Genomic View for DDX28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX28 Gene

Proteins for DDX28 Gene

  • Protein details for DDX28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX28
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DDX28 Gene

    540 amino acids
    Molecular mass:
    59581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDX28 Gene

Proteomics data for DDX28 Gene at MOPED

Selected DME Specific Peptides for DDX28 Gene

Post-translational modifications for DDX28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX28 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for DDX28 Gene

Gene Families for DDX28 Gene

Suggested Antigen Peptide Sequences for DDX28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family.
genes like me logo Genes that share domains with DDX28: view

Function for DDX28 Gene

Molecular function for DDX28 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity.

Enzyme Numbers (IUBMB) for DDX28 Gene

Gene Ontology (GO) - Molecular Function for DDX28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX28: view

Animal Model Products

miRNA for DDX28 Gene

miRTarBase miRNAs that target DDX28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX28

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX28 Gene

Localization for DDX28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX28 Gene

Nucleus. Mitochondrion. Note=Transported between these two compartments. Nuclear localization depends on active RNA polymerase II transcription.

Subcellular locations from

Jensen Localization Image for DDX28 Gene COMPARTMENTS Subcellular localization image for DDX28 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DDX28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with DDX28: view

Pathways for DDX28 Gene

SuperPathways for DDX28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX28: view

No data available for Pathways by source for DDX28 Gene

Drugs for DDX28 Gene

(4) HMDB Compounds for DDX28 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide
genes like me logo Genes that share compounds with DDX28: view

Transcripts for DDX28 Gene

mRNA/cDNA for DDX28 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(165) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDX28 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 28:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX28 Gene

No ASD Table

Relevant External Links for DDX28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX28 Gene

mRNA expression in normal human tissues for DDX28 Gene

Protein differential expression in normal tissues for DDX28 Gene

This gene is overexpressed in Lung (59.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX28 Gene

SOURCE GeneReport for Unigene cluster for DDX28 Gene Hs.458313

mRNA Expression by UniProt/SwissProt for DDX28 Gene

Tissue specificity: Expressed in all tissues tested, including brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, leukocytes, colon, small intestine, ovary and prostate.
genes like me logo Genes that share expressions with DDX28: view

Expression partners for DDX28 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDX28 Gene

Orthologs for DDX28 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX28 35
  • 85.68 (n)
  • 85.19 (a)
DDX28 36
  • 84 (a)
(Canis familiaris)
Mammalia DDX28 35
  • 84.89 (n)
  • 84 (a)
DDX28 36
  • 83 (a)
(Mus musculus)
Mammalia Ddx28 35
  • 79.68 (n)
  • 80.86 (a)
Ddx28 16
Ddx28 36
  • 81 (a)
(Pan troglodytes)
Mammalia DDX28 35
  • 99.07 (n)
  • 98.7 (a)
DDX28 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ddx28 35
  • 78.81 (n)
  • 78.62 (a)
(Monodelphis domestica)
Mammalia DDX28 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia DDX28 36
  • 66 (a)
(Gallus gallus)
Aves DDX28 35
  • 60.18 (n)
  • 56.42 (a)
DDX28 36
  • 50 (a)
(Anolis carolinensis)
Reptilia DDX28 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx28 35
  • 51.87 (n)
  • 50.2 (a)
(Danio rerio)
Actinopterygii ddx28 35
  • 54.32 (n)
  • 51 (a)
Dr.15079 35
ddx28 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3561 37
  • 36 (a)
KH1 35
  • 47.03 (n)
  • 37.58 (a)
KH1 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013035 35
  • 50.88 (n)
  • 40.91 (a)
(Caenorhabditis elegans)
Secernentea T26G10.1 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP3 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RH39 35
  • 43.99 (n)
  • 36.34 (a)
(Oryza sativa)
Liliopsida Os01g0184500 35
  • 46.55 (n)
  • 34.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for DDX28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX28 Gene

Gene Tree for DDX28 (if available)
Gene Tree for DDX28 (if available)

Paralogs for DDX28 Gene

Paralogs for DDX28 Gene

(4) SIMAP similar genes for DDX28 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDX28: view

Variants for DDX28 Gene

Sequence variations from dbSNP and Humsavar for DDX28 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs182952 -- 68,020,831(-) atata(C/T)acata downstream-variant-500B
rs192107 -- 68,020,878(-) tacgt(A/G)tatat downstream-variant-500B
rs10641000 -- 68,020,801(+) TATAC(-/AT)ATATA downstream-variant-500B
rs57021292 -- 68,020,810(+) ATATA(-/TATA)CGTAT downstream-variant-500B
rs57481882 -- 68,020,895(+) ATATA(-/TA)AAGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DDX28 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
esv2666619 CNV Deletion 23128226

Relevant External Links for DDX28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX28 Gene

Disorders for DDX28 Gene

Relevant External Links for DDX28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DDX28 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DDX28 Gene

Publications for DDX28 Gene

  1. Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization. (PMID: 11350955) Valgardsdottir R. … Prydz H. (J. Biol. Chem. 2001) 2 3 4 23
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for DDX28 Gene

Sources for DDX28 Gene

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