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DDX28 Gene

protein-coding   GIFtS: 54
GCID: GC16M068055

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 28

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28)
  Search for DDX28
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 281 2     Probable ATP-Dependent RNA Helicase DDX282
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 281 2     EC 3.6.4.133
Mitochondrial DEAD Box Protein 282 3     M5
MDDX282 3     EC 3.6.18
Mitochondrial DEAD-Box Polypeptide 282     

External Ids:    HGNC: 173301   Entrez Gene: 557942   Ensembl: ENSG000001828107   OMIM: 6076185   UniProtKB: Q9NUL73   

Export aliases for DDX28 gene to outside databases

Previous GC identifers: GC16M058750 GC16M068432 GC16M067790 GC16M067831 GC16M066612 GC16M053928


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX28 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase.
The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the
mitochondria and the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX28 Gene:
DDX28 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 28) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX47.

UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7
Function: May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX28 gene promoter:
         AML1a   SREBP-1c   MyoD   FOXD1   SREBP-1b   CREB   POU2F1   SREBP-1a   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX28 promoter sequence
   Search Chromatin IP Primers for DDX28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1-q22.3

DDX28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX28 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M068055:  view genomic region     (about GC identifiers)

Start:
68,055,177 bp from pter      End:
68,057,770 bp from pter
Size:
2,594 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX28  
Size: 540 amino acids; 59581 Da

Explore the universe of human proteins at neXtProt for DDX28: NX_Q9NUL7

Explore proteomics data for DDX28 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for DDX28 (Q9NUL7)
     TGSGKTLS  AETGSGKT 


    See DDX28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060850.2  
    ENSEMBL proteins: 
     ENSP00000332340  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9NUL7

    ProtoNet protein and cluster: Q9NUL7

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7
    Similarity: Belongs to the DEAD box helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX28           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX28_HUMAN, Q9NUL7
    Function: May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DDX28           About GenesLikeMe


    Animal Models:
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    miRTarBase miRNAs that target DDX28:
    hsa-let-7b-5p (MIRT032400), hsa-mir-484 (MIRT042050)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX28_HUMAN, Q9NUL7: Nucleus. Mitochondrion. Note=Transported between these two compartments. Nuclear
    localization depends on active RNA polymerase II transcription
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol3
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA--
    GO:0042645mitochondrial nucleoid IDA18063578

    Find genes that share ontologies with DDX28           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX28
    Interactions:

        Search GeneGlobe Interaction Network for DDX28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX28 (Q9NUL72, 3 ENSP000003323404) via UniProtKB, MINT, STRING, and/or I2D (see all 290)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    ACAD9Q9H8452MINT-8079030
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX28



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX28 gene: 
    NM_018380.3  

    Unigene Cluster for DDX28:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
    Hs.458313  [show with all ESTs]
    Unigene Representative Sequence: NM_018380
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332395(uc002evh.2)
    miRNA
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    Additional mRNA sequence: 

    AK002144.1 BC014517.2 BC024273.1 

    7 DOTS entries:

    DT.120665140  DT.444077  DT.101958141  DT.120665024  DT.120664978  DT.120665109  DT.95294833 

    Selected AceView cDNA sequences (see all 165):

    AK002144 BQ009574 BM831487 AI087964 CB159878 AI688630 BE273939 BM129155 
    AI380816 BM710170 BE280699 BE386337 AW194721 BM823674 BU528728 BQ687952 
    BM822377 BM839735 BQ649100 BM563666 BM128887 AI199039 Z25077 AI869985 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCTAACA
    DDX28 Expression
    About this image

    DDX28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458313

    UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7
    Tissue specificity: Expressed in all tissues tested, including brain, placenta, lung, liver, skeletal muscle,
    kidney, pancreas, leukocytes, colon, small intestine, ovary and prostate

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX28 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx281 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 281, 5 79.68(n)1
    80.86(a)1
      8 (53.08 cM)5
    719861  NM_028038.31  NP_082314.21 
     1060096215 
    chicken
    (Gallus gallus)
    Aves DDX281 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 60.18(n)
    56.42(a)
      427544  XM_425116.4  XP_425116.4 
    lizard
    (Anolis carolinensis)
    Reptilia DDX286
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
    52(a)
    1 ↔ 1
    LGc(6238828-6240441)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ddx281 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 51.87(n)
    50.2(a)
      100487122  XM_002940974.2  XP_002941020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.150792 Transcribed sequence with weak similarity to protein more 75.89(n)    BM181654.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35613
    KH11
    helicase3
    KH11
    36(a)3
    47.03(n)1
    37.58(a)1
      21D33
    332541  NM_134700.41  NP_608544.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T26G10.16
    Protein T26G10.1 (T26G10.1) mRNA, complete cds
    27(a)
    1 → many
    III(9404504-9406641) WBGene00012059
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRP36
    Protein involved in rRNA processing; required for ...
    25(a)
    1 → many
    VIII(227532-229037) YHR065C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RH391 RH39 43.99(n)
    36.34(a)
      826559  NM_179017.2  NP_849348.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01845001 Os01g0184500 46.55(n)
    34.09(a)
      4325344  NM_001048769.1  NP_001042234.1 


    ENSEMBL Gene Tree for DDX28 (if available)
    TreeFam Gene Tree for DDX28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX28 gene
    DDX472  
    4 SIMAP similar genes for DDX28 using alignment to 1 protein entry:     DDX28_HUMAN:
    MST162    DDX54    DDX47    E4-DBP

    Find genes that share paralogs with DDX28           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX28 (see all 32)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847404411,2
    --53933228(+) ATTCAA/CCAAAT 1 -- us2k10--------
    rs1456717541,2
    --53933283(+) AACAGC/GCAAAA 1 -- us2k10--------
    rs1847912671,2
    --68054687(+) ATACAC/TGTATA 1 -- ds50010--------
    rs106410001,2
    C--68054704(+) ataca-/AT/CG 
            
    tatat
    1 -- ds50010--------
    rs1900512481,2
    --68054704(+) TATACA/GTATAT 1 -- ds50010--------
    rs2008377661,2
    --68054716(+) TATAT-/ACGTATA 1 -- ds50010--------
    rs2017821861,2
    --68054717(+) ATATA-/CGTATAT 1 -- ds50010--------
    rs1829521,2
    C,H--68054734(-) atataT/Cacata 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs1817747921,2
    --68054769(+) ATATAC/TATATA 1 -- ds50010--------
    rs1921071,2
    F--68054781(-) tacgtG/Atatat 1 -- ds50011Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for DDX28 (68055177 - 68057770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DDX28:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666619CNV Deletion23128226
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX28
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607618    OMIM disorders: --


    Find genes that share disorders with DDX28           About GenesLikeMe

    Genetic Association Database (GAD): DDX28
    Human Genome Epidemiology (HuGE) Navigator: DDX28 (1 document)

    Export disorders for DDX28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX28 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DDX28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization. (PubMed id 11350955)1, 2, 3, 9 Valgardsdottir R.... Prydz H. (J. Biol. Chem. 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 3 Loftus B.J.... Adams M.D. (Genomics 1999)
    6. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1 Close P.... Svejstrup J.Q. (Nature 2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55794 HGNC: 17330 AceView: DDX28 Ensembl:ENSG00000182810 euGenes: HUgn55794
    ECgene: DDX28 H-InvDB: DDX28

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDX28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX28 gene:
    Search GeneIP for patents involving DDX28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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