Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX28 Gene

protein-coding   GIFtS: 54
GCID: GC16M068055

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 28

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 281 2     Probable ATP-Dependent RNA Helicase DDX282
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 281 2     EC 3.6.4.133
Mitochondrial DEAD Box Protein 282 3     M5
MDDX282 3     EC 3.6.18
Mitochondrial DEAD-Box Polypeptide 282     

External Ids:    HGNC: 173301   Entrez Gene: 557942   Ensembl: ENSG000001828107   OMIM: 6076185   UniProtKB: Q9NUL73   

Export aliases for DDX28 gene to outside databases

Previous GC identifers: GC16M058750 GC16M068432 GC16M067790 GC16M067831 GC16M066612 GC16M053928


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDX28 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase.
The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the
mitochondria and the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX28 Gene: 
DDX28 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 28) is a protein-coding gene. Diseases associated with DDX28 include prostatitis. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX47.

UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7
Function: May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX28 gene promoter:
         AML1a   SREBP-1c   MyoD   FOXD1   SREBP-1b   CREB   POU2F1   SREBP-1a   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX28 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1-q22.3

DDX28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX28 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M068055:  view genomic region     (about GC identifiers)

Start:
68,055,177 bp from pter      End:
68,057,770 bp from pter
Size:
2,594 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX28  
Size: 540 amino acids; 59581 Da
Subcellular location: Nucleus. Mitochondrion. Note=Transported between these two compartments. Nuclear
localization depends on active RNA polymerase II transcription

Explore the universe of human proteins at neXtProt for DDX28: NX_Q9NUL7

Explore proteomics data for DDX28 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NUL7

  • 2 DME Specific Peptides for DDX28 (Q9NUL7)
     TGSGKTLS  AETGSGKT 

    DDX28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDX28 Protein Expression
    REFSEQ proteins: NP_060850.2  
    ENSEMBL proteins: 
     ENSP00000332340  

    Human Recombinant Protein Products for DDX28: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DDX28
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DDX28
    GenScript Custom Purified and Recombinant Proteins Services for DDX28
    Novus Biologicals DDX28 Protein
    Novus Biologicals DDX28 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX28 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0042645mitochondrial nucleoid IDA18063578

    DDX28 for ontologies           About GeneDecksing



    DDX28 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DDX28
    GenScript Custom Superior Antibodies Services for DDX28
    Novus Biologicals DDX28 Antibodies
    Abcam antibodies for DDX28
    Cloud-Clone Corp. Antibodies for DDX28 
    ThermoFisher Antibodies for DDX28
    LSBio Antibodies in human, mouse, rat for DDX28 

    Assay Products for DDX28: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDX28
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDX28
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX28 
    Cloud-Clone Corp. CLIAs for DDX28


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9NUL7

    ProtoNet protein and cluster: Q9NUL7

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7
    Similarity: Belongs to the DEAD box helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX28_HUMAN, Q9NUL7
    Function: May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    DDX28 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX28 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDX28

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX28 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX28 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX28
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DDX28
    SwitchGear 3'UTR luciferase reporter plasmidDDX28 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDX28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX28

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDX28
    Sirion Biotech Customized adenovirus for overexpression of DDX28

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DDX28 (see all 8)
    OriGene ORF clones in mouse, rat for DDX28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX28 (NM_018380)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX28
    Sirion Biotech Customized lentivirus for stable overexpression of DDX28 
                         Customized lentivirus expression plasmids for stable overexpression of DDX28 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDX28
    Search LifeMap BioReagents cell lines for DDX28
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX28


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX28

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/246 Interacting proteins for DDX28 (Q9NUL72, 3 ENSP000003323404) via UniProtKB, MINT, STRING, and/or I2D (see all 246)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    ACAD9Q9H8452MINT-8079030
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX28

    Search CenterWatch for drugs/clinical trials and news about DDX28

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDX28 gene: 
    NM_018380.3  

    Unigene Cluster for DDX28:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
    Hs.458313  [show with all ESTs]
    Unigene Representative Sequence: NM_018380
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332395(uc002evh.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX28
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DDX28
    SwitchGear 3'UTR luciferase reporter plasmidDDX28 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDX28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX28
    Clone
    Products:
         
    OriGene clones in human, mouse for DDX28 (see all 8)
    OriGene ORF clones in mouse, rat for DDX28
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX28 (NM_018380)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX28
    Sirion Biotech Customized lentivirus for stable overexpression of DDX28 
                         Customized lentivirus expression plasmids for stable overexpression of DDX28 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDX28
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX28
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX28
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX28
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX28

    Additional mRNA sequence: 

    AK002144.1 BC014517.2 BC024273.1 

    7 DOTS entries:

    DT.120665140  DT.444077  DT.101958141  DT.120665024  DT.120664978  DT.120665109  DT.95294833 

    24/165 AceView cDNA sequences (see all 165):

    BE280699 BM910625 AW194721 AI380816 Z25077 AI494294 AI199039 AI087964 
    AK002144 AI867482 BM831487 BM832061 BM823674 BE383674 BM822377 BM128887 
    BM710170 NM_018380 BM129155 BE273939 BQ687952 AI869985 BU528728 CB159878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCTAACA
    DDX28 Expression
    About this image


    See DDX28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX28

    SOURCE GeneReport for Unigene cluster: Hs.458313

    UniProtKB/Swiss-Prot: DDX28_HUMAN, Q9NUL7
    Tissue specificity: Expressed in all tissues tested, including brain, placenta, lung, liver, skeletal muscle,
    kidney, pancreas, leukocytes, colon, small intestine, ovary and prostate

        SABiosciences Custom PCR Arrays for DDX28
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDX28
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX28
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX28
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX28
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX28
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX28 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx281 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 281, 5 79.68(n)1
    80.86(a)1
      8 (53.08 cM)5
    719861  NM_028038.31  NP_082314.21 
     1060096215 
    chicken
    (Gallus gallus)
    Aves DDX281 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 60.48(n)
    55.43(a)
      427544  XM_425116.3  XP_425116.3 
    lizard
    (Anolis carolinensis)
    Reptilia DDX286
    Uncharacterized protein
    52(a)
    1 ↔ 1
    LGc(6238828-6240441)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.150792 Transcribed sequence with weak similarity to protein more 75.89(n)    BM181654.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35613
    KH11
    helicase3
    CG3561-PA1
    36(a)3
    47.26(n)1
    37.78(a)1
      21D33
    332541  NM_134700.31  NP_608544.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP86
    ATPase, putative RNA helicase of the DEAD-box fami...
    30(a)
    1 ↔ 1
    VIII(442181-443476)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RH391 DEAD-box ATP-dependent RNA helicase 39 44.85(n)
    36.86(a)
      826559  NM_179017.2  NP_849348.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01845001 hypothetical protein 46.8(n)
    34.34(a)
      4325344  NM_001048769.1  NP_001042234.1 


    ENSEMBL Gene Tree for DDX28 (if available)
    TreeFam Gene Tree for DDX28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX28 gene
    DDX472  
    4 SIMAP similar genes for DDX28 using alignment to 1 protein entry:     DDX28_HUMAN:
    MST162    DDX54    DDX47    E4-DBP

    DDX28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/32 SNPs in DDX28 are shown (see all 32)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0521634
    ----see VAR_0521632 T A mis40--------
    rs1847404411,2
    --53933228(+) ATTCAA/CCAAAT 1 -- us2k10--------
    rs1456717541,2
    --53933283(+) AACAGC/GCAAAA 1 -- us2k10--------
    rs1847912671,2
    --68054687(+) ATACAC/TGTATA 1 -- ds50010--------
    rs106410001,2
    C--68054704(+) ataca-/AT/CG 
            
    tatat
    1 -- ds50010--------
    rs1900512481,2
    --68054704(+) TATACA/GTATAT 1 -- ds50010--------
    rs2008377661,2
    --68054716(+) TATAT-/ACGTATA 1 -- ds50010--------
    rs2017821861,2
    --68054717(+) ATATA-/CGTATAT 1 -- ds50010--------
    rs1829521,2
    C,H--68054734(-) atataT/Cacata 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs1817747921,2
    --68054769(+) ATATAC/TATATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DDX28 (68055177 - 68057770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DDX28:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666619CNV Deletion23128226
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX28
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607618    OMIM disorders: --

    2 diseases for DDX28:    About MalaCards
    prostatitis    


    DDX28 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DDX28
    Human Genome Epidemiology (HuGE) Navigator: DDX28 (1 document)

    Export disorders for DDX28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX28 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with DDX28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization. (PubMed id 11350955)1, 2, 3, 9 Valgardsdottir R.... Prydz H. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 3 Loftus B.J.... Adams M.D. (1999)
    6. DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)1 Close P.... Svejstrup J.Q. (2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55794 HGNC: 17330 AceView: DDX28 Ensembl:ENSG00000182810 euGenes: HUgn55794
    ECgene: DDX28 H-InvDB: DDX28

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDX28 gene:
    Search GeneIP for patents involving DDX28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DDX28  
     OriGene qPCR primer pairs and template standards for DDX28   OriGene Protein Over-expression Lysate for DDX28  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DDX28  
     OriGene qSTAR qPCR primer pairs in human, mouse for DDX28   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DDX28   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDX28   OriGene Custom Protein Services for DDX28  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX28
     QIAGEN SeqTarget long-range PCR primers for resequencing DDX28
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX28
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX28
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX28
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX28
     GenScript Custom Purified and Recombinant Proteins Services for DDX28 GenScript cDNA clones with any tag delivered in your preferred vector for DDX28
     GenScript Custom Assay Services for DDX28 GenScript Custom Superior Antibodies Services for DDX28
     GenScript Custom overexpressing Cell Line Services for DDX28 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DDX28 promoter
     Search Chromatin IP Primers for DDX28
     RT2 qPCR Primer Assay in human, mouse, rat DDX28
     Search GNC Networks for DDX28
     SABiosciences Custom PCR Arrays for DDX28
     Search Tocris compounds for DDX28
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DDX28 antibodies
     DDX28 proteins
     DDX28 lysates
     Antibodies for DDX28
     See all of Abcam's Antibodies, Kits and Proteins for DDX28
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DDX28
     Antibodies for DDX28
     ELISAs for DDX28
     CLIAs for DDX28
     Search LifeMap BioReagents cell lines for DDX28
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX28
     SwitchGear 3'UTR luciferase reporter plasmids for DDX28
     SwitchGear Promoter luciferase reporter plasmids for DDX28
     ThermoFisher Antibodies for DDX28
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX28
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX28
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDX28
    Customized:
     lentivirus for stable overexpression of DDX28
     lentivirus expression plasmids for stable overexpression of DDX28
     adenovirus for overexpression of DDX28
     LSBio Antibodies in human, mouse, rat for DDX28
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DDX28 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4