Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX27 Gene

protein-coding   GIFtS: 50
GCID: GC20P047835

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27 )
 Explore 2 diseases affiliated with
DDX27 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDX27    

Aliases
for DDX27 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 271 2     PP32412
DRS11 2     Rrp3p2
DJ686N3.11     Probable ATP-Dependent RNA Helicase DDX272
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 271 2     RNA Helicase-Like Protein2
RHLP2 3     EC 3.6.4.133
DEAD Box Protein 272 3     EC 3.6.18

External Ids:    HGNC: 158371   Entrez Gene: 556612   Ensembl: ENSG000001242287   UniProtKB: Q96GQ73   

Export aliases for DDX27 gene to outside databases

Previous GC identifers: GC20P047564 GC20P048474 GC20P048521 GC20P047269 GC20P044584


Summaries
for DDX27 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDX27:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation
initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution
patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular
growth and division. This gene encodes a DEAD box protein, the function of which has not been determined. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DDX27_HUMAN, Q96GQ7
Function: Probable ATP-dependent RNA helicase

Gene Wiki entry for DDX27


Genomic Views
for DDX27 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX27 gene promoter:
         GR   c-Fos   AP-1   GR-beta   HNF-4alpha2   HNF-4alpha1   SEF-1 (1)   c-Jun   GR-alpha   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX27 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

DDX27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX27 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P047835:  view genomic region     (about GC identifiers)

Start:
 47,835,832 bp from pter      End:
 47,860,614 bp from pter
Size:
 24,783 bases      Orientation:
 plus strand

Proteins
for DDX27 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDX27_HUMAN, Q96GQ7 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX27  
Size: 796 amino acids; 89835 Da
Subcellular location: Nucleus (Potential)
Caution: It is uncertain whether Met-1 or Met-32 is the initiator
Sequence caution: Sequence=AAF28937.1; Type=Frameshift; Positions=Several; Sequence=AAF28937.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors; Sequence=AAG22482.1; Type=Frameshift; Positions=208, 427, 434, 532;
Sequence=AAH16060.2; Type=Erroneous initiation; Sequence=BAA91284.1; Type=Erroneous initiation; Sequence=BAB14343.1;
Type=Erroneous initiation;
Secondary accessions: A0AVB6 B7ZLY1 Q5VXM7 Q8WYG4 Q969N7 Q96F57 Q96L97 Q9BWY9 Q9BXF0 Q9H990 Q9NWU3
Q9P0C2 Q9UGD6

Explore the universe of human proteins at neXtProt for DDX27: NX_Q96GQ7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96GQ7

    • 4/16 DME Specific Peptides for DDX27 (Q96GQ7) (see all 16)
     RVGRTAR  LFSATMT  IQKACIP  DEADRML 

    DDX27 Protein expression data from MOPED and PaxDb:    About this image 
    DDX27 Protein Expression
    REFSEQ proteins: NP_060365.7  
    ENSEMBL proteins: 
     ENSP00000360828  

    Human Recombinant Protein Products for DDX27: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: DDX27
    OriGene Custom Protein Services for DDX27 
    GenScript Custom Purified and Recombinant Proteins Services for DDX27
    Novus Biologicals DDX27 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DDX27

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DDX27 for ontologies           About GeneDecksing



    DDX27 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DDX27 
    GenScript Custom Superior Antibodies Services for DDX27
    Novus Biologicals DDX27 Antibodies
    Abcam antibodies for DDX27 
    Uscn Antibodies for DDX27
    Search ThermoFisher Antibodies for DDX27

    Assay Products for DDX27: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDX27
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DDX27

    Protein Domains /
    Families
    for DDX27 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDX27 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q96GQ7

    ProtoNet protein and cluster: Q96GQ7

    1 Blocks protein family: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX27_HUMAN, Q96GQ7
    Similarity: Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for DDX27 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX27_HUMAN, Q96GQ7
    Function: Probable ATP-dependent RNA helicase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    DDX27 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DDX27:
     Decreased viability of wild-ty 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ddx27):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    DDX27 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DDX27 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DDX27
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX27
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX27:
    hsa-miR-188-3p hsa-miR-617 hsa-miR-3202 hsa-miR-1260b hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmid: DDX27 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX27 (see all 7)
    OriGene shRNA RFP: DDX27
    OriGene siRNA: DDX27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX27
    Sirion Biotech Custom design and validation of potent shRNA sequences against DDX27 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DDX27
    Sirion Biotech Customized adenovirus for overexpression of DDX27 
    Sirion Biotech Customized adenovirus for potent knockdown of DDX27

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX27 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX27 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DDX27 (NM_017895)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX27 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DDX27
    Search LifeMap BioReagents cell lines for DDX27
    Sirion Biotech Customized stable knockdown cell line services for DDX27 
    Sirion Biotech Customized inducible knockdown cell line services for DDX27
    Sirion Biotech Customized stable overexpressing cell line services for DDX27
    Sirion Biotech Customized inducible overexpressing cell line services for DDX27

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX27


    Pathways & Interactions
    for DDX27 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX27

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for DDX27 (Q96GQ72, 3 ENSP000003608284) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R16AQ96I342, 3MINT-65186 I2D: score=5 
    PES1O005413, ENSP000003467254I2D: score=5 STRING: ENSP00000346725
    BOP1Q141373, ENSP000003041514I2D: score=4 STRING: ENSP00000304151
    RPF2Q9H7B23, ENSP000004023384I2D: score=4 STRING: ENSP00000402338
    GNL3Q9BVP23, ENSP000003957724I2D: score=2 STRING: ENSP00000395772
    About this table

    Drugs & Compounds
    for DDX27 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX27
    Search CenterWatch for drugs/clinical trials and news about DDX27 

    Transcripts
    for DDX27 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDX27 gene: 
    NM_017895.7  

    Unigene Cluster for DDX27:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
    Hs.65234  [show with all ESTs]
    Unigene Representative Sequence: AL832131
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371764(uc002xuh.3) ENST00000484427 ENST00000462328 ENST00000493252
    ENST00000471144

    miRNA
    Products:             		 OriGene 3'-UTR Clone: DDX27
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX27
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX27:
    hsa-miR-188-3p hsa-miR-617 hsa-miR-3202 hsa-miR-1260b hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmid: DDX27 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX27 (see all 7)
    OriGene shRNA RFP: DDX27
    OriGene siRNA: DDX27
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX27
    Sirion Biotech Custom design and validation of potent shRNA sequences against DDX27 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX27 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX27 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DDX27 (NM_017895)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX27 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX27
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX27
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX27

    Additional cDNA sequence: 

    AF336851.1 AK000603.1 AK022979.1 AK025891.1 AK127128.1 AK223116.1 AK300135.1 AL832131.1 
    AY044431.1 BC009304.1 BC011927.2 BC016060.1 BC104480.1 BC126287.1 BC130275.1 BC144125.1 
    EU718675.1 

    23 DOTS entries:

    DT.95264299  DT.111661  DT.120795507  DT.120795659  DT.100826370  DT.100826377  DT.101967845  DT.100030136 
    DT.120795670  DT.100826373  DT.97848016  DT.120795594  DT.40314857  DT.86853499  DT.92025660  DT.92456187 
    DT.95264296  DT.100826372  DT.120795693  DT.92456175  DT.100651867  DT.95264291  DT.97763707 

    24/332 AceView cDNA sequences (see all 332):

    AK022979 AA505931 CB119280 BE409137 BQ651484 CA396361 BM817732 BC016060 
    BP356413 AW157361 AW118341 AI570373 AY044431 AK025891 BX471775 BU686481 
    AI088778 BM753923 BQ648934 BI084573 CB143241 BF477358 BP357013 AL701957 

    GeneLoc Exon Structure


    Expression
    for DDX27 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX27 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGTCAATC
    DDX27 Expression
    About this image
    See DDX27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX27

    SOURCE GeneReport for Unigene cluster: Hs.65234
        SABiosciences Custom PCR Arrays for DDX27

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX27
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX27
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX27
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX27
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX27

    Orthologs
    for DDX27 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX27 gene from 8/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DDX271 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 74.48(n)
    80.26(a)    		   419308  NM_001006293.1  NP_001006293.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.299762 Xenopus laevis transcribed sequence with weak similarity to protein pirS71758 (H.sapiens) S71758 DEAD box protein MrDb, Myc-regulated - human less 78.6(n)    BQ730622.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ddx272 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 76.8(n)   378844  CF417047.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rs11 , 3 ribosome biogenesis ATP dependent RNA
    helicase less3
    CG2173-PA1    		 51(a)
    (best of 2)3
    55.29(n)1
    51.12(a)1    		   44B93
    440871  NM_143713.21  NP_651970.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y71G12B.81 , 3 Protein Y71G12B.81 45(a)3
    52.81(n)1
    50.58(a)1    		   I(1767943-1790006)3
    1717431  NM_058490.31  NP_490891.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DRS1(YLL008W)4
    DRS11    		 Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles less4
    Drs1p1    		 48.4(n)1
    39.26(a)1    		   12(131729-133987)4
    8506521, 4  NP_013093.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G166301 DEAD-box ATP-dependent RNA helicase 28 50.43(n)
    44.36(a)    		   827364  NM_117764.4  NP_193396.3 
    rice
    (Oryza sativa)    		 Liliopsida Os.276742 Oryza sativa (japonica cultivar-group) cDNA cloneJ033074G02, full insert sequence less 71.2(n)    AK073151.1 


    ENSEMBL Gene Tree for DDX27 (if available)
    TreeFam Gene Tree for DDX27 (if available) 

    Paralogs
    for DDX27 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DDX27 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/545 NCBI SNPs in DDX27 are shown (see all 545)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1433696481,2
    		--47833923(+) TAGAAA/GGGTTA 1 -- us2k10--------
    rs1496823191,2
    		C--47833931(+) TAGTT-/TGA   
       AGCTG    TGAAG     		1 -- us2k10--------
    rs1177948231,2
    		F--47834081(+) GTATAT/CCCTTC 1 -- us2k11Minor allele frequency- C:0.10EA 120
    rs736240691,2
    		C--47834089(+) TTCCT-/AACA  
                GTGTC     		1 -- us2k10--------
    rs60954651,2
    		C,F,H--47834199(+) GTTTTT/GTTTTT 1 -- us2k1 trp37Minor allele frequency- G:0.09NS EA NA WA 536
    rs1471382071,2
    		C--47834213(+) TTAAA-/ATATATA 1 -- us2k10--------
    rs577039731,2
    		C--47834231(+) TATAT-/ATTTTTA 1 -- us2k10--------
    rs72630691,2
    		C,A--47834232(+) TATATA/TTTTAG 1 -- us2k10--------
    rs60126151,2
    		--47834255(+) ggctcA/Gtgcct 1 -- us2k10--------
    rs60126161,2
    		C,F,H--47834352(+) ACACTC/TTCACC 1 -- us2k18Minor allele frequency- T:0.40NS EA CSA WA NA 769

    HapMap Linkage Disequilibrium report for DDX27 (47835832 - 47860614 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DDX27: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX27
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX27

    Disorders / Diseases
    for DDX27 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDX27 for disorders           About GeneDecksing

    2 diseases for DDX27:    About MalaCards
    leprosy    malaria


    Export disorders for DDX27 gene to outside databases

    Publications
    for DDX27 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX27 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with DDX27)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    9. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    10. Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)

    External Searches for DDX27 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDX27 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55661 HGNC: 15837 AceView: DDX27 Ensembl:ENSG00000124228 euGenes: HUgn55661
    ECgene: DDX27 H-InvDB: DDX27

    Other Databases showing DDX27 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDX27 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX27 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDX27 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDX27 gene:
    Search GeneIP for patents involving DDX27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DDX27 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DDX27  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX27   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX27  
     OriGene Protein Over-expression Lysate for DDX27   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DDX27   OriGene 3'-UTR Clone for DDX27  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX27   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX27  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDX27   OriGene Custom Protein Services for DDX27  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX27
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX27
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX27
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX27
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX27
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX27
     GenScript Custom Purified and Recombinant Proteins Services for DDX27 GenScript cDNA clones with any tag delivered in your preferred vector for DDX27
     GenScript Custom Assay Services for DDX27 GenScript Custom Superior Antibodies Services for DDX27
     GenScript Custom overexpressing Cell Line Services for DDX27 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DDX27 promoter
     Search Chromatin IP Primers for DDX27
     RT2 qPCR Primer Assay in human, mouse, rat DDX27
     Search GNC Networks for DDX27
     SABiosciences Custom PCR Arrays for DDX27
     Search Tocris compounds for DDX27
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DDX27 antibodies
     DDX27 lysates
     Antibodies for DDX27
     See all of Abcam's Antibodies, Kits and Proteins for DDX27
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DDX27 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DDX27
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX27
     SwitchGear 3'UTR luciferase reporter plasmids for DDX27
     SwitchGear Promoter luciferase reporter plasmids for DDX27
     Search ThermoFisher Antibodies for DDX27
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX27
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DDX27
    Sirion Biotech Customized:
     stable knockdown cell line services for DDX27
     inducible knockdown cell line services for DDX27
     design and validation of potent shRNA sequences against DDX27
     adenovirus for potent knockdown of DDX27
     adenovirus for overexpression of DDX27
     stable overexpressing cell line services for DDX27
     inducible overexpressing cell line services for DDX27
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DDX27 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4