Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDX27 Gene

Aliases for DDX27 Gene

  • DEAD-Box Helicase 27 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 27 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 27 2 3
  • DEAD Box Protein 27 3 4
  • RHLP 3 4
  • Deficiency Of Ribosomal Subunits Protein 1 Homolog 3
  • RNA Helicase-Like Protein 3
  • EC 4
  • DJ686N3.1 3
  • EC 3.6.1 63
  • HSPC259 3
  • PP3241 3
  • Drs1p 3
  • DRS1 3

External Ids for DDX27 Gene

Previous GeneCards Identifiers for DDX27 Gene

  • GC20P047564
  • GC20P048474
  • GC20P048521
  • GC20P047269
  • GC20P047835
  • GC20P044584

Summaries for DDX27 Gene

Entrez Gene Summary for DDX27 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX27 Gene

DDX27 (DEAD-Box Helicase 27) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for DDX27 Gene

  • Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3 end formation of ribosomal 47S rRNA (PubMed:25825154).

Gene Wiki entry for DDX27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX27 Gene

Genomics for DDX27 Gene

Regulatory Elements for DDX27 Gene

Enhancers for DDX27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX27 on UCSC Golden Path with GeneCards custom track

Promoters for DDX27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX27 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX27 Gene

49,219,295 bp from pter
49,244,077 bp from pter
24,783 bases
Plus strand

Genomic View for DDX27 Gene

Genes around DDX27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX27 Gene

Proteins for DDX27 Gene

  • Protein details for DDX27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX27
    Protein Accession:
    Secondary Accessions:
    • A0AVB6
    • B7ZLY1
    • Q5VXM7
    • Q8WYG4
    • Q969N7
    • Q96F57
    • Q96L97
    • Q9BWY9
    • Q9BXF0
    • Q9H990
    • Q9NWU3
    • Q9P0C2
    • Q9UGD6

    Protein attributes for DDX27 Gene

    796 amino acids
    Molecular mass:
    89835 Da
    Quaternary structure:
    • Associates with PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:25825154). Interacts directly with BOP1 and PES1 (PubMed:25825154).
    • Sequence=AAF28937.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28937.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAG22482.1; Type=Frameshift; Positions=208, 427, 434, 532; Evidence={ECO:0000305}; Sequence=AAH16060.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91284.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14343.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DDX27 Gene

Proteomics data for DDX27 Gene at MOPED

Post-translational modifications for DDX27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX27 Gene

Domains & Families for DDX27 Gene

Gene Families for DDX27 Gene

Suggested Antigen Peptide Sequences for DDX27 Gene

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal domain regulates nucleolar localization (PubMed:25825154).
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
  • The C-terminal domain regulates nucleolar localization (PubMed:25825154).
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
genes like me logo Genes that share domains with DDX27: view

Function for DDX27 Gene

Molecular function for DDX27 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3 end formation of ribosomal 47S rRNA (PubMed:25825154).

Enzyme Numbers (IUBMB) for DDX27 Gene

Gene Ontology (GO) - Molecular Function for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX27: view
genes like me logo Genes that share phenotypes with DDX27: view

Animal Models for DDX27 Gene

MGI Knock Outs for DDX27:

Animal Model Products

miRNA for DDX27 Gene

miRTarBase miRNAs that target DDX27

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX27 Gene

Localization for DDX27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX27 Gene

Nucleus, nucleolus. Note=Associates with 60S and 90S pre-ribosomal particles (PubMed:25825154). {ECO:0000269 PubMed:25825154}.

Subcellular locations from

Jensen Localization Image for DDX27 Gene COMPARTMENTS Subcellular localization image for DDX27 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for DDX27 Gene

Pathways & Interactions for DDX27 Gene

SuperPathways for DDX27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX27 Gene


No data available for Pathways by source and SIGNOR curated interactions for DDX27 Gene

Drugs & Compounds for DDX27 Gene

(1) Drugs for DDX27 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX27 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DDX27: view

Transcripts for DDX27 Gene

Unigene Clusters for DDX27 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX27 Gene

No ASD Table

Relevant External Links for DDX27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX27 Gene

mRNA expression in normal human tissues for DDX27 Gene

Protein differential expression in normal tissues from HIPED for DDX27 Gene

This gene is overexpressed in Lung (50.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX27 Gene

SOURCE GeneReport for Unigene cluster for DDX27 Gene Hs.65234

genes like me logo Genes that share expression patterns with DDX27: view

Protein tissue co-expression partners for DDX27 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX27 Gene

Orthologs for DDX27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX27 35
  • 91.55 (n)
  • 95.03 (a)
DDX27 36
  • 95 (a)
(Canis familiaris)
Mammalia DDX27 35
  • 91.99 (n)
  • 95.48 (a)
DDX27 36
  • 93 (a)
(Mus musculus)
Mammalia Ddx27 35
  • 87.94 (n)
  • 92.63 (a)
Ddx27 16
Ddx27 36
  • 93 (a)
(Pan troglodytes)
Mammalia DDX27 35
  • 99.46 (n)
  • 99.87 (a)
DDX27 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx27 35
  • 87.6 (n)
  • 92.77 (a)
(Monodelphis domestica)
Mammalia DDX27 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia DDX27 36
  • 83 (a)
(Gallus gallus)
Aves DDX27 35
  • 74.73 (n)
  • 80.59 (a)
DDX27 36
  • 79 (a)
(Anolis carolinensis)
Reptilia DDX27 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx27 35
  • 70.14 (n)
  • 76.68 (a)
Str.11808 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29976 35
(Danio rerio)
Actinopterygii ddx27 35
  • 70.2 (n)
  • 74.97 (a)
ddx27 36
  • 73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4514 35
fruit fly
(Drosophila melanogaster)
Insecta Dbp45A 37
  • 32 (a)
Rs1 37
  • 51 (a)
Rs1 35
  • 62.45 (n)
  • 63.4 (a)
Rs1 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011084 35
  • 59.29 (n)
  • 56.8 (a)
(Caenorhabditis elegans)
Secernentea Y71G12B.8 37
  • 45 (a)
Y71G12B.8 35
  • 55.36 (n)
  • 54.13 (a)
Y71G12B.8 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DRS1 36
  • 33 (a)
DRS1 38
(Oryza sativa)
Liliopsida Os.27674 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8743 36
  • 60 (a)
Species with no ortholog for DDX27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX27 Gene

Gene Tree for DDX27 (if available)
Gene Tree for DDX27 (if available)

Paralogs for DDX27 Gene

(13) SIMAP similar genes for DDX27 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDX27: view

No data available for Paralogs for DDX27 Gene

Variants for DDX27 Gene

Sequence variations from dbSNP and Humsavar for DDX27 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1130146 - 49,242,680(+) GAGCT(A/G)GGTAG reference, missense
rs106491 -- 49,232,034(+) gcaca(C/T)gctac intron-variant
rs171130 -- 49,230,049(-) TTCCC(A/G)GAAAC intron-variant
rs173204 -- 49,241,535(-) agatc(A/G)cgcca intron-variant
rs487639 -- 49,235,812(-) aagcc(A/G)agatt intron-variant

Variation tolerance for DDX27 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.80; 94.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for DDX27 Gene

Disorders for DDX27 Gene

Relevant External Links for DDX27

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDX27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX27 Gene

Publications for DDX27 Gene

  1. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. An integrative approach identified genes associated with drug response in gastric cancer. (PMID: 25742747) Zhou J. … Goh L.K. (Carcinogenesis 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for DDX27 Gene

Sources for DDX27 Gene