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Aliases for DDX27 Gene

Aliases for DDX27 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 27 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 27 2 3
  • DEAD Box Protein 27 3 4
  • RHLP 3 4
  • Deficiency Of Ribosomal Subunits Protein 1 Homolog 3
  • RNA Helicase-Like Protein 3
  • EC 3.6.4.13 4
  • DJ686N3.1 3
  • EC 3.6.1 63
  • HSPC259 3
  • PP3241 3
  • Drs1p 3
  • DRS1 3

External Ids for DDX27 Gene

Previous GeneCards Identifiers for DDX27 Gene

  • GC20P047564
  • GC20P048474
  • GC20P048521
  • GC20P047269
  • GC20P047835
  • GC20P044584

Summaries for DDX27 Gene

Entrez Gene Summary for DDX27 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX27 Gene

DDX27 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 27) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for DDX27 Gene

  • Probable ATP-dependent RNA helicase

Gene Wiki entry for DDX27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX27 Gene

Genomics for DDX27 Gene

Regulatory Elements for DDX27 Gene

Genomic Location for DDX27 Gene

Chromosome:
20
Start:
49,219,295 bp from pter
End:
49,244,077 bp from pter
Size:
24,783 bases
Orientation:
Plus strand

Genomic View for DDX27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX27 Gene

Proteins for DDX27 Gene

  • Protein details for DDX27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GQ7-DDX27_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX27
    Protein Accession:
    Q96GQ7
    Secondary Accessions:
    • A0AVB6
    • B7ZLY1
    • Q5VXM7
    • Q8WYG4
    • Q969N7
    • Q96F57
    • Q96L97
    • Q9BWY9
    • Q9BXF0
    • Q9H990
    • Q9NWU3
    • Q9P0C2
    • Q9UGD6

    Protein attributes for DDX27 Gene

    Size:
    796 amino acids
    Molecular mass:
    89835 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28937.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28937.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAG22482.1; Type=Frameshift; Positions=208, 427, 434, 532; Evidence={ECO:0000305}; Sequence=AAH16060.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91284.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14343.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DDX27 Gene

Proteomics data for DDX27 Gene at MOPED

Post-translational modifications for DDX27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX27 Gene

Domains & Families for DDX27 Gene

Gene Families for DDX27 Gene

Suggested Antigen Peptide Sequences for DDX27 Gene

Graphical View of Domain Structure for InterPro Entry

Q96GQ7

UniProtKB/Swiss-Prot:

DDX27_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
genes like me logo Genes that share domains with DDX27: view

Function for DDX27 Gene

Molecular function for DDX27 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase

Enzyme Numbers (IUBMB) for DDX27 Gene

Gene Ontology (GO) - Molecular Function for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX27: view
genes like me logo Genes that share phenotypes with DDX27: view

Animal Model Products

miRNA for DDX27 Gene

miRTarBase miRNAs that target DDX27

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX27

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX27 Gene

Localization for DDX27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX27 Gene COMPARTMENTS Subcellular localization image for DDX27 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DDX27: view

Pathways & Interactions for DDX27 Gene

SuperPathways for DDX27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX27: view

No data available for Pathways by source and SIGNOR curated interactions for DDX27 Gene

Drugs & Compounds for DDX27 Gene

(1) Drugs for DDX27 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX27 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX27: view

Transcripts for DDX27 Gene

Unigene Clusters for DDX27 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX27 Gene

No ASD Table

Relevant External Links for DDX27 Gene

GeneLoc Exon Structure for
DDX27
ECgene alternative splicing isoforms for
DDX27

Expression for DDX27 Gene

mRNA expression in normal human tissues for DDX27 Gene

Protein differential expression in normal tissues from HIPED for DDX27 Gene

This gene is overexpressed in Lung (50.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX27 Gene



SOURCE GeneReport for Unigene cluster for DDX27 Gene Hs.65234

genes like me logo Genes that share expression patterns with DDX27: view

Protein tissue co-expression partners for DDX27 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX27 Gene

Orthologs for DDX27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX27 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX27 35
  • 91.55 (n)
  • 95.03 (a)
DDX27 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX27 35
  • 91.99 (n)
  • 95.48 (a)
DDX27 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx27 35
  • 87.94 (n)
  • 92.63 (a)
Ddx27 16
Ddx27 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX27 35
  • 99.46 (n)
  • 99.87 (a)
DDX27 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx27 35
  • 87.6 (n)
  • 92.77 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX27 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX27 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX27 35
  • 74.73 (n)
  • 80.59 (a)
DDX27 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX27 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx27 35
  • 70.14 (n)
  • 76.68 (a)
Str.11808 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29976 35
zebrafish
(Danio rerio)
Actinopterygii ddx27 35
  • 70.2 (n)
  • 74.97 (a)
ddx27 36
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4514 35
fruit fly
(Drosophila melanogaster)
Insecta Dbp45A 37
  • 32 (a)
Rs1 37
  • 51 (a)
Rs1 35
  • 62.45 (n)
  • 63.4 (a)
Rs1 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011084 35
  • 59.29 (n)
  • 56.8 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.8 37
  • 45 (a)
Y71G12B.8 35
  • 55.36 (n)
  • 54.13 (a)
Y71G12B.8 36
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DRS1 36
  • 33 (a)
OneToOne
DRS1 38
rice
(Oryza sativa)
Liliopsida Os.27674 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8743 36
  • 60 (a)
OneToOne
Species with no ortholog for DDX27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX27 Gene

ENSEMBL:
Gene Tree for DDX27 (if available)
TreeFam:
Gene Tree for DDX27 (if available)

Paralogs for DDX27 Gene

(13) SIMAP similar genes for DDX27 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDX27: view

No data available for Paralogs for DDX27 Gene

Variants for DDX27 Gene

Sequence variations from dbSNP and Humsavar for DDX27 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs106491 -- 49,232,034(+) gcaca(C/T)gctac intron-variant
rs171130 -- 49,230,049(-) TTCCC(A/G)GAAAC intron-variant
rs173204 -- 49,241,535(-) agatc(A/G)cgcca intron-variant
rs238148 -- 49,233,645(-) CGCAG(A/G)AAGGG reference, synonymous-codon
rs238149 -- 49,234,220(-) ctcca(A/C)ggctg intron-variant

Variation tolerance for DDX27 Gene

Residual Variation Intolerance Score: 17.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.80; 94.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX27 Gene

HapMap Linkage Disequilibrium report
DDX27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DDX27 Gene

Disorders for DDX27 Gene

Relevant External Links for DDX27

Genetic Association Database (GAD)
DDX27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX27
genes like me logo Genes that share disorders with DDX27: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX27 Gene

Publications for DDX27 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. An integrative approach identified genes associated with drug response in gastric cancer. (PMID: 25742747) Zhou J. … Goh L.K. (Carcinogenesis 2015) 67

Products for DDX27 Gene

Sources for DDX27 Gene

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