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Aliases for DDX27 Gene

Aliases for DDX27 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 27 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 27 2 3
  • DEAD Box Protein 27 3 4
  • RHLP 3 4
  • Deficiency Of Ribosomal Subunits Protein 1 Homolog 3
  • Probable ATP-Dependent RNA Helicase DDX27 3
  • RNA Helicase-Like Protein 3
  • EC 4
  • DJ686N3.1 3
  • EC 3.6.1 63
  • HSPC259 3
  • PP3241 3
  • Drs1p 3
  • DRS1 3

External Ids for DDX27 Gene

Previous GeneCards Identifiers for DDX27 Gene

  • GC20P047564
  • GC20P048474
  • GC20P048521
  • GC20P047269
  • GC20P047835
  • GC20P044584

Summaries for DDX27 Gene

Entrez Gene Summary for DDX27 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX27 Gene

DDX27 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 27) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity.

UniProtKB/Swiss-Prot for DDX27 Gene

  • Probable ATP-dependent RNA helicase

Gene Wiki entry for DDX27 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX27 Gene

Genomics for DDX27 Gene

Regulatory Elements for DDX27 Gene

Genomic Location for DDX27 Gene

49,219,295 bp from pter
49,244,077 bp from pter
24,783 bases
Plus strand

Genomic View for DDX27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX27 Gene

Proteins for DDX27 Gene

  • Protein details for DDX27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX27
    Protein Accession:
    Secondary Accessions:
    • A0AVB6
    • B7ZLY1
    • Q5VXM7
    • Q8WYG4
    • Q969N7
    • Q96F57
    • Q96L97
    • Q9BWY9
    • Q9BXF0
    • Q9H990
    • Q9NWU3
    • Q9P0C2
    • Q9UGD6

    Protein attributes for DDX27 Gene

    796 amino acids
    Molecular mass:
    89835 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF28937.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28937.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAG22482.1; Type=Frameshift; Positions=208, 427, 434, 532; Evidence={ECO:0000305}; Sequence=AAH16060.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91284.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14343.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DDX27 Gene

Proteomics data for DDX27 Gene at MOPED

Post-translational modifications for DDX27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX27 Gene

Antibody Products

Domains for DDX27 Gene

Gene Families for DDX27 Gene

  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96GQ7
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
genes like me logo Genes that share domains with DDX27: view

Function for DDX27 Gene

Molecular function for DDX27 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase

Enzyme Numbers (IUBMB) for DDX27 Gene

Gene Ontology (GO) - Molecular Function for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
genes like me logo Genes that share ontologies with DDX27: view
genes like me logo Genes that share phenotypes with DDX27: view

Animal Model Products

miRNA for DDX27 Gene

miRTarBase miRNAs that target DDX27

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX27

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX27 Gene

Localization for DDX27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX27 Gene

Subcellular locations from

Jensen Localization Image for DDX27 Gene COMPARTMENTS Subcellular localization image for DDX27 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DDX27: view

Pathways for DDX27 Gene

SuperPathways for DDX27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX27: view

No data available for Pathways by source for DDX27 Gene

Transcripts for DDX27 Gene

Unigene Clusters for DDX27 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX27 Gene

No ASD Table

Relevant External Links for DDX27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX27 Gene

mRNA expression in normal human tissues for DDX27 Gene

Protein differential expression in normal tissues for DDX27 Gene

This gene is overexpressed in Lung (50.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX27 Gene

SOURCE GeneReport for Unigene cluster for DDX27 Gene Hs.65234

genes like me logo Genes that share expressions with DDX27: view

Expression partners for DDX27 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX27 Gene

Orthologs for DDX27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX27 35
  • 91.55 (n)
  • 95.03 (a)
DDX27 36
  • 95 (a)
(Canis familiaris)
Mammalia DDX27 35
  • 91.99 (n)
  • 95.48 (a)
DDX27 36
  • 93 (a)
(Mus musculus)
Mammalia Ddx27 35
  • 87.94 (n)
  • 92.63 (a)
Ddx27 16
Ddx27 36
  • 93 (a)
(Pan troglodytes)
Mammalia DDX27 35
  • 99.46 (n)
  • 99.87 (a)
DDX27 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx27 35
  • 87.6 (n)
  • 92.77 (a)
(Monodelphis domestica)
Mammalia DDX27 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia DDX27 36
  • 83 (a)
(Gallus gallus)
Aves DDX27 35
  • 74.73 (n)
  • 80.59 (a)
DDX27 36
  • 79 (a)
(Anolis carolinensis)
Reptilia DDX27 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx27 35
  • 70.14 (n)
  • 76.68 (a)
Str.11808 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29976 35
(Danio rerio)
Actinopterygii ddx27 35
  • 70.2 (n)
  • 74.97 (a)
ddx27 36
  • 73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4514 35
fruit fly
(Drosophila melanogaster)
Insecta Dbp45A 37
  • 32 (a)
Rs1 37
  • 51 (a)
Rs1 35
  • 62.45 (n)
  • 63.4 (a)
Rs1 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011084 35
  • 59.29 (n)
  • 56.8 (a)
(Caenorhabditis elegans)
Secernentea Y71G12B.8 37
  • 45 (a)
Y71G12B.8 35
  • 55.36 (n)
  • 54.13 (a)
Y71G12B.8 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DRS1 36
  • 33 (a)
DRS1 38
(Oryza sativa)
Liliopsida Os.27674 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8743 36
  • 60 (a)
Species with no ortholog for DDX27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX27 Gene

Gene Tree for DDX27 (if available)
Gene Tree for DDX27 (if available)

Paralogs for DDX27 Gene

Selected SIMAP similar genes for DDX27 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDX27: view

No data available for Paralogs for DDX27 Gene

Variants for DDX27 Gene

Sequence variations from dbSNP and Humsavar for DDX27 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs106491 -- 49,232,034(+) gcaca(C/T)gctac intron-variant
rs171130 -- 49,230,049(-) TTCCC(A/G)GAAAC intron-variant, upstream-variant-2KB
rs173204 -- 49,241,535(-) agatc(A/G)cgcca intron-variant
rs238148 -- 49,233,645(-) CGCAG(A/G)AAGGG reference, synonymous-codon
rs238149 -- 49,234,220(-) ctcca(A/C)ggctg intron-variant

Relevant External Links for DDX27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DDX27 Gene

Disorders for DDX27 Gene

Relevant External Links for DDX27

Genetic Association Database (GAD)

No disorders were found for DDX27 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DDX27 Gene

Publications for DDX27 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen J.S. … Lamond A.I. (Curr. Biol. 2002) 3

Products for DDX27 Gene

Sources for DDX27 Gene

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