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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX26B Gene

protein-coding   GIFtS: 44
GCID: GC0XP134654

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

 Explore 4 diseases affiliated with
DDX26B via our new
 Human Malady Compendium 
Biological research products
for DDX26B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26B1 2
FLJ412151
Protein DDX26B2

External Ids:    HGNC: 273341   Entrez Gene: 2035222   Ensembl: ENSG000001653597   UniProtKB: Q5JSJ43   

Export aliases for DDX26B gene to outside databases

Previous GC identifers: GC0XP134380 GC0XP134482 GC0XP124012


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX26B gene promoter:
         HEN1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX26B promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX26B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX26B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26

DDX26B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX26B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP134654:  view genomic region     (about GC identifiers)

Start:
134,654,555 bp from pter      End:
134,716,460 bp from pter
Size:
61,906 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DX26B_HUMAN, Q5JSJ4 (See protein sequence)
Recommended Name: Protein DDX26B  
Size: 861 amino acids; 96673 Da
Secondary accessions: Q5CZA2 Q6IPS3 Q6ZTU5 Q6ZWE4
Alternative splicing: 2 isoforms:  Q5JSJ4-1   Q5JSJ4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX26B: NX_Q5JSJ4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5JSJ4

  • DDX26B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_872346.3  
    ENSEMBL proteins: 
     ENSP00000359788  

    Human Recombinant Protein Products: 
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    Uscn Proteins for DDX26B


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    Uscn Antibodies for DDX26B
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    Uscn ELISAs and CLIAs for DDX26B


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DDX26B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q5JSJ4

    ProtoNet protein and cluster: Q5JSJ4

    UniProtKB/Swiss-Prot: DX26B_HUMAN, Q5JSJ4
    Similarity: Contains 1 VWFA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX26B
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    hsa-miR-3149 hsa-miR-429 hsa-let-7d hsa-let-7c hsa-miR-486-3p hsa-let-7g hsa-miR-124 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidDDX26B 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX26B

    2 GenomeRNAi human phenotypes for DDX26B:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX26B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for DDX26B (Q5JSJ43 ENSP000003597884) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    CEP63Q96MT83, ENSP000003365244I2D: score=2 STRING: ENSP00000336524
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX26B
    Search CenterWatch for drugs/clinical trials and news about DDX26B / DX26B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDX26B gene: 
    NM_182540.4  

    Unigene Cluster for DDX26B:

    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
    Hs.496829  [show with all ESTs]
    Unigene Representative Sequence: BX648113
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370752(uc004eyw.4 uc004eyx.4) ENST00000481908 ENST00000493637
    ENST00000494957 ENST00000481429

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX26B
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX26B (see all 27):
    hsa-miR-3149 hsa-miR-429 hsa-let-7d hsa-let-7c hsa-miR-486-3p hsa-let-7g hsa-miR-124 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidDDX26B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX26B (see all 4)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX26B
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX26B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX26B
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    GenScript: all cDNA clones in your preferred vector: DDX26B (NM_182540)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX26B 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX26B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX26B

    Additional cDNA sequence: 

    AK096544.1 AK308423.1 AL833319.1 BC140715.1 BX648113.1 CR936620.1 

    10 DOTS entries:

    DT.97764531  DT.443474  DT.100782019  DT.100801610  DT.97779661  DT.121303322  DT.97825102  DT.95319507 
    DT.92419314  DT.100782018 

    24/90 AceView cDNA sequences (see all 90):

    CB160378 BQ446698 BM977827 CA412551 AK126202 AW274563 BQ028227 NM_182540 
    AI420341 AI085076 BX350756 BQ220487 AV727880 AI968298 BF000403 BF446452 
    CB162968 AI251025 BX497708 AI912053 AA804561 AI200742 AA332956 AK096544 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DDX26B (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:              -                                                                       -     -           -     -                                   -     -   
    SP2:                                                                                                              -                                         -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -     -                                             
    SP5:              -                 -                                                                                                                           

    ExUns: 16b ^ 17 ^ 18a · 18b · 18c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for DDX26B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX26B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATGATAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DDX26B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX26B

    SOURCE GeneReport for Unigene cluster: Hs.496829
        SABiosciences Custom PCR Arrays for DDX26B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX26B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DDX26B gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DDX26B1 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B 78.7(n)
    80.38(a)
      422239  XM_420227.3  XP_420227.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    72(a)
    1 ↔ 1
    GL343761.1(61201-94263)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.57282 Transcribed sequence with moderate similarity to protein more 77.72(n)    137725081 
    zebrafish
    (Danio rerio)
    Actinopterygii ddx26b1 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B 65.8(n)
    71.87(a)
      393406  NM_200434.1  NP_956728.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta IntS61 Integrator 6 51.32(n)
    47.69(a)
      31496  NM_132025.2  NP_572253.2 
    worm
    (Caenorhabditis elegans)
    Secernentea dic-16
    --
    22(a)
    1 → many
    IV(8692086-8696443)


    ENSEMBL Gene Tree for DDX26B (if available)
    TreeFam Gene Tree for DDX26B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX26B gene
    CT45A42  CT45A32  CT45A22  INTS62  CT45A52  CT45A12  SAGE12  CT45A62  
    8 SIMAP similar genes for DDX26B using alignment to 3 protein entries:     DX26B_HUMAN (see all proteins):
    INTS6    CT45A1    CT45A2    CT45A3    CT45A4    CT45A5
    CT45A6    SAGE1

    DDX26B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/604 NCBI SNPs in DDX26B are shown (see all 604    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815278711,2
    --134652578(+) CTGCCC/TCCAAC 1 -- us2k10--------
    rs1860388991,2
    --134652591(+) TCCTAC/TATTTT 1 -- us2k10--------
    rs1895771051,2
    --134652603(+) TGTACC/TCTAGC 1 -- us2k10--------
    rs575460631,2
    C--134653005(+) ATATA-/TATA  
            
    GAGAG
    1 -- us2k10--------
    rs584588541,2
    C--134653006(+) ATATAT/GAGAGA 1 -- us2k12Minor allele frequency- G:0.33WA CSA 3
    rs134405441,2
    C,--134653027(+) gagagA/Tgtgta 1 -- us2k1 trp30--------
    rs1819168221,2
    --134653052(+) AATACC/TTTTTT 1 -- us2k10--------
    rs1854707771,2
    --134653283(+) TGATCC/TACCCA 1 -- us2k10--------
    rs128401691,2
    C,--134653289(+) ACCCAA/CCTCGG 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1906215371,2
    --134653332(+) CACTGC/TGCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDX26B (134654555 - 134716460 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DDX26B
         1 CNV: 4174

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX26B
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX26B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DDX26B for disorders           About GeneDecksing

    4 diseases for DDX26B:    About MalaCards
    non-small cell lung carcinoma    lung carcinoma    carcinoma    schizophrenia


    Export disorders for DDX26B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX26B gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DDX26B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    6. Streamlined analysis schema for high-throughput ident ification of endogenous protein complexes. (PubMed id 20133760)1 Malovannaya A....Qin J. (2010)
    7. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 203522 HGNC: 27334 AceView: DDX26B Ensembl:ENSG00000165359 euGenes: HUgn203522
    ECgene: DDX26B H-InvDB: DDX26B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX26B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDX26B gene:
    Search GeneIP for patents involving DDX26B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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