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Aliases for DDX26B Gene

Aliases for DDX26B Gene

  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26B 2 3

External Ids for DDX26B Gene

Previous GeneCards Identifiers for DDX26B Gene

  • GC0XP134380
  • GC0XP134482
  • GC0XP134654
  • GC0XP124012

Summaries for DDX26B Gene

GeneCards Summary for DDX26B Gene

DDX26B (DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26B) is a Protein Coding gene. An important paralog of this gene is INTS6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX26B Gene

Genomics for DDX26B Gene

Regulatory Elements for DDX26B Gene

Transcription factor binding sites by QIAGEN in the DDX26B gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX26B Gene

Chromosome:
X
Start:
135,520,630 bp from pter
End:
135,582,535 bp from pter
Size:
61,906 bases
Orientation:
Plus strand

Genomic View for DDX26B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX26B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX26B Gene

Proteins for DDX26B Gene

  • Protein details for DDX26B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSJ4-DX26B_HUMAN
    Recommended name:
    Protein DDX26B
    Protein Accession:
    Q5JSJ4
    Secondary Accessions:
    • Q5CZA2
    • Q6IPS3
    • Q6ZTU5
    • Q6ZWE4

    Protein attributes for DDX26B Gene

    Size:
    861 amino acids
    Molecular mass:
    96673 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX26B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX26B Gene

Proteomics data for DDX26B Gene at MOPED

Post-translational modifications for DDX26B Gene

  • Ubiquitination at Lys 838
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX26B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DDX26B Gene

Domains & Families for DDX26B Gene

Protein Domains for DDX26B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JSJ4

UniProtKB/Swiss-Prot:

DX26B_HUMAN :
  • Contains 1 VWFA domain.
Domain:
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with DDX26B: view

No data available for Gene Families for DDX26B Gene

Function for DDX26B Gene

Phenotypes for DDX26B Gene

genes like me logo Genes that share phenotypes with DDX26B: view

Animal Model Products

miRNA for DDX26B Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX26B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX26B Gene

Localization for DDX26B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DDX26B Gene

Pathways & Interactions for DDX26B Gene

SuperPathways for DDX26B Gene

No Data Available

Interacting Proteins for DDX26B Gene

Selected Interacting proteins: Q5JSJ4-DX26B_HUMAN for DDX26B Gene via I2D

Gene Ontology (GO) - Biological Process for DDX26B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DDX26B Gene

Drugs & Compounds for DDX26B Gene

No Compound Related Data Available

Transcripts for DDX26B Gene

Unigene Clusters for DDX26B Gene

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX26B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX26B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - -
SP2: - -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8:

ExUns: 16b ^ 17 ^ 18a · 18b · 18c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for DDX26B Gene

GeneLoc Exon Structure for
DDX26B
ECgene alternative splicing isoforms for
DDX26B

Expression for DDX26B Gene

mRNA expression in normal human tissues for DDX26B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX26B Gene

This gene is overexpressed in Ovary (48.1) and Plasma (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DDX26B Gene



SOURCE GeneReport for Unigene cluster for DDX26B Gene Hs.496829

genes like me logo Genes that share expression patterns with DDX26B: view

Protein tissue co-expression partners for DDX26B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX26B Gene

Orthologs for DDX26B Gene

This gene was present in the common ancestor of animals.

Orthologs for DDX26B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC540312 35
  • 93.54 (n)
  • 93.34 (a)
DDX26B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX26B 35
  • 93.34 (n)
  • 93.73 (a)
DDX26B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx26b 35
  • 90.4 (n)
  • 90.36 (a)
Ddx26b 16
Ddx26b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX26B 35
  • 99.69 (n)
  • 99.54 (a)
DDX26B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx26b 35
  • 87.04 (n)
  • 84.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX26B 35
  • 78.53 (n)
  • 80.23 (a)
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx26b 35
  • 72.1 (n)
  • 76.79 (a)
Str.5728 35
zebrafish
(Danio rerio)
Actinopterygii ddx26b 35
  • 65.84 (n)
  • 71.87 (a)
ddx26b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta IntS6 35
  • 54.23 (n)
  • 52.73 (a)
IntS6 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dic-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for DDX26B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX26B Gene

ENSEMBL:
Gene Tree for DDX26B (if available)
TreeFam:
Gene Tree for DDX26B (if available)

Paralogs for DDX26B Gene

Paralogs for DDX26B Gene

(8) SIMAP similar genes for DDX26B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDX26B: view

Variants for DDX26B Gene

Sequence variations from dbSNP and Humsavar for DDX26B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs967139 -- 135,563,633(+) TGTGT(A/G)TATAT intron-variant
rs975962 -- 135,549,224(-) TCTGA(C/T)AAAAA intron-variant
rs1397384 -- 135,548,039(-) TTACA(A/C)ATTTA intron-variant
rs1812552 -- 135,579,498(-) GCTTT(A/T)CAAGT intron-variant
rs1890585 -- 135,536,756(-) AACTT(C/T)AGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX26B Gene

Variant ID Type Subtype PubMed ID
nsv522205 CNV Gain 19592680
dgv2477e1 CNV Complex 17122850
esv785 CNV CNV 17122850
dgv531n21 CNV Gain 19592680

Variation tolerance for DDX26B Gene

Residual Variation Intolerance Score: 19.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX26B Gene

HapMap Linkage Disequilibrium report
DDX26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX26B Gene

Disorders for DDX26B Gene

Relevant External Links for DDX26B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX26B
genes like me logo Genes that share disorders with DDX26B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX26B Gene

Publications for DDX26B Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  2. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 67
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 67
  5. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. (PMID: 20133760) Malovannaya A. … Qin J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 67

Products for DDX26B Gene

Sources for DDX26B Gene

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