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DDX25 Gene

protein-coding   GIFtS: 53
GCID: GC11P125773

DEAD (Asp-Glu-Ala-Asp) Box Helicase 25

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 25, DEAD (Asp-Glu-Ala-Asp)...)
  Search for DDX25
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 251 2     DEAD Box Protein 252 3
Gonadotropin-Regulated Testicular RNA Helicase1 2 3     ATP-Dependent RNA Helicase DDX252
GRTH2 3 5     EC 3.6.4.133
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 251 2     EC 3.6.18
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 251 2     

External Ids:    HGNC: 186981   Entrez Gene: 291182   Ensembl: ENSG000001098327   OMIM: 6076635   UniProtKB: Q9UHL03   

Export aliases for DDX25 gene to outside databases

Previous GC identifers: GC11P127774 GC11P127287 GC11P125806 GC11P125312 GC11P125279 GC11P121716


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX25 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein
is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain
testicular functions related to steroidogenesis and spermatogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX25 Gene:
DDX25 (DEAD (Asp-Glu-Ala-Asp) box helicase 25) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX19A.

UniProtKB/Swiss-Prot: DDX25_HUMAN, Q9UHL0
Function: ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid
development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX25 gene promoter:
         TBP   Pax-6   Pax-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Pax-2a   POU3F2   E47   CBF-B   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX25 promoter sequence
   Search Chromatin IP Primers for DDX25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24

DDX25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX25 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P125773:  view genomic region     (about GC identifiers)

Start:
125,773,271 bp from pter      End:
125,793,158 bp from pter
Size:
19,888 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX25_HUMAN, Q9UHL0 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX25  
Size: 483 amino acids; 54692 Da
1 PDB 3D structure from and Proteopedia for DDX25:
2RB4 (3D)    
Secondary accessions: B2R6Z0 Q5XVN2 Q86W81 Q8IYP1
Alternative initiation: 2 isoforms:  Q9UHL0-1   Q9UHL0-2   

Explore the universe of human proteins at neXtProt for DDX25: NX_Q9UHL0

Explore proteomics data for DDX25 at MOPED

Post-translational modifications: 

  • Phosphorylated on threonine residues. The phosphorylated form is found in the cytoplasm but not in the nucleus (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX25 (Q9UHL0) (see all 15)
     KVLITTN  FVLDEAD  ALPMMLA  SPLYSVK 


    See DDX25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037396.3  
    ENSEMBL proteins: 
     ENSP00000263576   ENSP00000463333   ENSP00000432800   ENSP00000436087   ENSP00000464251  

    DDX25 Human Recombinant Protein Products:

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    Novus Biologicals DDX25 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX25

     
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    LSBio Antibodies in human, mouse, rat for DDX25

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    Search eBioscience for ELISAs for DDX25 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9UHL0

    ProtoNet protein and cluster: Q9UHL0

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX25_HUMAN, Q9UHL0
    Similarity: Belongs to the DEAD box helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX25_HUMAN, Q9UHL0
    Function: ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid
    development (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: Up-regulated at transcriptional level by chorionic gonadotropin via cyclic AMP-induced androgen
    formation in the Leydig cell

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004004ATP-dependent RNA helicase activity ISS--
    GO:0004386helicase activity ----
    GO:0005524ATP binding ISS--
         
    Find genes that share ontologies with DDX25           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DDX25:
     Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ddx25):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with DDX25           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ddx25tm1Mld for DDX25

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX25
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    miRNA
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    miRTarBase miRNAs that target DDX25:
    hsa-mir-26b-5p (MIRT029791)

    Block miRNA regulation of human, mouse, rat DDX25 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DDX25:
    hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDX25 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DDX25
    Predesigned siRNA for gene silencing in human, mouse, rat DDX25

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DDX25
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX25 (NM_013264)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX25
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX25

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX25_HUMAN, Q9UHL0: Cytoplasm. Nucleus (By similarity). Note=Detected in both cytoplasm and nucleus of
    testicular cells. Also detected in chromatoid bodies of round spermatids (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0033391chromatoid body ISS--

    Find genes that share ontologies with DDX25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX25
    Interactions:

        Search GeneGlobe Interaction Network for DDX25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX25 (ENSP000002635764) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GLE1ENSP000003086224STRING: ENSP00000308622
    MCM3APENSP000002916884STRING: ENSP00000291688
    DRAP1ENSP000003078504STRING: ENSP00000307850
    ZC3H14ENSP000002510384STRING: ENSP00000251038
    EEF1B2ENSP000002369574STRING: ENSP00000236957
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process ISS--
    GO:0006406mRNA export from nucleus ISS--
    GO:0006417regulation of translation ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development ISS--

    Find genes that share ontologies with DDX25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX25

    1 Novoseek inferred chemical compound relationship for DDX25 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 44.5 13 12734186 (4), 20108248 (4), 11384877 (2), 10608860 (1)



    Find genes that share compounds with DDX25           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX25 gene: 
    NM_013264.4  

    Unigene Cluster for DDX25:

    DEAD (Asp-Glu-Ala-Asp) box helicase 25
    Hs.420263  [show with all ESTs]
    Unigene Representative Sequence: NM_013264
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525943 ENST00000263576(uc010sbk.2 uc001qcz.4) ENST00000530414
    ENST00000530129 ENST00000526875 ENST00000531000 ENST00000584970 ENST00000532928

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDX25 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DDX25:
    hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDX25 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDX25
    Predesigned siRNA for gene silencing in human, mouse, rat DDX25
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX25 (NM_013264)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX25
    Primer
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    OriGene qPCR primer pairs and template standards for DDX25
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX25
      QuantiTect SYBR Green Assays in human, mouse, rat DDX25
      QuantiFast Probe-based Assays in human, mouse, rat DDX25

    Additional mRNA sequence: 

    AF155140.2 AK295121.1 AK312772.1 BC031098.1 BC035388.1 BC050360.1 

    9 DOTS entries:

    DT.100754605  DT.120687123  DT.86850830  DT.92066927  DT.100754604  DT.120687103  DT.70100592  DT.91920621 
    DT.435846 

    Selected AceView cDNA sequences (see all 74):

    CR605679 CR604125 CR603268 BI522483 BP361103 BP371065 BP369622 NM_013264 
    AI348350 BP369142 CD359894 BM553313 BC050360 AA960953 AW961528 BX108659 
    BC035388 AA431471 AL520665 CD359014 BP371544 AA431674 BP370564 AL534333 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAAATTG
    DDX25 Expression
    About this image


    DDX25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    DDX25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.420263

    UniProtKB/Swiss-Prot: DDX25_HUMAN, Q9UHL0
    Tissue specificity: Highly expressed in the Leydig and germ cells of the testis and weakly expressed in the
    pituitary and hypothalamus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDX25 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx251 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 251, 5 87.65(n)1
    93.17(a)1
      9 (20.31 cM)5
    309591  NM_013932.41  NP_038960.21 
     355418475 
    chicken
    (Gallus gallus)
    Aves DDX251 DEAD (Asp-Glu-Ala-Asp) box helicase 25 68.16(n)
    68.79(a)
      427073  XM_424667.3  XP_424667.3 
    lizard
    (Anolis carolinensis)
    Reptilia DDX256
    DEAD (Asp-Glu-Ala-Asp) box helicase 25
    64(a)
    1 ↔ 1
    GL343322.1(203924-219190)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF190623.12   -- 75.33(n)    AF190623.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1936906
    zgc:193690
    60(a)
    many ↔ many
    23(37193902-37211540) ENSDARG00000044325
    fruit fly
    (Drosophila melanogaster)
    Insecta Dbp803 ATP dependent RNA helicase 58(a)   80F   --
    worm
    (Caenorhabditis elegans)
    Secernentea T07D4.4a3 ATP-dependent helicase 48(a)
    (best of 3)
      II(8884820-8889218)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP56
    Cytoplasmic ATP-dependent RNA helicase of the DEAD...
    41(a)
    1 → many
    XV(414459-415907) YOR046C


    ENSEMBL Gene Tree for DDX25 (if available)
    TreeFam Gene Tree for DDX25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX25 gene
    DDX19A2  ENSG000002605372  DDX19B2  
    16 SIMAP similar genes for DDX25 using alignment to 6 protein entries:     DDX25_HUMAN (see all proteins):
    DDX19A    DKFZp762C1313    DDX19B    DKFZp686C21137    DDX19L    EIF4A3
    DDX56    EIF4A2    EIF4A1    BAT1    DDX6    DKFZp547B159
    DDX39A    DDX54    DDX59    DDX39B

    Find genes that share paralogs with DDX25           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DDX25
    PGOHUM00000235603


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX25 (see all 423)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156792901,2
    C,F--125775239(+) CATCAC/TGTCCC 1 -- int12Minor allele frequency- T:0.01WA NA 238
    rs736266231,2
    C,F--125775306(+) TCCCAG/ATCGTT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1173914471,2
    F--125775454(+) TGGTTC/TTATTA 2 S F mis11Minor allele frequency- T:0.01EA 120
    rs1382490171,2
    C--125775558(+) TAGTGC/TGAGTG 1 -- int10--------
    rs1178444301,2
    C,F--125775660(+) ATTTAT/CTTAAA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs800164251,2
    C,F--125775837(+) CTTTCT/CGGAAC 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1161589181,2
    C,F--125775966(+) TTTTCT/CAGTGG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs43297031,2
    H--125776060(+) GATCCC/GAGCTC 2 P syn1 ese34Minor allele frequency- G:0.00NS EA 420
    rs346922231,2
    C--125776216(+) TTTTTTT/-GTTAT 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1879857351,2
    --125776238(+) GAGACA/GGAGTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for DDX25 (125773271 - 125793158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DDX25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv535CNV Loss18451855
    dgv248n67CNV Gain20364138
    esv32964CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): DDX25
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX25
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607663    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DDX25:
    Male infertility

    Find genes that share disorders with DDX25           About GenesLikeMe

    Genetic Association Database (GAD): DDX25
    Human Genome Epidemiology (HuGE) Navigator: DDX25 (4 documents)

    Export disorders for DDX25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX25 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with DDX25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gonadotropin-regulated testicular RNA helicase: a new member of the DEAD-box family. (PubMed id 10608860)1, 2, 3, 9 Tang P.-Z.... Dufau M.L. (J. Biol. Chem. 1999)
    2. Single nucleotide polymorphisms of the gonadotrophin-regulated testicular helicase (GRTH) gene may be associated with the human spermatogenesis impairment. (PubMed id 16293649)1, 4, 9 A Z....Zhang W. (Hum. Reprod. 2006)
    3. Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation. (PubMed id 17848414)1, 4, 9 Tsai-Morris C.H....Dufau M.L. (Mol. Hum. Reprod. 2007)
    4. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    5. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)
    6. Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis. (PubMed id 15096601)1, 3 Tsai-Morris C.H....Dufau M.L. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25): a multifunctional protein essential for spermatogenesis. (PubMed id 19875492)1, 9 Tsai-Morris C.H....Dufau M.L. (J. Androl. 2010)
    9. Comparative structural analysis of human DEAD-box RNA helicases. (PubMed id 20941364)2 Schutz P.... Schuler H. (PLoS ONE 2010)
    10. Gonadotropin-regulated testicular helicase (GRTH/DDX25): an essential regulator of spermatogenesis. (PubMed id 17889551)1 Dufau M.L. and Tsai-Morris C.H. (Trends Endocrinol. Metab. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29118 HGNC: 18698 AceView: DDX25 Ensembl:ENSG00000109832 euGenes: HUgn29118
    ECgene: DDX25 H-InvDB: DDX25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX25 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDX25 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX25 gene:
    Search GeneIP for patents involving DDX25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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