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Aliases for DDX24 Gene

Aliases for DDX24 Gene

  • DEAD-Box Helicase 24 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 24 2
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 24 2
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 24 2
  • DEAD Box Protein 24 4
  • EC 3.6.4.13 4
  • EC 3.6.1 58

External Ids for DDX24 Gene

Previous GeneCards Identifiers for DDX24 Gene

  • GC14M092024
  • GC14M088333
  • GC14M092507
  • GC14M093587
  • GC14M094517
  • GC14M074697

Summaries for DDX24 Gene

Entrez Gene Summary for DDX24 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX24 Gene

DDX24 (DEAD-Box Helicase 24) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX24 Gene

  • ATP-dependent RNA helicase.

Gene Wiki entry for DDX24 Gene

Additional gene information for DDX24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX24 Gene

Genomics for DDX24 Gene

Regulatory Elements for DDX24 Gene

Enhancers for DDX24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H094065 1.2 Ensembl ENCODE 23.9 +15.0 14982 1.6 FOXA2 NFIB ZNF133 KLF17 ZNF195 FEZF1 ZNF2 RARA GLIS2 ZNF366 DDX24 BTBD7 IFI27 PIR58882 GC14M094051 GC14M094050
GH14H093953 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +121.2 121245 13.2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 BTBD7 SERPINA1 CCDC197 DDX24 UBR7 IFI27L2 IFI27 RPSAP4 FAM181A-AS1 ASB2
GH14H094056 0.9 ENCODE 23.8 +22.6 22620 4.4 ELF3 FOXA2 ATF1 MLX ARID4B BATF THRB ZSCAN9 RAD21 RARA DDX24 IFI27L1 IFI27 PPP4R4 IFI27L2 GC14M094051 GC14M094050 PIR58882
GH14H094025 1.1 ENCODE 17.2 +53.2 53230 4.1 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B ZNF207 ZNF548 FOS SP3 BTBD7 DDX24 CCDC197 ASB2 IFI27L2 IFI27L1 IFI27 OTUB2 GC14M094051 GC14M094050
GH14H094036 1 Ensembl ENCODE 17.7 +44.5 44545 0.6 HDGF CTCF ARID4B ZIC2 ZNF644 RAD21 TEAD3 CTBP1 GATA3 SMC3 DDX24 IFI27L1 IFI27L2 IFI27 GC14M094050 GC14M094051 OTUB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX24 on UCSC Golden Path with GeneCards custom track

Promoters for DDX24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072475 345 2201 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ELK1 ZNF207

Genomic Locations for DDX24 Gene

Genomic Locations for DDX24 Gene
chr14:94,048,291-94,081,245
(GRCh38/hg38)
Size:
32,955 bases
Orientation:
Minus strand
chr14:94,517,266-94,547,591
(GRCh37/hg19)

Genomic View for DDX24 Gene

Genes around DDX24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX24 Gene

Proteins for DDX24 Gene

  • Protein details for DDX24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZR7-DDX24_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX24
    Protein Accession:
    Q9GZR7
    Secondary Accessions:
    • E7EMJ4
    • Q4V9L5

    Protein attributes for DDX24 Gene

    Size:
    859 amino acids
    Molecular mass:
    96332 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX24 Gene

Selected DME Specific Peptides for DDX24 Gene

Q9GZR7:
  • VAARGLDI
  • VQHVIHYQVPRT
  • HRSGRTARA
  • TGSGKTLA
  • AARGLDIP
  • VLTPTREL
  • TPTRELA
  • AETGSGKT
  • LVFANSI
  • TRELAVQ
  • VATPGRL
  • IVVATPGR
  • TDVAARGLD

Post-translational modifications for DDX24 Gene

  • Ubiquitination at isoforms=195, isoforms=2429, isoforms=2541, and posLast=601601
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX24 Gene

Domains & Families for DDX24 Gene

Gene Families for DDX24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDX24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZR7

UniProtKB/Swiss-Prot:

DDX24_HUMAN :
  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
Family:
  • Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
genes like me logo Genes that share domains with DDX24: view

Function for DDX24 Gene

Molecular function for DDX24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase.

Enzyme Numbers (IUBMB) for DDX24 Gene

Phenotypes From GWAS Catalog for DDX24 Gene

Gene Ontology (GO) - Molecular Function for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0003724 RNA helicase activity NAS 10936056
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX24: view
genes like me logo Genes that share phenotypes with DDX24: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX24 Gene

Localization for DDX24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX24 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDX24 Gene

Pathways & Interactions for DDX24 Gene

SuperPathways for DDX24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
GO:0016070 RNA metabolic process NAS 10936056
genes like me logo Genes that share ontologies with DDX24: view

No data available for Pathways by source and SIGNOR curated interactions for DDX24 Gene

Drugs & Compounds for DDX24 Gene

(3) Drugs for DDX24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DDX24 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX24: view

Transcripts for DDX24 Gene

Unigene Clusters for DDX24 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 24:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX24 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: - -
SP3:
SP4: - -
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for DDX24 Gene

GeneLoc Exon Structure for
DDX24
ECgene alternative splicing isoforms for
DDX24

Expression for DDX24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX24 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.7) and Tlymphocyte (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX24 Gene



Protein tissue co-expression partners for DDX24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX24 Gene:

DDX24

SOURCE GeneReport for Unigene cluster for DDX24 Gene:

Hs.510328

mRNA Expression by UniProt/SwissProt for DDX24 Gene:

Q9GZR7-DDX24_HUMAN
Tissue specificity: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.

Evidence on tissue expression from TISSUES for DDX24 Gene

  • Nervous system(4.9)
  • Liver(4.8)
  • Intestine(4.6)
  • Lung(4)
  • Pancreas(3.6)
  • Skin(3.5)
  • Kidney(3.1)
  • Eye(2.9)
  • Stomach(2.9)
  • Heart(2.5)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with DDX24: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX24 Gene

Orthologs for DDX24 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX24 33 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia DDX24 33 34
  • 86.76 (n)
dog
(Canis familiaris)
Mammalia DDX24 33 34
  • 85.56 (n)
rat
(Rattus norvegicus)
Mammalia Ddx24 33
  • 82.25 (n)
mouse
(Mus musculus)
Mammalia Ddx24 33 16 34
  • 81.75 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX24 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX24 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX24 33 34
  • 63.01 (n)
lizard
(Anolis carolinensis)
Reptilia DDX24 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx24 33
  • 60.35 (n)
Str.14965 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398446 33
zebrafish
(Danio rerio)
Actinopterygii LOC553462 33
  • 62.3 (n)
ddx24 34
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2533 33
fruit fly
(Drosophila melanogaster)
Insecta CG9143 35 33 34
  • 57.41 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010702 33
  • 51.33 (n)
worm
(Caenorhabditis elegans)
Secernentea F55F8.2 33 34
  • 50.53 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK5 34 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3498 34
  • 41 (a)
OneToOne
Species where no ortholog for DDX24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX24 Gene

ENSEMBL:
Gene Tree for DDX24 (if available)
TreeFam:
Gene Tree for DDX24 (if available)

Paralogs for DDX24 Gene

(4) SIMAP similar genes for DDX24 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DDX24 Gene

genes like me logo Genes that share paralogs with DDX24: view

No data available for Paralogs for DDX24 Gene

Variants for DDX24 Gene

Sequence variations from dbSNP and Humsavar for DDX24 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000081904 -- 94,074,053(+) AAAAA(A/G)AAAAG intron-variant
rs1000147075 -- 94,075,352(+) CCACA(C/T)CTATA intron-variant
rs1000176612 -- 94,058,424(+) ACATA(C/T)CCAAT intron-variant
rs1000202291 -- 94,068,628(+) CCTCA(A/G)TAAAT intron-variant
rs1000250016 -- 94,079,754(+) TGAAA(A/G)GGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DDX24 Gene

Variant ID Type Subtype PubMed ID
esv3635373 CNV gain 21293372
esv3581391 CNV loss 25503493
esv34067 CNV loss 18971310

Variation tolerance for DDX24 Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX24 Gene

Human Gene Mutation Database (HGMD)
DDX24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX24 Gene

Disorders for DDX24 Gene

Relevant External Links for DDX24

Human Genome Epidemiology (HuGE) Navigator
DDX24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX24

No disorders were found for DDX24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX24 Gene

Publications for DDX24 Gene

  1. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. (PMID: 10936056) Zhao Y … Zhao S (Genomics 2000) 2 3 4 60
  2. The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. (PMID: 18289627) Ma J … Liang C (Virology 2008) 2 3 60
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for DDX24 Gene

Sources for DDX24 Gene

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