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DDX24 Gene

protein-coding   GIFtS: 57
GCID: GC14M094517

DEAD (Asp-Glu-Ala-Asp) Box Helicase 24

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24, DEAD (Asp-Glu-Ala-Asp)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 241 2     ATP-Dependent RNA Helicase DDX242
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 241 2     S. Cerevisiae CHL1-Like Helicase2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 241 2     EC 3.6.4.133
DEAD Box Protein 242 3     EC 3.6.18

External Ids:    HGNC: 132661   Entrez Gene: 570622   Ensembl: ENSG000000897377   OMIM: 6061815   UniProtKB: Q9GZR73   

Export aliases for DDX24 gene to outside databases

Previous GC identifers: GC14M092024 GC14M088333 GC14M092507 GC14M093587 GC14M074697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX24 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of
the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DDX24 Gene:
DDX24 (DEAD (Asp-Glu-Ala-Asp) box helicase 24) is a protein-coding gene. Diseases associated with DDX24 include hepatitis b, and hiv-1. GO annotations related to this gene include RNA helicase activity and RNA binding.

UniProtKB/Swiss-Prot: DDX24_HUMAN, Q9GZR7
Function: ATP-dependent RNA helicase (Potential)

Gene Wiki entry for DDX24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  NT_187601.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX24 gene promoter:
         HOXA9B   HOXA9   STAT1   CUTL1   Tal-1beta   LCR-F1   E47   c-Rel   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX24 promoter sequence
   Search Chromatin IP Primers for DDX24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32

DDX24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX24 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M094517:  view genomic region     (about GC identifiers)

Start:
94,517,266 bp from pter      End:
94,547,591 bp from pter
Size:
30,326 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DDX24_HUMAN, Q9GZR7 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX24  
Size: 859 amino acids; 96332 Da
Secondary accessions: E7EMJ4 Q4V9L5
Alternative splicing: 2 isoforms:  Q9GZR7-1   Q9GZR7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX24: NX_Q9GZR7

Explore proteomics data for DDX24 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys195, Lys429, Lys541, Lys601
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX24 (Q9GZR7) (see all 13)
     TPTRELA  TRELAVQ  LVFANSI  VATPGRL 


    See DDX24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065147.1  
    ENSEMBL proteins: 
     ENSP00000328690   ENSP00000440623   ENSP00000452145  

    DDX24 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DDX24
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    Novus Biologicals DDX24 Proteins
    Novus Biologicals DDX24 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX24

    DDX24 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q9GZR7

    ProtoNet protein and cluster: Q9GZR7

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX24_HUMAN, Q9GZR7
    Similarity: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX24_HUMAN, Q9GZR7
    Function: ATP-dependent RNA helicase (Potential)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003724RNA helicase activity NAS10936056
    GO:0004004ATP-dependent RNA helicase activity ----
    GO:0004386helicase activity ----
         
    DDX24 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX24:
     Decreased TP53 protein express  Nuclear 60S biogenesis defects 

         1 MGI phenotypic allele for Ddx24 (no phenotypes)

    DDX24 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX24
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX24

    miRNA
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    miRTarBase miRNAs that target DDX24:
    hsa-mir-505-5p (MIRT037975), hsa-mir-769-5p (MIRT039208), hsa-mir-34a-5p (MIRT025483), hsa-mir-423-5p (MIRT038160), hsa-mir-744-5p (MIRT037565)

    Block miRNA regulation of human, mouse, rat DDX24 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DDX24:
    hsa-miR-550b hsa-miR-3919 hsa-miR-3925-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDX24 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX24

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DDX24 (see all 6)
    OriGene ORF clones in mouse, rat for DDX24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX24 (NM_020414)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX24

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ----

    DDX24 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX24
    Interactions:

        Search GeneGlobe Interaction Network for DDX24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX24 (Q9GZR72, 3 ENSP000003286904) via UniProtKB, MINT, STRING, and/or I2D (see all 251)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IDO1P149022, 3, ENSP000002535134MINT-65410 I2D: score=5 STRING: ENSP00000253513
    MRPL4Q9BYD32, 3, ENSP000002530994MINT-65430 I2D: score=4 STRING: ENSP00000253099
    RAE1P784062, 3, ENSP000003602864MINT-65413 I2D: score=4 STRING: ENSP00000360286
    BCS1LQ9Y2762, 3MINT-65427 I2D: score=5 
    EIF3EP602282, 3MINT-65412 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016070RNA metabolic process NAS10936056

    DDX24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX24



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DDX24 gene: 
    NM_020414.3  

    Unigene Cluster for DDX24:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
    Hs.510328  [show with all ESTs]
    Unigene Representative Sequence: BX537533
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555762 ENST00000553400 ENST00000553451 ENST00000330836(uc001ycj.3 uc010twq.2 uc010twr.2)
    ENST00000544005 ENST00000555054 ENST00000556635 ENST00000555324
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDX24 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DDX24:
    hsa-miR-550b hsa-miR-3919 hsa-miR-3925-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDX24 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DDX24
    Predesigned siRNA for gene silencing in human, mouse, rat DDX24
    Clone
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    OriGene clones in human, mouse for DDX24 (see all 6)
    OriGene ORF clones in mouse, rat for DDX24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX24 (NM_020414)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX24
    Primer
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    OriGene qPCR primer pairs and template standards for DDX24
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX24
      QuantiTect SYBR Green Assays in human, mouse, rat DDX24
      QuantiFast Probe-based Assays in human, mouse, rat DDX24

    Additional mRNA sequence: 

    AB209382.1 AF134475.1 AF145022.1 AF161446.1 AF214731.1 AK025162.1 AK294613.1 AK296726.1 
    AK297232.1 AK304504.1 AL136886.1 BC000778.2 BC008847.2 BC009406.2 BC096826.1 BX537533.1 

    Selected DOTS entries (see all 37):

    DT.100045283  DT.40194546  DT.100805292  DT.95158971  DT.100881341  DT.100881334  DT.120774513  DT.87010521 
    DT.120774532  DT.120774567  DT.95278831  DT.95278807  DT.100881333  DT.120774578  DT.92460644  DT.100045281 
    DT.120774500  DT.120774541  DT.120774558  DT.75148906  DT.87079269  DT.95278842  DT.100638833  DT.100881342 

    Selected AceView cDNA sequences (see all 1050):

    BQ181938 BX093378 BU553663 BQ688161 BM833868 BM423944 BQ721394 BQ065898 
    CB125731 BQ064384 BQ940033 BQ878442 BP336788 AI265911 BQ678106 BQ065584 
    BU174036 BU168872 BU956610 CO249395 BQ898154 CA429668 BQ220964 BM756048 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX24 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                                                                                              -           -                     
    SP2:                                                                                                              -           -                     
    SP3:                                                                                                                                                
    SP4:                                      -     -                                                                                                   
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for DDX24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX24 expression in normal human tissues (normalized intensities)      DDX24 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTTGCA
    DDX24 Expression
    About this image


    DDX24 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    DDX24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510328

    UniProtKB/Swiss-Prot: DDX24_HUMAN, Q9GZR7
    Tissue specificity: Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small
    intestine

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    QuantiFast Probe-based Assays in human, mouse, rat DDX24
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDX24 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx241 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 241, 5 81.75(n)1
    79.6(a)1
      12 (52.92 cM)5
    272251  NM_001159502.11  NP_001152974.11 
     1034079765 
    chicken
    (Gallus gallus)
    Aves DDX241 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 63.01(n)
    62.4(a)
      423429  XM_421338.4  XP_421338.3 
    lizard
    (Anolis carolinensis)
    Reptilia DDX246
    DEAD (Asp-Glu-Ala-Asp) box helicase 24
    59(a)
    1 ↔ 1
    1(10295412-10313224)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984462 similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide more 73.88(n)    BC043900.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5534621 uncharacterized LOC553462 62.3(n)
    61.07(a)
      553462  XM_005169906.1  XP_005169963.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91431 , 3 ATP dependent RNA helicase3
    CG91431
    48(a)3
    57.41(n)1
    50.99(a)1
      372961  NM_137623.21  NP_611467.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F55F8.21 F55F8.2 50.53(n)
    44.34(a)
      172223  NM_059251.3  NP_491652.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAK5(YBR142W)4 Essential nucleolar protein, putative DEAD-box RNA more   --   2(528317-530638) 852439  NP_009700.1 


    ENSEMBL Gene Tree for DDX24 (if available)
    TreeFam Gene Tree for DDX24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX24 gene
    4 SIMAP similar genes for DDX24 using alignment to 3 protein entries:     DDX24_HUMAN (see all proteins):
    DDX56    MST162    DDX47    E4-DBP

    DDX24 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DDX24
    PGOHUM00000263156


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX24 (see all 688)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs601630251,2
    C--75513005(+) TGTTT-/CTTTTAG 1 -- int11Minor allele frequency- CT:0.00NA 2
    rs118491011,2
    C,F,H--94517242(+) AAAAAA/GAAAAA 1 -- ds50011Minor allele frequency- G:0.19WA 118
    rs49051501,2
    C--94517258(+) GGATGA/CCACAA 1 -- ds50012Minor allele frequency- C:0.00NA 4
    rs1468795731,2
    C--94517305(+) TTTAAC/TACACA 1 -- ut310--------
    rs1907270671,2
    --94517314(+) CAAGAA/GGCCTA 1 -- ut310--------
    rs802715961,2
    C,F--94517348(+) TAAGCT/CGCTGC 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1817276971,2
    C--94517514(+) ATGTGC/TAGTCA 1 -- ut310--------
    rs1995991131,2
    C--94517538(-) AAATTA/CACTGG 2 * S --0--------
    rs617442651,2
    F--94517543(+) TAATTT/CGCACT 2 /A syn11Minor allele frequency- C:0.04NS 66
    rs1118125161,2
    C,F--94517561(+) GGCTGT/CGGCTG 2 /P syn12Minor allele frequency- C:0.00CSA NA 4519

    HapMap Linkage Disequilibrium report for DDX24 (94517266 - 94547591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDX24:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34067CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX24
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606181    OMIM disorders: --

    6 diseases for DDX24:    About MalaCards
    hepatitis b    hiv-1    hepatitis    multiple myeloma
    myeloma    malaria


    DDX24 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: DDX24 (1 document)

    Export disorders for DDX24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX24 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with DDX24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-box proteins, and mapping DDX24 to human chromosome 14q32. (PubMed id 10936056)1, 2, 3 Zhao Y.... Zhao S. (Genomics 2000)
    2. The requirement of the DEAD-box protein DDX24 for the packaging of human immunodeficiency virus type 1 RNA. (PubMed id 18289627)1, 3 Ma J....Liang C. (Virology 2008)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57062 HGNC: 13266 AceView: DDX24 Ensembl:ENSG00000089737 euGenes: HUgn57062
    ECgene: DDX24 H-InvDB: DDX24

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX24 gene:
    Search GeneIP for patents involving DDX24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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