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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DDX23 Gene

protein-coding GIFtS: 57
GCID: GC12M049223

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

(Previous names: PRP28 homolog, yeast )

Explore 7 diseases affiliated with
DDX23 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 23¹ ²		Probable ATP-Dependent RNA Helicase DDX23²
PRPF28¹ ²		PRP28p Homolog²
U5-100K¹ ²		U5 SnRNP 100 KD Protein²
Prp28¹		EC 3.6.4.13³
PRP28 Homolog, Yeast¹ ²		U5-100kD³
100 KDa U5 SnRNP-Specific Protein² ³		PRP28 Homolog³
DEAD Box Protein 23² ³		PRP28⁵
U5-100KD²		EC 3.6.1⁸

External Ids:	HGNC: 17347¹	Entrez Gene: 9416²	Ensembl: ENSG00000174243⁷	OMIM: 612172⁵	UniProtKB: Q9BUQ8³

Export aliases for DDX23 gene to outside databases

Previous GC identifers: GC12M048940 GC12M047509 GC12M046256

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDX23:

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif

Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving

alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and

ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to

be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a

component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA

splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has

not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DDX23_HUMAN, Q9BUQ8

Function: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex

formation

Gene Wiki entry for DDX23

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DDX23 gene promoter:
NF-YA Egr-4 NF-YB POU2F1 CBF-A CBF-B CP1A POU2F1c NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX23 promoter sequence

Search SABiosciences Chromatin IP Primers for DDX23

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX23

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.11

DDX23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX23 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M049223: view genomic region (about GC identifiers)

Start:	49,223,539 bp from pter	End:	49,246,625 bp from pter
Size:	23,087 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DDX23_HUMAN, Q9BUQ8 (See protein sequence)

Recommended Name: Probable ATP-dependent RNA helicase DDX23

Size: 820 amino acids; 95583 Da

Subunit: The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and

U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH,

NHP2L1, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4

Subcellular location: Nucleus

Secondary accessions: B2R600 O43188

Explore the universe of human proteins at neXtProt for DDX23: NX_Q9BUQ8

Post-translational modifications:

In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase. Phosphorylated by SRPK2 and this

phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and

subsequent spliceosomal B complex formation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BUQ8

4/15 DME Specific Peptides for DDX23 (Q9BUQ8) (see all 15)

TPGRLID

GRTGRAG

VIATPGR

LAPTREL

DDX23 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004809.2

ENSEMBL proteins:

ENSP00000449657 ENSP00000310723 ENSP00000448542 ENSP00000446770 ENSP00000449639

ENSP00000446948

Reactome Protein details: Q9BUQ8
Human Recombinant Protein Products for DDX23:

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	Novus Biologicals DDX23 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DDX23

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005682	U5 snRNP	IDA	9539711
GO:0005730	NOT nucleolus	IDA	--
GO:0005739	mitochondrion	IDA	--

DDX23 for ontologies About GeneDecksing

DDX23 Antibody Products:

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	Uscn Antibodies for DDX23
	ThermoFisher Antibody for DDX23

Assay Products for DDX23:

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	Uscn ELISAs and CLIAs for DDX23

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DDX23 for domains About GeneDecksing

5 InterPro domains/families:

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

IPR014014 RNA_helicase_DEAD_Q_motif

IPR000629 RNA-helicase_DEAD-box_CS

IPR014001 Helicase_ATP-bd

IPR001650 Helicase_C

Graphical View of Domain Structure for InterPro Entry Q9BUQ8

ProtoNet protein and cluster: Q9BUQ8

1 Blocks protein family: IPB000629 ATP-dependent helicase

UniProtKB/Swiss-Prot: DDX23_HUMAN, Q9BUQ8

Similarity: Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DDX23_HUMAN, Q9BUQ8

Function: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex

formation

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004004	ATP-dependent RNA helicase activity	TAS	9409622
GO:0004386	helicase activity	--	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

DDX23 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DDX23:

Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DDX23

miRNA Products:		OriGene 3'-UTR Clone: DDX23 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX23
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX23:
		hsa-miR-186* hsa-miR-3065-3p hsa-miR-622 hsa-miR-589* hsa-miR-570 hsa-miR-942 hsa-miR-4330 hsa-miR-3919

		SwitchGear 3'UTR luciferase reporter plasmid: DDX23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX23 (see all 7) OriGene shRNA RFP: DDX23 OriGene siRNA: DDX23
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX23
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DDX23
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX23

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA Splicing - Minor Pathway	0.40
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for DDX23 (see all 6)

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	mRNA Splicing - Minor Pathway

1 Kegg Pathway (Kegg details for DDX23):

Spliceosome

DDX23 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DDX23

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/646 Interacting proteins for DDX23 (Q9BUQ8^{2, 3} ENSP00000310723⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 646)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000354	cis assembly of pre-catalytic spliceosome	IC	9539711
GO:0000375	RNA splicing, via transesterification reactions	TAS	9409622
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--

DDX23 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DDX23
Search CenterWatch for drugs/clinical trials and news about DDX23

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DDX23 gene:

NM_004818.2

Unigene Cluster for DDX23:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Hs.130098 [show with all ESTs]

Unigene Representative Sequence: NM_004818

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000550834 ENST00000308025(uc001rsm.3) ENST00000551331 ENST00000549795

ENST00000547842 ENST00000552802 ENST00000547290 ENST00000553065 ENST00000547135

ENST00000547165 ENST00000552069 ENST00000551189 ENST00000553182 ENST00000551098

ENST00000552512 ENST00000552369 ENST00000551468 ENST00000552555

miRNA Products:		OriGene 3'-UTR Clone: DDX23 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX23
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX23:
		hsa-miR-186* hsa-miR-3065-3p hsa-miR-622 hsa-miR-589* hsa-miR-570 hsa-miR-942 hsa-miR-4330 hsa-miR-3919

		SwitchGear 3'UTR luciferase reporter plasmid: DDX23 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX23 (see all 7) OriGene shRNA RFP: DDX23 OriGene siRNA: DDX23
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		Sirion Biotech Custom design and validation of potent shRNA sequences against DDX23

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Additional cDNA sequence:

AF026402.1 AK128428.1 AK292921.1 AK294877.1 AK312379.1 BC002366.2

22 DOTS entries:

DT.40285691 DT.95328987 DT.100789693 DT.97782679 DT.121145776 DT.121145804 DT.100029819 DT.100774710

DT.121145764 DT.92447995 DT.218939 DT.100789690 DT.100789692 DT.121145798 DT.91952335 DT.100029820

DT.100703072 DT.121145793 DT.218942 DT.95241762 DT.97765233 DT.75182618

4 AceView cDNA sequences:

AK128428 NM_004818 BC002366 AF026402

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DDX23 (see all 13) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^
SP1:									-								-										-																								-
SP2:									-						-		-		-								-																								-
SP3:									-								-										-								-		-
SP4:			-		-		-		-								-										-
SP5:																	-

ExUns:	16	^	17a	·	17b	^	18a	·	18b	^	19a	·	19b	^	20a	·	20b	^	21a	·	21b
SP1:							-						-
SP2:							-						-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DDX23

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DDX23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATTAAGA

About this image
See DDX23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX23

SOURCE GeneReport for Unigene cluster: Hs.130098
SABiosciences Custom PCR Arrays for DDX23

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX23 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX23 gene from 8/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DDX23¹	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	82.66(n) 99.24(a)		100858001 XM_003643448.1 XP_003643496.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	98(a) 91(a)	1 ↔ many 1 ↔ many	2(94321965-94325837) 2(94311518-94320268)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24773²	Xenopus laevis transcribed sequence with strong similarity more	79.82(n)		BJ042526.1
zebrafish (Danio rerio)	Actinopterygii	wufi39b12²	wufi39b12	74.33(n)		334283 BC060524.1
fruit fly (Drosophila melanogaster)	Insecta	CG10333¹	CG10333	63.43(n) 67.55(a)		35112 NM_136044.2 NP_609888.2
worm (Caenorhabditis elegans)	Secernentea	ddx-23¹	Protein DDX-23	60.29(n) 63.97(a)		175818 NM_065859.3 NP_498260.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G33730¹	DEAD-box ATP-dependent RNA helicase 21	55.5(n) 54.17(a)		817938 NM_128931.2 NP_180929.1
rice (Oryza sativa)	Liliopsida	Os.3228²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	75.33(n)		AK069199.1

ENSEMBL Gene Tree for DDX23 (if available)
TreeFam Gene Tree for DDX23 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DDX23 gene

ARGLU1²

12 SIMAP similar genes for DDX23 using alignment to 6 protein entries: DDX23_HUMAN (see all proteins):

DDX56 SH2B3 ATL2 DDX5 DDX41 TUBA1C

BAT1 DDX39B DDX43 EIF4A2 DDX6 DDX46

DDX23 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DDX23
PGOHUM00000239785

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188348734^1,2		--	49223440(+)	`TTCTCC/TTAATG`	1	--	ds500¹		0	--	--	--	--
rs138460113^1,2	C	--	49223452(+)	`GGCTG-/TCTCTCA`	1	--	ds500¹		0	--	--	--	--
rs17123349^1,2	C,F	--	49223541(+)	`ATCTAA/GCAGTC`	1	--	ut3¹		7		NA	264
rs150677223^1,2		--	49223550(+)	`TCTTAA/GTATTC`	1	--	ut3¹		0	--	--	--	--
rs114420242^1,2	F	--	49223649(+)	`TTCACC/TGTGTC`	1	--	ut3¹		1		WA	118
rs11551273^1,2	C	--	49223678(+)	`ATCCCC/TTGGGG`	1	--	ut3¹		3		NA CSA WA	122
rs77301571^1,2	C	--	49223681(+)	`CCCTGG/AGGGAG`	1	--	ut3¹		2		WA	120
rs145620140^1,2	C	--	49223696(+)	`GCCTA-/GGAGCA`	1	--	ut3¹		0	--	--	--	--
rs7164^1,2	C,F,A,H	--	49223719(-)	`GCCCCG/ACACCA`	1	--	ut3¹ ese³		29		MN EA NS NA CSA WA	4651
rs140121807^1,2		--	49223725(+)	`GGGGCC/TGTGCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DDX23 (49223539 - 49246625 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DDX23: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DDX23 for disorders           About GeneDecksing

OMIM gene information: 612172    OMIM disorders: --

7 diseases for DDX23:    About MalaCards

distal hereditary motor neuropathy distal hereditary motor neuropathy, type ii neuropathy pneumonia

tuberculosis malaria mycobacterium tuberculosis

Export disorders for DDX23 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DDX23 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with DDX23)

Utopia: connect your pdf to the dynamic
world of online information

The human U5 snRNP-specific 100-kD protein is an RS domain- containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p. (PubMed id 9409622)^{1, 2, 3, 9} Teigelkamp S.... Luehrmann R. (1997)
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. (PubMed id 18425142)^{1, 2, 9} Mathew R....Luhrmann R. (2008)
The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro. (PubMed id 9539711)^{1, 3, 9} Laggerbauer B.... Luehrmann R. (1998)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{1, 2} Jurica M.S.... Moore M.J. (2002)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. (PubMed id 22446626)¹ Close P.... Svejstrup J.Q. (2012)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9416	HGNC: 17347	AceView: DDX23	Ensembl:ENSG00000174243	euGenes: HUgn9416
ECgene: DDX23	Kegg: 9416	H-InvDB: DDX23

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DDX23	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DDX23 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DDX23 gene:
Search GeneIP for patents involving DDX23

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

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DDX23 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

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