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Aliases for DDX23 Gene

Aliases for DDX23 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 23 2 3
  • 100 KDa U5 SnRNP-Specific Protein 3 4
  • PRP28 Homolog, Yeast 2 3
  • DEAD Box Protein 23 3 4
  • U5-100KD 3 4
  • Prp28 3 6
  • Probable ATP-Dependent RNA Helicase DDX23 3
  • U5 SnRNP 100 KD Protein 3
  • PRP28p Homolog 3
  • PRP28 Homolog 4
  • EC 4
  • SNRNP100 3
  • EC 3.6.1 63
  • U5-100K 3
  • PRPF28 3

External Ids for DDX23 Gene

Previous GeneCards Identifiers for DDX23 Gene

  • GC12M048940
  • GC12M047509
  • GC12M049223
  • GC12M046256

Summaries for DDX23 Gene

Entrez Gene Summary for DDX23 Gene

  • This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX23 Gene

DDX23 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 23) is a Protein Coding gene. Diseases associated with DDX23 include distal hereditary motor neuropathy, type ii. Among its related pathways are Gene Expression and Spliceosome. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX59.

UniProtKB/Swiss-Prot for DDX23 Gene

  • Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation.

Gene Wiki entry for DDX23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX23 Gene

Genomics for DDX23 Gene

Regulatory Elements for DDX23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX23 Gene

48,829,756 bp from pter
48,852,842 bp from pter
23,087 bases
Minus strand

Genomic View for DDX23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX23 Gene

Proteins for DDX23 Gene

  • Protein details for DDX23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ATP-dependent RNA helicase DDX23
    Protein Accession:
    Secondary Accessions:
    • B2R600
    • B4DH15
    • O43188

    Protein attributes for DDX23 Gene

    820 amino acids
    Molecular mass:
    95583 Da
    Quaternary structure:
    • The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4.

    Three dimensional structures from OCA and Proteopedia for DDX23 Gene

    Alternative splice isoforms for DDX23 Gene


neXtProt entry for DDX23 Gene

Proteomics data for DDX23 Gene at MOPED

Post-translational modifications for DDX23 Gene

  • In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase. Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX23 Gene

Antibody Products

Domains for DDX23 Gene

Gene Families for DDX23 Gene

Suggested Antigen Peptide Sequences for DDX23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
genes like me logo Genes that share domains with DDX23: view

Function for DDX23 Gene

Molecular function for DDX23 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation.

Enzyme Numbers (IUBMB) for DDX23 Gene

Gene Ontology (GO) - Molecular Function for DDX23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity TAS 9409622
GO:0005515 protein binding IPI 20858735
GO:0005524 ATP binding IEA --
GO:0008026 NOT ATP-dependent helicase activity IDA 9539711
genes like me logo Genes that share ontologies with DDX23: view

Phenotypes for DDX23 Gene

genes like me logo Genes that share phenotypes with DDX23: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX23 Gene

Localization for DDX23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX23 Gene

Subcellular locations from

Jensen Localization Image for DDX23 Gene COMPARTMENTS Subcellular localization image for DDX23 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for DDX23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005682 U5 snRNP IDA 9539711
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with DDX23: view

Pathways for DDX23 Gene

genes like me logo Genes that share pathways with DDX23: view

Pathways by source for DDX23 Gene

Gene Ontology (GO) - Biological Process for DDX23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000354 cis assembly of pre-catalytic spliceosome IC 9539711
GO:0000375 RNA splicing, via transesterification reactions TAS 9409622
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with DDX23: view

Drugs for DDX23 Gene

(4) HMDB Compounds for DDX23 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Dihydrogen oxide
genes like me logo Genes that share compounds with DDX23: view

Transcripts for DDX23 Gene

mRNA/cDNA for DDX23 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDX23 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX23

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX23 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7: - - -
SP9: -
SP10: -

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b
SP1: - -
SP2: - -
SP12: -
SP13: -

Relevant External Links for DDX23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX23 Gene

mRNA expression in normal human tissues for DDX23 Gene

Protein differential expression in normal tissues for DDX23 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.1) and CD8 Tcells (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX23 Gene

SOURCE GeneReport for Unigene cluster for DDX23 Gene Hs.130098

genes like me logo Genes that share expressions with DDX23: view

Expression partners for DDX23 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX23 Gene

Orthologs for DDX23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX23 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDX23 35
  • 92.97 (n)
  • 99.39 (a)
DDX23 36
  • 99 (a)
(Canis familiaris)
Mammalia DDX23 35
  • 94.02 (n)
  • 99.63 (a)
DDX23 36
  • 100 (a)
(Mus musculus)
Mammalia Ddx23 35
  • 90.96 (n)
  • 98.66 (a)
Ddx23 16
Ddx23 36
  • 99 (a)
(Pan troglodytes)
Mammalia DDX23 35
  • 99.63 (n)
  • 99.88 (a)
DDX23 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddx23 35
  • 90.92 (n)
  • 98.66 (a)
(Monodelphis domestica)
Mammalia DDX23 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
-- 36
  • 100 (a)
-- 36
  • 91 (a)
-- 36
  • 87 (a)
(Gallus gallus)
Aves DDX23 35
  • 82.49 (n)
  • 98.99 (a)
-- 36
  • 98 (a)
-- 36
  • 98 (a)
(Anolis carolinensis)
Reptilia DDX23 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24773 35
(Danio rerio)
Actinopterygii ddx23 35
  • 77.13 (n)
  • 88.9 (a)
wufi39b12 35
ddx23 36
  • 85 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007825 35
  • 54.6 (n)
  • 50.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10333 35
  • 64.86 (n)
  • 70.38 (a)
CG10333 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea ddx-23 35
  • 62.75 (n)
  • 67.88 (a)
ddx-23 36
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP28 36
  • 38 (a)
PRP28 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G33730 35
  • 57.38 (n)
  • 56.79 (a)
(Glycine max)
eudicotyledons Gma.3548 35
(Hordeum vulgare)
Liliopsida Hv.2391 35
(Oryza sativa)
Liliopsida Os.3228 35
Os03g0708600 35
  • 57.69 (n)
  • 54.58 (a)
(Triticum aestivum)
Liliopsida Ta.3307 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11344 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02803 35
  • 57.78 (n)
  • 57.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp28 35
  • 53.22 (n)
  • 50.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
Species with no ortholog for DDX23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for DDX23 Gene

Gene Tree for DDX23 (if available)
Gene Tree for DDX23 (if available)

Paralogs for DDX23 Gene

Paralogs for DDX23 Gene

(11) SIMAP similar genes for DDX23 Gene using alignment to 6 proteins: Pseudogenes for DDX23 Gene

genes like me logo Genes that share paralogs with DDX23: view

Variants for DDX23 Gene

Sequence variations from dbSNP and Humsavar for DDX23 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7164 -- 48,829,936(-) GCCCC(A/G)CACCA utr-variant-3-prime
rs11533 -- 48,829,985(-) TTCCT(G/T)TTTGG utr-variant-3-prime
rs1057907 -- 48,836,979(-) TTGAC(C/T)TCAAG reference, missense
rs1057908 -- 48,836,252(-) CCTAT(A/C)CAGCG reference, synonymous-codon
rs2270578 -- 48,832,241(+) TGAAA(C/T)GCCCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DDX23 Gene

Variant ID Type Subtype PubMed ID
nsv826363 CNV Gain 20364138

Relevant External Links for DDX23 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX23 Gene

Disorders for DDX23 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DDX23 Gene in MalaCards »

(1) Disease for DDX23 Gene

genes like me logo Genes that share disorders with DDX23: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DDX23 Gene

Publications for DDX23 Gene

  1. The human U5 snRNP-specific 100-kD protein is an RS domain- containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p. (PMID: 9409622) Teigelkamp S. … Luehrmann R. (RNA 1997) 2 3 4 23
  2. The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro. (PMID: 9539711) Laggerbauer B. … Luehrmann R. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 23
  3. Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. (PMID: 18425142) Mathew R. … Luehrmann R. (Nat. Struct. Mol. Biol. 2008) 3 4 23
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DDX23 Gene

Sources for DDX23 Gene

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