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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX21 Gene

protein-coding   GIFtS: 57
GCID: GC10P070715

DEAD (Asp-Glu-Ala-Asp) Box Helicase 21

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21, DEAD (Asp-Glu-Ala-Asp)...)
Microbiology & Infectious Diseases Congress
  4 related diseases
at
MalaCards
 

Aliases
for DDX21 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 211 2     RH-II/GU2
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 211 2     RH-II/GuA2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 211 2     Gu Protein2
Nucleolar RNA Helicase Gu2 3     gu-alpha2
Nucleolar RNA Helicase II2 3     Nucleolar RNA Helicase 22
DEAD Box Protein 212 3     RNA Helicase II/Gu Alpha2
RH II/Gu2 3     EC 3.6.4.133
GUA2     Gu-alpha3
GURDB2     EC 3.6.18

External Ids:    HGNC: 27441   Entrez Gene: 91882   Ensembl: ENSG000001657327   OMIM: 6063575   UniProtKB: Q9NR303   

Export aliases for DDX21 gene to outside databases

Previous GC identifers: GC10P069527 GC10P069802 GC10P070608 GC10P070060 GC10P070385 GC10P064717


Summaries
for DDX21 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDX21 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by
autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA,
folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport,
and general transcription. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX21 Gene: 
DDX21 (DEAD (Asp-Glu-Ala-Asp) box helicase 21) is a protein-coding gene. Diseases associated with DDX21 include stomach disease, and pneumonia. GO annotations related to this gene include double-stranded RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX46.

UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30
Function: Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a
single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing

Gene Wiki entry for DDX21 Gene


Genomic Views
for DDX21 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX21 gene promoter:
         ATF-2   STAT5A   HNF-3beta   Ik-3   Evi-1   E47   CRE-BP1   FOXJ2 (long isoform)   Hand1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX21 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21

DDX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX21 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070715:  view genomic region     (about GC identifiers)

Start:
 70,715,884 bp from pter      End:
 70,744,829 bp from pter
Size:
 28,946 bases      Orientation:
 plus strand

Proteins
for DDX21 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30 (See protein sequence)
Recommended Name: Nucleolar RNA helicase 2  
Size: 783 amino acids; 87344 Da
Subunit: Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C,
ERCC6, MYBBP1A and DDX21. Interacts with C1QBP
Subcellular location: Nucleus, nucleolus
Miscellaneous: Autoantibodies against DDX21 are found in patients with watermelon stomach disease, which is
characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon
Sequence caution: Sequence=AAB02546.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DDX21:
2M3D (3D)    
Secondary accessions: B2RDL0 Q13436 Q5VX41 Q68D35
Alternative splicing: 2 isoforms:  Q9NR30-1   Q9NR30-2   

Explore the universe of human proteins at neXtProt for DDX21: NX_Q9NR30

Explore proteomics data for DDX21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NR30

    • 4/16 DME Specific Peptides for DDX21 (Q9NR30) (see all 16)
     LAPTREL  NGKLDLT  VGTPGRI  APTRELA 

    DDX21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDX21 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243839.1  NP_004719.2  

    ENSEMBL proteins: 
     ENSP00000346120  

    Human Recombinant Protein Products for DDX21: 
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    Novus Biologicals DDX21 Protein
    Novus Biologicals DDX21 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX21 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    DDX21 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for DDX21 
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    Protein Domains /
    Families
    for DDX21 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    DDX: DEAD-boxes

    5/6 InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR012562 GUCT
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q9NR30

    ProtoNet protein and cluster: Q9NR30

    2 Blocks protein domains:
    IPB000629 ATP-dependent helicase
    IPB012562 GUCT


    UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30
    Domain: The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the
    foldase in the C-terminus
    Domain: The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity)
    Similarity: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX21 for domains           About GeneDecksing


    Function
    for DDX21 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX21_HUMAN, Q9NR30
    Function: Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a
    single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IEA--
    GO:0004004ATP-dependent RNA helicase activity TAS8614622
         
    DDX21 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX21:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDX21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX21 

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX21:
    hsa-miR-141* hsa-miR-642a hsa-miR-607 hsa-miR-3185 hsa-miR-16-1* hsa-miR-518f* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: DDX21 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DDX21

    Clone
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    OriGene clones in human, mouse for DDX21 (see all 7)
    OriGene ORF clones in mouse, rat for DDX21
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX21
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                         Customized lentivirus expression plasmids for stable overexpression of DDX21 

    Cell Line
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    Search LifeMap BioReagents cell lines for DDX21
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX21


    Pathways & Interactions
    for DDX21 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDX21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/762 Interacting proteins for DDX21 (Q9NR302, 3 ENSP000003461204) via UniProtKB, MINT, STRING, and/or I2D (see all 762)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054122, 3, ENSP000003602664MINT-14075 MINT-14076 MINT-14077 I2D: score=4 STRING: ENSP00000360266
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-8395092 I2D: score=2 STRING: ENSP00000356520
    PRPF8Q6P2Q92, 3, ENSP000003043504MINT-7945693 MINT-8395092 I2D: score=2 STRING: ENSP00000304350
    HNRNPCP079102, 3, ENSP000003196904MINT-7945693 I2D: score=2 STRING: ENSP00000319690
    NFKB2Q006532, 3, ENSP000001894444MINT-48717 I2D: score=2 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009615response to virus IEA--
    GO:0043330response to exogenous dsRNA IEA--

    DDX21 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDX21 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX21

    Search CenterWatch for drugs/clinical trials and news about DDX21

    Transcripts
    for DDX21 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDX21 gene (2 alternative transcripts): 
    NM_001256910.1  NM_004728.3  

    Unigene Cluster for DDX21:

    DEAD (Asp-Glu-Ala-Asp) box helicase 21
    Hs.223141  [show with all ESTs]
    Unigene Representative Sequence: NM_001256910
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000354185(uc001jov.1 uc001jow.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX21:
    hsa-miR-141* hsa-miR-642a hsa-miR-607 hsa-miR-3185 hsa-miR-16-1* hsa-miR-518f* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: DDX21 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DDX21
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX21
    Clone
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    OriGene ORF clones in mouse, rat for DDX21
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    GenScript: all cDNA clones in your preferred vector: DDX21 (NM_004728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX21
    Sirion Biotech Customized lentivirus for stable overexpression of DDX21 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX21

    Additional mRNA sequence: 

    AB062394.1 AK025629.1 AK315585.1 BC004182.2 BC008071.2 BC009432.1 BC017228.2 BC104671.1 
    BX648405.1 CR749598.1 U41387.1 

    22 DOTS entries:

    DT.75163013  DT.92462688  DT.101977114  DT.100743879  DT.100868338  DT.95333220  DT.121226053  DT.95159396 
    DT.87017380  DT.92462656  DT.100663550  DT.102832789  DT.102845384  DT.121226072  DT.91743672  DT.95159395 
    DT.95159397  DT.95234063  DT.95360926  DT.121226087  DT.92462660  DT.97795373 

    24/650 AceView cDNA sequences (see all 650):

    CB130412 BE674775 AA125774 CA503389 CR620487 BM796291 BM698415 BU688170 
    BQ425141 BE263173 BM474854 CN485005 BU184553 BM803096 CB136117 AU132711 
    BM834296 CB132612 BU633042 BP359164 H22098 BP335974 BP344932 BM551348 

    GeneLoc Exon Structure


    Expression
    for DDX21 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX21 expression in normal human tissues (normalized intensities)      DDX21 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAAGGTGG
    DDX21 Expression
    About this image


    DDX21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; squamous epithelial cells   

    See DDX21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX21

    SOURCE GeneReport for Unigene cluster: Hs.223141
        SABiosciences Custom PCR Arrays for DDX21
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    In Situ
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    Orthologs
    for DDX21 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX21 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ddx211 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 211, 5 80.66(n)1
    82.41(a)1    		   10 (32.43 cM)5
    562001  NM_019553.21  NP_062426.21 
     625802485 
    chicken
    (Gallus gallus)    		 Aves DDX501 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 70.52(n)
    70.03(a)    		   768898  XM_001232051.2  XP_001232052.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DDX216
    		 DEAD (Asp-Glu-Ala-Asp) box helicase 21
    		 58(a)
    		 1 ↔ 1
    		 GL343215.1(1871445-1926394)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AF302422.12   -- 72.64(n)    AF302422.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CA472805.12   -- 79.2(n)   334078  CA472805.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DBP36
    		 Putative ATP-dependent RNA helicase of the DEAD-bo...
    		 27(a)
    		 1 → many
    		 VII(360288-361859)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PRH751 DEAD-box ATP-dependent RNA helicase 7 49.16(n)
    42.09(a)    		   836340  NM_125613.2  NP_201025.1 
    rice
    (Oryza sativa)    		 Liliopsida NM_186269.12   -- 74.74(n)    NM_186269.1 


    ENSEMBL Gene Tree for DDX21 (if available)
    TreeFam Gene Tree for DDX21 (if available)

    Paralogs
    for DDX21 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX21 gene
    DDX462  DDX502  DDX52  DDX172  DDX422  DDX432  DDX532  
    8 SIMAP similar genes for DDX21 using alignment to 2 protein entries:     DDX21_HUMAN (see all proteins):
    DDX50    DKFZp761E0323    mcdrh    DDX54    EIF4A2    EIF4A1
    EIF4A3    DDX47

    DDX21 for paralogs           About GeneDecksing



    Genomic Variants
    for DDX21 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/629 SNPs in DDX21 are shown (see all 629)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs122614921,2
    		C,A--70713953(+) ggatcA/Gtgagg 1 -- us2k10--------
    rs1906128661,2
    		C--70714593(+) AAAAAG/TTAGCC 2 -- us2k10--------
    rs109985011,2
    		C--70714615(+) CACATA/GCCTGT 2 -- us2k10--------
    rs1129951271,2
    		C,F--70714714(+) TCCACT/CCCAGC 2 -- us2k12Minor allele frequency- C:0.20CSA WA 120
    rs1169851891,2
    		F--70714737(+) GGGAGA/CACCTG 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1828100971,2
    		--70714762(+) AATAGA/GTAAAG 2 -- us2k10--------
    rs1379385261,2
    		--70714774(+) CTGGGC/TGCTGT 2 -- us2k10--------
    rs732683901,2
    		C,F--70714820(+) GAGGCG/AGATGG 2 -- us2k13Minor allele frequency- A:0.17CSA WA NA 240
    rs1417080091,2
    		--70714860(+) CCAGCC/TTGGTG 2 -- us2k10--------
    rs763823351,2
    		C,F--70714945(+) CTACTC/GGGGAG 2 -- us2k13Minor allele frequency- G:0.07CSA NA EA 242

    HapMap Linkage Disequilibrium report for DDX21 (70715884 - 70744829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DDX21:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519999CNV Loss19592680
    nsv831907CNV Gain17160897

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    Disorders / Diseases
    for DDX21 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 606357    OMIM disorders: --

    4 diseases for DDX21:    About MalaCards
    stomach disease    pneumonia    alzheimer's disease    breast cancer


    DDX21 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): DDX21
    Human Genome Epidemiology (HuGE) Navigator: DDX21 (1 document)

    Export disorders for DDX21 gene to outside databases

    Publications
    for DDX21 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX21 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with DDX21)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. (PubMed id 8614622)1, 2, 3 Valdez B.C.... Busch H. (1996)
    2. c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. (PubMed id 18180292)1, 3 Holmstrom T.H....Westermarck J. (2008)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. (PubMed id 14559904)1, 2 Henning D.... Valdez B.C. (2003)
    8. The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun- activated transcription. (PubMed id 11823437)1, 2 Westermarck J.... Bohmann D. (2002)
    9. Human RNA helicase II/Gu gene: genomic organization and promoter analysis. (PubMed id 11237763)1, 2 Zhu K....Busch H. (2001)
    10. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. (PubMed id 11891046)1, 9 Valdez B.C.... Sequitin A.M. (2002)

    External Searches for DDX21 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDX21 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9188 HGNC: 2744 AceView: DDX21 Ensembl:ENSG00000165732 euGenes: HUgn9188
    ECgene: DDX21 H-InvDB: DDX21

    Other Databases showing DDX21 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDX21 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX21 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDX21 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDX21 gene:
    Search GeneIP for patents involving DDX21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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