Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

DDX21 Gene

protein-coding GIFtS: 57
GCID: GC10P070715

DEAD (Asp-Glu-Ala-Asp) Box Helicase 21

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21, DEAD (Asp-Glu-Ala-Asp)...)

See DDX21-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 21¹ ²		RH-II/GU²
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21¹ ²		RH-II/GuA²
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 21¹ ²		Gu Protein²
Nucleolar RNA Helicase Gu² ³		gu-alpha²
Nucleolar RNA Helicase II² ³		Nucleolar RNA Helicase 2²
DEAD Box Protein 21² ³		RNA Helicase II/Gu Alpha²
RH II/Gu² ³		EC 3.6.4.13³
GUA²		Gu-alpha³
GURDB²		EC 3.6.1⁸

External Ids:	HGNC: 2744¹	Entrez Gene: 9188²	Ensembl: ENSG00000165732⁷	OMIM: 606357⁵	UniProtKB: Q9NR30³

Export aliases for DDX21 gene to outside databases

Previous GC identifers: GC10P069527 GC10P069802 GC10P070608 GC10P070060 GC10P070385 GC10P064717

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DDX21 Gene:

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They

are implicated in a number of cellular processes involving alteration of RNA secondary structure such as

translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their

distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,

and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by

autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA,

folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport,

and general transcription. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX21 Gene:

DDX21 (DEAD (Asp-Glu-Ala-Asp) box helicase 21) is a protein-coding gene. Diseases associated with DDX21 include stomach disease. GO annotations related to this gene include double-stranded RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX50.

UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30

Function: Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a

single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing

Gene Wiki entry for DDX21 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000010.10 NC_018921.2 NT_030059.14

Regulatory elements:

Regulatory transcription factor binding sites in the DDX21 gene promoter:
ATF-2 STAT5A HNF-3beta Ik-3 Evi-1 E47 CRE-BP1 FOXJ2 (long isoform) Hand1 FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX21 promoter sequence

Search Chromatin IP Primers for DDX21

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX21

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q21

DDX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX21 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P070715: view genomic region (about GC identifiers)

Start:	70,715,884 bp from pter	End:	70,744,829 bp from pter
Size:	28,946 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30 (See protein sequence)

Recommended Name: Nucleolar RNA helicase 2

Size: 783 amino acids; 87344 Da

Subunit: Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C,

ERCC6, MYBBP1A and DDX21. Interacts with C1QBP

Miscellaneous: Autoantibodies against DDX21 are found in patients with watermelon stomach disease, which is

characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon

Sequence caution: Sequence=AAB02546.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for DDX21:

2M3D (3D)

Secondary accessions: B2RDL0 Q13436 Q5VX41 Q68D35

Alternative splicing: 2 isoforms: Q9NR30-1 Q9NR30-2

Explore the universe of human proteins at neXtProt for DDX21: NX_Q9NR30

Explore proteomics data for DDX21 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for DDX21 (Q9NR30) (see all 16)

LAPTREL

NGKLDLT

VGTPGRI

APTRELA

See DDX21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001243839.1 NP_004719.2

ENSEMBL proteins:

ENSP00000346120

DDX21 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for DDX21 OriGene Protein Over-expression Lysate for DDX21 OriGene MassSpec for DDX21 OriGene Custom Protein Services for DDX21
	GenScript Custom Purified and Recombinant Proteins Services for DDX21
	Novus Biologicals DDX21 Protein Novus Biologicals DDX21 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DDX21
	Search eBioscience for Proteins for DDX21
	antibodies-online proteins for DDX21 (2 products)
	antibodies-online peptides for DDX21

DDX21 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DDX21
	Novus Biologicals DDX21 Antibodies
	Abcam antibodies for DDX21
	Cloud-Clone Corp. Antibodies for DDX21
	ThermoFisher Antibodies for DDX21
	antibodies-online antibodies for DDX21 (25 products)

DDX21 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DDX21
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DDX21
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DDX21 Cloud-Clone Corp. CLIAs for DDX21
	Search eBioscience for ELISAs for DDX21
	antibodies-online kits for DDX21 (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

DDX: DEAD-boxes

Selected InterPro protein domains (see all 6):

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

IPR012562 GUCT

IPR027417 P-loop_NTPase

IPR014014 RNA_helicase_DEAD_Q_motif

IPR014001 Helicase_ATP-bd

Graphical View of Domain Structure for InterPro Entry Q9NR30

ProtoNet protein and cluster: Q9NR30

2 Blocks protein domains:

IPB000629 ATP-dependent helicase

IPB012562 GUCT

UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30

Domain: The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the

foldase in the C-terminus

Domain: The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity)

Similarity: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

Find genes that share domains with DDX21 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: DDX21_HUMAN, Q9NR30

Function: Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a

single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹

Gene Ontology (GO): Selected molecular function terms (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	--	--
GO:0003723	RNA binding	--	--
GO:0003725	double-stranded RNA binding	IEA	--
GO:0004004	ATP-dependent RNA helicase activity	TAS	8614622

Find genes that share ontologies with DDX21 About GenesLikeMe

Phenotypes:
2 GenomeRNAi human phenotypes for DDX21:

Increased S DNA content

Synthetic lethal with Ras

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for DDX21

miRNA Products:		miRTarBase miRNAs that target DDX21: hsa-mir-331-3p (MIRT043386), hsa-mir-29c-3p (MIRT020395), hsa-mir-16-5p (MIRT031736), hsa-mir-423-5p (MIRT038053), hsa-mir-186-5p (MIRT045036), hsa-mir-100-5p (MIRT048581), hsa-mir-877-3p (MIRT036938), hsa-mir-193b-3p (MIRT016482), hsa-mir-222-3p (MIRT046685), hsa-mir-34a-5p (MIRT025491), hsa-let-7b-5p (MIRT032414)

		Block miRNA regulation of human, mouse, rat DDX21 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate DDX21:
		hsa-miR-141* hsa-miR-642a hsa-miR-607 hsa-miR-3185 hsa-miR-16-1* hsa-miR-518f* hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: DDX21 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DDX21
		Predesigned siRNA for gene silencing in human, mouse, rat DDX21

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DDX21

Clone Products:		OriGene clones in human, mouse for DDX21 (see all 7) OriGene ORF clones in mouse, rat for DDX21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DDX21 (NM_004728)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX21

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DDX21
		Browse ESI BIO Cell Lines and PureStem Progenitors for DDX21

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX21

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

DDX21_HUMAN, Q9NR30: Nucleus, nucleolus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
chloroplast	2
cytosol	2
mitochondrion	2

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--

Find genes that share ontologies with DDX21 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DDX21
Interactions:

GeneGlobe Interaction Network for DDX21

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DDX21 (Q9NR30^{2, 3} ENSP00000346120⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 847)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUN	P05412²^,³, ENSP00000360266⁴	MINT-14075 MINT-14076 MINT-14077 I2D: score=4 STRING: ENSP00000360266
DHX9	Q08211²^,³, ENSP00000356520⁴	MINT-7945693 MINT-8395092 I2D: score=2 STRING: ENSP00000356520
PRPF8	Q6P2Q9²^,³, ENSP00000304350⁴	MINT-7945693 MINT-8395092 I2D: score=2 STRING: ENSP00000304350
HNRNPC	P07910²^,³, ENSP00000319690⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000319690
NFKB2	Q00653²^,³, ENSP00000189444⁴	MINT-48717 I2D: score=2 STRING: ENSP00000189444

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006200	ATP catabolic process	TAS	8614622
GO:0009615	response to virus	IEA	--
GO:0043330	response to exogenous dsRNA	IEA	--

Find genes that share ontologies with DDX21 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DDX21

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DDX21 gene (2 alternative transcripts):

NM_001256910.1 NM_004728.3

Unigene Cluster for DDX21:

DEAD (Asp-Glu-Ala-Asp) box helicase 21

Hs.223141 [show with all ESTs]

Unigene Representative Sequence: NM_001256910

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000354185(uc001jov.1 uc001jow.1)

miRNA Products:		Block miRNA regulation of human, mouse, rat DDX21 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate DDX21:
		hsa-miR-141* hsa-miR-642a hsa-miR-607 hsa-miR-3185 hsa-miR-16-1* hsa-miR-518f* hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: DDX21 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DDX21
		Predesigned siRNA for gene silencing in human, mouse, rat DDX21

Clone Products:		OriGene clones in human, mouse for DDX21 (see all 7) OriGene ORF clones in mouse, rat for DDX21 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DDX21 (NM_004728)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX21
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX21

Primer Products:		OriGene qPCR primer pairs and template standards for DDX21 OriGene qSTAR qPCR primer pairs in human, mouse for DDX21
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DDX21
		QuantiTect SYBR Green Assays in human, mouse, rat DDX21
		QuantiFast Probe-based Assays in human, mouse, rat DDX21

Additional mRNA sequence:

AB062394.1 AK025629.1 AK315585.1 BC004182.2 BC008071.2 BC009432.1 BC017228.2 BC104671.1

BX648405.1 CR749598.1 U41387.1

22 DOTS entries:

DT.75163013 DT.92462688 DT.101977114 DT.100743879 DT.100868338 DT.95333220 DT.121226053 DT.95159396

DT.87017380 DT.92462656 DT.100663550 DT.102832789 DT.102845384 DT.121226072 DT.91743672 DT.95159395

DT.95159397 DT.95234063 DT.95360926 DT.121226087 DT.92462660 DT.97795373

Selected AceView cDNA sequences (see all 650):

AI159886 BQ049191 AA736609 BE740684 BU677713 BQ045124 BQ423952 BE328822

CB130412 BE674775 AA125774 BQ642423 AI863719 AI393194 CR611336 BC008071

AI628417 BC009432 CR749598 CB128411 AA724717 CB070143 AI174929 AA713669

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DDX21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TATAAGGTGG

About this image

DDX21 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Brain (Nervous System) fully expand to see all 2 entries
Cerebellum

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Ovary (Reproductive System)
Oviduct

Intermediate Mesoderm (Gastrulation Derivatives)
Mesonephros

Bone (Muscoskeletal System)
Bone Marrow

DDX21 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DDX21 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.223141

Custom PCR Arrays for DDX21

Primer Products:		OriGene qPCR primer pairs and template standards for DDX21 OriGene qSTAR qPCR primer pairs in human, mouse for DDX21
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DDX21
		QuantiTect SYBR Green Assays in human, mouse, rat DDX21
		QuantiFast Probe-based Assays in human, mouse, rat DDX21

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX21

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX21 gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ddx21^{1 , 5}	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21^{1, 5}	86.07(n)¹ 89.97(a)¹		10 (32.43 cM)⁵ 56200¹ NM_019553.2¹ NP_062426.2¹ 62580248⁵
chicken (Gallus gallus)	Aves	DDX50¹	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	70.39(n) 69.85(a)		768898 XM_001232051.3 XP_001232052.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	61(a)	1 → many	GL343215.1(1871445-1926394)
African clawed frog (Xenopus laevis)	Amphibia	AF302422.1²	--	72.64(n)		AF302422.1
zebrafish (Danio rerio)	Actinopterygii	CA472805.1²	--	79.2(n)		334078 CA472805.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TIF2⁶ TIF1⁶ (see all 3)	Translation initiation factor eIF4A, identical to ... Translation initiation factor eIF4A, identical to ... (see all 3)	32(a) 32(a) (see all 3)	many ↔ many many ↔ many (see all 3)	X(153504-154691) YJL138C XI(554987-556174) YKR059W
thale cress (Arabidopsis thaliana)	eudicotyledons	PRH75¹	PRH75	49.35(n) 43.29(a)		836340 NM_125613.2 NP_201025.1
rice (Oryza sativa)	Liliopsida	NM_186269.1²	--	74.74(n)		NM_186269.1

ENSEMBL Gene Tree for DDX21 (if available)
TreeFam Gene Tree for DDX21 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for DDX21 gene

DDX50²

8 SIMAP similar genes for DDX21 using alignment to 2 protein entries: DDX21_HUMAN (see all proteins):

DDX50 DKFZp761E0323 mcdrh DDX54 EIF4A2 EIF4A1

EIF4A3 DDX47

Find genes that share paralogs with DDX21 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12261492^1,2	C,A	--	70713953(+)	`ggatcA/Gtgagg`	1	--	us2k¹		0	--	--	--	--
rs190612866^1,2	C	--	70714593(+)	`AAAAAG/TTAGCC`	2	--	us2k¹		0	--	--	--	--
rs10998501^1,2	C	--	70714615(+)	`CACATA/GCCTGT`	2	--	us2k¹		0	--	--	--	--
rs112995127^1,2	C,F	--	70714714(+)	`TCCACT/CCCAGC`	2	--	us2k¹		2		CSA WA	120
rs116985189^1,2	F	--	70714737(+)	`GGGAGA/CACCTG`	2	--	us2k¹		1		NA	120
rs182810097^1,2		--	70714762(+)	`AATAGA/GTAAAG`	2	--	us2k¹		0	--	--	--	--
rs137938526^1,2		--	70714774(+)	`CTGGGC/TGCTGT`	2	--	us2k¹		0	--	--	--	--
rs73268390^1,2	C,F	--	70714820(+)	`GAGGCG/AGATGG`	2	--	us2k¹		3		CSA WA NA	240
rs141708009^1,2		--	70714860(+)	`CCAGCC/TTGGTG`	2	--	us2k¹		0	--	--	--	--
rs76382335^1,2	C,F	--	70714945(+)	`CTACTC/GGGGAG`	2	--	us2k¹		3		CSA NA EA	242

HapMap Linkage Disequilibrium report for DDX21 (70715884 - 70744829 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for DDX21: About this table

Variant ID	Type	Subtype	PubMed ID
nsv519999	CNV	Loss	19592680
nsv831907	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DDX21

DNA2.0 Custom Variant and Variant Library Synthesis for DDX21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 606357 OMIM disorders: --

1 disease for DDX21:
About MalaCards

stomach disease

Find genes that share disorders with DDX21 About GenesLikeMe

Genetic Association Database (GAD): DDX21
Human Genome Epidemiology (HuGE) Navigator: DDX21 (1 document)

Export disorders for DDX21 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DDX21 gene, integrated from 10 sources (see all 84):
(articles sorted by number of sources associating them with DDX21)

Utopia: connect your pdf to the dynamic
world of online information

A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. (PubMed id 8614622)^{1, 2, 3} Valdez B.C.... Busch H. (Nucleic Acids Res. 1996)
c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. (PubMed id 18180292)^{1, 3} HolmstrAPm T.H....Westermarck J. (J. Biol. Chem. 2008)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)^{1, 4} Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (Nature 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. (PubMed id 14559904)^{1, 2} Henning D.... Valdez B.C. (J. Biol. Chem. 2003)
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun- activated transcription. (PubMed id 11823437)^{1, 2} Westermarck J.... Bohmann D. (EMBO J. 2002)
Human RNA helicase II/Gu gene: genomic organization and promoter analysis. (PubMed id 11237763)^{1, 2} Zhu K.... Busch H. (Biochem. Biophys. Res. Commun. 2001)
Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. (PubMed id 11891046)^{1, 9} Valdez B.C.... Sequitin A.M. (Gene 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 9188	HGNC: 2744	AceView: DDX21	Ensembl:ENSG00000165732	euGenes: HUgn9188
ECgene: DDX21	H-InvDB: DDX21

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for DDX21	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DDX21 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for DDX21 gene:
Search GeneIP for patents involving DDX21

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for DDX21
	OriGene qPCR primer pairs and template standards for DDX21		OriGene Protein Over-expression Lysate for DDX21
	OriGene MassSpec for DDX21		OriGene clones in human, mouse for DDX21
	OriGene qSTAR qPCR primer pairs in human, mouse for DDX21		OriGene Purified Protein for DDX21
	OriGene ORF clones in mouse, rat for DDX21		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DDX21		OriGene Custom Protein Services for DDX21

	Block miRNA regulation of human, mouse, rat DDX21 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing DDX21
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX21		Predesigned siRNA for gene silencing in human, mouse, rat DDX21
	QuantiFast Probe-based Assays in human, mouse, rat DDX21		QuantiTect SYBR Green Assays in human, mouse, rat DDX21
	Custom PCR Arrays for DDX21		Search Chromatin IP Primers for DDX21
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat DDX21		GeneGlobe Interaction Network for DDX21
	Regulatory tfbs in DDX21 promoter

	GenScript Custom Purified and Recombinant Proteins Services for DDX21		GenScript cDNA clones with any tag delivered in your preferred vector for DDX21
	GenScript Custom Assay Services for DDX21		GenScript Custom overexpressing Cell Line Services for DDX21
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for DDX21

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DDX21 antibodies
	DDX21 proteins
	DDX21 lysates

	Antibodies for DDX21
	See all of Abcam's Antibodies, Kits and Proteins for DDX21
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for DDX21
	Antibodies for DDX21
	ELISAs for DDX21
	CLIAs for DDX21

Browse ESI BIO Cell Lines and PureStem Progenitors for DDX21

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX21

	SwitchGear 3'UTR luciferase reporter plasmids for DDX21
	SwitchGear Promoter luciferase reporter plasmids for DDX21

ThermoFisher Antibodies for DDX21

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX21

Browse compounds at ApexBio

Search Addgene for plasmids for DDX21

	Search eBioscience for proteins for DDX21
	Search eBioscience for elisas for DDX21
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for DDX21

	antibodies-online antibodies for DDX21 (25 products)
	antibodies-online kits for DDX21 (6 products)
	antibodies-online peptides for DDX21
	antibodies-online proteins for DDX21 (2 products)

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DDX21 gene at Home site.

Version: 3.12.300 21 Jan 2015
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

DDX21 Gene

DEAD (Asp-Glu-Ala-Asp) Box Helicase 21

Aliases
for DDX21 gene

Summaries
for DDX21 gene

Genomic Views
for DDX21 gene

Proteins
for DDX21 gene

DDX21 Human Recombinant Protein Products:

DDX21 Antibody Products:

DDX21 Assay Products:

Domains /
Families
for DDX21 gene

Function
for DDX21 gene

Localization
for DDX21 gene

Pathways & Interactions
for DDX21 gene

Drugs & Compounds
for DDX21 gene

Transcripts
for DDX21 gene

Expression
for DDX21 gene

Orthologs
for DDX21 gene

Paralogs
for DDX21 gene

Genomic Variants
for DDX21 gene

Disorders / Diseases
for DDX21 gene

Publications
for DDX21 gene

External Searches for DDX21 gene

Genome Databases showing DDX21 gene

Other Databases showing DDX21 gene

Specialized Databases showing DDX21 gene

Intellectual Property
for DDX21 gene

Products
for DDX21 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

DDX21 Gene

DEAD (Asp-Glu-Ala-Asp) Box Helicase 21

Aliasesfor DDX21 gene

Summariesfor DDX21 gene

Genomic Viewsfor DDX21 gene

Proteinsfor DDX21 gene

DDX21 Human Recombinant Protein Products:

DDX21 Antibody Products:

DDX21 Assay Products:

Domains /Familiesfor DDX21 gene

Functionfor DDX21 gene

Localizationfor DDX21 gene

Pathways & Interactionsfor DDX21 gene

Drugs & Compoundsfor DDX21 gene

Transcriptsfor DDX21 gene

Expression for DDX21 gene

Orthologsfor DDX21 gene

Paralogsfor DDX21 gene

Genomic Variantsfor DDX21 gene

Disorders / Diseasesfor DDX21 gene

Publicationsfor DDX21 gene

External Searches for DDX21 gene

Genome Databases showing DDX21 gene

Other Databases showing DDX21 gene

Specialized Databases showing DDX21 gene

Intellectual Propertyfor DDX21 gene

Productsfor DDX21 gene

View Random Gene

Aliases
for DDX21 gene

Summaries
for DDX21 gene

Genomic Views
for DDX21 gene

Proteins
for DDX21 gene

Domains /
Families
for DDX21 gene

Function
for DDX21 gene

Localization
for DDX21 gene

Pathways & Interactions
for DDX21 gene

Drugs & Compounds
for DDX21 gene

Transcripts
for DDX21 gene

Expression
for DDX21 gene

Orthologs
for DDX21 gene

Paralogs
for DDX21 gene

Genomic Variants
for DDX21 gene

Disorders / Diseases
for DDX21 gene

Publications
for DDX21 gene

Intellectual Property
for DDX21 gene

Products
for DDX21 gene