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DDX21 Gene

protein-coding   GIFtS: 57
GCID: GC10P070715

DEAD (Asp-Glu-Ala-Asp) Box Helicase 21

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21, DEAD (Asp-Glu-Ala-Asp)...)
  See DDX21-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 211 2     RH-II/GU2
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 211 2     RH-II/GuA2
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 211 2     Gu Protein2
Nucleolar RNA Helicase Gu2 3     gu-alpha2
Nucleolar RNA Helicase II2 3     Nucleolar RNA Helicase 22
DEAD Box Protein 212 3     RNA Helicase II/Gu Alpha2
RH II/Gu2 3     EC 3.6.4.133
GUA2     Gu-alpha3
GURDB2     EC 3.6.18

External Ids:    HGNC: 27441   Entrez Gene: 91882   Ensembl: ENSG000001657327   OMIM: 6063575   UniProtKB: Q9NR303   

Export aliases for DDX21 gene to outside databases

Previous GC identifers: GC10P069527 GC10P069802 GC10P070608 GC10P070060 GC10P070385 GC10P064717


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX21 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by
autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA,
folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport,
and general transcription. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX21 Gene:
DDX21 (DEAD (Asp-Glu-Ala-Asp) box helicase 21) is a protein-coding gene. Diseases associated with DDX21 include stomach disease. GO annotations related to this gene include double-stranded RNA binding and ATP-dependent RNA helicase activity. An important paralog of this gene is DDX50.

UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30
Function: Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a
single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing

Gene Wiki entry for DDX21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX21 gene promoter:
         ATF-2   STAT5A   HNF-3beta   Ik-3   Evi-1   E47   CRE-BP1   FOXJ2 (long isoform)   Hand1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX21 promoter sequence
   Search Chromatin IP Primers for DDX21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q21

DDX21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX21 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P070715:  view genomic region     (about GC identifiers)

Start:
70,715,884 bp from pter      End:
70,744,829 bp from pter
Size:
28,946 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30 (See protein sequence)
Recommended Name: Nucleolar RNA helicase 2  
Size: 783 amino acids; 87344 Da
Subunit: Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C,
ERCC6, MYBBP1A and DDX21. Interacts with C1QBP
Miscellaneous: Autoantibodies against DDX21 are found in patients with watermelon stomach disease, which is
characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon
Sequence caution: Sequence=AAB02546.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DDX21:
2M3D (3D)    
Secondary accessions: B2RDL0 Q13436 Q5VX41 Q68D35
Alternative splicing: 2 isoforms:  Q9NR30-1   Q9NR30-2   

Explore the universe of human proteins at neXtProt for DDX21: NX_Q9NR30

Explore proteomics data for DDX21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX21 (Q9NR30) (see all 16)
     LAPTREL  NGKLDLT  VGTPGRI  APTRELA 


    See DDX21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243839.1  NP_004719.2  

    ENSEMBL proteins: 
     ENSP00000346120  

    DDX21 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR012562 GUCT
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q9NR30

    ProtoNet protein and cluster: Q9NR30

    2 Blocks protein domains:
    IPB000629 ATP-dependent helicase
    IPB012562 GUCT


    UniProtKB/Swiss-Prot: DDX21_HUMAN, Q9NR30
    Domain: The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the
    foldase in the C-terminus
    Domain: The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity)
    Similarity: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX21_HUMAN, Q9NR30
    Function: Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a
    single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IEA--
    GO:0004004ATP-dependent RNA helicase activity TAS8614622
         
    Find genes that share ontologies with DDX21           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX21:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX21
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    miRNA
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    miRTarBase miRNAs that target DDX21:
    hsa-mir-331-3p (MIRT043386), hsa-mir-29c-3p (MIRT020395), hsa-mir-16-5p (MIRT031736), hsa-mir-423-5p (MIRT038053), hsa-mir-186-5p (MIRT045036), hsa-mir-100-5p (MIRT048581), hsa-mir-877-3p (MIRT036938), hsa-mir-193b-3p (MIRT016482), hsa-mir-222-3p (MIRT046685), hsa-mir-34a-5p (MIRT025491), hsa-let-7b-5p (MIRT032414)

    Block miRNA regulation of human, mouse, rat DDX21 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate DDX21:
    hsa-miR-141* hsa-miR-642a hsa-miR-607 hsa-miR-3185 hsa-miR-16-1* hsa-miR-518f* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDDX21 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX21

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    GenScript: all cDNA clones in your preferred vector: DDX21 (NM_004728)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX21

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX21_HUMAN, Q9NR30: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    chloroplast2
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with DDX21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX21
    Interactions:

        GeneGlobe Interaction Network for DDX21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX21 (Q9NR302, 3 ENSP000003461204) via UniProtKB, MINT, STRING, and/or I2D (see all 847)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054122, 3, ENSP000003602664MINT-14075 MINT-14076 MINT-14077 I2D: score=4 STRING: ENSP00000360266
    DHX9Q082112, 3, ENSP000003565204MINT-7945693 MINT-8395092 I2D: score=2 STRING: ENSP00000356520
    PRPF8Q6P2Q92, 3, ENSP000003043504MINT-7945693 MINT-8395092 I2D: score=2 STRING: ENSP00000304350
    HNRNPCP079102, 3, ENSP000003196904MINT-7945693 I2D: score=2 STRING: ENSP00000319690
    NFKB2Q006532, 3, ENSP000001894444MINT-48717 I2D: score=2 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process TAS8614622
    GO:0009615response to virus IEA--
    GO:0043330response to exogenous dsRNA IEA--

    Find genes that share ontologies with DDX21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX21



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX21 gene (2 alternative transcripts): 
    NM_001256910.1  NM_004728.3  

    Unigene Cluster for DDX21:

    DEAD (Asp-Glu-Ala-Asp) box helicase 21
    Hs.223141  [show with all ESTs]
    Unigene Representative Sequence: NM_001256910
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000354185(uc001jov.1 uc001jow.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat DDX21 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate DDX21:
    hsa-miR-141* hsa-miR-642a hsa-miR-607 hsa-miR-3185 hsa-miR-16-1* hsa-miR-518f* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDDX21 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX21
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    GenScript: all cDNA clones in your preferred vector: DDX21 (NM_004728)
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      QuantiTect SYBR Green Assays in human, mouse, rat DDX21
      QuantiFast Probe-based Assays in human, mouse, rat DDX21

    Additional mRNA sequence: 

    AB062394.1 AK025629.1 AK315585.1 BC004182.2 BC008071.2 BC009432.1 BC017228.2 BC104671.1 
    BX648405.1 CR749598.1 U41387.1 

    22 DOTS entries:

    DT.75163013  DT.92462688  DT.101977114  DT.100743879  DT.100868338  DT.95333220  DT.121226053  DT.95159396 
    DT.87017380  DT.92462656  DT.100663550  DT.102832789  DT.102845384  DT.121226072  DT.91743672  DT.95159395 
    DT.95159397  DT.95234063  DT.95360926  DT.121226087  DT.92462660  DT.97795373 

    Selected AceView cDNA sequences (see all 650):

    AI159886 BQ049191 AA736609 BE740684 BU677713 BQ045124 BQ423952 BE328822 
    CB130412 BE674775 AA125774 BQ642423 AI863719 AI393194 CR611336 BC008071 
    AI628417 BC009432 CR749598 CB128411 AA724717 CB070143 AI174929 AA713669 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAAGGTGG
    DDX21 Expression
    About this image


    DDX21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DDX21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.223141
        Custom PCR Arrays for DDX21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX21 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx211 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 211, 5 86.07(n)1
    89.97(a)1
      10 (32.43 cM)5
    562001  NM_019553.21  NP_062426.21 
     625802485 
    chicken
    (Gallus gallus)
    Aves DDX501 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 70.39(n)
    69.85(a)
      768898  XM_001232051.3  XP_001232052.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    1 → many
    GL343215.1(1871445-1926394)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF302422.12   -- 72.64(n)    AF302422.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA472805.12   -- 79.2(n)   334078  CA472805.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF26
    TIF16
    (see all 3)
    Translation initiation factor eIF4A, identical to ...
    Translation initiation factor eIF4A, identical to ...
    (see all 3)
    32(a)
    32(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    X(153504-154691) YJL138C
    XI(554987-556174) YKR059W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRH751 PRH75 49.35(n)
    43.29(a)
      836340  NM_125613.2  NP_201025.1 
    rice
    (Oryza sativa)
    Liliopsida NM_186269.12   -- 74.74(n)    NM_186269.1 


    ENSEMBL Gene Tree for DDX21 (if available)
    TreeFam Gene Tree for DDX21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX21 gene
    DDX502  
    8 SIMAP similar genes for DDX21 using alignment to 2 protein entries:     DDX21_HUMAN (see all proteins):
    DDX50    DKFZp761E0323    mcdrh    DDX54    EIF4A2    EIF4A1
    EIF4A3    DDX47

    Find genes that share paralogs with DDX21           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX21 (see all 629)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122614921,2
    C,A--70713953(+) ggatcA/Gtgagg 1 -- us2k10--------
    rs1906128661,2
    C--70714593(+) AAAAAG/TTAGCC 2 -- us2k10--------
    rs109985011,2
    C--70714615(+) CACATA/GCCTGT 2 -- us2k10--------
    rs1129951271,2
    C,F--70714714(+) TCCACT/CCCAGC 2 -- us2k12Minor allele frequency- C:0.20CSA WA 120
    rs1169851891,2
    F--70714737(+) GGGAGA/CACCTG 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1828100971,2
    --70714762(+) AATAGA/GTAAAG 2 -- us2k10--------
    rs1379385261,2
    --70714774(+) CTGGGC/TGCTGT 2 -- us2k10--------
    rs732683901,2
    C,F--70714820(+) GAGGCG/AGATGG 2 -- us2k13Minor allele frequency- A:0.17CSA WA NA 240
    rs1417080091,2
    --70714860(+) CCAGCC/TTGGTG 2 -- us2k10--------
    rs763823351,2
    C,F--70714945(+) CTACTC/GGGGAG 2 -- us2k13Minor allele frequency- G:0.07CSA NA EA 242

    HapMap Linkage Disequilibrium report for DDX21 (70715884 - 70744829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DDX21:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519999CNV Loss19592680
    nsv831907CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX21
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606357    OMIM disorders: --

    1 disease for DDX21:    
    About MalaCards
    stomach disease


    Find genes that share disorders with DDX21           About GenesLikeMe

    Genetic Association Database (GAD): DDX21
    Human Genome Epidemiology (HuGE) Navigator: DDX21 (1 document)

    Export disorders for DDX21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX21 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with DDX21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease. (PubMed id 8614622)1, 2, 3 Valdez B.C.... Busch H. (Nucleic Acids Res. 1996)
    2. c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. (PubMed id 18180292)1, 3 HolmstrAPm T.H....Westermarck J. (J. Biol. Chem. 2008)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. (PubMed id 14559904)1, 2 Henning D.... Valdez B.C. (J. Biol. Chem. 2003)
    8. The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun- activated transcription. (PubMed id 11823437)1, 2 Westermarck J.... Bohmann D. (EMBO J. 2002)
    9. Human RNA helicase II/Gu gene: genomic organization and promoter analysis. (PubMed id 11237763)1, 2 Zhu K.... Busch H. (Biochem. Biophys. Res. Commun. 2001)
    10. Genomic structure of newly identified paralogue of RNA helicase II/Gu: detection of pseudogenes and multiple alternatively spliced mRNAs. (PubMed id 11891046)1, 9 Valdez B.C.... Sequitin A.M. (Gene 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9188 HGNC: 2744 AceView: DDX21 Ensembl:ENSG00000165732 euGenes: HUgn9188
    ECgene: DDX21 H-InvDB: DDX21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDX21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX21 gene:
    Search GeneIP for patents involving DDX21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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