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DDX20 Gene

protein-coding   GIFtS: 64
GCID: GC01P112298

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 20

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 201 2     DEAD-Box Protein DP1032
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 20, 103kD1 2     gemin-32
Component Of Gems 32 3     Probable ATP-Dependent RNA Helicase DDX202
DP1032 3     SMN-Interacting Protein2
GEMIN32 3     EC 3.6.4.133
DEAD Box Protein 202 3     Gemin-33
DEAD Box Protein DP 1032 3     

External Ids:    HGNC: 27431   Entrez Gene: 112182   Ensembl: ENSG000000647037   OMIM: 6061685   UniProtKB: Q9UHI63   

Export aliases for DDX20 gene to outside databases

Previous GC identifers: GC01P112714 GC01P111169 GC01P111400 GC01P111596 GC01P112010 GC01P110169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX20 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a
component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal
muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DDX20 Gene:
DDX20 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 20) is a protein-coding gene. Diseases associated with DDX20 include spinal cord disease, and spinal muscular atrophy. GO annotations related to this gene include ATP-dependent RNA helicase activity. An important paralog of this gene is DDX39B.

UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6
Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)

Gene Wiki entry for DDX20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX20 gene promoter:
         HFH-3   Pbx1a   p300   CUTL1   MIF-1   Meis-1b   CHOP-10   FOXI1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX20 promoter sequence
   Search Chromatin IP Primers for DDX20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21.1-p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p21.1-p13.2

DDX20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P112298:  view genomic region     (about GC identifiers)

Start:
112,297,867 bp from pter      End:
112,310,638 bp from pter
Size:
12,772 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX20  
Size: 824 amino acids; 92241 Da
Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6,
GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4,
GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and
SNRPG. Interacts directly with GEMIN5. Interacts directly with SNUPN. Interacts with PPP4R2. Interacts with
FOXL2. Interacts with EBV EBNA2 and EBNA3C. Interacts with NANOS1 and PUM2
2 PDB 3D structures from and Proteopedia for DDX20:
2OXC (3D)        3B7G (3D)    
Secondary accessions: Q96F72 Q9NVM3 Q9UF59 Q9UIY0 Q9Y659

Explore the universe of human proteins at neXtProt for DDX20: NX_Q9UHI6

Explore proteomics data for DDX20 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys91, Lys192, Lys332, Lys487
  • Modification sites at PhosphoSitePlus

  • See DDX20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009135.4  
    ENSEMBL proteins: 
     ENSP00000434085   ENSP00000358716   ENSP00000435660   ENSP00000439026  
    Reactome Protein details: Q9UHI6

    DDX20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for DDX20
    OriGene Protein Over-expression Lysate for DDX20
    OriGene MassSpec for DDX20
    OriGene Custom Protein Services for DDX20
    GenScript Custom Purified and Recombinant Proteins Services for DDX20
    Novus Biologicals DDX20 Proteins
    Novus Biologicals DDX20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX20

    DDX20 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DDX20
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DDX20
    OriGene Custom Antibody Services for DDX20
    Novus Biologicals DDX20 Antibodies
    Abcam antibodies for DDX20
    Cloud-Clone Corp. Antibodies for DDX20
    ThermoFisher Antibodies for DDX20
    LSBio Antibodies in human, mouse, rat for DDX20

    DDX20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDX20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDX20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX20
    Cloud-Clone Corp. CLIAs for DDX20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q9UHI6

    ProtoNet protein and cluster: Q9UHI6

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6
    Similarity: Belongs to the DEAD box helicase family. DDX20 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX20_HUMAN, Q9UHI6
    Function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the
    building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most
    spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG
    that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the
    cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by
    the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from
    the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their
    transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004004ATP-dependent RNA helicase activity TAS10383418
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI11714716
         
    DDX20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DDX20:
     Increased number of cells in m 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ddx20):
     embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  reproductive system 

    DDX20 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDX20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX20

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX20:
    hsa-let-7b-5p (MIRT051902), hsa-mir-324-5p (MIRT043191), hsa-mir-421 (MIRT039368)

    Block miRNA regulation of human, mouse, rat DDX20 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DDX20:
    hsa-miR-187* hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDDX20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDX20
    Predesigned siRNA for gene silencing in human, mouse, rat DDX20

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DDX20

    Clone
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    OriGene clones in human, mouse for DDX20 (see all 7)
    OriGene ORF clones in mouse, rat for DDX20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX20 (NM_007204)
    Sino Biological Human cDNA Clone for DDX20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX20

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX20_HUMAN, Q9UHI6: Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies,
    called Gemini of Cajal bodies (Gems)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    DDX20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDX20 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    2mRNA Splicing - Major Pathway
    mRNA processing0.44
    3Gene Expression
    Gene Expression0.40
    4Macrophage Differentiation and Growth Inhibition by METS
    Macrophage Differentiation and Growth Inhibition by METS0.30
    5RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DDX20
        Macrophage Differentiation and Growth Inhibition by METS

    1 BioSystems Pathway for DDX20
        mRNA processing


    1 Reactome Pathway for DDX20
        snRNP Assembly


    1 Kegg Pathway  (Kegg details for DDX20):
        RNA transport


    DDX20 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DDX20: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DDX20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX20 (Q9UHI62, 3 ENSP000003587164) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62622 MINT-62720 MINT-62796 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62622 MINT-62720 MINT-62796 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486342, 3, ENSP000003651754MINT-62622 MINT-62720 MINT-62796 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62622 MINT-62720 MINT-62796 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62622 MINT-62720 MINT-62796 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000244spliceosomal tri-snRNP complex assembly TAS10601333
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0006200ATP catabolic process TAS10383418
    GO:0006396RNA processing TAS10601333

    DDX20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX20



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DDX20 gene: 
    NM_007204.4  

    Unigene Cluster for DDX20:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
    Hs.591405  [show with all ESTs]
    Unigene Representative Sequence: NM_007204
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533164 ENST00000369702(uc001ebs.3 uc010owf.2) ENST00000475700(uc001ebt.3)
    ENST00000524894 ENST00000534200 ENST00000536167
    miRNA
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    Block miRNA regulation of human, mouse, rat DDX20 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DDX20:
    hsa-miR-187* hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDDX20 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDX20
    Clone
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    GenScript: all cDNA clones in your preferred vector: DDX20 (NM_007204)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX20
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX20
      QuantiTect SYBR Green Assays in human, mouse, rat DDX20
      QuantiFast Probe-based Assays in human, mouse, rat DDX20

    Additional mRNA sequence: 

    AF106019.1 AF155803.1 AF171063.1 AK001506.1 AK301697.1 AK314312.1 AY007146.1 BC011556.1 
    BC031062.1 BC034953.2 

    4 DOTS entries:

    DT.40264749  DT.100781303  DT.121440552  DT.102836236 

    Selected AceView cDNA sequences (see all 149):

    AF155803 AA742597 BE552268 AA303940 BQ005336 BM979942 AA437386 BI258023 
    AL044363 BE617455 BP345130 AI203023 AA731204 AA366168 CA438597 CD673747 
    AI828851 AI634406 CB054293 BG250061 AI091758 BX399986 CA438259 BF195810 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACCATTT
    DDX20 Expression
    About this image


    DDX20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    DDX20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591405

    UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including DDX20: 
              Apoptosis 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DDX20
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX20
    QuantiTect SYBR Green Assays in human, mouse, rat DDX20
    QuantiFast Probe-based Assays in human, mouse, rat DDX20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDX20 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx201 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 201, 5 84.47(n)1
    82.73(a)1
      3 (46.43 cM)5
    539751  NM_017397.31  NP_059093.31 
     1056782705 
    chicken
    (Gallus gallus)
    Aves DDX201 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 66.94(n)
    64.25(a)
      419869  XM_417996.4  XP_417996.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX206
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
    58(a)
    1 ↔ 1
    4(126743366-126753481)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101252 Transcribed sequence with moderate similarity to protein spQ9UHI6 (H.sapiens) DD20_HUMAN Probable ATP-dependent RNA helicase DDX20 (DEAD-box protein 20) (DEAD-box protein DP 103) (Component of gems 3) (Gemin3) less 77.05(n)    142030400 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc03g102 Transcribed sequence with moderate similarity to protein spQ9UHI6 (H.sapiens) DD20_HUMAN Probable ATP-dependent RNA helicase DDX20 (DEAD-box protein 20) (DEAD-box protein DP 103) (Component of gems 3) (Gemin3) less 72.46(n)    57038751 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dhh13 ATP dependent RNA helicase 30(a)   67E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T06A10.13   -- 40(a)   IV(16855282-16863597)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SUB26
    Component of the TREX complex required for nuclear...
    28(a)
    1 → many
    IV(305237-306577) YDL084W


    ENSEMBL Gene Tree for DDX20 (if available)
    TreeFam Gene Tree for DDX20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX20 gene
    DDX39B2  DDX39A2  
    9 SIMAP similar genes for DDX20 using alignment to 6 protein entries:     DDX20_HUMAN (see all proteins):
    EIF4A1    EIF4A2    EIF4A3    DDX54    DDX39B    DDX39A
    DDX6    DDX19B    DDX19A

    DDX20 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DDX20
    PGOHUM00000238330


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX20 (see all 300)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446452251,2
    C--112300451(+) CAGAT-/AAAATG 1 -- int10--------
    rs1973951,2
    C,F,A--112300483(+) ATCAAC/TTCATT 1 -- int16Minor allele frequency- T:0.37NA WA CSA 246
    rs679519201,2
    C--112300531(+) GAGTC-/GAGTGG 1 -- int10--------
    rs1413662501,2
    C--112300654(+) TTGTA-/TTTTTT 1 -- int10--------
    rs716734341,2
    C,F--112300668(+) AGAGAC/TGGTGT 1 -- int14Minor allele frequency- T:0.50NA 8
    rs1445686721,2
    --112300775(+) ATGCCC/TGGCAA 1 -- int10--------
    rs789880611,2
    C,F--112300897(+) AGGACG/ATACCA 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1478710741,2
    --112300921(+) GTAATC/GTTACT 1 -- int10--------
    rs1825342851,2
    --112300958(+) TTTTGA/GCATGT 1 -- int10--------
    rs1973961,2
    C,F,A--112300962(+) GGCATG/ATTTTC 1 -- int14Minor allele frequency- A:0.34NA CSA WA 242

    HapMap Linkage Disequilibrium report for DDX20 (112297867 - 112310638 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DDX20: --
    Human Gene Mutation Database (HGMD): DDX20
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX20
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606168    OMIM disorders: --

    9 diseases for DDX20:    
    About MalaCards
    spinal cord disease    spinal muscular atrophy    muscular atrophy    esophageal cancer
    pneumonia    renal cell carcinoma    neuropathy    neuronitis
    esophagitis

    2 diseases from the University of Copenhagen DISEASES database for DDX20:
    Muscular atrophy     Spinal muscular atrophy

    DDX20 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DDX20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular atrophy spinal 87.1 2 10601333 (1), 10909848 (1)

    Genetic Association Database (GAD): DDX20
    Human Genome Epidemiology (HuGE) Navigator: DDX20 (6 documents)

    Export disorders for DDX20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX20 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with DDX20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C. (PubMed id 10383418)1, 2, 3 Grundhoff A.T.... Grasser F.A. (J. Biol. Chem. 1999)
    2. Gemin3: a novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and a component of gems. (PubMed id 10601333)1, 2, 9 Charroux B....Dreyfuss G. (J. Cell Biol. 1999)
    3. NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells. (PubMed id 21800163)1, 2 Ginter-Matuszewska B....Jaruzelska J. (Histochem. Cell Biol. 2011)
    4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    5. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PubMed id 20732906)1, 4 Lin J....Wu X. (Carcinogenesis 2010)
    6. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. (PubMed id 18381463)1, 4 Yang H....Wu X. (Cancer Res. 2008)
    7. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    8. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PubMed id 19138993)1, 4 Ye Y....Wu X. (Cancer Prev Res (Phila) 2008)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11218 HGNC: 2743 AceView: DDX20 Ensembl:ENSG00000064703 euGenes: HUgn11218
    ECgene: DDX20 Kegg: 11218 H-InvDB: DDX20

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX20 gene:
    Search GeneIP for patents involving DDX20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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