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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX20 Gene

protein-coding   GIFtS: 62
GCID: GC01P112298

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 20

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 201 2     DEAD-Box Protein DP1032
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 20, 103kD1 2     gemin-32
Component Of Gems 32 3     Probable ATP-Dependent RNA Helicase DDX202
DP1032 3     SMN-Interacting Protein2
GEMIN32 3     EC 3.6.4.133
DEAD Box Protein 202 3     Gemin-33
DEAD Box Protein DP 1032 3     

External Ids:    HGNC: 27431   Entrez Gene: 112182   Ensembl: ENSG000000647037   OMIM: 6061685   UniProtKB: Q9UHI63   

Export aliases for DDX20 gene to outside databases

Previous GC identifers: GC01P112714 GC01P111169 GC01P111400 GC01P111596 GC01P112010 GC01P110169


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDX20 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a
component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal
muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DDX20 Gene: 
DDX20 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 20) is a protein-coding gene. Diseases associated with DDX20 include spinal cord disease, and spinal muscular atrophy, and among its related super-pathways are Metabolism of non-coding RNA and Metabolism of mRNA. GO annotations related to this gene include ATP-dependent RNA helicase activity and ATP binding. An important paralog of this gene is DDX39B.

UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6
Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required
for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs

Gene Wiki entry for DDX20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX20 gene promoter:
         HFH-3   Pbx1a   p300   CUTL1   MIF-1   Meis-1b   CHOP-10   FOXI1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX20 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21.1-p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p21.1-p13.2

DDX20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P112298:  view genomic region     (about GC identifiers)

Start:
112,297,867 bp from pter      End:
112,310,638 bp from pter
Size:
12,772 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX20  
Size: 824 amino acids; 92241 Da
Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6,
GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with SMN1 and with several spliceosomal snRNP core Sm
proteins, including SNUPN, SNRPB, SNRPD2 and SNRPD3. Interacts with PPP4R2. Interacts with EBV EBNA2 and EBNA3C.
Interacts with FOXL2
Subcellular location: Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies,
called Gemini of Cajal bodies (Gems)
2 PDB 3D structures from and Proteopedia for DDX20:
2OXC (3D)        3B7G (3D)    
Secondary accessions: Q96F72 Q9NVM3 Q9UF59 Q9UIY0 Q9Y659

Explore the universe of human proteins at neXtProt for DDX20: NX_Q9UHI6

Explore proteomics data for DDX20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHI6

  • DDX20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDX20 Protein Expression
    REFSEQ proteins: NP_009135.4  
    ENSEMBL proteins: 
     ENSP00000434085   ENSP00000358716   ENSP00000435660   ENSP00000439026  
    Reactome Protein details: Q9UHI6
    Human Recombinant Protein Products for DDX20: 
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    Novus Biologicals DDX20 Proteins
    Novus Biologicals DDX20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX20 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    DDX20 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    5/6 InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q9UHI6

    ProtoNet protein and cluster: Q9UHI6

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6
    Similarity: Belongs to the DEAD box helicase family. DDX20 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX20_HUMAN, Q9UHI6
    Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required
    for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.4.131

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004004ATP-dependent RNA helicase activity TAS10383418
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI11714716
         
    DDX20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DDX20:
     Increased number of cells in m 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ddx20):
     embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  reproductive system 

    DDX20 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX20 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX20 
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    SwitchGear 3'UTR luciferase reporter plasmidDDX20 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DDX20 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1snRNP Assembly
    Metabolism of non-coding RNA1.00
    snRNP Assembly1.00
    2Metabolism of mRNA
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.47
    4mRNA Splicing - Major Pathway
    mRNA processing0.46
    5DNA Methylation and Transcriptional Repression
    Macrophage Differentiation and Growth Inhibition by METS0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DDX20
        Macrophage Differentiation and Growth Inhibition by METS

    1 BioSystems Pathway for DDX20
        mRNA processing


    4        Reactome Pathways for DDX20
        snRNP Assembly
    Metabolism of RNA
    Gene Expression
    Metabolism of non-coding RNA


    1         Kegg Pathway  (Kegg details for DDX20):
        RNA transport


    DDX20 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDX20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for DDX20 (Q9UHI62, 3 ENSP000003587164) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62622 MINT-62720 MINT-62796 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62622 MINT-62720 MINT-62796 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486342, 3, ENSP000003651754MINT-62622 MINT-62720 MINT-62796 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62622 MINT-62720 MINT-62796 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62622 MINT-62720 MINT-62796 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000244assembly of spliceosomal tri-snRNP TAS10601333
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0006396RNA processing TAS10601333
    GO:0010467gene expression TAS--

    DDX20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX20

    Search CenterWatch for drugs/clinical trials and news about DDX20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDX20 gene: 
    NM_007204.4  

    Unigene Cluster for DDX20:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
    Hs.591405  [show with all ESTs]
    Unigene Representative Sequence: NM_007204
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533164 ENST00000369702(uc001ebs.3 uc010owf.2) ENST00000475700(uc001ebt.3)
    ENST00000524894 ENST00000534200 ENST00000536167
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX20:
    hsa-miR-187* hsa-miR-3133
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    Additional mRNA sequence: 

    AF106019.1 AF155803.1 AF171063.1 AK001506.1 AK301697.1 AK314312.1 AY007146.1 BC011556.1 
    BC031062.1 BC034953.2 

    4 DOTS entries:

    DT.40264749  DT.100781303  DT.121440552  DT.102836236 

    24/149 AceView cDNA sequences (see all 149):

    AI467963 BF195810 AA742597 BQ005336 CD673747 AA437386 CB054293 BE617455 
    AW016713 BM564794 AA366168 BE552268 BQ930358 AU129544 AL044363 BX399986 
    AA460305 AA747576 BM455034 BP345130 AA461593 AL133598 AI203023 BI258023 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACCATTT
    DDX20 Expression
    About this image


    See DDX20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX20

    SOURCE GeneReport for Unigene cluster: Hs.591405

    UniProtKB/Swiss-Prot: DDX20_HUMAN, Q9UHI6
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including DDX20: 
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDX20 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx201 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 201, 5 84.47(n)1
    82.73(a)1
      3 (46.43 cM)5
    539751  NM_017397.31  NP_059093.31 
     1056782705 
    chicken
    (Gallus gallus)
    Aves DDX201 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 67.11(n)
    63.94(a)
      419869  XM_417996.3  XP_417996.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX206
    Uncharacterized protein
    60(a)
    1 ↔ 1
    4(126743366-126753481)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101252 Transcribed sequence with moderate similarity to protein more 77.05(n)    142030400 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc03g102 Transcribed sequence with moderate similarity to protein more 72.46(n)    57038751 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dhh13 ATP dependent RNA helicase 30(a)   67E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T06A10.13   -- 40(a)   IV(16855282-16863597)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TIF26
    TIF16
    Translation initiation factor eIF4A, identical to ...
    Translation initiation factor eIF4A, identical to ...
    36(a)
    36(a)
    many ↔ many
    many ↔ many
    X(153504-154691)
    XI(554987-556174)


    ENSEMBL Gene Tree for DDX20 (if available)
    TreeFam Gene Tree for DDX20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX20 gene
    DDX39B2  DDX39A2  
    9 SIMAP similar genes for DDX20 using alignment to 6 protein entries:     DDX20_HUMAN (see all proteins):
    EIF4A1    EIF4A2    EIF4A3    DDX54    DDX39B    DDX39A
    DDX6    DDX19B    DDX19A

    DDX20 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DDX20
    PGOHUM00000238330


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/300 SNPs in DDX20 are shown (see all 300)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446452251,2
    C--112300451(+) CAGAT-/AAAATG 1 -- int10--------
    rs1973951,2
    C,F,A--112300483(+) ATCAAC/TTCATT 1 -- int16Minor allele frequency- T:0.37NA WA CSA 246
    rs679519201,2
    C--112300531(+) GAGTC-/GAGTGG 1 -- int10--------
    rs1413662501,2
    C--112300654(+) TTGTA-/TTTTTT 1 -- int10--------
    rs716734341,2
    C,F--112300668(+) AGAGAC/TGGTGT 1 -- int14Minor allele frequency- T:0.50NA 8
    rs1445686721,2
    --112300775(+) ATGCCC/TGGCAA 1 -- int10--------
    rs789880611,2
    C,F--112300897(+) AGGACG/ATACCA 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1478710741,2
    --112300921(+) GTAATC/GTTACT 1 -- int10--------
    rs1825342851,2
    --112300958(+) TTTTGA/GCATGT 1 -- int10--------
    rs1973961,2
    C,F,A--112300962(+) GGCATG/ATTTTC 1 -- int14Minor allele frequency- A:0.34NA CSA WA 242

    HapMap Linkage Disequilibrium report for DDX20 (112297867 - 112310638 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DDX20: --

    Human Gene Mutation Database (HGMD): DDX20
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX20
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606168    OMIM disorders: --

    10 diseases for DDX20:    About MalaCards
    spinal cord disease    spinal muscular atrophy    muscular atrophy    esophageal cancer
    pneumonia    renal cell carcinoma    neuronitis    esophagitis
    neuropathy    colon cancer

    2 diseases from the University of Copenhagen DISEASES database for DDX20:
    Muscular atrophy     Spinal muscular atrophy

    DDX20 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DDX20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    muscular atrophy spinal 87.1 2 10601333 (1), 10909848 (1)

    Genetic Association Database (GAD): DDX20
    Human Genome Epidemiology (HuGE) Navigator: DDX20 (6 documents)

    Export disorders for DDX20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX20 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with DDX20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C. (PubMed id 10383418)1, 2, 3 Grundhoff A.T.... Grasser F.A. (1999)
    2. Gemin3: a novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and a component of gems. (PubMed id 10601333)1, 2, 9 Charroux B....Dreyfuss G. (1999)
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    4. Genetic variations in microRNA-related genes are asso ciated with survival and recurrence in patients with renal cell carcinoma. (PubMed id 20732906)1, 4 Lin J....Wu X. (2010)
    5. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. (PubMed id 18381463)1, 4 Yang H....Wu X. (2008)
    6. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PubMed id 19138993)1, 4 Ye Y....Wu X. (2008)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. (PubMed id 16153597)1, 2 Lee K....Bae J. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11218 HGNC: 2743 AceView: DDX20 Ensembl:ENSG00000064703 euGenes: HUgn11218
    ECgene: DDX20 Kegg: 11218 H-InvDB: DDX20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDX20 gene:
    Search GeneIP for patents involving DDX20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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