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Aliases for DDX19B Gene

Aliases for DDX19B Gene

  • DEAD-Box Helicase 19B 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 19 (Dbp5, Yeast, Homolog) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19B 2 3
  • DEAD Box Protein 19B 3 4
  • DDX19 3 4
  • DBP5 3 4
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19B 3
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19 2
  • ATP-Dependent RNA Helicase DDX19B 3
  • ATP-Dependent RNA Helicase DDX19 3
  • DEAD-Box RNA Helicase DEAD5 3
  • DEAD Box RNA Helicase DEAD5 4
  • DEAD-Box Protein 5 3
  • Yeast Dbp5 Homolog 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61
  • RNAH 3
  • TDBP 4

External Ids for DDX19B Gene

Previous HGNC Symbols for DDX19B Gene

  • DDX19

Previous GeneCards Identifiers for DDX19B Gene

  • GC16P068891
  • GC16P070328
  • GC16P056165

Summaries for DDX19B Gene

Entrez Gene Summary for DDX19B Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX19B Gene

DDX19B (DEAD-Box Helicase 19B) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ENSG00000260537.

UniProtKB/Swiss-Prot for DDX19B Gene

  • ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

Gene Wiki entry for DDX19B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX19B Gene

Genomics for DDX19B Gene

Regulatory Elements for DDX19B Gene

Enhancers for DDX19B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G070414 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +129.6 129593 10.3 HDGF PKNOX1 CREB3L1 MLX ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 COG4 RPS27P26 RNU6-23P LOC100506083 AARS DDX19B SMG1P7 PDXDC2P-NPIPB14P FUK WWP2
GH16G070436 1.4 ENCODE dbSUPER 9.8 +148.5 148478 3.9 CREB3L1 AGO1 FEZF1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1 ZNF610 SMG1P7 CLEC18A PDXDC2P-NPIPB14P SF3B3 LOC400541 NONOP1 PDXDC2P EXOSC6 COG4 PDPR
GH16G069857 1.5 Ensembl ENCODE dbSUPER 9.1 -429.4 -429387 5.6 FOXA2 MLX ARID4B ZNF48 TCF12 ZNF121 SP5 ZHX2 MXD4 MIER2 NPIPB14P ENSG00000252443 WWP2 AARS DDX19B PDXDC2P-NPIPB14P NQO1 LOC100506083 CLEC18A PDXDC2P
GH16G070255 1.1 ENCODE 11.6 -33.9 -33903 1.1 FOXA2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 SF3B3 PDPR NONOP1 EXOSC6 AARS DDX19B COG4 PDXDC2P-NPIPB14P NIP7 PDXDC2P
GH16G070767 1.3 ENCODE dbSUPER 9.3 +478.5 478493 1.4 HDGF ATF1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ELK1 SF3B3 EXOSC6 PDPR VAC14 COG4 PDXDC2P-NPIPB14P PDXDC2P SNORD111 AARS DDX19B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX19B on UCSC Golden Path with GeneCards custom track

Promoters for DDX19B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087550 -563 2201 PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for DDX19B Gene

Chromosome:
16
Start:
70,289,663 bp from pter
End:
70,335,283 bp from pter
Size:
45,621 bases
Orientation:
Plus strand

Genomic View for DDX19B Gene

Genes around DDX19B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX19B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX19B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX19B Gene

Proteins for DDX19B Gene

  • Protein details for DDX19B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMR2-DD19B_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX19B
    Protein Accession:
    Q9UMR2
    Secondary Accessions:
    • B3KNE9
    • B4DXS6
    • E7EMK4
    • Q6FIB7
    • Q6IAE0
    • Q96KE7
    • Q9H0U0

    Protein attributes for DDX19B Gene

    Size:
    479 amino acids
    Molecular mass:
    53927 Da
    Quaternary structure:
    • Interacts with NUP214 or RNA in a mutually exclusive manner.

    Three dimensional structures from OCA and Proteopedia for DDX19B Gene

    Alternative splice isoforms for DDX19B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX19B Gene

Selected DME Specific Peptides for DDX19B Gene

Q9UMR2:
  • IGTPGTVLDWC
  • VINFDLP
  • FVLDEAD
  • SVKSFEEL
  • HRIGRTGR
  • ALCNLYG
  • GTGKTAAF
  • EEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDP
  • YLHRIGR
  • SPLYSVK
  • GHQVALLSGE
  • YAMGFNRPSKIQE
  • CQMLLFSATFEDSVW
  • TTNVCARGIDV
  • PDPNVIKL

Post-translational modifications for DDX19B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX19B Gene

Gene Families for DDX19B Gene

Suggested Antigen Peptide Sequences for DDX19B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMR2

UniProtKB/Swiss-Prot:

DD19B_HUMAN :
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
Domain:
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
Family:
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
genes like me logo Genes that share domains with DDX19B: view

Function for DDX19B Gene

Molecular function for DDX19B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

Enzyme Numbers (IUBMB) for DDX19B Gene

Gene Ontology (GO) - Molecular Function for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS,IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 10428971
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with DDX19B: view
genes like me logo Genes that share phenotypes with DDX19B: view

Animal Model Products

CRISPR Products

miRNA for DDX19B Gene

miRTarBase miRNAs that target DDX19B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX19B Gene

Localization for DDX19B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX19B Gene

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX19B gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore TAS,IEA --
GO:0005737 cytoplasm IEA,TAS --
GO:0016020 membrane IDA,IEA 19946888
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with DDX19B: view

Pathways & Interactions for DDX19B Gene

SuperPathways for DDX19B Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus TAS 10428971
GO:0006810 transport IEA --
GO:0008380 RNA splicing IBA --
GO:0010468 regulation of gene expression IBA --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX19B: view

No data available for Pathways by source and SIGNOR curated interactions for DDX19B Gene

Drugs & Compounds for DDX19B Gene

(3) Drugs for DDX19B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX19B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX19B: view

Transcripts for DDX19B Gene

Unigene Clusters for DDX19B Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX19B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - -
SP3:

Relevant External Links for DDX19B Gene

GeneLoc Exon Structure for
DDX19B
ECgene alternative splicing isoforms for
DDX19B

Expression for DDX19B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX19B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX19B Gene

This gene is overexpressed in Lymph node (22.5) and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX19B Gene



Protein tissue co-expression partners for DDX19B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX19B Gene:

DDX19B

SOURCE GeneReport for Unigene cluster for DDX19B Gene:

Hs.221761

Evidence on tissue expression from TISSUES for DDX19B Gene

  • Nervous system(4.6)
  • Stomach(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with DDX19B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX19B Gene

Orthologs for DDX19B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX19B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX19B 34 35
  • 99.72 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DDX19B 34 35
  • 92.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia DDX19B 34
  • 91.21 (n)
rat
(Rattus norvegicus)
Mammalia Ddx19b 34
  • 90.81 (n)
mouse
(Mus musculus)
Mammalia Ddx19b 34 16 35
  • 90.26 (n)
chicken
(Gallus gallus)
Aves DDX19B 34 35
  • 82.88 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx19b 34
  • 77.92 (n)
MGC75870 34
African clawed frog
(Xenopus laevis)
Amphibia ddx19-prov 34
zebrafish
(Danio rerio)
Actinopterygii ddx19 34 35
  • 76.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003397 34
  • 63.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 34 35
  • 60 (n)
worm
(Caenorhabditis elegans)
Secernentea ddx-19 35
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 35
  • 44 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 35
  • 59 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4088 34
Species where no ortholog for DDX19B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX19B Gene

ENSEMBL:
Gene Tree for DDX19B (if available)
TreeFam:
Gene Tree for DDX19B (if available)

Paralogs for DDX19B Gene

Paralogs for DDX19B Gene

genes like me logo Genes that share paralogs with DDX19B: view

Variants for DDX19B Gene

Sequence variations from dbSNP and Humsavar for DDX19B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs779683414 Uncertain significance 70,289,507(+) GCTGT(A/G)CCGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000108116 -- 70,328,796(+) TTTAT(G/T)TCCAT intron-variant
rs1000152214 -- 70,320,965(+) TTTTT(-/C)TTTTT intron-variant
rs1000162255 -- 70,320,720(+) AGCTA(A/G)TTTTT intron-variant
rs1000185848 -- 70,287,901(+) GCTGG(C/G)AATAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DDX19B Gene

Variant ID Type Subtype PubMed ID
esv23255 CNV loss 19812545
esv2714670 CNV deletion 23290073
nsv1061286 CNV gain 25217958
nsv7285 OTHER inversion 18451855
nsv833271 CNV gain+loss 17160897
nsv977994 CNV duplication 23825009

Variation tolerance for DDX19B Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX19B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX19B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX19B Gene

Disorders for DDX19B Gene

Relevant External Links for DDX19B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX19B

No disorders were found for DDX19B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX19B Gene

Publications for DDX19B Gene

  1. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. (PMID: 19219046) von Moeller H. … Conti E. (Nat. Struct. Mol. Biol. 2009) 3 4 22 64
  2. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. (PMID: 10428971) Schmitt C. … Izaurralde E. (EMBO J. 1999) 2 3 4 64
  3. The DEXD/H-box RNA helicase DDX19 is regulated by an alpha-helical switch. (PMID: 19244245) Collins R. … Schuler H. (J. Biol. Chem. 2009) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DDX19B Gene

Sources for DDX19B Gene

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