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Aliases for DDX19B Gene

Aliases for DDX19B Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19B 2 3
  • DDX19 3 4 6
  • DBP5 3 4 6
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 19 (Dbp5, Yeast, Homolog) 2 3
  • DEAD Box RNA Helicase DEAD5 3 4
  • DEAD Box Protein 19B 3 4
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19B 3
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19 2
  • ATP-Dependent RNA Helicase DDX19B 3
  • ATP-Dependent RNA Helicase DDX19 3
  • DEAD-Box RNA Helicase DEAD5 3
  • DEAD-Box Protein 5 3
  • Yeast Dbp5 Homolog 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • RNAH 3
  • TDBP 4

External Ids for DDX19B Gene

Previous HGNC Symbols for DDX19B Gene

  • DDX19

Previous GeneCards Identifiers for DDX19B Gene

  • GC16P068891
  • GC16P070328
  • GC16P056165

Summaries for DDX19B Gene

Entrez Gene Summary for DDX19B Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX19B Gene

DDX19B (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19B) is a Protein Coding gene. GO annotations related to this gene include RNA binding and helicase activity. An important paralog of this gene is ENSG00000260537.

UniProtKB/Swiss-Prot for DDX19B Gene

  • ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins

Gene Wiki entry for DDX19B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX19B Gene

Genomics for DDX19B Gene

Regulatory Elements for DDX19B Gene

Genomic Location for DDX19B Gene

Start:
70,289,663 bp from pter
End:
70,335,283 bp from pter
Size:
45,621 bases
Orientation:
Plus strand

Genomic View for DDX19B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX19B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX19B Gene

Proteins for DDX19B Gene

  • Protein details for DDX19B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMR2-DD19B_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX19B
    Protein Accession:
    Q9UMR2
    Secondary Accessions:
    • B3KNE9
    • B4DXS6
    • E7EMK4
    • Q6FIB7
    • Q6IAE0
    • Q96KE7
    • Q9H0U0

    Protein attributes for DDX19B Gene

    Size:
    479 amino acids
    Molecular mass:
    53927 Da
    Quaternary structure:
    • Interacts with NUP214 or RNA in a mutually exclusive manner.

    Three dimensional structures from OCA and Proteopedia for DDX19B Gene

    Alternative splice isoforms for DDX19B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX19B Gene

Proteomics data for DDX19B Gene at MOPED

Post-translational modifications for DDX19B Gene

  • Ubiquitination at Lys64, Lys92, and Lys187
  • Modification sites at PhosphoSitePlus

Domains for DDX19B Gene

Gene Families for DDX19B Gene

HGNC:
  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX19B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMR2

UniProtKB/Swiss-Prot:

DD19B_HUMAN :
  • Q9UMR2
Domain:
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
genes like me logo Genes that share domains with DDX19B: view

Function for DDX19B Gene

Molecular function for DDX19B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins

Enzyme Numbers (IUBMB) for DDX19B Gene

Gene Ontology (GO) - Molecular Function for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity TAS 10428971
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DDX19B: view
genes like me logo Genes that share phenotypes with DDX19B: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDX19B Gene

Localization for DDX19B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX19B Gene

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX19B Gene COMPARTMENTS Subcellular localization image for DDX19B gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA --
GO:0005643 nuclear pore IEA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX19B: view

Pathways for DDX19B Gene

SuperPathways for DDX19B Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus TAS 10428971
GO:0008152 metabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with DDX19B: view

No data available for Pathways by source for DDX19B Gene

Transcripts for DDX19B Gene

Unigene Clusters for DDX19B Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX19B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - -
SP3:

Relevant External Links for DDX19B Gene

GeneLoc Exon Structure for
DDX19B
ECgene alternative splicing isoforms for
DDX19B

Expression for DDX19B Gene

mRNA expression in normal human tissues for DDX19B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX19B Gene

SOURCE GeneReport for Unigene cluster for DDX19B Gene Hs.221761

genes like me logo Genes that share expressions with DDX19B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX19B Gene

Orthologs for DDX19B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDX19B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX19B 35
  • 99.72 (n)
  • 100 (a)
DDX19B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX19B 35
  • 92.46 (n)
  • 97.83 (a)
DDX19B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX19B 35
  • 91.21 (n)
  • 94.56 (a)
mouse
(Mus musculus)
Mammalia Ddx19b 35
  • 90.26 (n)
  • 97.29 (a)
Ddx19b 16
Ddx19b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ddx19b 35
  • 90.81 (n)
  • 97.08 (a)
chicken
(Gallus gallus)
Aves DDX19B 35
  • 82.88 (n)
  • 93.95 (a)
DDX19B 36
  • 94 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia ddx19-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx19b 35
  • 77.92 (n)
  • 85.95 (a)
MGC75870 35
zebrafish
(Danio rerio)
Actinopterygii ddx19 35
  • 76.9 (n)
  • 85.59 (a)
ddx19 36
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003397 35
  • 63.83 (n)
  • 64.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 35
  • 60 (n)
  • 60.78 (a)
Dbp80 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ddx-19 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 36
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4088 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 36
  • 59 (a)
OneToMany
Species with no ortholog for DDX19B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX19B Gene

ENSEMBL:
Gene Tree for DDX19B (if available)
TreeFam:
Gene Tree for DDX19B (if available)

Paralogs for DDX19B Gene

Paralogs for DDX19B Gene

genes like me logo Genes that share paralogs with DDX19B: view

Variants for DDX19B Gene

Sequence variations from dbSNP and Humsavar for DDX19B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3848280 -- 70,295,810(-) agcac(A/G)tacta intron-variant
rs3974177 -- 70,299,168(-) GGCGC(-/GC)NCACA utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs5817690 -- 70,294,810(+) AGCAG(-/G)CGGTT utr-variant-5-prime, upstream-variant-2KB, intron-variant
rs7184733 -- 70,310,375(+) actcc(A/G)cctca intron-variant
rs7187629 -- 70,314,563(+) ggagg(C/G)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX19B Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833271 CNV Gain+Loss 17160897
dgv2903n71 CNV Gain 21882294
esv23255 CNV Loss 19812545
esv2714670 CNV Deletion 23290073

Relevant External Links for DDX19B Gene

HapMap Linkage Disequilibrium report
DDX19B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX19B Gene

Disorders for DDX19B Gene

(1) University of Copenhagen DISEASES for DDX19B Gene

genes like me logo Genes that share disorders with DDX19B: view

No data available for UniProtKB/Swiss-Prot for DDX19B Gene

Publications for DDX19B Gene

  1. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. (PMID: 19219046) von Moeller H. … Conti E. (Nat. Struct. Mol. Biol. 2009) 3 4 23
  2. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. (PMID: 10428971) Schmitt C. … Izaurralde E. (EMBO J. 1999) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Identification and characterization of a gene coding a novel isoform of DEAD-box protein. (PMID: 12219940) Yin L. … Sha J. (Reprod. Fertil. Dev. 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DDX19B Gene

Sources for DDX19B Gene

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