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DDX19B Gene

protein-coding   GIFtS: 53
GCID: GC16P070328

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19B

(Previous names: DEAD (Asp-Glu-Ala-As) box polypeptide 19, DEAD/H (Asp-Glu-Ala-Asp/His)...)
(Previous symbol: DDX19)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19B1 2     ATP-Dependent RNA Helicase DDX19B2
DDX191 2 3 5     DEAD (Asp-Glu-Ala-As) Box Polypeptide 19B2
DBP52 3 5     DEAD-Box Protein 52
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 19 (Dbp5, Yeast, Homolog)1 2     DEAD-Box RNA Helicase DEAD52
DEAD Box Protein 19B2 3     Yeast Dbp5 Homolog2
DEAD Box RNA Helicase DEAD52 3     EC 3.6.4.133
DEAD (Asp-Glu-Ala-As) Box Polypeptide 191     TDBP3
RNAh2     EC 3.6.18
ATP-Dependent RNA Helicase DDX192     

External Ids:    HGNC: 27421   Entrez Gene: 112692   Ensembl: ENSG000001573497   OMIM: 6058125   UniProtKB: Q9UMR23   

Export aliases for DDX19B gene to outside databases

Previous GC identifers: GC16P068891 GC16P056165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX19B Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and
ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore
complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX19B Gene:
DDX19B (DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B) is a protein-coding gene. GO annotations related to this gene include RNA binding and helicase activity. An important paralog of this gene is DDX25.

UniProtKB/Swiss-Prot: DD19B_HUMAN, Q9UMR2
Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes,
DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are
dissociated and replaced by cytoplasmic mRNA binding proteins

Gene Wiki entry for DDX19B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX19B gene promoter:
         Elk-1   C/EBPbeta   Pbx1a   ATF-2   GATA-2   MZF-1   CRE-BP1   E2F   E2F-1   NF-Y   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DDX19B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX19B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.3

DDX19B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX19B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P070328:  view genomic region     (about GC identifiers)

Start:
70,323,566 bp from pter      End:
70,369,186 bp from pter
Size:
45,621 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DD19B_HUMAN, Q9UMR2 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX19B  
Size: 479 amino acids; 53927 Da
Subunit: Interacts with NUP214 or RNA in a mutually exclusive manner
6 PDB 3D structures from and Proteopedia for DDX19B:
3EWS (3D)        3FHC (3D)        3FHT (3D)        3FMO (3D)        3FMP (3D)        3G0H (3D)    
Secondary accessions: B3KNE9 B4DXS6 E7EMK4 Q6FIB7 Q6IAE0 Q96KE7 Q9H0U0
Alternative splicing: 4 isoforms:  Q9UMR2-1   Q9UMR2-2   Q9UMR2-3   Q9UMR2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX19B: NX_Q9UMR2

Explore proteomics data for DDX19B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64, Lys92, Lys187
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX19B (Q9UMR2) (see all 15)
     FVLDEAD  ALCNLYG  VINFDLP  SPLYSVK 


    See DDX19B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001014449.1  NP_001014451.1  NP_001244101.1  NP_001244102.1  NP_001244103.1  NP_001244104.1  NP_009173.1  

    ENSEMBL proteins: 
     ENSP00000454495   ENSP00000456574   ENSP00000455813   ENSP00000392639   ENSP00000456757  
     ENSP00000288071   ENSP00000455193   ENSP00000377267   ENSP00000454571   ENSP00000459407  
     ENSP00000457633   ENSP00000348271   ENSP00000457366  

    DDX19B Human Recombinant Protein Products:

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    Novus Biologicals DDX19B Proteins
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    Cloud-Clone Corp. Proteins for DDX19B

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9UMR2

    ProtoNet protein and cluster: Q9UMR2

    UniProtKB/Swiss-Prot: DD19B_HUMAN, Q9UMR2
    Domain: The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the
    N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into
    position for catalysis
    Similarity: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX19B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DD19B_HUMAN, Q9UMR2
    Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes,
    DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are
    dissociated and replaced by cytoplasmic mRNA binding proteins
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity TAS10428971
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with DDX19B           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for DDX19B:
     Decreased TP53 protein express  Decreased viability of wild-ty  Increased cell number in G1, a  Increased gamma-H2AX phosphory 
     Wnt reporter downregulated 

    Animal Models:
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    hsa-miR-579 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548m hsa-let-7g hsa-let-7a hsa-miR-630
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DD19B_HUMAN, Q9UMR2: Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein;
    Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA--
    GO:0005643nuclear pore IEA--
    GO:0005737cytoplasm IEA--
    GO:0031965nuclear membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with DDX19B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX19B
    Interactions:

        Search GeneGlobe Interaction Network for DDX19B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX19B (Q9UMR22, 3 ENSP000002880714) via UniProtKB, MINT, STRING, and/or I2D (see all 881)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    B3GALT4O960243, ENSP000003907844I2D: score=3 STRING: ENSP00000390784
    ENSG00000236802O960243, ENSP000004148804I2D: score=3 STRING: ENSP00000414880
    ENSG00000206285O960243, ENSP000003726964I2D: score=3 STRING: ENSP00000372696
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006406mRNA export from nucleus TAS10428971
    GO:0015031protein transport IEA--

    Find genes that share ontologies with DDX19B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX19B (DD19B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX19B gene (7 alternative transcripts): 
    NM_001014449.2  NM_001014451.2  NM_001257172.1  NM_001257173.1  NM_001257174.1  NM_001257175.1  NM_007242.5  

    Unigene Cluster for DDX19B:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
    Hs.221761  [show with all ESTs]
    Unigene Representative Sequence: NM_007242
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566216 ENST00000563392 ENST00000570055 ENST00000563206(uc010vlv.2)
    ENST00000451014 ENST00000569099 ENST00000568625(uc010vlw.2) ENST00000288071(uc002eyo.3 uc002eyp.3 uc002eyq.3)
    ENST00000562519(uc010vlx.2) ENST00000393657 ENST00000568008 ENST00000562912
    ENST00000568460 ENST00000355992 ENST00000568408 ENST00000569224
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DDX19B (see all 17):
    hsa-miR-579 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-548m hsa-let-7g hsa-let-7a hsa-miR-630
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      QuantiTect SYBR Green Assays in human, mouse, rat DDX19B
      QuantiFast Probe-based Assays in human, mouse, rat DDX19B

    Additional mRNA sequence: 

    AF353720.1 AJ237946.1 AK027378.1 AK223115.1 AK296868.1 AK301938.1 AK302107.1 AK316346.1 
    AL136639.1 BC003626.2 BC010008.2 BC110805.1 CR457215.1 CR533509.1 

    19 DOTS entries:

    DT.92466978  DT.409196  DT.95240705  DT.100795831  DT.95266037  DT.92467020  DT.95266038  DT.92466985 
    DT.95266032  DT.100795842  DT.453128  DT.120659649  DT.120659666  DT.99967772  DT.97860045  DT.100795830 
    DT.100795833  DT.101959511  DT.120659573 

    Selected AceView cDNA sequences (see all 474):

    BQ920804 BM551646 BU855365 CA307640 BQ887457 BQ883412 CR594442 BU178055 
    BQ936330 CR604732 BM918229 BU680471 AK027378 BU552534 BU553605 BE894824 
    BG743543 AL138068 BQ940784 AL832970 BM719178 BE746608 BU543117 AK125701 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DDX19B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                                      -     -               
    SP2:              -                       -                     
    SP3:                                                            


    ECgene alternative splicing isoforms for DDX19B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX19B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATACACAGA
    DDX19B Expression
    About this image


    DDX19B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
    DDX19B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX19B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.221761
        Custom PCR Arrays for DDX19B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX19B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDX19B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx19b1 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b1, 5 90.26(n)1
    97.29(a)1
      8 (57.88 cM)5
    2347331  NM_172284.51  NP_758488.11 
     1110031885 
    chicken
    (Gallus gallus)
    Aves DDX19B1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 82.88(n)
    93.95(a)
      426504  NM_001006568.1  NP_001006568.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia ddx19-prov2 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 more 80.07(n)    BC046696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddx192 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 more 77.62(n)   192339  BC044541.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dbp801 Dead box protein 80 60(n)
    60.78(a)
      3354919  NM_001276242.1  NP_001263171.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ddx-196
    Protein DDX-19, isoform a
    23(a)
    1 → many
    II(8884901-8889683) WBGene00011580
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP56
    Cytoplasmic ATP-dependent RNA helicase of the DEAD...
    44(a)
    1 → many
    XV(414459-415907) YOR046C


    ENSEMBL Gene Tree for DDX19B (if available)
    TreeFam Gene Tree for DDX19B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX19B gene
    DDX252  DDX19A2  ENSG000002605372  
    Selected SIMAP similar genes for DDX19B using alignment to 8 protein entries:     DD19B_HUMAN (see all proteins) (see all similar genes):
    DDX19L    DKFZp686C21137    DKFZp762C1313    DDX19A    DDX25    DDX56
    BAT1    EIF4A2    DKFZp547B159    EIF4A3    MST162    EIF4A1
    DDX39B    DDX6    DDX39A    DDX47    E4-DBP    DDX20

    Find genes that share paralogs with DDX19B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX19B (see all 434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020074841,2
    --70325661(+) TGAGC-/CGAG  
            
    CGAGA
    1 -- int10--------
    rs1870883111,2
    --70325761(+) TAAGAC/GAGATT 1 -- int10--------
    rs598498981,2
    C,F--70325940(+) TCCCAG/TCTGCT 1 -- int12Minor allele frequency- T:0.31WA 120
    rs1173049071,2
    C,F--70326011(+) GATCTC/TGCGAC 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1480557721,2
    C--70326189(+) AGGCG-/CCCACC 1 -- int10--------
    rs1900466771,2
    --70326189(+) CAGGCA/GCCACC 1 -- int10--------
    rs1159697861,2
    C,F--70326345(+) GCGTCC/TGGCCC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs614663211,2
    C,F--70326346(+) CGTCCG/AGCCCC 1 -- int12Minor allele frequency- A:0.15WA 120
    rs1409156941,2
    --70326434(+) ATATTC/TTTCTG 1 -- int10--------
    rs118663781,2
    C,F,H--70326467(+) TCAACT/AACATG 1 -- int19Minor allele frequency- A:0.12NS EA NA WA 720

    HapMap Linkage Disequilibrium report for DDX19B (70323566 - 70369186 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DDX19B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714670CNV Deletion23290073
    esv23255CNV Loss19812545
    dgv2903n71CNV Gain21882294
    nsv833271CNV Gain+Loss17160897
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX19B
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX19B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605812    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DDX19B:
    Werner syndrome

    Find genes that share disorders with DDX19B           About GenesLikeMe


    Export disorders for DDX19B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX19B gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DDX19B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. (PubMed id 10428971)1, 2, 3 Schmitt C....Izaurralde E. (EMBO J. 1999)
    2. The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner. (PubMed id 19219046)1, 2, 9 von Moeller H.... Conti E. (Nat. Struct. Mol. Biol. 2009)
    3. The DEXD/H-box RNA helicase DDX19 is regulated by an alpha-helical switch. (PubMed id 19244245)1, 2 Collins R.... Schuler H. (J. Biol. Chem. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification and characterization of a gene coding a novel isoform of DEAD-box protein. (PubMed id 12219940)1, 2 Yin L.... Sha J. (Reprod. Fertil. Dev. 2002)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. (PubMed id 23277564)1 Delker R.K....Papavasiliou F.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11269 HGNC: 2742 AceView: DDX19andFLJ11126 Ensembl:ENSG00000157349 euGenes: HUgn11269
    ECgene: DDX19B H-InvDB: DDX19B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDX19B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX19B gene:
    Search GeneIP for patents involving DDX19B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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